Detailed information for compound 563012

Basic information

Technical information
  • TDR Targets ID: 563012
  • Name: 1-(o-tolyl)-4-[3-(2-thienyloxy)propyl]piperaz ine hydrochloride
  • MW: 352.922 | Formula: C18H25ClN2OS
  • H donors: 0 H acceptors: 0 LogP: 5.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1N1CCN(CC1)CCCOc1cccs1.Cl
  • InChi: 1S/C18H24N2OS.ClH/c1-16-6-2-3-7-17(16)20-12-10-19(11-13-20)9-5-14-21-18-8-4-15-22-18;/h2-4,6-8,15H,5,9-14H2,1H3;1H
  • InChiKey: LHSALRSAMSISAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-methylphenyl)-4-(3-thiophen-2-yloxypropyl)piperazine hydrochloride
  • HOE 510
  • 40737-73-3
  • Hoe-510
  • Piperazine, 1-(2-methylphenyl)-4-(3-(2-thienyloxy)propyl)-, hydrochloride
  • 1-(2-Methylphenyl)-4-(3-(2-thienyloxy)propyl)piperazine hydrochloride
  • 3-gamma-(N-o-Tolylpiperazino)propoxythiophene hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Schistosoma mansoni jumonji domain containing protein 0.0055 0.033 0.033
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0058 0.035 0.7421
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0075 0.0163
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.019 0.0177
Plasmodium falciparum importin beta, putative 0.0025 0.0091 0.1279
Echinococcus granulosus TGF beta signal transducer SmadC 0.0023 0.0075 0.0062
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0021 0.0447
Trypanosoma cruzi PAB1-binding protein , putative 0.0071 0.0459 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.019 0.0488
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0219 0.1652 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.004 0.0056
Brugia malayi Bromodomain containing protein 0.0074 0.048 0.1303
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.004 0.0027
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0064 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.007 0.0261
Brugia malayi hypothetical protein 0.0071 0.0459 0.1243
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.1929 0.5411
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Leishmania major importin beta-1 subunit, putative 0.0021 0.0053 0.1151
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.019 0.0513
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0144 0.1045 0.1034
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Loa Loa (eye worm) Smad1 0.0023 0.0075 0.0163
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0057 0.03
Brugia malayi Flap endonuclease-1 0.0024 0.0079 0.0166
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.019 0.0177
Echinococcus granulosus transcription factor eb 0.0099 0.0682 0.067
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0077
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0021 0.0447
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0057 0.03
Toxoplasma gondii FATC domain-containing protein 0.0023 0.007 0.0405
Brugia malayi nuclear hormone receptor 0.0019 0.004 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0023 0.0075 0.0062
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0058 0.035 0.7632
Plasmodium falciparum ataxin-2 like protein, putative 0.0071 0.0459 1
Loa Loa (eye worm) inositol-1 0.0041 0.0216 0.0562
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0028 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.004 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0179 0.0458
Schistosoma mansoni bromodomain containing protein 0.0063 0.0394 0.0394
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.004 0.0027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0367 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0198 0.0185
Schistosoma mansoni ap endonuclease 0.0039 0.0198 0.0198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0219 0.1652 0.4626
Entamoeba histolytica hypothetical protein 0.0426 0.3315 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0216 0.1023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0058 0.035 0.0338
Schistosoma mansoni hypothetical protein 0.0789 0.6239 0.6239
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0426 0.3315 0.3306
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0198 0.4311
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.004 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0039 0.0062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0053 0.0169
Echinococcus granulosus serine protein kinase ATM 0.0023 0.007 0.0057
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0094 0.0081
Treponema pallidum fructose-bisphosphate aldolase 0.0212 0.1593 1
Schistosoma mansoni mucolipin 0.0064 0.0403 0.0403
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0367 0.345
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.004 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.1652 0.1652
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.004 0.0027
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0079 0.0175
Brugia malayi isocitrate dehydrogenase 0.0058 0.035 0.0935
Schistosoma mansoni transcription factor LCR-F1 0.0426 0.3315 0.3315
Giardia lamblia Flap structure-specific endonuclease 0.0024 0.0079 0.0373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.004 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Schistosoma mansoni cpg binding protein 0.0095 0.0652 0.0652
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.125 0.1238
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0174 0.0435
Echinococcus multilocularis Smad4 0.0023 0.0075 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0058 0.035 0.035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.004 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0311 0.2389 0.6716
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0216 0.1587
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0048 0.0145
Echinococcus granulosus zinc finger protein 0.0023 0.0072 0.0059
Schistosoma mansoni cpg binding protein 0.0095 0.0652 0.0652
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.019 0.4132
Schistosoma mansoni smad1 5 8 and 0.0023 0.0075 0.0075
Plasmodium falciparum phd finger protein, putative 0.0021 0.0057 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0354 0.0354
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0198 0.1127
Trichomonas vaginalis helicase, putative 0.002 0.0048 0.0145
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0144 0.1045 0.1034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.004 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0148 0.0369
Onchocerca volvulus Alhambra homolog 0.0021 0.0057 0.0144
Schistosoma mansoni hypothetical protein 0.0032 0.0144 0.0144
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0094 0.0094
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0107 0.0094
