Detailed information for compound 56165

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 623.741 | Formula: C36H41N5O5
  • H donors: 2 H acceptors: 5 LogP: 4.2 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(c1c2[nH]c(c1C)/C=C/1\N=C([C@H]([C@@H]1C)CCC(=O)OC)C1=C3N=C(/C=c/4\[nH]/c(=C\2)/c(C)c4CC)C(=C3C(=O)N(C1=O)C)C)C
  • InChi: 1S/C36H41N5O5/c1-10-21-16(2)23-15-28-30(20(6)45-8)18(4)25(38-28)13-24-17(3)22(11-12-29(42)46-9)33(39-24)32-34-31(35(43)41(7)36(32)44)19(5)26(40-34)14-27(21)37-23/h13-15,17,20,22,37-38H,10-12H2,1-9H3/b23-15-,24-13-,25-13-,26-14-,27-14-,28-15-,33-32+/t17-,20?,22-/m0/s1
  • InChiKey: SHYXLTMMPSGUKZ-XAWYEAFISA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0098 0.2188
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.1166 0.4512
Plasmodium falciparum glutathione reductase 0.0036 0.0125 0.2803
Brugia malayi TAR-binding protein 0.0067 0.0269 0.1188
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0161 0.061
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0125 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0279 0.7639
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0196
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0128
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.0149 0.9234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Brugia malayi endoprotease bli-4 precursor 0.0143 0.0625 0.276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0022
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0125 0.2803
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0011
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0069 0.0279 0.1231
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0011
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Leishmania major DNA polymerase kappa, putative 0.0013 0.0022 0.0428
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0279 0.7639
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.1327
Brugia malayi CXXC zinc finger family protein 0.0029 0.0092 0.0408
Schistosoma mansoni Smad4 0.0018 0.0042 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0022 0.0428
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0148
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0069 0.0279 0.6347
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus granulosus bloom syndrome protein 0.002 0.0051 0.0196
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0161 0.022
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus multilocularis geminin 0.0368 0.1672 0.6471
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0125 0.3374
Schistosoma mansoni hypothetical protein 0.0407 0.1854 0.7173
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0125 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0027
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0083
Schistosoma mansoni cpg binding protein 0.003 0.01 0.0375
Brugia malayi MH2 domain containing protein 0.0018 0.0042 0.0184
Entamoeba histolytica hypothetical protein 0.0038 0.0135 0.8377
Schistosoma mansoni DNA helicase recq5 0.002 0.0051 0.0185
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Giardia lamblia DNA damage repair protein 0.0013 0.0022 0.0072
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0125 0.0471
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0006 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0022
Brugia malayi neuroendocrine convertase 1 precursor 0.009 0.0378 0.1668
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0027
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0027
Plasmodium vivax glutathione reductase, putative 0.0103 0.0437 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0125 0.3374
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0022 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0022
Trypanosoma brucei unspecified product 0.003 0.0098 0.2188
Mycobacterium ulcerans hypothetical protein 0.0013 0.0022 0.0019
Treponema pallidum NADH oxidase 0.0036 0.0125 0.0122
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0279 0.1077
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0279 0.6347
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0022 0.0067
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0006 0.0027
Schistosoma mansoni smad 0.0018 0.0042 0.0148
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0022 0.0428
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0069 0.0279 0.1077
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Trichomonas vaginalis C-MYB, putative 0.0041 0.0149 0.4033
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3629
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0027
Loa Loa (eye worm) endoprotease bli-4 0.0143 0.0625 0.2418
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0269 0.103
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.0437 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0428
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0564 0.2584 1
Plasmodium falciparum glutathione reductase 0.0103 0.0437 1
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.1854 0.7177
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0126 0.0556
Entamoeba histolytica hypothetical protein 0.0038 0.0135 0.8377
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0027
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0279 0.7639
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0139
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0609 0.279 0.2788
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0249 0.0952
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0125 0.2803
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0006 0.0321
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0011
Entamoeba histolytica recQ family helicase, putative 0.002 0.0051 0.3039
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0125 0.2803
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0051 0.1103
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0011
Loa Loa (eye worm) RecQ helicase 0.002 0.0051 0.0196
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.0149 0.9234
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0098 0.2188
Brugia malayi Smad1 0.0018 0.0042 0.0184
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0143 0.0625 0.2418
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0069 0.0279 0.1077
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0069 0.0279 0.1068
Brugia malayi glutathione reductase 0.0103 0.0437 0.1931
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0015
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0004 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0125 0.2803
Echinococcus multilocularis GPCR, family 2 0.0017 0.0036 0.0139
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0161 0.0158
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0269 0.104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0139
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.105 0.146
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0135 0.0522
Giardia lamblia Myb 1-like protein 0.0041 0.015 0.0567
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0036 0.0139
