Detailed information for compound 561919

Basic information

Technical information
  • TDR Targets ID: 561919
  • Name: (2-amino-6,7-diisopropyl-pteridin-4-yl)amine
  • MW: 246.312 | Formula: C12H18N6
  • H donors: 2 H acceptors: 4 LogP: 1.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2nc(C(C)C)c(nc2c(n1)N)C(C)C
  • InChi: 1S/C12H18N6/c1-5(2)7-8(6(3)4)16-11-9(15-7)10(13)17-12(14)18-11/h5-6H,1-4H3,(H4,13,14,16,17,18)
  • InChiKey: LIVXWXAMTVJGCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,4-Diamino-6,7-diisopropylpteridine
  • 3810-29-5
  • 6,7-Bis(1-methylethyl)-2,4-pteridinediamine
  • 6,7-Bis(methylethyl)pteridine-2,4-diamine
  • 6,7-di(propan-2-yl)pteridine-2,4-diamine
  • 6,7-diisopropylpteridine-2,4-diamine
  • AIDS-057041
  • AIDS057041
  • O 129
  • O-129
  • O129
  • Oprea1_328446
  • TimTec1_005030
  • ZINC00040831

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Leishmania major pteridine reductase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Trypanosoma brucei pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Trypanosoma congolense pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase pteridine reductase 1 288 aa 281 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0061 0.1645 0.1685
Loa Loa (eye worm) hypothetical protein 0.0046 0.1125 0.0989
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.026 0.8432 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0141
Schistosoma mansoni starch branching enzyme II 0.0046 0.1125 0.0878
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0355 0.0418
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0355 0.0421
Mycobacterium tuberculosis 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) 0.0046 0.1125 0.1334
Entamoeba histolytica alpha-amylase family protein 0.0104 0.3097 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0355 0.0207
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0355 0.0103
Trichomonas vaginalis starch branching enzyme II, putative 0.0046 0.1125 0.3024
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0046 0.1125 0.3024
Entamoeba histolytica hypothetical protein 0.0071 0.1961 0.5983
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.027 0.0319
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.026 0.8432 1
Giardia lamblia 1,4-alpha-glucan branching enzyme 0.0046 0.1125 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.026 0.8432 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0262 0.8485 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0355 0.0421
Echinococcus granulosus dihydrofolate reductase 0.026 0.8432 0.8389
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0529 0.0623
Brugia malayi hypothetical protein 0.0062 0.1655 0.1696
Leishmania major importin beta-1 subunit, putative 0.0023 0.0344 0.0405
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1961 0.1738
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0344 0.0405
Trichomonas vaginalis alpha-amylase, putative 0.0104 0.3097 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1645 0.1413
Echinococcus granulosus glucan 14 alpha branching enzyme 1 0.0046 0.1125 0.0878
Entamoeba histolytica alpha-amylase family protein 0.0104 0.3097 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0355 0.0207
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0344 0.0259
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0355 0.0421
Schistosoma mansoni hypothetical protein 0.0306 1 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.027 0.0319
Mycobacterium ulcerans hypothetical protein 0.0024 0.0355 0.0421
Echinococcus multilocularis snurportin 1 0.0306 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0344 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1645 0.1413
Brugia malayi dihydrofolate reductase family protein 0.026 0.8432 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0262 0.8485 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0529 0.0317
Trichomonas vaginalis alpha-amylase, putative 0.0104 0.3097 1
Brugia malayi TAR-binding protein 0.0061 0.1645 0.1685
Loa Loa (eye worm) hypothetical protein 0.0029 0.0529 0.0383
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.027 0.0143
Loa Loa (eye worm) TAR-binding protein 0.0061 0.1645 0.1517
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.027 0.0121
Leishmania major pteridine reductase 1 0.0238 0.7658 0.9026
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0355 0.0421
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1645 0.1413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0355 0.0299
Brugia malayi Dihydrofolate reductase 0.026 0.8432 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1961 0.1738
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.3975 0.3807
Loa Loa (eye worm) thymidylate synthase 0.013 0.3975 0.3882
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 1 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.1645 0.1413
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0355 0.0299
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0529 0.0623
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.3975 0.4714
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0529 0.0623
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0355 0.0418
Trypanosoma brucei pteridine reductase 1 0.0235 0.7552 0.8901
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0141
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0355 0.0421
