Detailed information for compound 56089

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.776 | Formula: C12H14ClN3O2S
  • H donors: 1 H acceptors: 1 LogP: 3.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1N=C(N(C1C)Nc1cccc(c1)Cl)S
  • InChi: 1S/C12H14ClN3O2S/c1-7-10(11(17)18-2)14-12(19)16(7)15-9-5-3-4-8(13)6-9/h3-7,10,15H,1-2H3,(H,14,19)
  • InChiKey: VOHHTGKRTTUDDQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0051 0.022
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0571 0.2649 1
Leishmania major DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0006 0.0027
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0022 0.0068
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.007 0.0287 0.1081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2132 1 1
Echinococcus multilocularis Smad4 0.0018 0.0043 0.0159
Brugia malayi MH2 domain containing protein 0.0018 0.0043 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0043 0.0159
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0043 0.0159
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0024
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0051 0.0191
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.1063 0.1478
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0131
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0038 0.0166
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.6442
Plasmodium falciparum thioredoxin reductase 0.0103 0.0443 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0127 0.0172
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0051 0.0191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0051 0.1072
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Loa Loa (eye worm) glutathione reductase 0.0103 0.0443 0.1671
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Echinococcus granulosus glutamate synthase 0.0009 0.0004 0.0013
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.007 0.0287 0.1081
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0083 0.0356
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0161 0.0157
Onchocerca volvulus 0.0028 0.0092 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0155 0.3438
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.0374 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0051 0.1274
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0008
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1531 0.7169 1
Giardia lamblia DINP protein human, muc B family 0.0043 0.0161 0.0593
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0287 0.6442
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0155 0.0542
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0131
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0287 0.1081
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Entamoeba histolytica hypothetical protein 0.0038 0.014 0.865
Brugia malayi RNA binding protein 0.0067 0.0277 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0027
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0051 0.0191
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0277 0.1032
Schistosoma mansoni hypothetical protein 0.0368 0.1693 0.6384
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.005
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0088 0.0374 0.1408
Leishmania major cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.6442
Brugia malayi hypothetical protein 0.0038 0.014 0.0602
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.007 0.0287 0.6442
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0443 0.1671
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0004 0.0013
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0127 0.2803
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.012 0.0453
Trichomonas vaginalis MYB3r3, putative 0.004 0.0149 0.3919
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0149 0.923
Trichomonas vaginalis MYB, putative 0.004 0.015 0.3944
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Mycobacterium tuberculosis Probable reductase 0.0234 0.1063 0.1478
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0051 0.0178
Brugia malayi proprotein convertase 2 0.0091 0.0388 0.167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Loa Loa (eye worm) hypothetical protein 0.007 0.0287 0.1081
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0013
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0127 0.0465
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.6442
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0287 0.6442
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0004 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0006 0.0251
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0161 0.0605
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0004 0.0013
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0127 0.2803
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0502 0.2322 1
Loa Loa (eye worm) hypothetical protein 0.0571 0.2649 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0127 0.2803
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0161 0.0219
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0277 0.1043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0211 0.0743
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Leishmania major DNA damage repair protein, putative 0.0013 0.0022 0.0411
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0277 0.1032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.1063 0.1478
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Plasmodium falciparum phosphodiesterase delta, putative 0.007 0.0287 0.6442
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Treponema pallidum NADH oxidase 0.0036 0.0127 0.0123
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.012 0.044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0088 0.0374 1
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0161 0.0693
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0149 0.923
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0502 0.2322 0.8764
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.007 0.0287 0.1081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Brugia malayi Thioredoxin reductase 0.0103 0.0443 0.1908
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0083 0.0356
Schistosoma mansoni hypothetical protein 0.0028 0.0091 0.033
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0004 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0021
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Onchocerca volvulus 0.001 0.0006 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0411
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0043 0.0159
Brugia malayi TAR-binding protein 0.0067 0.0277 0.1192
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Echinococcus granulosus Smad4 0.0018 0.0043 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0027
Echinococcus multilocularis 0.0117 0.0509 0.192
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0571 0.2649 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Echinococcus granulosus geminin 0.0368 0.1693 0.6389
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Brugia malayi MH1 domain containing protein 0.0018 0.0043 0.0184
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0287 0.6442
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0098 0.215
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Leishmania major hypothetical protein, conserved 0.007 0.0287 0.6442