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0125 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0022
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2159 1 1
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0022 0.0428
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.1103
Echinococcus granulosus GPCR family 2 0.0017 0.0036 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0125 0.2803
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0022
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0022 0.0428
Brugia malayi MH2 domain containing protein 0.026 0.1166 0.515
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0069 0.0279 0.6347
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0279 0.6347
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Giardia lamblia High cysteine membrane protein Group 2 0.0053 0.0207 0.0788
Echinococcus granulosus smad 0.0018 0.0042 0.0159
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0027
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0496 0.2264 0.8763
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0022 0.0428
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0003 0.0011
Giardia lamblia DINP protein human, muc B family 0.0043 0.0161 0.061
Leishmania major trypanothione reductase 0.0103 0.0437 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0022
Brugia malayi glutamate synthase 0.0009 0.0003 0.0015
Plasmodium falciparum phosphodiesterase gamma, putative 0.0069 0.0279 0.6347
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0496 0.2264 0.8763
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0022 0.0428
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0564 0.2584 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0069 0.0279 0.1077
Echinococcus multilocularis glutamate synthase 0.0009 0.0003 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0022
Echinococcus granulosus dna polymerase kappa 0.0043 0.0161 0.062
Toxoplasma gondii thioredoxin reductase 0.0103 0.0437 0.1558
Giardia lamblia hypothetical protein 0.0069 0.0279 0.1068
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0564 0.2584 0.926
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0161 0.3629
Echinococcus multilocularis smad 0.0018 0.0042 0.0159
Loa Loa (eye worm) hypothetical protein 0.0056 0.022 0.0851
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0135 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.105 0.146
Echinococcus granulosus dna polymerase eta 0.0072 0.0294 0.1135
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.0437 0.0606
Leishmania major hypothetical protein, conserved 0.0069 0.0279 0.6347
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0125 0.0122
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.1171 0.163
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0022 0.0428
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0036 0.0139
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Trichomonas vaginalis pc-MYB2, putative 0.0041 0.0149 0.4033
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.0149 0.9234
Echinococcus granulosus furin 0.0143 0.0625 0.2418
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0407 0.1854 0.7177
Echinococcus granulosus cpg binding protein 0.003 0.01 0.0385
Schistosoma mansoni cpg binding protein 0.0029 0.0092 0.0345
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0042 0.0159
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0069 0.0279 0.1068
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0269 0.103
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0564 0.2584 1
Trichomonas vaginalis pc-MYB2, putative 0.0041 0.0149 0.4033
Loa Loa (eye worm) hypothetical protein 0.0072 0.0294 0.1135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0203 0.0897
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0161 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Plasmodium vivax phosphodiesterase gamma, putative 0.0069 0.0279 0.6347
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.015 0.4058
Trypanosoma brucei hypothetical protein, conserved 0.0069 0.0279 0.6347
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0027
Trichomonas vaginalis MYB72, putative 0.0041 0.0149 0.4033
Loa Loa (eye worm) hypothetical protein 0.0069 0.0279 0.1077
Brugia malayi polk-prov protein 0.0013 0.0022 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0172
Brugia malayi RNA binding protein 0.0067 0.0269 0.1188
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0006 0.0022
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0003 0.0011
Onchocerca volvulus 0.0029 0.0092 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.1103
Trypanosoma brucei unspecified product 0.003 0.0098 0.2188
Brugia malayi ecdysteroid receptor 0.001 0.0006 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0437 0.1691
Loa Loa (eye worm) Smad1 0.0018 0.0042 0.0159
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.1171 0.163
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Brugia malayi celfurPC protein 0.0115 0.0496 0.2192
Schistosoma mansoni cpg binding protein 0.003 0.01 0.0375
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Giardia lamblia Hypothetical protein 0.0069 0.0279 0.1068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0036 0.0161
Echinococcus granulosus neuroendocrine convertase 2 0.009 0.0378 0.146
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0564 0.2584 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0042 0.0148
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0125 0.0482
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0161 0.062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0027
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.155 0.7169 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0269 0.1188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0125 0.2803
Echinococcus multilocularis neuroendocrine convertase 2 0.009 0.0378 0.146
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0172
Schistosoma mansoni hypothetical protein 0.0036 0.0126 0.0475
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0042 0.0148
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0069 0.0279 0.1077
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0069 0.0279 0.1231
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0028 0.0088 0.2352
Giardia lamblia Furin precursor putative serine protease 0.0028 0.0088 0.0329
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0069 0.0279 0.1077
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0041 0.015 0.0525
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3629
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0125 0.2803
Schistosoma mansoni DNA polymerase eta 0.0072 0.0294 0.1126
Plasmodium falciparum thioredoxin reductase 0.0036 0.0125 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0125 0.0122
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0011
Echinococcus multilocularis dna polymerase eta 0.0072 0.0294 0.1135
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0125 0.0482
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0036 0.0139
