Detailed information for compound 562016

Basic information

Technical information
  • TDR Targets ID: 562016
  • Name: (E)-2,3-dibromo-4,4-bis(4-ethylphenyl)but-2-e noic acid
  • MW: 452.18 | Formula: C20H20Br2O2
  • H donors: 1 H acceptors: 2 LogP: 6.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)C(/C(=C(/C(=O)O)\Br)/Br)c1ccc(cc1)CC
  • InChi: 1S/C20H20Br2O2/c1-3-13-5-9-15(10-6-13)17(18(21)19(22)20(23)24)16-11-7-14(4-2)8-12-16/h5-12,17H,3-4H2,1-2H3,(H,23,24)/b19-18+
  • InChiKey: VJHYTULURZUAAF-VHEBQXMUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-2,3-dibromo-4,4-bis(4-ethylphenyl)-2-butenoic acid
  • edikron
  • 2,3-dibromo-4,4-bis(4-ethylphenyl)but-2-enoic acid
  • 38273-00-6
  • 2,3-Dibromo-4,4-bis(4-ethylphenyl)-2-butenoic acid
  • 2-Butenoic acid, 2,3-dibromo-4,4-bis(4-ethylphenyl)-
  • gamma,gamma-Bis(4-ethylphenyl)-alpha,beta-dibromoisocrotonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Smad1 0.0026 0.0064 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.008 0.008
Toxoplasma gondii proteasome subunit alpha type, putative 0.0347 0.1897 0.1897
Schistosoma mansoni metabotropic glutamate receptor 0.0039 0.0136 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0187 0.0187
Leishmania major proteasome alpha 1 subunit, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.1374 0.775 0.775
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1768 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0267 0.0267
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) proteasome subunit beta type 3 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0182 0.0951 0.0951
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0448 0.2469 0.2469
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0347 0.1897 0.1897
Echinococcus granulosus proteasome prosome macropain 0.1768 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0118 0.0118
Brugia malayi Pre-SET motif family protein 0.0029 0.008 0.008
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0347 0.1897 0.1897
Brugia malayi proteasome subunit alpha type 6 0.0347 0.1897 0.1897
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0031 0.0031
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0066 0.0294 0.0294
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.008 0.008
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.0064
Echinococcus multilocularis tumor protein p63 0.0349 0.1907 0.1907
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0347 0.1897 0.1897
Leishmania major proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0187 0.0187
Brugia malayi proteasome subunit beta type 1 0.1374 0.775 0.775
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0064 0.0064
Brugia malayi proteasome subunit alpha type 3 0.0347 0.1897 0.1897
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1374 0.775 0.775
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Loa Loa (eye worm) proteasome subunit beta type 2 0.0851 0.477 0.477
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.013 0.013
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0347 0.1897 0.1897
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0347 0.1897 0.1897
Giardia lamblia 20S proteasome alpha subunit 5 0.0347 0.1897 0.1838
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.0967 0.0967
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.1768 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.0128 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0267 0.0267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0315 0.0315
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0103 0.0501 0.0501
Schistosoma mansoni microtubule-associated protein tau 0.0714 0.399 0.399
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.0073 0.0073
Leishmania major proteasome beta 2 subunit, putative 0.0851 0.477 0.477
Plasmodium vivax proteasome subunit beta type-4, putative 0.0347 0.1897 0.1897
Brugia malayi beta-lactamase family protein 0.007 0.0315 0.0315
Brugia malayi Pre-SET motif family protein 0.0201 0.1063 0.1063
Trypanosoma brucei proteasome beta 7 subunit 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0184 0.0967 0.0967
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0187 0.0187
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0347 0.1897 0.1897
Toxoplasma gondii proteasome subunit beta type 1, putative 0.1374 0.775 0.775
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0051 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0202
Plasmodium vivax hypothetical protein, conserved 0.007 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0086 0.0408 0.0408
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0315 0.0315
Brugia malayi proteasome subunit beta type 2 0.0851 0.477 0.477
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0347 0.1897 0.1897
Echinococcus granulosus tumor protein p63 0.0349 0.1907 0.1907
Leishmania major proteasome beta 5 subunit, putative 0.1768 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0267 0.0267
Plasmodium vivax thioredoxin reductase, putative 0.008 0.037 0.037
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0073 0.0073
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Conserved protein 0.007 0.0315 0.0315
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1374 0.775 0.775
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0202 0.0202
Brugia malayi MH2 domain containing protein 0.038 0.2082 0.2082
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0347 0.1897 0.1897
Leishmania major hypothetical protein, conserved 0.007 0.0315 0.0315
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0426 0.0426
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0267 0.0267
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.1105 0.1105
Schistosoma mansoni hypothetical protein 0.0086 0.0408 0.0408
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0347 0.1897 0.1897