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Loa Loa (eye worm) PDE1B protein 0.007 0.0287 0.1081
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3574
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.1063 0.1478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0021
Brugia malayi MH1 domain containing protein 0.0018 0.0043 0.0184
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0006 0.0027
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0161 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0006 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.007 0.0287 0.1081
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0022 0.0411
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0161 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0008
Trichomonas vaginalis C-MYB, putative 0.004 0.0149 0.3919
Entamoeba histolytica hypothetical protein 0.0038 0.014 0.865
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0131
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0601 0.279 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0008
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0004 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0006 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.014 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.026 0.1186 0.1649
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0004 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0021
Giardia lamblia High cysteine membrane protein Group 2 0.0054 0.0213 0.0789
Trypanosoma brucei trypanothione reductase 0.0103 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0209 0.0788
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0088 0.0374 0.1408
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0008
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.007 0.0287 0.6442
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0051 0.0191
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0127 0.0123
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.1063 0.1478
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0051 0.1274
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0028 0.0091 0.2362
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.0346
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.026 0.1186 0.1649
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0001
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0287 0.6442
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.7654
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0161 0.4246
Loa Loa (eye worm) nuclear factor I 0.001 0.0005 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0043 0.0159
Leishmania major DNA polymerase eta, putative 0.0042 0.0155 0.3438
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2132 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0127 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0051 0.1072
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0008
Leishmania major DNA polymerase eta, putative 0.0071 0.0294 0.6601
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.0287 0.6442
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0004 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0027
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0145 0.0641 0.2408
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0022 0.0411
Echinococcus granulosus tar DNA binding protein 0.0067 0.0277 0.1043
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0043 0.0159
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0287 0.1236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0287 0.6442
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0443 0.1671
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0241 0.0896
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0051 0.0191
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.007 0.0287 0.1081
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0161 0.0593
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.007 0.0287 0.1081
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0127 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Echinococcus multilocularis Furin 1 0.0034 0.012 0.0453
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0004 0.0017
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0443 1
Trypanosoma brucei unspecified product 0.0043 0.0161 0.3574
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0277 0.1032
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0022 0.0065
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni hypothetical protein 0.0368 0.1693 0.6384
Plasmodium falciparum cGMP-specific phosphodiesterase 0.007 0.0287 0.6442
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.007 0.0287 0.1069
Brugia malayi steroid hormone receptor 0.001 0.0006 0.0027
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0022 0.0411
Schistosoma mansoni hypothetical protein 0.0036 0.013 0.0477
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0287 0.1236
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0287 0.6442
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0143
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.007 0.0287 0.1081
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0161 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0004 0.0013
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0601 0.279 0.2787
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0127 0.0442
Trypanosoma brucei DNA polymerase eta, putative 0.0071 0.0294 0.6601
Echinococcus granulosus Furin 1 0.0034 0.012 0.0453
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.0294 0.6601
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.015 0.3944
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0051 0.0191
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.014
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.007 0.0287 0.6442
Brugia malayi MH2 domain containing protein 0.0259 0.1181 0.5085
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0021
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0022 0.0411
Echinococcus granulosus GPCR family 2 0.0017 0.0038 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0127 0.0123
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0022 0.0411
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2132 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0051 0.1072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.1063 0.1478
Giardia lamblia Myb 1-like protein 0.004 0.015 0.0551
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.014 0.0525
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0143
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0127 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0143
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0127 0.2803
Echinococcus multilocularis GPCR, family 2 0.0017 0.0038 0.0143
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0161 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0277 0.1192
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0004 0.0009
Brugia malayi glutathione reductase 0.0103 0.0443 0.1908
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0004 0.0017
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.007 0.0287 0.1069
Echinococcus granulosus cpg binding protein 0.003 0.01 0.0375
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0021
Brugia malayi Smad1 0.0018 0.0043 0.0184