Schistosoma mansoni DNA helicase recq1 0.002 0.0051 0.0185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0203 0.0897
Echinococcus multilocularis cpg binding protein 0.003 0.01 0.0385
Schistosoma mansoni hypothetical protein 0.0038 0.0135 0.0511
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0092 0.0356
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0006 0.0022
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Entamoeba histolytica recQ family helicase, putative 0.001 0.0004 0.0067
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0011
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0609 0.279 0.3889
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.0065
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0004
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0294 0.1297
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0125 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.0279 0.1231
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0006 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0125 0.2803
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.1166 0.4512
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0428
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0042 0.0159
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Onchocerca volvulus 0.001 0.0006 0.0321
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0081 0.0358
Schistosoma mansoni hypothetical protein 0.0028 0.0088 0.0329
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0069 0.0279 0.1231
Brugia malayi Thioredoxin reductase 0.0103 0.0437 0.1931
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0496 0.2264 0.8763
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0069 0.0279 0.1077
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.0149 0.9234
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0364 1
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0161 0.071
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0125 0.0552
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0269 0.103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.105 0.146
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Leishmania major DNA damage repair protein, putative 0.0013 0.0022 0.0428
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0269 0.104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0203 0.0784
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0161 0.022
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0125 0.0122
Loa Loa (eye worm) hypothetical protein 0.0564 0.2584 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0011
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0125 0.2803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0496 0.2264 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0161 0.4367
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0006 0.0321
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0125 0.0471
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0069 0.0279 0.1077
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0117 0.0439
Brugia malayi proprotein convertase 2 0.009 0.0378 0.1668
Echinococcus granulosus Furin 1 0.0034 0.0117 0.0449
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.0149 0.4033
Mycobacterium tuberculosis Probable reductase 0.0234 0.105 0.146
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0051 0.0185
Trichomonas vaginalis MYB, putative 0.0041 0.015 0.4058
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0041 0.0149 0.9234
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0011
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0125 0.2803
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Trichomonas vaginalis MYB3r3, putative 0.0041 0.0149 0.4033
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0069 0.0279 0.6347
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0437 0.1691
Schistosoma mansoni hypothetical protein 0.0368 0.1672 0.6468
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.0065
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.0364 0.1407
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0069 0.0279 0.6347
Brugia malayi hypothetical protein 0.0038 0.0135 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0027
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0051 0.0196
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0269 0.103
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0269 0.104
Entamoeba histolytica hypothetical protein 0.0038 0.0135 0.8377
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0161 0.4367
Plasmodium falciparum phosphodiesterase delta, putative 0.0069 0.0279 0.6347
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0155 0.0544
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0069 0.0279 0.1077
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0128
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.155 0.7169 1
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0011
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0051 0.1327
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0364 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0027
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0161 0.0158
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0155 0.3491
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0081 0.0358
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus granulosus glutamate synthase 0.0009 0.0003 0.0011
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0069 0.0279 0.1077
Loa Loa (eye worm) glutathione reductase 0.0103 0.0437 0.1691
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0051 0.1103
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0051 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Leishmania major hypothetical protein, conserved 0.0069 0.0279 0.6347
Plasmodium falciparum thioredoxin reductase 0.0103 0.0437 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0125 0.017
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0036 0.0161
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0128
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.105 0.146
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0017
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0042 0.0159
Echinococcus multilocularis bloom syndrome protein 0.002 0.0051 0.0196
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0021
Brugia malayi MH2 domain containing protein 0.0018 0.0042 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0042 0.0159
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0069 0.0279 0.1077
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0117 0.0449
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2159 1 1
Echinococcus multilocularis Smad4 0.0018 0.0042 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0006 0.0027
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0022 0.0072
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0161 0.062
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0051 0.0226
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0564 0.2584 1
Brugia malayi MH1 domain containing protein 0.001 0.0005 0.0021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0051 0.0196
