Detailed information for compound 562067

Basic information

Technical information
  • TDR Targets ID: 562067
  • Name: (5-bromo-4-chloro-1H-indol-3-yl) dihydrogen p hosphate
  • MW: 326.468 | Formula: C8H6BrClNO4P
  • H donors: 3 H acceptors: 3 LogP: 1.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1c(Br)ccc2c1c(c[nH]2)OP(=O)(O)O
  • InChi: 1S/C8H6BrClNO4P/c9-4-1-2-5-7(8(4)10)6(3-11-5)15-16(12,13)14/h1-3,11H,(H2,12,13,14)
  • InChiKey: QRXMUCSWCMTJGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-bromo-4-chloro-3-indoxyl phosphate
  • 38404-93-2
  • Indole der.
  • 5-Bromo-4-chloro-3-indoyl-phosphate
  • AIDS-081053
  • 1H-Indol-3-ol, 5-bromo-4-chloro-, dihydrogen phosphate (ester)
  • 5-Bcip
  • 5-Bromo-4-chloro-3-indolyl phosphate
  • AIDS081053

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0036 0.0886 0.2313
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0229 0.0229
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0886 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4395 0.4395
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.1717 0.1716
Echinococcus granulosus intermediate filament protein 0.0027 0.0567 0.0567
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0757 0.5173
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.1461 0.146
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.1243 0.1245
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.1461 0.146
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.1717 0.1523
Echinococcus granulosus lamin 0.0027 0.0567 0.0567
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0567 0.0568
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0229 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Onchocerca volvulus 0.0036 0.0886 0.2313
Onchocerca volvulus Huntingtin homolog 0.0123 0.383 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.1243 0.1243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.4395 0.4395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.1243 0.1243
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.4662 0.4669
Leishmania major hypothetical protein, conserved 0.0036 0.0886 0.0884
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1415 0.1417
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0995 0.0792
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.0229 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1461 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0995 0.6806
Entamoeba histolytica hypothetical protein 0.0071 0.2045 0.188
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.4395 0.4395
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0886 0.6059
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0017 0.0229 0.023
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0886 0.068
Loa Loa (eye worm) RNA binding protein 0.0125 0.3887 0.3893
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.1243 0.1243
Echinococcus multilocularis geminin 0.0185 0.5917 0.5917
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0886 0.0887
Echinococcus multilocularis muscleblind protein 0.0306 0.9985 0.9985
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0995 0.6806
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0995 0.0996
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3887 0.3887
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.4658 1
Schistosoma mansoni hypothetical protein 0.0047 0.1243 0.1243
Schistosoma mansoni aldehyde dehydrogenase 0.0306 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.3079 0.3084
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0886 0.0672
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0886 0.0672
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0886 0.0886
Schistosoma mansoni intermediate filament proteins 0.0027 0.0567 0.0567
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0229 0.0229
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0229 0.0228
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0013 0.0098 0.0098
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0229 0.156
Mycobacterium ulcerans beta-lactamase 0.0036 0.0886 0.0672
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0995 0.0792
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.4003 0.4009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.4658 0.4532
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.1243 0.1243
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.2045 0.2045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.4395 0.4402
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.1461 0.1461
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.1243 0.1245
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.3887 0.3893
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.1461 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0306 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0306 1 1
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.0229 0.023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1717 0.1523
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3887 0.3887
Schistosoma mansoni hypothetical protein 0.0047 0.1243 0.1243
Echinococcus granulosus GPCR family 2 0.0047 0.1243 0.1243
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1579 0.1581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Onchocerca volvulus 0.0052 0.1415 0.3694
Mycobacterium ulcerans aldehyde dehydrogenase 0.0306 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1461 0.1275
Toxoplasma gondii ABC1 family protein 0.0036 0.0886 0.0884
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0757 0.0546
Loa Loa (eye worm) hypothetical protein 0.0027 0.0567 0.0568
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0995 0.0993
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0757 0.5173
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0995 0.0784
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.1461 0.1275
Mycobacterium ulcerans aldehyde dehydrogenase 0.0306 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1717 0.1717