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.009 0.0429 0.0429
Echinococcus multilocularis proteasome (prosome, macropain) 0.1768 1 1
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0347 0.1897 0.1897
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0967 0.0967
Onchocerca volvulus Notchless protein homolog 0.0347 0.1897 1
Echinococcus granulosus proteasome subunit alpha type 2 0.0347 0.1897 0.1897
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.0984 0.0984
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0347 0.1897 0.1897
Brugia malayi hypothetical protein 0.0037 0.0128 0.0128
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi proteasome subunit alpha type 2 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0347 0.1897 0.1897
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0064
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.0073 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0202 0.0202
Mycobacterium ulcerans beta-lactamase 0.007 0.0315 0.0315
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0073 0.0073
Schistosoma mansoni smad 0.0026 0.0064 0.0064
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0347 0.1897 0.1897
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0032
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0347 0.1897 0.1897
Mycobacterium leprae proteasome (beta subunit) PrcB 0.1768 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.018 0.018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0184 0.0967 0.0967
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0315 0.0315
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.008
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0347 0.1897 0.1897
Brugia malayi 20S proteasome alpha5 subunit 0.0347 0.1897 0.1897
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.0073 0.0073
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0813 0.0813
Leishmania major proteasome beta 2 subunit, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0851 0.477 0.477
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0347 0.1897 0.1897
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0984 0.0984
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0771 0.0771
Plasmodium vivax proteasome subunit beta type-3, putative 0.0347 0.1897 0.1897
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0128 0.0128
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0347 0.1897 0.1897
Leishmania major proteasome alpha 1 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi Proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0347 0.1897 0.1897
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0347 0.1897 0.1897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0984 0.0984
Leishmania major proteasome beta-1 subunit, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0315 0.0315
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0315 0.0315
Entamoeba histolytica hypothetical protein 0.0037 0.0128 0.0128
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0347 0.1897 0.1897
Onchocerca volvulus 0.007 0.0315 0.1663
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0086 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0209 0.1105 0.1105
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0426 0.0426
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Entamoeba histolytica hypothetical protein 0.0037 0.0128 0.0128
Plasmodium vivax glutathione reductase, putative 0.008 0.037 0.037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0967 0.0967
Brugia malayi proteasome subunit alpha type 4 0.0347 0.1897 0.1897
Toxoplasma gondii proteasome subunit alpha1, putative 0.0347 0.1897 0.1897
Schistosoma mansoni hypothetical protein 0.0103 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0097 0.0472 0.0472
Giardia lamblia 20S proteasome alpha subunit 1 0.0347 0.1897 0.1838
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0347 0.1897 0.1897
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0158 0.0085
Schistosoma mansoni hypothetical protein 0.0047 0.0187 0.0187
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0086 0.0408 0.0408
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0851 0.477 0.477
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.0073 0.0073
Loa Loa (eye worm) acetyltransferase 0.0157 0.0813 0.0813
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.008
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Echinococcus granulosus tar DNA binding protein 0.0061 0.0267 0.0267
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0202 0.0202
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.02 0.02
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0073 0.0073
Leishmania major proteasome beta 3 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi Cytochrome P450 family protein 0.0025 0.006 0.006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0315 0.0315
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0851 0.477 0.477
Echinococcus multilocularis protein dispatched 1 0.0102 0.0499 0.0499
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0347 0.1897 0.1897
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0771 0.0771
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1221 0.1221
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.018 0.018
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0072 0.0325 0.0325
Mycobacterium leprae Probable lipase LipE 0.007 0.0315 0.0315
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0347 0.1897 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0118 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0984 0.0984
Onchocerca volvulus 0.007 0.0315 0.1663
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0037 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.015 0.0771 0.0771
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.008 0.008
