TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.349 | Formula: C23H14F2NNaO3
H donors: 1 H acceptors: 4 LogP: 5.86 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(c(c1)F)c1ccc(cc1)c1nc2ccc(cc2c(c1C)C(=O)[O-])F.[Na+]
InChi: 1S/C23H15F2NO3.Na/c1-12-21(23(28)29)18-10-15(24)6-9-20(18)26-22(12)14-4-2-13(3-5-14)17-8-7-16(27)11-19(17)25;/h2-11,27H,1H3,(H,28,29);/q;+1/p-1
InChiKey: LPXLTLAFRZTULY-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dihydroorotate dehydrogenase (quinone)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium berghei	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Theileria parva	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania infantum	dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania major	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium yoelii	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium knowlesi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Babesia bovis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma japonicum	ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma mansoni	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma congolense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania donovani	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei gambiense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania braziliensis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania mexicana	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Neospora caninum	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	dihydroorotate dehydrogenase (quinone)	395 aa	361 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3126	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0395	0.0395
Onchocerca volvulus		0.0017	0.032	0.1898
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	1	1
Brugia malayi	dehydrogenases, short chain protein 2	0.0017	0.032	0.032
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.001	0.0007	0.0008
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus granulosus	WW domain containing oxidoreductase	0.0017	0.032	0.032
Onchocerca volvulus		0.0018	0.0395	0.2345
Echinococcus granulosus	carbonyl reductase 1	0.0017	0.032	0.032
Onchocerca volvulus	Putative nachr subunit	0.0018	0.0395	0.2345
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Entamoeba histolytica	hypothetical protein, conserved	0.0017	0.032	0.1003
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3126	1
Echinococcus multilocularis	carbonyl reductase 1	0.0017	0.032	0.032
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.3126	0.3126
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0395	0.0395
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0395	0.0395
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1574	0.1809
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Echinococcus granulosus	carbonyl reductase 1	0.0017	0.032	0.032
Onchocerca volvulus		0.0017	0.032	0.1898
Brugia malayi	Retinol dehydrogenase 12	0.0017	0.032	0.032
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0017	0.032	0.1898
Echinococcus granulosus	mitogen activated protein kinase 3	0.0049	0.1805	0.1805
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0395	0.0395
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.3126	0.3126
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Loa Loa (eye worm)	dehydrogenase	0.0017	0.032	0.032
Echinococcus multilocularis	carbonyl reductase 1	0.0017	0.032	0.032
Schistosoma mansoni	carbonyl reductase	0.0017	0.032	0.0367
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Onchocerca volvulus		0.0018	0.0395	0.2345
Onchocerca volvulus		0.0017	0.032	0.1898
Loa Loa (eye worm)	hypothetical protein	0.0228	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0395	0.0395
Onchocerca volvulus		0.0017	0.032	0.1898
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0017	0.032	0.032
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Onchocerca volvulus		0.0017	0.032	0.1898
Echinococcus multilocularis	transient receptor potential cation channel	0.0017	0.032	0.032
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0018	0.0395	0.0395
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.3126	0.3126
Echinococcus granulosus	carbonyl reductase 1	0.0017	0.032	0.032
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0018	0.0395	0.0395
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0017	0.032	0.032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1574	0.1809
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0018	0.0395	0.0454
Entamoeba histolytica	short chain dehydrogenase family protein	0.0017	0.032	0.1003
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0395	0.0395
Echinococcus granulosus	retinol dehydrogenase 11	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Schistosoma mansoni	carbonyl reductase	0.0017	0.032	0.0367
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Giardia lamblia	Kinase, CMGC MAPK	0.0049	0.1805	1
Onchocerca volvulus		0.0018	0.0395	0.2345
Brugia malayi	MAP kinase sur-1	0.0049	0.1805	0.1805
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Entamoeba histolytica	short chain dehydrogenase family protein	0.0017	0.032	0.1003
Echinococcus granulosus	nAChR subunit	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0018	0.0395	0.0395
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0018	0.0395	0.0395
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.1805	0.5291
Echinococcus multilocularis	steroid dehydrogenase	0.0017	0.032	0.032
Onchocerca volvulus		0.0018	0.0395	0.2345
Loa Loa (eye worm)	LGC-31 protein	0.0018	0.0395	0.0395
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	0.8703	1