Trypanosoma brucei protein kinase, putative 0.0053 0.1461 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.9891 1
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Brugia malayi beta-lactamase family protein 0.0036 0.0886 0.0887
Toxoplasma gondii aldehyde dehydrogenase 0.0306 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0886 0.0886
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0995 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0783 0.0784
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0757 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0783 0.0573
Loa Loa (eye worm) hypothetical protein 0.0306 0.9985 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0757 0.0546
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0017 0.0229 0.2292
Echinococcus multilocularis lamin 0.0027 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0123 0.383 0.3836
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0783 0.0784
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0886 0.0887
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.1461 0.1461
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0886 0.0672
Schistosoma mansoni hypothetical protein 0.0047 0.1243 0.1243
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0886 0.068
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.1461 0.1463
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1461 0.1275
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3887 0.3887
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0886 0.6059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0995 1
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0229 0.156
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0229 0.156
Loa Loa (eye worm) hypothetical protein 0.0255 0.8262 0.8275
Mycobacterium tuberculosis Conserved protein 0.0036 0.0886 0.0672
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1461 0.1275
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0886 0.0672
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0229 0.156
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0995 0.0995
Mycobacterium ulcerans lipase LipD 0.0036 0.0886 0.0672
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.0229 0.0229
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.0229 0.0229
Schistosoma mansoni lamin 0.0027 0.0567 0.0567
Schistosoma mansoni hypothetical protein 0.0071 0.2045 0.2045
Echinococcus multilocularis lamin dm0 0.0027 0.0567 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4395 0.4395
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0229 0.0228
Brugia malayi Muscleblind-like protein 0.0306 0.9985 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0886 0.0672
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1461 0.1461
Brugia malayi beta-lactamase family protein 0.0036 0.0886 0.0887
Echinococcus granulosus expressed protein 0.0033 0.0783 0.0783
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.4658 0.4532
Brugia malayi Latrophilin receptor protein 2 0.0047 0.1243 0.1245
Schistosoma mansoni rotamase 0.0033 0.0783 0.0783
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0995 0.0996
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.1717 0.1523
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0146 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.4662 0.4669
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Loa Loa (eye worm) aldehyde dehydrogenase 0.0017 0.0229 0.023
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.0229 0.0229
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0229 0.0229
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0886 0.0672
Schistosoma mansoni aldehyde dehydrogenase 0.0306 1 1
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.0229 0.023
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0995 0.0792
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0757 0.0755
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.0229 0.0228
Loa Loa (eye worm) TAR-binding protein 0.0125 0.3887 0.3893
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.1461 1
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.8262 0.8262
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0757 0.5173
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1717 0.172
Loa Loa (eye worm) hypothetical protein 0.0306 0.9985 1
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.0229 0.0229
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.9891 1
Schistosoma mansoni hypothetical protein 0.0185 0.5917 0.5917
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0229 0.0229
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0229 0.156
Trichomonas vaginalis esterase, putative 0.0036 0.0886 0.068
Entamoeba histolytica hypothetical protein 0.0071 0.2045 0.188
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.4003 0.4009
Mycobacterium leprae Probable lipase LipE 0.0036 0.0886 0.1482
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0229 0.156
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.4395 0.4402
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.0229 0.0229
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.0229 0.023
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.1461 0.1461
Mycobacterium tuberculosis Conserved protein 0.0036 0.0886 0.0672
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.0229 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0125 0.3887 0.3887
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0567 0.0568
Onchocerca volvulus Huntingtin homolog 0.0123 0.383 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Brugia malayi hypothetical protein 0.0123 0.383 0.3836
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0886 0.1482
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.749 0.7431
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.9891 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.3079 0.3084
Onchocerca volvulus 0.0036 0.0886 0.2313
Echinococcus multilocularis muscleblind protein 1 0.0306 0.9985 0.9985
