Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | geminin | 0.0173 | 0.9419 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 1 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2636 | 0.2798 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 1 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9419 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0339 | 0.036 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0173 | 0.9419 | 1 |
Onchocerca volvulus | 0.0154 | 0.8285 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1167 | 0.1239 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.9419 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.3581 | 0.3969 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0339 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1582 | 0.1909 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0154 | 0.8285 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1167 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3317 | 0.4003 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0038 | 0.0046 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2636 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1464 | 0.1767 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2857 | 0.3033 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0339 | 0.036 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1317 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.8285 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1313 | 0.1061 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0156 | 0.0166 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0221 | 0.0235 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0221 | 0.0267 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.