Detailed information for compound 562927

Basic information

Technical information
  • TDR Targets ID: 562927
  • Name: 1-indan-4-yloxy-3-(isopropylamino)propan-2-ol
  • MW: 249.349 | Formula: C15H23NO2
  • H donors: 2 H acceptors: 1 LogP: 2.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COc1cccc2c1CCC2)CNC(C)C
  • InChi: 1S/C15H23NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h4,6,8,11,13,16-17H,3,5,7,9-10H2,1-2H3
  • InChiKey: GZDBSFAQFPWZFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-indanyloxy)-3-(isopropylamino)-2-propanol
  • 1-(2,3-dihydro-1H-inden-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
  • USVC 6524
  • 1-(4-indanyloxy)-3-(isopropylamino)propan-2-ol
  • 2-Propanol, 1-((2,3-dihydro-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-
  • 2-Propanol, 1-(4-indanyloxy)-3-(isopropylamino)-
  • 2-Propanol, 1-[(2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0063 0.243 0.2386
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.243 0.8119
Loa Loa (eye worm) hypothetical protein 0.0042 0.1265 0.1214
Schistosoma mansoni hypothetical protein 0.0063 0.243 0.3741
Brugia malayi Bromodomain containing protein 0.0074 0.3039 0.2829
Schistosoma mansoni hypothetical protein 0.0063 0.243 0.3741
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1391 0.1341
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.2993 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.243 0.8119
Entamoeba histolytica hypothetical protein 0.0073 0.2993 0.5
Loa Loa (eye worm) hypothetical protein 0.0199 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.2993 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0897 0.2996
Schistosoma mansoni hypothetical protein 0.0136 0.6496 1
Loa Loa (eye worm) hypothetical protein 0.004 0.116 0.1109
Loa Loa (eye worm) hypothetical protein 0.0136 0.6496 0.6476
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0163 0.0543
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.22 0.7349
Brugia malayi Bromodomain containing protein 0.0038 0.1027 0.0756
Entamoeba histolytica hypothetical protein 0.0073 0.2993 0.5
Schistosoma mansoni hypothetical protein 0.0063 0.243 0.3741
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.2993 0.4608
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0163 0.0543
Loa Loa (eye worm) hypothetical protein 0.007 0.2804 0.2762
Schistosoma mansoni bromodomain containing protein 0.0062 0.2396 0.3689
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.6496 0.6391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1391 0.2142
Echinococcus granulosus GPCR family 2 0.0063 0.243 0.8119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1391 0.4648
Entamoeba histolytica hypothetical protein 0.0073 0.2993 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.22 0.7349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.243 0.8119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1391 0.4648
Echinococcus multilocularis GPCR, family 2 0.0063 0.243 0.8119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.243 0.8119
Brugia malayi Latrophilin receptor protein 2 0.0063 0.243 0.2202
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0163 0.025
Loa Loa (eye worm) hypothetical protein 0.0038 0.103 0.0978
Schistosoma mansoni hypothetical protein 0.0063 0.243 0.3741
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0897 0.2996
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.243 0.2386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1391 0.2142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1391 0.4648
Entamoeba histolytica hypothetical protein 0.0073 0.2993 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1391 0.4648
Brugia malayi hypothetical protein 0.0073 0.2993 0.2782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1391 0.2142
Brugia malayi Calcitonin receptor-like protein seb-1 0.0199 1 1
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.243 0.2202
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1391 0.1132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0199 1 1
Schistosoma mansoni hypothetical protein 0.0073 0.2993 0.4608

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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