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0851 0.477 0.477
Onchocerca volvulus 0.0029 0.008 0.0424
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0347 0.1897 0.1897
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0514 0.0514
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.0073 0.0073
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0074 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0202 0.0202
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0426 0.0426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0347 0.1897 0.1897
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0202 0.0202
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Loa Loa (eye worm) glutamate receptor 0.0079 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.008
Onchocerca volvulus 0.005 0.0202 0.1066
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0347 0.1897 0.1838
Loa Loa (eye worm) thioredoxin reductase 0.008 0.037 0.037
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0315 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0202 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0315 0.0315
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.1105 0.1105
Giardia lamblia 20S proteasome alpha subunit 4 0.0347 0.1897 0.1838
Echinococcus multilocularis proteasome subunit alpha type 6 0.0347 0.1897 0.1897
Brugia malayi Proteasome subunit alpha type 7-1 0.0347 0.1897 0.1897
Toxoplasma gondii proteasome beta subunit 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0267 0.0267
Toxoplasma gondii aldehyde dehydrogenase 0.0184 0.0967 0.0967
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0347 0.1897 0.1897
Onchocerca volvulus 0.005 0.02 0.1055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0315 0.0315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.0984 0.0984
Echinococcus granulosus metabotropic glutamate receptor 5 0.0097 0.0472 0.0472
Trypanosoma brucei proteasome beta 6 subunit 0.1374 0.775 0.775
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0426 0.0426
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.1374 0.775 0.775
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.0073 0.0073
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0182 0.0951 0.0951
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.0073 0.0073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.0376 0.0376
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.006 0.006
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Schistosoma mansoni hypothetical protein 0.0047 0.0187 0.0187
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.002 0.0032 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0771 0.0771
Loa Loa (eye worm) MH2 domain-containing protein 0.038 0.2082 0.2082
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.1374 0.775 0.775
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0064 0.0064
Plasmodium falciparum proteasome subunit beta type-5 0.1768 1 1
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0347 0.1897 0.1897
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0315 0.0315
Echinococcus granulosus smad 0.0026 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0047 0.0187 0.0187
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0315 0.0315
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0501 0.0501
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0347 0.1897 0.1897
Mycobacterium ulcerans hypothetical protein 0.005 0.0202 0.0202
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0347 0.1897 0.1897
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0347 0.1897 0.1897
Trypanosoma brucei proteasome alpha 7 subunit 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0089 0.0426 0.0426
Giardia lamblia Proteasome subunit beta type 5 precursor 0.1768 1 1
Brugia malayi glutathione reductase 0.008 0.037 0.037
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.1105 0.1105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.0984 0.0984
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.1309 0.1309
Entamoeba histolytica hypothetical protein 0.0037 0.0128 0.0128
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0347 0.1897 0.1897
Brugia malayi AMP-binding enzyme family protein 0.005 0.0202 0.0202
Brugia malayi RNA binding protein 0.0061 0.0267 0.0267
Leishmania major proteasome beta 7 subunit, putative 0.0347 0.1897 0.1897
Giardia lamblia 20S proteasome alpha subunit 6 0.0347 0.1897 0.1838
Schistosoma mansoni hypothetical protein 0.0524 0.2907 0.2907
Echinococcus multilocularis proteasome subunit beta type 6 0.0347 0.1897 0.1897
Plasmodium vivax proteasome subunit beta type-2, putative 0.0851 0.477 0.477
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0158 0.0158
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0347 0.1897 0.1897
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0202 0.0202
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0813 0.0813
Loa Loa (eye worm) glutamate receptor 0.0031 0.0094 0.0094
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0347 0.1897 0.1897
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0128 0.0128
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0851 0.477 0.477
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0182 0.0951 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0984 0.0984
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0315 0.0315
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.1768 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0244 0.1309 0.1309
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0105 0.0514 0.0514
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.005 0.02 0.02
Entamoeba histolytica proteasome subunit beta type 1, putative 0.1374 0.775 0.775
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0315 0.0315
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0347 0.1897 0.1838