Loa Loa (eye worm) hypothetical protein 0.0145 0.0641 0.2417
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.0287 0.1081
Loa Loa (eye worm) RecQ helicase 0.0019 0.0051 0.0191
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0149 0.923
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0004 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0006 0.0251
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0191
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0127 0.2803
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0051 0.1072
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0601 0.279 0.2787
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni furin-1 (S08 family) 0.0063 0.0256 0.0952
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0127 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0287 0.7654
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0143
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.013 0.0561
Entamoeba histolytica hypothetical protein 0.0038 0.014 0.865
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0571 0.2649 1
Plasmodium falciparum glutathione reductase 0.0103 0.0443 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0004 0.0013
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.1849 0.698
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0277 0.1032
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0443 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.007 0.0287 0.7654
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3574
Loa Loa (eye worm) endoprotease bli-4 0.0145 0.0641 0.2417
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trichomonas vaginalis C-MYB, putative 0.004 0.0149 0.3919
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0022 0.0411
Schistosoma mansoni smad 0.0018 0.0043 0.0146
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0287 0.1081
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0006 0.0027
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.007 0.0287 0.1236
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0022 0.0065
Mycobacterium ulcerans hypothetical protein 0.0013 0.0022 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0127 0.2803
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.007 0.0287 0.1081
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.0397
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0022 0.0411
Echinococcus multilocularis cpg binding protein 0.003 0.01 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0127 0.3331
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Plasmodium vivax glutathione reductase, putative 0.0103 0.0443 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Brugia malayi neuroendocrine convertase 1 precursor 0.0091 0.0388 0.167
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0027
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0127 0.2803
Giardia lamblia DNA damage repair protein 0.0013 0.0022 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0021
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0006 0.0002
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Schistosoma mansoni DNA helicase recq5 0.0019 0.0051 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0081
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Trypanosoma brucei unspecified product 0.0029 0.0098 0.215
Entamoeba histolytica hypothetical protein 0.0038 0.014 0.865
Brugia malayi MH2 domain containing protein 0.0018 0.0043 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0027
Echinococcus multilocularis geminin 0.0368 0.1693 0.6389
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0127 0.3331
Schistosoma mansoni hypothetical protein 0.0401 0.1849 0.6976
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.049
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus granulosus bloom syndrome protein 0.0019 0.0051 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0161 0.0219
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0287 0.6442
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0161 0.3574
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0022 0.0411
Schistosoma mansoni Smad4 0.0018 0.0043 0.0146
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0146
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0028 0.0091 0.2362
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0051 0.1274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0287 0.7654
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Leishmania major DNA polymerase kappa, putative 0.0013 0.0022 0.0411
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0051 0.022
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0008
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.007 0.0287 0.1236
Brugia malayi endoprotease bli-4 precursor 0.0145 0.0641 0.276
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0127 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0027
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0051 0.3001
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0131
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0149 0.923
Loa Loa (eye worm) RNA binding protein 0.0067 0.0277 0.1043
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0161 0.0593
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0287 0.7654
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0127 0.0442
Loa Loa (eye worm) MH2 domain-containing protein 0.0259 0.1181 0.4455
Plasmodium falciparum glutathione reductase 0.0036 0.0127 0.2803
Schistosoma mansoni cpg binding protein 0.003 0.01 0.0362
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0127 0.2803
Loa Loa (eye worm) transcription factor SMAD2 0.0259 0.1181 0.4455
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.007 0.0287 0.1236
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Brugia malayi ImpB/MucB/SamB family protein 0.0071 0.0294 0.1265
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0127 0.2803
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0601 0.279 0.3888
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.005
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Leishmania major hypothetical protein, conserved 0.007 0.0287 0.6442
Entamoeba histolytica recQ family helicase, putative 0.001 0.0004 0.0026
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0004 0.0013
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0006 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0098 0.215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0209 0.0788
Schistosoma mansoni hypothetical protein 0.0038 0.014 0.0513
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0127 0.0478
Schistosoma mansoni DNA helicase recq1 0.0019 0.0051 0.0178
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0143
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0008
Echinococcus multilocularis dna polymerase eta 0.0071 0.0294 0.1107
Schistosoma mansoni DNA polymerase eta 0.0071 0.0294 0.1096
Plasmodium falciparum thioredoxin reductase 0.0036 0.0127 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0127 0.0123
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.012 0.315
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.0287 0.1015
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.0149 0.3919
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3574
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0127 0.0123
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.0287 0.1081