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	GABA receptor subunit	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.001	0.0007	0.0008
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.02	0.8703	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.02	0.8703	1
Brugia malayi	Zinc finger, C2H2 type family protein	0.0078	0.3126	0.3126
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Echinococcus multilocularis	carbonyl reductase 1	0.0017	0.032	0.032
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0395	0.0395
Brugia malayi	excitatory GABA receptor EXP-1A	0.0018	0.0395	0.0395
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3126	1
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0017	0.032	0.032
Onchocerca volvulus		0.0017	0.032	0.1898
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0049	0.1805	0.1771
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0018	0.0395	0.0395
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus multilocularis	mitogen activated protein kinase	0.0049	0.1805	0.1805
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1574	0.1574
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0017	0.032	0.032
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0017	0.032	0.1003
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0017	0.032	0.032
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Onchocerca volvulus		0.0017	0.032	0.1898
Brugia malayi	dehydrogenases, short chain protein 9	0.0017	0.032	0.032
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.1805	0.5291
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0017	0.032	0.1003
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0078	0.3126	0.3348
Onchocerca volvulus		0.0018	0.0395	0.2345
Onchocerca volvulus		0.001	0.0007	0.004
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0395	0.0395
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Plasmodium falciparum	dihydroorotate dehydrogenase	0.02	0.8703	1
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1574	0.1574
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0049	0.1805	0.1805
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0395	0.0395
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0018	0.0395	0.0454
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.8703	1
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0395	0.0395
Echinococcus multilocularis	retinol dehydrogenase 11	0.0017	0.032	0.032
Echinococcus multilocularis	carbonyl reductase 1	0.0017	0.032	0.032
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.1574	0.1574
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0395	0.0454
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0017	0.032	0.1898
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0049	0.1805	0.1771
Brugia malayi	Dehydrogenases, short chain protein 2	0.0017	0.032	0.032
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0049	0.1805	0.1805
Schistosoma mansoni	retinal dehydrogenase	0.0017	0.032	0.0367
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.3126	0.3126
Echinococcus granulosus	oxidoreductase	0.0017	0.032	0.032
Onchocerca volvulus	Sepiapterin reductase homolog	0.0017	0.032	0.1898
Echinococcus granulosus	hypothetical protein	0.0017	0.032	0.032
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0018	0.0395	0.0395
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0017	0.032	0.032
Onchocerca volvulus		0.0017	0.032	0.1898
Onchocerca volvulus		0.0018	0.0395	0.2345
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.02	0.8703	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0018	0.0395	0.0395
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0049	0.1805	0.1771
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.02	0.8703	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3126	1
Onchocerca volvulus		0.0047	0.1684	1
Echinococcus granulosus	carbonyl reductase 1	0.0017	0.032	0.032
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.1805	0.1771
Schistosoma mansoni	carbonyl reductase	0.0017	0.032	0.0367
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0395	0.0454
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.1805	0.5291
Echinococcus granulosus	hypothetical protein	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0017	0.032	0.032
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0049	0.1805	0.1771
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0018	0.0395	0.0395
Echinococcus multilocularis	nAChR subunit	0.001	0.0007	0.0007
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.1574	0.1809
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Brugia malayi	Cation transporter family protein	0.0018	0.0395	0.0395
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0395	0.0395
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Brugia malayi	Cation transporter family protein	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Echinococcus granulosus	nAChR subunit	0.0018	0.0395	0.0395
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0018	0.0395	0.0395
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0017	0.032	0.032
Entamoeba histolytica	hypothetical protein	0.0017	0.032	0.1003
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Schistosoma mansoni	hypothetical protein	0.0047	0.1684	0.1935
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Entamoeba histolytica	hypothetical protein, conserved	0.0017	0.032	0.1003
Onchocerca volvulus		0.0017	0.032	0.1898
Leishmania major	dihydroorotate dehydrogenase	0.02	0.8703	1
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0017	0.032	0.1003
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0049	0.1805	0.1771
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0395	0.0395