Leishmania major proteasome alpha 3 subunit, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.1309 0.1309
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0097 0.0472 0.0472
Brugia malayi AMP-binding enzyme family protein 0.005 0.0202 0.0202
Treponema pallidum NADH oxidase 0.0028 0.0073 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0202 0.0202
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0851 0.477 0.477
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Echinococcus granulosus metabotropic glutamate receptor 2 0.0066 0.0294 0.0294
Brugia malayi Metabotropic glutamate receptor precursor. 0.0079 0.0367 0.0367
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0064
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0347 0.1897 0.1897
Brugia malayi beta-lactamase 0.007 0.0315 0.0315
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.0967 0.0967
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0118 0.0118
Toxoplasma gondii proteasome subunit 0.0347 0.1897 0.1897
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Echinococcus granulosus proteasome subunit beta type 7 0.0347 0.1897 0.1897
Echinococcus granulosus Proteasome subunit alpha beta 0.0347 0.1897 0.1897
Brugia malayi Smad1 0.0026 0.0064 0.0064
Echinococcus granulosus geminin 0.0524 0.2907 0.2907
Brugia malayi Proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0064 0.0064
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0347 0.1897 0.1897
Echinococcus granulosus microtubule associated protein 2 0.0714 0.399 0.399
Brugia malayi Thioredoxin reductase 0.008 0.037 0.037
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Giardia lamblia Proteasome subunit beta type 1 0.1374 0.775 0.7734
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0187 0.0187
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis proteasome subunit alpha type 2 0.0347 0.1897 0.1897
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis proteasome subunit beta type 7 0.0347 0.1897 0.1897
Schistosoma mansoni hypothetical protein 0.0524 0.2907 0.2907
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0514 0.0514
Brugia malayi proteasome subunit alpha type 1 0.0347 0.1897 0.1897
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0267 0.0267
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0347 0.1897 0.1897
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0347 0.1897 0.1897
Echinococcus granulosus proteasome subunit alpha type 6 0.0347 0.1897 0.1897
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0788 0.0788
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0347 0.1897 0.1897
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.0073 0.0073
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0347 0.1897 0.1897
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0315 0.0315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.0984 0.0984
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.037 0.037
Echinococcus granulosus proteasome subunit beta t family 0.0347 0.1897 0.1897
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0347 0.1897 0.1897
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0426 0.0426
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0187 0.0187
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0073 0.0073
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Onchocerca volvulus 0.007 0.0315 0.1663
Leishmania major proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi CHE-14 protein 0.0089 0.0426 0.0426
Echinococcus granulosus subfamily T1A non peptidase ue 0.0347 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0047 0.0187 0.0187
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0347 0.1897 0.1897
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0064 0.0064
Mycobacterium ulcerans proteasome PrcB 0.1768 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0315 0.0315
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.013 0.013
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0202 0.0202
Brugia malayi Proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Giardia lamblia 20S proteasome alpha subunit 3 0.0347 0.1897 0.1838
Trichomonas vaginalis esterase, putative 0.007 0.0315 0.0315
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0267 0.0267
Toxoplasma gondii proteasome subunit beta type, putative 0.1768 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0202 0.1067 0.1067
Loa Loa (eye worm) glutathione reductase 0.008 0.037 0.037
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0347 0.1897 0.1897
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.013 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Plasmodium vivax proteasome subunit beta type-7, putative 0.0347 0.1897 0.1897
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.0073 0.0073
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0851 0.477 0.477
Echinococcus multilocularis Smad4 0.0026 0.0064 0.0064
Echinococcus granulosus GPCR family 2 0.0047 0.0187 0.0187
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0347 0.1897 0.1897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0128 0.0128
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0315 0.0315
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0347 0.1897 0.1897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0064 0.0064
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0347 0.1897 0.1897
Plasmodium vivax SET domain protein, putative 0.0029 0.008 0.008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0182 0.0951 0.0951
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi metabotropic glutamate receptor type 2 0.0039 0.0136 0.0136
Echinococcus multilocularis GPCR, family 2 0.0047 0.0187 0.0187
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.002 0.0032 0.0032
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0202 0.0202
