Detailed information for compound 561634

Basic information

Technical information
  • TDR Targets ID: 561634
  • Name: 3-[3-(dimethylamino)propyl]-3-phenyl-isobenzo furan-1-one
  • MW: 295.376 | Formula: C19H21NO2
  • H donors: 0 H acceptors: 1 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCC1(OC(=O)c2c1cccc2)c1ccccc1)C
  • InChi: 1S/C19H21NO2/c1-20(2)14-8-13-19(15-9-4-3-5-10-15)17-12-7-6-11-16(17)18(21)22-19/h3-7,9-12H,8,13-14H2,1-2H3
  • InChiKey: BHDBEMWNWGBDBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[3-(dimethylamino)propyl]-3-phenyl-1-isobenzofuranone
  • 3-[3-(dimethylamino)propyl]-3-phenyl-2-benzofuran-1-one
  • 3-[3-(dimethylamino)propyl]-3-phenyl-phthalide
  • ICI 53165
  • 3-(3-dimethylaminopropyl)-3-phenyl-2-benzofuran-1-one
  • 3-(3-dimethylaminopropyl)-3-phenyl-isobenzofuran-1-one
  • 3-(3-dimethylaminopropyl)-3-phenyl-1-isobenzofuranone
  • 37401-68-6
  • Phthalide, 3-(3-dimethylaminopropyl)-3-phenyl-
  • 3-(gamma-Dimethylaminopropyl)-3-phenylphthalide
  • 3-gamma-Dimethylaminopropyl-3-phenylphthalide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0063 0.1215 0.1401
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0245 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0245 0.023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0223 0.1208
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0223 0.1208
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0223 0.5
Schistosoma mansoni hypothetical protein 0.0094 0.1888 0.2186
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0484 0.5406
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0245 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0791 0.0905
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0355 0.3322
Brugia malayi hypothetical protein 0.0016 0.0162 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0791 0.0791
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0223 0.0209
Brugia malayi steroid hormone receptor 0.002 0.0245 0.023
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0015 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0245 0.0268
Brugia malayi isocitrate dehydrogenase 0.0015 0.0148 0.0134
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0048 0.088 0.088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0426 0.0426
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0245 0.0268
Schistosoma mansoni hypothetical protein 0.0395 0.8585 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0791 0.0791
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.2534 0.2534
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0223 0.1208
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Loa Loa (eye worm) RNA binding protein 0.0067 0.1296 0.1296
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0791 0.0791
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0223 0.0223
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0015 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0245 0.0245
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0245 0.0245
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0223 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0148 0.0148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0245 0.0245
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0039 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0015 0.0015
Brugia malayi hypothetical protein 0.0025 0.0355 0.0341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0791 0.0905
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1215 0.1215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0015 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0223 0.0223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0223 0.5
Loa Loa (eye worm) hypothetical protein 0.02 0.4253 0.4253
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0223 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0245 0.023
Brugia malayi nuclear receptor NHR-88 0.002 0.0245 0.023
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0223 0.1904
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1215 0.1202
Schistosoma mansoni hypothetical protein 0.0164 0.3445 0.4002
Schistosoma mansoni hypothetical protein 0.0063 0.1215 0.1401
Brugia malayi RNA binding protein 0.0067 0.1296 0.1283
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1215 0.1215
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.088 0.1009
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.2534 0.2534
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0245 0.023
Schistosoma mansoni thyroid hormone receptor 0.0142 0.2969 0.3447
Schistosoma mansoni hypothetical protein 0.0164 0.3445 0.4002
Echinococcus multilocularis tumor protein p63 0.0329 0.7121 0.7121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0791 0.0777
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0245 0.0245
Schistosoma mansoni DNA polymerase eta 0.0043 0.077 0.0881
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0355 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0245 0.0268
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Schistosoma mansoni thyroid hormone receptor 0.0142 0.2969 0.3447
Schistosoma mansoni cpg binding protein 0.0029 0.0461 0.052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.1888 0.1876
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0039 0.0029
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0223 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0123 0.2534 0.2939
Brugia malayi CXXC zinc finger family protein 0.0028 0.0426 0.0411
Echinococcus granulosus tumor protein p63 0.0329 0.7121 0.7121
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0015 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0039 0.0039
Trypanosoma brucei unspecified product 0.0019 0.0223 0.1904
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0245 0.0245
Schistosoma mansoni nuclear hormone receptor 0.002 0.0245 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0245 0.023
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1296 0.1495
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0039 0.0025
Echinococcus granulosus tar DNA binding protein 0.0067 0.1296 0.1296
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.077 0.0756
Echinococcus multilocularis survival motor neuron protein 1 0.0459 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0245 0.0245
Echinococcus granulosus FTZ F1 alpha 0.002 0.0245 0.0245
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0015 0.0015
Loa Loa (eye worm) DR-78 0.0009 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0245 0.0245
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.077 1
Schistosoma mansoni hypothetical protein 0.0063 0.1215 0.1401
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.4253 0.4253
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0484 0.4057
Echinococcus granulosus dna polymerase eta 0.0043 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Brugia malayi ecdysteroid receptor 0.002 0.0245 0.023
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0148 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0245 0.0245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0015 0.0015
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0223 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1215 0.1215
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0245 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Leishmania major DNA polymerase kappa, putative 0.0019 0.0223 0.1208
