Detailed information for compound 561307

Basic information

Technical information
  • TDR Targets ID: 561307
  • Name: 3689-24-5
  • MW: 322.319 | Formula: C8H20O5P2S2
  • H donors: 0 H acceptors: 0 LogP: 3.88 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=S)(OP(=S)(OCC)OCC)OCC
  • InChi: 1S/C8H20O5P2S2/c1-5-9-14(16,10-6-2)13-15(17,11-7-3)12-8-4/h5-8H2,1-4H3
  • InChiKey: XIUROWKZWPIAIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-01-00-01351 (Beilstein Handbook Reference)
  • 45664_RIEDEL
  • 8054-28-2
  • AI3-16273
  • ASP 47
  • ASP47
  • Bay-e-393
  • Bayer-E 393
  • Bis(O,O-diethylphosphorothionic) anhydride
  • Bis-O,O-diethylphosphorothionic anhydride
  • Bis[O,O-diethylphosphorothionic] anhydride
  • Bladafum
  • Bladafume
  • Bladafun
  • BRN 1714019
  • Caswell No. 837
  • CCRIS 4725
  • CHEBI:38945
  • Di(thiophosphoric) acid, tetraethyl ester
  • diethoxyphosphinothioyloxy-diethoxy-thioxo-phosphorane
  • diethoxyphosphinothioyloxy-diethoxy-thioxophosphorane
  • diethoxyphosphinothioyloxy-diethoxy-sulfanylidene-$l^{5}-phosphane
  • diethoxyphosphinothioyloxy-diethoxy-sulfanylidenephosphorane
  • diethoxyphosphinothioyloxy-diethoxy-sulfanylidene-phosphorane
  • diethoxythiophosphoryloxy-diethoxy-thioxo-phosphorane
  • Dithio
  • Dithio (pesticide)
  • Dithiodiphosphoric acid, tetraethyl ester
  • Dithiofos
  • Dithion
  • Dithion (VAN)
  • Dithione
  • Dithiophos
  • Dithiopyrophosphate de tetraethyle [French]
  • Dithiopyrophosphate de tetraethyle
  • Dithiotep
  • E393
  • EINECS 222-995-2
  • ENT 16,273
  • EPA Pesticide Chemical Code 079501
  • Ethyl thiopyrophosphate ((EtO)2(PS)2O)
  • Ethyl thiopyrophosphate
  • Ethyl thiopyrophosphate ([(EtO)2PS]2O)
  • Fulex
  • HSDB 380
  • Lethalaire g-57
  • NSC 66403
  • NSC66403
  • O,O,O',O'-Tetraethyl dithiopyrophosphate
  • O,O,O,O-Tetraaethyl-dithionopyrophosphat [German]
  • O,O,O,O-Tetraethyl-dithio-difosfaat [Dutch]
  • O,O,O,O-Tetraetil-ditio-pirofosfato [Italian]
  • O,O,O,O-Tetraethyl dithiopyrophosphate
  • O,O,O,O-Tetraethyl-dithio-difosfaat
  • O,O,O,O-Tetraetil-ditio-pirofosfato
  • O,O,O,O-tetraethyl dithiodiphosphate
  • Pirofos
  • Plant dithio aerosol
  • Plantfume 103 smoke generator
  • PS2024_SUPELCO
  • Pyrophosphoric acid, dithiono-, tetraethyl ester
  • Pyrophosphoric acid, tetraethyldithio-, (liquid mixture)
  • Pyrophosphorodithioic acid, O,O,O,O-tetraethyl ester
  • Pyrophosphorodithioic acid, tetraethyl ester
  • RCRA waste no. P109
  • RCRA waste number P109
  • ST5409443
  • Sulfatep
  • Sulfotep
  • Sulfotep [BSI:ISO]
  • sulfotepp
  • Sulfotepp [ESA]
  • TEDP
  • TEDTP
  • Tetraethyl dithiopyrophosphate [UN1704] [Poison]
  • Tetraethyl thiodiphosphate
  • Tetraethyl thiopyrophosphate (8CI)
  • Tetraethyldithiodifosfat [Czech]
  • Tetraethyldithiopyrophosphate
  • Tetraethyl dithio pyrophosphate, liquid
  • Tetraethyl dithionopyrophosphate
  • Tetraethyl dithiopyrophosphate
  • Tetraethyl dithiopyrophosphate mixture, liquid
  • Thiodiphosphoric acid (((HO)2P(S))2O), tetraethyl ester (9CI)
  • Thiodiphosphoric acid tetraethyl ester
  • Thiodiphosphoric acid, tetraethyl ester
  • Thiodiphosphoric acid ([(HO)2P(S)]2O), tetraethyl ester
  • Thiopyrophosphoric acid (((HO)2PS)2O), tetraethyl ester (8CI)
  • Thiopyrophosphoric acid ([(HO)2PS]2O), tetraethyl ester
  • Thiopyrophosphoric acid, tetraethyl ester
  • Thiotepp
  • UN1704
  • WLN: 2OPS&O2&OPS&O2&O2
  • WLN: 2OPS&O2&OPS&O2&O2 -LIQUID MIX

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Loa Loa (eye worm) glutaminase 2 0.0269 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0167 0.5037 0.9809
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Loa Loa (eye worm) glutaminase 0.0269 1 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0169 0.5134 0.1302
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0153 0.4406 0.5
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0153 0.4406 0.5
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0153 0.4406 0.4406
Schistosoma mansoni methylthioadenosine phosphorylase 0.0169 0.5134 0.5134
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0169 0.5134 0.5134
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0169 0.5134 0.5
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Schistosoma mansoni glutaminase 0.0269 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0169 0.5134 0.5
Echinococcus multilocularis purine nucleoside phosphorylase 0.0101 0.186 0.3622
Schistosoma mansoni purine nucleoside phosphorylase 0.0153 0.4406 0.4406
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0167 0.5037 0.9809
Brugia malayi MTAP 0.0169 0.5134 0.5134
Schistosoma mansoni purine nucleoside phosphorylase 0.0153 0.4406 0.4406
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0169 0.5134 0.5
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0153 0.4406 0.5
Schistosoma mansoni methylthioadenosine phosphorylase 0.0169 0.5134 0.5134
Leishmania major methylthioadenosine phosphorylase, putative 0.0169 0.5134 0.5
Trichomonas vaginalis glutaminase, putative 0.0269 1 1
Echinococcus granulosus methylthioadenosine phosphorylase 0.0169 0.5134 1
Loa Loa (eye worm) hypothetical protein 0.02 0.6659 0.6659
Mycobacterium ulcerans glutaminase 0.0269 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.186 0.186
Echinococcus granulosus purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis purine nucleoside phosphorylase 0.0101 0.186 0.3622
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0153 0.4406 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.6659 0.6659
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0101 0.186 0.3622
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis purine nucleoside phosphorylase 0.0153 0.4406 0.8582
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0169 0.5134 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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