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0262 0.8485 1
Toxoplasma gondii glycosyltransferase 0.0046 0.1125 0.1326
Toxoplasma gondii 1,4-alpha-glucan-branching enzyme 0.0046 0.1125 0.1326
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0262 0.8485 1
Trichomonas vaginalis alpha-amylase, putative 0.0104 0.3097 1
Trichomonas vaginalis amylase, putative 0.0046 0.1125 0.3024
Chlamydia trachomatis 1,4-alpha-glucan branching enzyme 0.0046 0.1125 0.1176
Trichomonas vaginalis amylase, putative 0.0104 0.3097 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.3975 0.4481
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.027 0.0319
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0355 0.0421
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0151 0.0179
Trichomonas vaginalis amylase, putative 0.0104 0.3097 1
Schistosoma mansoni dihydrofolate reductase 0.026 0.8432 0.8389
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1645 0.1413
Echinococcus granulosus tar DNA binding protein 0.0061 0.1645 0.1413
Entamoeba histolytica hypothetical protein 0.0071 0.1961 0.5983
Echinococcus multilocularis glucan (1,4 alpha), branching enzyme 1 0.0046 0.1125 0.0878
Entamoeba histolytica hypothetical protein 0.0071 0.1961 0.5983
Brugia malayi hypothetical protein 0.0071 0.1961 0.2072
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.027 0.0143
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1961 0.1738
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0529 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0141
Echinococcus granulosus importin subunit beta 1 0.0029 0.0529 0.0266
Leishmania major GTP-binding protein, putative 0.0021 0.027 0.0319
Mycobacterium ulcerans thymidylate synthase 0.013 0.3975 0.4714
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0355 0.0299
Entamoeba histolytica 1,4-alpha-glucan branching enzyme, putative 0.0046 0.1125 0.3024
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.1645 0.1685
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0355 0.0421
Echinococcus multilocularis thymidylate synthase 0.013 0.3975 0.3807
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.1655 0.195
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0355 0.0421
Schistosoma mansoni tar DNA-binding protein 0.0061 0.1645 0.1413
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0355 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.1655 0.4898
Chlamydia trachomatis dihydrofolate reductase 0.026 0.8432 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0262 0.8485 1
Schistosoma mansoni importin beta-1 0.0029 0.0529 0.0266
Plasmodium falciparum importin beta, putative 0.0029 0.0529 0.0453
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0355 0.0103
Schistosoma mansoni hypothetical protein 0.0071 0.1961 0.1738
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0141
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0355 0.0418
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0344 0.0259
Trichomonas vaginalis alpha-amylase, putative 0.0093 0.2709 0.8627
Entamoeba histolytica hypothetical protein 0.0071 0.1961 0.5983
Loa Loa (eye worm) hypothetical protein 0.0024 0.0355 0.0207
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0355 0.0103
Echinococcus multilocularis dihydrofolate reductase 0.026 0.8432 0.8389
Toxoplasma gondii alpha amylase, catalytic domain-containing protein 0.0046 0.1125 0.1326
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.1645 0.1517
Mycobacterium ulcerans glycogen branching protein 0.0046 0.1125 0.1334
Loa Loa (eye worm) dihydrofolate reductase 0.026 0.8432 0.8408
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0344 0.0259
Trichomonas vaginalis alpha-amylase, putative 0.0104 0.3097 1
Brugia malayi thymidylate synthase 0.013 0.3975 0.4538
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.027 0.0319
Brugia malayi 1,4-alpha-glucan branching enzyme 0.0046 0.1125 0.1047
Echinococcus granulosus thymidylate synthase 0.013 0.3975 0.3807
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.1655 0.1963
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0151 0.0179
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0262 0.8485 1
Brugia malayi RNA, U transporter 1 0.0082 0.2334 0.2528
Plasmodium vivax importin-beta 2, putative 0.0029 0.0529 0.0453
Onchocerca volvulus 0.013 0.3975 1
Loa Loa (eye worm) RNA binding protein 0.0061 0.1645 0.1517
Onchocerca volvulus 0.0024 0.0355 0.0893

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 8.1 uM Antibacterial activity against sensitive Escherichia coli ATCC 10536 assessed as reduction in growth ChEMBL. 137981
Inhibition (functional) Antibacterial activity against sensitive Escherichia coli ATCC 10536 assessed as reduction in growth in presence of p-aminobenzoic acid ChEMBL. 137981
Ki (binding) = 0.24 uM Inhibition of Leishmania major recombinant PTR1 ChEMBL. 19916554
MED (functional) = 640 mg kg-1 Antimalarial activity against Plasmodium berghei infected in sc dosed mouse assessed as active dose required to increase of 100% in mean survival time ChEMBL. 137981

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Escherichia coli ChEMBL23 137981

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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Bibliographic References

3 literature references were collected for this gene.

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