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.004 0.015 0.0523
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.007 0.0287 0.1236
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Trichomonas vaginalis hypothetical protein 0.0028 0.0091 0.2362
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0043 0.0146
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.007 0.0287 0.1081
Echinococcus multilocularis neuroendocrine convertase 2 0.0091 0.0388 0.1462
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0051 0.0169
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0127 0.2803
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1531 0.7169 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0277 0.1043
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.007 0.0287 0.6442
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0127 0.0465
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0161 0.0605
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0127 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0027
Echinococcus granulosus neuroendocrine convertase 2 0.0091 0.0388 0.1462
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0571 0.2649 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0146
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0051 0.022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0127 0.2803
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Brugia malayi celfurPC protein 0.0117 0.0509 0.2192
Trypanosoma brucei unspecified product 0.0029 0.0098 0.215
Giardia lamblia Hypothetical protein 0.007 0.0287 0.1069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0038 0.0166
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0443 0.1671
Loa Loa (eye worm) Smad1 0.0018 0.0043 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.026 0.1186 0.1649
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0051 0.1072
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni cpg binding protein 0.003 0.01 0.0362
Brugia malayi ecdysteroid receptor 0.001 0.0006 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0006 0.0021
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0028 0.0091 0.2362
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0004 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0277 0.1043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0051 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0021
Brugia malayi polk-prov protein 0.0013 0.0022 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0027
Trichomonas vaginalis MYB72, putative 0.004 0.0149 0.3919
Loa Loa (eye worm) hypothetical protein 0.007 0.0287 0.1081
Plasmodium vivax phosphodiesterase gamma, putative 0.007 0.0287 0.6442
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.004 0.015 0.3944
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0209 0.0901
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0287 0.6442
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Loa Loa (eye worm) hypothetical protein 0.0071 0.0294 0.1107
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0571 0.2649 1
Trichomonas vaginalis pc-MYB2, putative 0.004 0.0149 0.3919
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0277 0.1032
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.007 0.0287 0.1069
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0043 0.0159
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0401 0.1849 0.698
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0098 0.215
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0091 0.2362
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0021
Echinococcus granulosus furin 0.0145 0.0641 0.2417
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.004 0.0149 0.923
Plasmodium falciparum phosphodiesterase gamma, putative 0.007 0.0287 0.6442
Trichomonas vaginalis pc-MYB2, putative 0.004 0.0149 0.3919
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0333
Schistosoma mansoni smad1 5 8 and 0.0018 0.0043 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0038 0.0143
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.026 0.1186 0.1649
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0022 0.0411
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0127 0.0123
Trypanosoma brucei cAMP-specific phosphodiesterase 0.007 0.0287 0.6442
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.7654
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.1063 0.1478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0021
Echinococcus granulosus dna polymerase eta 0.0071 0.0294 0.1107
Giardia lamblia Furin precursor putative serine protease 0.0028 0.0091 0.033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0443 0.0613
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.014 0.0525
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0161 0.4246
Echinococcus multilocularis smad 0.0018 0.0043 0.0159
Loa Loa (eye worm) hypothetical protein 0.0057 0.0227 0.0854
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.007 0.0287 0.1069
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0571 0.2649 0.9495
Echinococcus granulosus dna polymerase kappa 0.0043 0.0161 0.0605
Toxoplasma gondii thioredoxin reductase 0.0103 0.0443 0.1576
Giardia lamblia hypothetical protein 0.007 0.0287 0.1069
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.007 0.0287 0.1081
Echinococcus multilocularis glutamate synthase 0.0009 0.0004 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0021
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0571 0.2649 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0502 0.2322 0.8764
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0022 0.0411
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.0287 0.6442
Leishmania major trypanothione reductase 0.0103 0.0443 1
Brugia malayi glutamate synthase 0.0009 0.0004 0.0017
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0021
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0004 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3574
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0027
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0022 0.0411
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0502 0.2322 0.8764
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0021
Echinococcus granulosus smad 0.0018 0.0043 0.0159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0209 0.0901
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.007 0.0287 0.7654

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 48.8 uM Concentration that reducedthe MT-4 cell viability by 50%. ChEMBL. 12672256
CC50 (functional) = 48.8 uM Concentration that reducedthe MT-4 cell viability by 50%. ChEMBL. 12672256
IC50 (functional) ND 0 uM Concentration required to inhibit the viral (HIV-1 NNRTI resistant strain) cytopathic effect by 50% in MT-4 cells. ChEMBL. 12672256
IC50 (functional) > 48.8 uM Concentration required to inhibit the viral (HIV-1 IIIB strain) cytopathic effect by 50% in MT-4 cells. ChEMBL. 12672256
IC50 (functional) > 48.8 uM Concentration required to inhibit the viral (HIV-1 NL4.3 strain) cytopathic effect by 50% in MT-4 cells. ChEMBL. 12672256
IC50 (functional) > 48.8 uM Concentration required to inhibit the viral (HIV-2 ROD) cytopathic effect by 50% in MT-4 cells. ChEMBL. 12672256
IC50 (functional) > 48.8 uM Concentration required to inhibit the viral (SIV mac251) cytopathic effect by 50% in MT-4 cells. ChEMBL. 12672256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.