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0021 0.0021
Echinococcus granulosus tar DNA binding protein 0.0058 0.0354 0.0341
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0216 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0216 0.0203
Brugia malayi follicle stimulating hormone receptor 0.0256 0.1946 0.546
Onchocerca volvulus 0.0098 0.0675 0.5352
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.004 0.0027
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0198 0.0503
Loa Loa (eye worm) hypothetical protein 0.0071 0.0459 0.1251
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0098 0.0678 0.1873
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0198 0.0929
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0075 0.0163
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0367 0.0355
Entamoeba histolytica Ran family GTPase 0.0019 0.0038 0.0052
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0032 0.0144 0.0131
Brugia malayi RNA, U transporter 1 0.0072 0.0468 0.1268
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0045 0.0973
Loa Loa (eye worm) hypothetical protein 0.0144 0.1045 0.2912
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0024 0.0079 0.1724
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.004 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.004 0.0056
Plasmodium falciparum flap endonuclease 1 0.0024 0.0079 0.0987
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Brugia malayi jmjC domain containing protein 0.0069 0.0445 0.1202
Echinococcus granulosus FTZ F1 alpha 0.0019 0.004 0.0027
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0021 0.0447
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.004 0.0027
Brugia malayi Isocitrate dehydrogenase 0.0058 0.035 0.0935
Giardia lamblia Fructose-bisphosphate aldolase 0.0212 0.1593 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.019 0.0886
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.125 0.3485
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0219 0.1652 0.4631
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0099 0.0682 0.1877
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0886
Brugia malayi Bromodomain containing protein 0.0035 0.0169 0.0422
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0091 0.0577
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0091 0.0079
Schistosoma mansoni ran 0.0019 0.0038 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0219 0.1652 0.1641
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0455 0.3547 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0064 0.0051
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0058 0.035 0.7632
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0354 0.0354
Trichomonas vaginalis importin beta-1, putative 0.0021 0.0053 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0455 0.3547 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0144 0.1045 0.1034
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0021 0.0447
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.004 0.0056
Brugia malayi Smad1 0.0023 0.0075 0.0154
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0198 0.0538
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.007 0.1531
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.004 0.004
Brugia malayi MH1 domain containing protein 0.0023 0.0075 0.0154
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0239 0.0627
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0079 0.0307
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0216 0.0592
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0367 0.3242
Brugia malayi nuclear receptor NHR-88 0.0019 0.004 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0057 0.0113
Loa Loa (eye worm) hypothetical protein 0.0311 0.2389 0.6719
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.004 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.019 0.4132
Entamoeba histolytica hypothetical protein 0.0021 0.0053 0.0098
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0019 0.0038 0.0025
Schistosoma mansoni flap endonuclease-1 0.0022 0.0061 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0886
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0119 0.0119
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0019 0.0038 0.0108
Echinococcus granulosus mothers against decapentaplegic 5 0.0023 0.0075 0.0062
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0198 0.3804
Echinococcus multilocularis cpg binding protein 0.0095 0.0652 0.064
Leishmania major hypothetical protein, conserved 0.0071 0.0459 1
Brugia malayi Bromodomain containing protein 0.0023 0.0075 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.004 0.0056
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0021 0.0021
Loa Loa (eye worm) transcription factor SMAD2 0.0342 0.264 0.7429
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.004 0.004
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0367 0.0367
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0216 0.1023
Entamoeba histolytica hypothetical protein 0.0426 0.3315 1
Brugia malayi MH1 domain containing protein 0.0023 0.0075 0.0154
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.125 0.1238
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0021 0.0453
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.1929 0.5415
Echinococcus granulosus Smad4 0.0023 0.0075 0.0062
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.004 0.004
Echinococcus multilocularis peregrin 0.0023 0.0075 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0021 0.0447
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Schistosoma mansoni coup transcription factor 0.0019 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.004 0.0027
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.019 0.1375
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0212 0.1593 0.4773
Schistosoma mansoni hypothetical protein 0.1257 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0017 0.0021 0.0453
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0198 0.0185
Echinococcus multilocularis GPCR, family 2 0.0144 0.1045 0.1034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0013 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0367 0.2821
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0198 0.0929
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0216 0.0203
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.004 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.125 1
Schistosoma mansoni ran 0.0019 0.0038 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.1652 0.1652
Entamoeba histolytica hypothetical protein 0.0426 0.3315 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0886
Schistosoma mansoni alpha-glucosidase 0.0146 0.106 0.106