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.1574	0.1574
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Echinococcus granulosus	retinol dehydrogenase 11	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0017	0.032	0.1898
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0049	0.1805	0.1771
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0395	0.0395
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	0.8703	1
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.02	0.8703	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.8703	0.8703
Trichomonas vaginalis	CMGC family protein kinase	0.0049	0.1805	0.5291
Echinococcus multilocularis	retinol dehydrogenase 13	0.0017	0.032	0.032
Echinococcus multilocularis	retinol dehydrogenase 11	0.0017	0.032	0.032
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0017	0.032	0.1003
Brugia malayi	hypothetical protein	0.0017	0.032	0.032
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1684	0.1684
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0018	0.0395	0.0395
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0017	0.032	0.032
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0018	0.0395	0.0454
Onchocerca volvulus		0.001	0.0007	0.004
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0017	0.032	0.0367
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0078	0.3126	1
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Onchocerca volvulus		0.0017	0.032	0.1898
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.1574	0.1574
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1684	0.1935
Echinococcus granulosus	steroid dehydrogenase	0.0017	0.032	0.032
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0395	0.0395
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0395	0.0395
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.001	0.0007	0.0007
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Echinococcus multilocularis	conserved hypothetical protein	0.0017	0.032	0.032
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0018	0.0395	0.0395
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0017	0.032	0.1003
Echinococcus multilocularis	oxidoreductase	0.0017	0.032	0.032
Brugia malayi	Cation transporter family protein	0.0018	0.0395	0.0395
Loa Loa (eye worm)	oxidoreductase	0.0017	0.032	0.032
Schistosoma mansoni	neurotransmitter gated ion channel	0.001	0.0007	0.0008
Echinococcus multilocularis	steroid dehydrogenase	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0007
Onchocerca volvulus		0.0017	0.032	0.1898
Schistosoma mansoni	nAChR subunit	0.0018	0.0395	0.0454
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0395	0.0395
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.8703	0.8703
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.1805	0.2074
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.02	0.8703	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0017	0.032	0.032
Loa Loa (eye worm)	dehydrogenase	0.0017	0.032	0.032
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0017	0.032	0.0367
Brugia malayi	oxidoreductase	0.0017	0.032	0.032
Echinococcus granulosus	mitogen activated protein kinase	0.0049	0.1805	0.1805
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0017	0.032	0.032
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0049	0.1805	0.1771
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0395	0.0395
Onchocerca volvulus		0.0017	0.032	0.1898
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.02	0.8703	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0395	0.0395
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Echinococcus multilocularis	nAChR subunit	0.0018	0.0395	0.0395
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3126	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0017	0.032	0.032
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0017	0.032	0.0367
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0017	0.032	0.032
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0017	0.032	0.032
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0395	0.0454
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0078	0.3126	1
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0018	0.0395	0.0395
Schistosoma mansoni	short chain dehydrogenase	0.0017	0.032	0.0367
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.02	0.8703	1
Brugia malayi	Dehydrogenases, short chain protein 30	0.0017	0.032	0.032
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0395	0.0395
Onchocerca volvulus		0.0017	0.032	0.1898
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0395	0.0395
Trypanosoma brucei	protein kinase, putative	0.0049	0.1805	0.1771
Loa Loa (eye worm)	hypothetical protein	0.0017	0.032	0.032
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0395	0.0395
Echinococcus granulosus	survival motor neuron protein 1	0.0228	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.1574	0.1574
Schistosoma mansoni	steroid dehydrogenase	0.0017	0.032	0.0367

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 300 nM	Ability to inhibit proliferation in human lymphocytes by mixed lymphocyte reaction (MLR)	ChEMBL.	No reference
Ki (binding)	= 11 nM	Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.	ChEMBL.	No reference
Ki (binding)	= 11 nM	Inhibition measurement of orotate formation from radiolabelled dihydroorotate, using partially purified DHODase isolated from human liver.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL43639

Bibliographic References

No literature references available for this target.

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Detailed information for compound 56285