Toxoplasma gondii exonuclease III APE 0.004 0.0995 0.0993
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0306 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0229 0.0229
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.1461 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.4395 0.4395
Schistosoma mansoni ap endonuclease 0.004 0.0995 0.0995
Echinococcus granulosus lamin dm0 0.0027 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0017 0.0229 0.023
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.1461 1
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.0229 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0886 0.068
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.0229 0.0228
Brugia malayi beta-lactamase 0.0036 0.0886 0.0887
Brugia malayi MAP kinase sur-1 0.0053 0.1461 0.1463
Echinococcus granulosus tar DNA binding protein 0.0125 0.3887 0.3887
Echinococcus multilocularis musashi 0.0027 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0047 0.1243 0.1245
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.1717 0.1717
Brugia malayi hypothetical protein 0.0255 0.8262 0.8275
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3887 0.3887
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0995 0.0995
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0229 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.2045 0.2045
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0995 0.0792
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0081
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.0229 0.0229
Echinococcus multilocularis GPCR, family 2 0.0047 0.1243 0.1243
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0886 0.0672
Echinococcus multilocularis expressed protein 0.0033 0.0783 0.0783
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0229 0.156
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0229 0.156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.4662 0.4669
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.1717 0.1717
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0886 0.6059
Onchocerca volvulus 0.0027 0.0567 0.1479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0995 0.6806
Onchocerca volvulus 0.0027 0.0567 0.1479
Brugia malayi MH2 domain containing protein 0.0129 0.4003 0.4009
Schistosoma mansoni survival motor neuron protein 0.0052 0.1415 0.1415
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0017 0.0229 0.0599
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.0229 0.0228
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0017 0.0229 0.023
Echinococcus granulosus muscleblind protein 0.0306 0.9985 0.9985
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.1461 0.1461
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.9891 1
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0229 0.0229
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0886 0.0672
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0886 0.0886
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0229 0.156
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3887 0.3887
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0886 0.0886
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.2045 0.2045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0995 0.5
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0229 0.0228
Trichomonas vaginalis rotamase, putative 0.0033 0.0783 0.0573
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.1461 0.146
Loa Loa (eye worm) hypothetical protein 0.0148 0.4662 0.4669
Schistosoma mansoni ap endonuclease 0.004 0.0995 0.0995
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0886 0.0672
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0098 0.0098
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.8262 0.8262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0886 0.0887
Brugia malayi TAR-binding protein 0.0125 0.3887 0.3893
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0567 0.0568
Schistosoma mansoni lamin 0.0027 0.0567 0.0567
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0229 0.156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0229 0.023
Schistosoma mansoni hypothetical protein 0.0185 0.5917 0.5917
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.1461 0.1275
Loa Loa (eye worm) hypothetical protein 0.0123 0.383 0.3836
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.3887 0.3893
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.4395 0.4395
Entamoeba histolytica hypothetical protein 0.0071 0.2045 0.188
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0229 0.0228
Entamoeba histolytica hypothetical protein 0.0071 0.2045 0.188
Schistosoma mansoni hypothetical protein 0.0101 0.3079 0.3079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.9891 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0886 0.0672
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0995 0.0784
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0146 0.0146
Mycobacterium tuberculosis Conserved protein 0.0036 0.0886 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0886 0.068
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0026 0.055 0.0551
Echinococcus granulosus geminin 0.0185 0.5917 0.5917
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0081
Brugia malayi RNA binding protein 0.0125 0.3887 0.3893
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0995 0.0792
Brugia malayi hypothetical protein 0.0071 0.2045 0.2048
Loa Loa (eye worm) beta-lactamase 0.0036 0.0886 0.0887
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0306 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4395 0.4395
Brugia malayi intermediate filament protein 0.0027 0.0567 0.0568
Schistosoma mansoni hypothetical protein 0.0047 0.1243 0.1243
Schistosoma mansoni hypothetical protein 0.0052 0.1415 0.1415
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.0229 0.0229
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0229 0.156
Brugia malayi aldehyde dehydrogenase 0.0017 0.0229 0.023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.