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0294 0.6692
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0041 0.015 0.4058
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0125 0.0437
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0294 0.6692
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0003 0.0011
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0609 0.279 0.2788
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0139
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0069 0.0279 0.1077
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0161 0.062
Brugia malayi steroid hormone receptor 0.001 0.0006 0.0027
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0022 0.0428
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0069 0.0279 0.1068
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.0279 0.1231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0126 0.0486
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0022 0.0067
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni hypothetical protein 0.0368 0.1672 0.6468
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0069 0.0279 0.6347
Echinococcus granulosus tar DNA binding protein 0.0067 0.0269 0.104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus multilocularis Furin 1 0.0034 0.0117 0.0449
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.0437 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0069 0.0279 0.6347
Trypanosoma brucei unspecified product 0.0043 0.0161 0.3629
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0003 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0161 0.061
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0125 0.2803
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0279 0.1077
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0069 0.0279 0.1077
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0051 0.0196
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.0437 0.1691
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0242 0.0923
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0042 0.0159
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0069 0.0279 0.1231
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0125 0.2803
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0022 0.0428
Loa Loa (eye worm) RNA binding protein 0.0067 0.0269 0.104
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0143 0.0625 0.2409
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0027
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0003 0.0011
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0069 0.0279 0.6347
Leishmania major DNA polymerase eta, putative 0.0072 0.0294 0.6692
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0051 0.0196
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0028 0.0088 0.2352
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0042 0.0159
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0125 0.0122
Leishmania major DNA polymerase eta, putative 0.0042 0.0155 0.3491
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2159 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Loa Loa (eye worm) nuclear factor I 0.001 0.0005 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.7639
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0279 0.6347
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.1171 0.163
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0125 0.0122
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.105 0.146
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.1327
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.1103
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.0364 0.1407
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0203 0.0784
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0211 0.0747
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0022
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0011
Trichomonas vaginalis hypothetical protein 0.0028 0.0088 0.2352
Trypanosoma brucei trypanothione reductase 0.0103 0.0437 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.1171 0.163
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0135 0.0511
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0006 0.0321
Leishmania major DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0011
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0609 0.279 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0038 0.0135 0.8377
Trichomonas vaginalis C-MYB, putative 0.0041 0.0149 0.4033
Schistosoma mansoni hypothetical protein 0.0017 0.0036 0.0128
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0069 0.0279 0.0989
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0161 0.3629
Loa Loa (eye worm) hypothetical protein 0.0069 0.0279 0.1077
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0022 0.0428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0006 0.0027
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0161 0.062
Brugia malayi MH1 domain containing protein 0.0018 0.0042 0.0184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0006 0.0027
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.6347
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.105 0.146
Leishmania major cAMP-specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.0279 0.7639
Loa Loa (eye worm) PDE1B protein 0.0069 0.0279 0.1077
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0161 0.3629
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0098 0.2188
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0279 0.7639
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0069 0.0279 0.1068
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0028 0.0088 0.2352
Brugia malayi MH1 domain containing protein 0.0018 0.0042 0.0184
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0279 0.6347
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0088 0.2352
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0564 0.2584 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0034 0.0117 0.3141
Echinococcus granulosus geminin 0.0368 0.1672 0.6471
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0027
Echinococcus multilocularis 0.0115 0.0496 0.1919
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0022
Echinococcus granulosus Smad4 0.0018 0.0042 0.0159
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0269 0.103

Activities

Activity type Activity value Assay description Source Reference
logP (ADMET) = 5.32 Partition coefficient (logP) ChEMBL. 11334564
Ratio (functional) = 2.87 Tumor and skin uptake ratio of the compound ChEMBL. 11334564
Skin uptake (functional) = 0.1 uM Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Skin uptake (functional) = 0.1 uM Skin uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Tumor uptake (functional) = 0.3 uM Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564
Tumor uptake (functional) = 0.3 uM Tumor uptake in C3H mice bearing RIF tumors, determined by in vivo reflectance spectroscopy following 5.0 uMol/kg administration. ChEMBL. 11334564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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