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0355 0.0355
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1215 0.1215
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0355 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0148 0.0148
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0245 0.0268
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0245 0.0245
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.2969 0.2969
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1296 0.1495
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0245 0.0268
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1116 0.1285
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0223 0.0243
Loa Loa (eye worm) hypothetical protein 0.0248 0.531 0.531
Echinococcus multilocularis geminin 0.0164 0.3445 0.3445
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0245 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0245 0.0245
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0223 0.1904
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0015 0.0015
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0148 0.0148
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0148 0.0156
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1296 0.1296
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0063 0.1215 0.1401
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0148 0.0134
Giardia lamblia DINP protein human, muc B family 0.0019 0.0223 0.5
Brugia malayi nuclear hormone receptor 0.002 0.0245 0.023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.8585 0.8585
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0977 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1296 0.1283
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0245 0.0268
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1296 0.1495
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0063 0.1215 0.1215
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0355 0.385
Echinococcus granulosus geminin 0.0164 0.3445 0.3445
Leishmania major DNA polymerase eta, putative 0.003 0.0484 0.5406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1215 0.1215
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0245 0.1228
Brugia malayi TAR-binding protein 0.0067 0.1296 0.1283
Loa Loa (eye worm) hypothetical protein 0.0137 0.2847 0.2847
Onchocerca volvulus 0.002 0.0245 0.1228
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0223 0.1208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0459 1 1
Echinococcus granulosus GPCR family 2 0.0063 0.1215 0.1215
Echinococcus granulosus dnaJ subfamily B 0.0395 0.8585 0.8585
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0355 0.3322
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1296 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0245 0.023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0015 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0355 0.2493
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0245 0.0245
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0015 0.0015
Onchocerca volvulus 0.0028 0.0426 0.2193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0245 0.0245
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0039 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0223 0.0223
Echinococcus granulosus survival motor neuron protein 1 0.0459 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.2847 0.2837
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.4253 0.4245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0245 0.023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0245 0.023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0039 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus granulosus dna polymerase kappa 0.0019 0.0223 0.0223
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0245 0.1228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0791 0.0791
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Echinococcus granulosus cpg binding protein 0.0029 0.0461 0.0461
Schistosoma mansoni hypothetical protein 0.0137 0.2847 0.3305
Schistosoma mansoni cpg binding protein 0.0029 0.0461 0.052
Schistosoma mansoni coup transcription factor 0.002 0.0245 0.0268
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Leishmania major DNA polymerase eta, putative 0.0043 0.077 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0245 0.023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0223 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0245 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0015 0.0015
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0148 0.0791
Echinococcus multilocularis dna polymerase eta 0.0043 0.077 0.077
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0355 1
Brugia malayi hypothetical protein 0.001 0.0039 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0245 0.023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0245 0.023
Schistosoma mansoni cpg binding protein 0.0028 0.0426 0.0479
Echinococcus multilocularis cpg binding protein 0.0029 0.0461 0.0461
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0054 0.0054
Onchocerca volvulus 0.0094 0.1888 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.4253 0.4245
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0223 0.1904
Echinococcus multilocularis GPCR, family 2 0.0063 0.1215 0.1215
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0223 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0245 0.0245
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0043 0.077 0.077
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0223 0.0243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0791 0.0905
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1215 0.1202
Leishmania major hypothetical protein, conserved 0.0025 0.0355 0.3322
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0054 0.0054
Onchocerca volvulus 0.0048 0.088 0.4617
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0223 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1296 0.1296
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0245 0.023
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0245 0.0268
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0245
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0791 0.0791
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0245 0.0245
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1296 0.1296
Schistosoma mansoni survival motor neuron protein 0.0094 0.1888 0.2186
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.077 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0245 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0245 0.0245
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0245 0.1228
Brugia malayi nuclear receptor RXR 0.001 0.0039 0.0025
Brugia malayi hypothetical protein 0.001 0.0039 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0248 0.531 0.5303
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0245 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1296 0.1495
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0245 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0245 0.023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0223 0.1208

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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