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0347 0.1897 0.1897
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.018 0.018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1063 0.1063
Mycobacterium tuberculosis Probable dehydrogenase 0.0182 0.0951 0.0951
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0347 0.1897 0.1897
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0001 0.0001
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.1768 1 1
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Conserved protein 0.007 0.0315 0.0315
Echinococcus multilocularis protein patched 0.0089 0.0426 0.0426
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0851 0.477 0.477
Mycobacterium tuberculosis Conserved protein 0.007 0.0315 0.0315
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) proteasome subunit beta type 1 0.1374 0.775 0.775
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0315 0.0315
Loa Loa (eye worm) beta-lactamase 0.007 0.0315 0.0315
Echinococcus multilocularis geminin 0.0524 0.2907 0.2907
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0315 0.0315
Mycobacterium ulcerans proteasome PrcA 0.0347 0.1897 0.1897
Schistosoma mansoni Smad4 0.0026 0.0064 0.0064
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.018 0.018
Plasmodium falciparum proteasome subunit beta type-1, putative 0.1374 0.775 0.775
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0073 0.0073
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0347 0.1897 0.1897
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0347 0.1897 0.1897
Brugia malayi proteasome subunit beta type 3 0.0347 0.1897 0.1897
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0158 0.0158
Mycobacterium leprae conserved hypothetical protein 0.007 0.0315 0.0315
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0347 0.1897 0.1897
Brugia malayi AMP-binding enzyme family protein 0.005 0.0202 0.0202
Toxoplasma gondii thioredoxin reductase 0.008 0.037 0.037
Echinococcus granulosus proteasome prosome macropain subunit beta 0.1374 0.775 0.775
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0315 0.0315
Plasmodium vivax proteasome subunit beta type-5, putative 0.1768 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0347 0.1897 0.1897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Loa Loa (eye worm) RNA binding protein 0.0061 0.0267 0.0267
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0347 0.1897 0.1897
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0073 0.0073
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0851 0.477 0.477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.0073 0.0073
Onchocerca volvulus 0.0229 0.1221 0.6436
Echinococcus granulosus Proteasome subunit alpha type 7 0.0347 0.1897 0.1897
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0267 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0118 0.0118
Giardia lamblia Proteasome subunit beta type 3 0.0347 0.1897 0.1838
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0187 0.0187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0073 0.0073
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.0064
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.008 0.008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Brugia malayi Melibiase family protein 0.007 0.0315 0.0315
Trypanosoma cruzi 20S proteasome subunit 0.0851 0.477 0.477
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0347 0.1897 0.1897
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0347 0.1897 0.1838
Brugia malayi hypothetical protein 0.0244 0.1309 0.1309
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0347 0.1897 0.1897
Plasmodium falciparum proteasome subunit beta type-4 0.0347 0.1897 0.1897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.008 0.008
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0851 0.477 0.477
Echinococcus granulosus Smad4 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0047 0.0187 0.0187
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0347 0.1897 0.1897
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.0376 0.0376
Schistosoma mansoni patched 1 0.0089 0.0426 0.0426
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0347 0.1897 0.1897
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0347 0.1897 0.1897
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis Niemann Pick C1 protein 0.0298 0.1616 0.1616
Plasmodium vivax proteasome subunit beta type-6, putative 0.0347 0.1897 0.1897
Echinococcus granulosus expressed conserved protein 0.0196 0.1033 0.1033
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0032 0.0032
Brugia malayi MH2 domain containing protein 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0315 0.0315
Toxoplasma gondii ABC1 family protein 0.007 0.0315 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0267 0.0267
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0187 0.0187
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.013 0.013
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0347 0.1897 0.1897
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0184 0.0967 0.0967
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0031 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.1105 0.1105
Trypanosoma brucei trypanothione reductase 0.008 0.037 0.037
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis microtubule associated protein 2 0.0714 0.399 0.399
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.1124 0.1124
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0347 0.1897 0.1897
Echinococcus multilocularis expressed conserved protein 0.0196 0.1033 0.1033
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0347 0.1897 0.1897
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0347 0.1897 0.1897
Plasmodium vivax proteasome subunit beta type-1, putative 0.1374 0.775 0.775
Plasmodium falciparum glutathione reductase 0.008 0.037 0.037
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0347 0.1897 0.1897
Plasmodium falciparum thioredoxin reductase 0.0028 0.0073 0.0073
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0064 0.0064
Giardia lamblia 20S proteasome alpha subunit 2 0.0347 0.1897 0.1838
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0184 0.0967 0.0967
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.0967 0.0967
Mycobacterium ulcerans lipase LipD 0.007 0.0315 0.0315
Giardia lamblia Proteasome subunit beta type 2 0.0851 0.477 0.4732
Plasmodium falciparum thioredoxin reductase 0.008 0.037 0.037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0202 0.1067 0.1067
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0105 0.0514 0.0514
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0347 0.1897 0.1897
Leishmania major proteasome alpha 2 subunit, putative 0.0347 0.1897 0.1897
Trypanosoma brucei proteasome subunit beta type-5, putative 0.1768 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1718 0.9714 0.9714
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0064 0.0064
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0347 0.1897 0.1897
Toxoplasma gondii melibiase subfamily protein 0.0105 0.0514 0.0514
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0347 0.1897 0.1897
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0347 0.1897 0.1897
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0813 0.0813
Echinococcus multilocularis smad 0.0026 0.0064 0.0064
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0514 0.0514
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.018 0.018
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0347 0.1897 0.1897
Schistosoma mansoni metabotropic glutamate receptor 0.0066 0.0294 0.0294
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.008 0.008
Echinococcus granulosus proteasome subunit beta type 6 0.0347 0.1897 0.1897
Toxoplasma gondii peptidase, T1 family protein 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.1768 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.0073 0.0073
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0202 0.1067 0.1067
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0347 0.1897 0.1897
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0315 0.0315
Plasmodium falciparum glutathione reductase 0.0028 0.0073 0.0073
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Probable reductase 0.0182 0.0951 0.0951
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.1374 0.775 0.775
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.013
Toxoplasma gondii heat shock protein hslv, putative 0.0347 0.1897 0.1897
Brugia malayi beta-lactamase family protein 0.007 0.0315 0.0315
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) PAS-3 protein 0.0347 0.1897 0.1897
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.013 0.013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.037 0.037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.0984 0.0984
Brugia malayi MH1 domain containing protein 0.0026 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.011 0.0541 0.0541
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0458 0.253 0.253
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0347 0.1897 0.1897
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0347 0.1897 0.1897
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0202 0.0202
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0202 0.1067 0.1067
Brugia malayi Proteasome subunit alpha type 1 0.0347 0.1897 0.1897
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0347 0.1897 0.1897
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0347 0.1897 0.1897
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0347 0.1897 0.1897
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0182 0.0951 0.0951
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0315 0.0315
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.018 0.018
Brugia malayi TAR-binding protein 0.0061 0.0267 0.0267
Onchocerca volvulus 0.0051 0.0207 0.1093
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0202 0.0202
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0073 0.0073
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0347 0.1897 0.1897
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.1768 1 1
Mycobacterium ulcerans hypothetical protein 0.007 0.0315 0.0315
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.1768 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0207 0.0207
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0347 0.1897 0.1897
Leishmania major trypanothione reductase 0.008 0.037 0.037
Schistosoma mansoni survival motor neuron protein 0.005 0.02 0.02
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.0073 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.038 0.2082 0.2082
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0347 0.1897 0.1897
Echinococcus granulosus Niemann Pick C1 protein 0.0298 0.1616 0.1616
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0315 0.0315
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0315 0.0315
Schistosoma mansoni smad1 5 8 and 0.0026 0.0064 0.0064
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0347 0.1897 0.1897
Giardia lamblia 20S proteasome alpha subunit 7 0.0347 0.1897 0.1838
Onchocerca volvulus 0.0019 0.0022 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.005 0.0202 0.0202
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0851 0.477 0.477
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0105 0.0514 0.0514
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0315 0.0315
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0105 0.0514 0.0514
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0347 0.1897 0.1897
Brugia malayi follicle stimulating hormone receptor 0.0458 0.253 0.253

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.