Echinococcus granulosus PHD finger protein rhinoceros 0.0021 0.0057 0.0045
Schistosoma mansoni Smad4 0.0023 0.0075 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.004 0.0056
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0021 0.0447
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.1946 0.5464
Brugia malayi Coelomocyte uptake defective protein 5 0.0064 0.0403 0.1084
Schistosoma mansoni cpg binding protein 0.0088 0.0597 0.0597
Plasmodium falciparum ataxin-2 like protein, putative 0.0071 0.0459 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0216 0.0341
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0426 0.3315 0.3306
Echinococcus multilocularis serine protein kinase ATM 0.0023 0.007 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0019 0.004 0.004
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0019 0.0038 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.004 0.0056
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0021 0.0447
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0198 0.4311
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.019 0.0513
Trypanosoma cruzi importin beta-1 subunit, putative 0.0021 0.0053 0.1151
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0079 0.0477
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0024 0.0079 0.1724
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0019 0.0038 0.0057
Echinococcus multilocularis mucolipin 3 0.0064 0.0403 0.039
Schistosoma mansoni inositol monophosphatase 0.0041 0.0216 0.0216
Echinococcus multilocularis smad 0.0023 0.0075 0.0062
Echinococcus granulosus cpg binding protein 0.0095 0.0652 0.064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.004 0.0065
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0152 0.0139
Brugia malayi MH2 domain containing protein 0.0023 0.0075 0.0154
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0367 0.8004
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0021 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0048 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.004 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0148 0.0148
Trypanosoma cruzi PAB1-binding protein , putative 0.0071 0.0459 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0198 0.4311
Echinococcus multilocularis dnaJ subfamily B 0.1257 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0187 0.0481
Echinococcus multilocularis mothers against decapentaplegic 5 0.0023 0.0075 0.0062
Loa Loa (eye worm) hypothetical protein 0.0035 0.017 0.0432
Brugia malayi MH2 domain containing protein 0.0023 0.0075 0.0154
Schistosoma mansoni hypothetical protein 0.0426 0.3315 0.3315
Echinococcus multilocularis lysine specific demethylase 5A 0.0026 0.0093 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.019 0.4132
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0023 0.007 0.1531
Schistosoma mansoni hypothetical protein 0.0271 0.2066 0.2066
Schistosoma mansoni inositol monophosphatase 0.0041 0.0216 0.0216
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.004 0.0056
Echinococcus granulosus jumonji domain containing protein 0.0029 0.0124 0.0111
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0021 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0021 0.0447
Toxoplasma gondii isocitrate dehydrogenase 0.0058 0.035 0.2682
Brugia malayi steroid hormone receptor 0.0019 0.004 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0071 0.0459 1
Toxoplasma gondii isocitrate dehydrogenase 0.0058 0.035 0.2682
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0021 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.004 0.0065
Brugia malayi jmjC domain containing protein 0.0032 0.0148 0.0361
Onchocerca volvulus 0.0088 0.0597 0.4695
Schistosoma mansoni zinc finger protein 0.0023 0.0072 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0354 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.004 0.0065
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0019 0.0038 0.0138
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0368 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.004 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1299 0.6699
Echinococcus multilocularis zinc finger protein 0.0023 0.0072 0.0059
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.019 0.0479
Trichomonas vaginalis ran, putative 0.0019 0.0038 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0597 0.1643
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.019 0.0886
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0445 0.0432
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Giardia lamblia PHD finger protein 15 0.0021 0.0057 0.0235
Echinococcus granulosus importin subunit beta 1 0.0025 0.0091 0.0079
Schistosoma mansoni alpha-glucosidase 0.0146 0.106 0.106
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0057 0.0473
Loa Loa (eye worm) latrophilin receptor protein 2 0.0144 0.1045 0.2912
Brugia malayi Importin beta-1 subunit 0.0025 0.0091 0.0201
Brugia malayi Latrophilin receptor protein 2 0.0144 0.1045 0.2906
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.1393 0.1393
Plasmodium vivax importin-beta 2, putative 0.0025 0.0091 0.1279
Loa Loa (eye worm) hypothetical protein 0.0065 0.0408 0.1107
Trypanosoma brucei PAB1-binding protein , putative 0.0071 0.0459 1
Echinococcus granulosus mucolipin 3 0.0064 0.0403 0.039
Echinococcus granulosus snurportin 1 0.0271 0.2066 0.2056
Echinococcus granulosus peregrin 0.0023 0.0075 0.0062
Schistosoma mansoni hypothetical protein 0.0021 0.0057 0.0057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0216 0.4699
Loa Loa (eye worm) RNA binding protein 0.0058 0.0354 0.0953
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0024 0.0079 0.1724
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0058 0.035 0.7632
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0144 0.1045 0.1045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.004 0.0056
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0038 0.0818
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.6565 0.656
Loa Loa (eye worm) mucolipin 1 0.0064 0.0403 0.1092
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0354 0.0953
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0064 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0021 0.0447
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0354 0.0945
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0058 0.035 0.7421
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.125 0.1238
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0021 0.0008
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0021 0.0447
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Echinococcus granulosus GTP binding nuclear protein Ran 0.0019 0.0038 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0342 0.264 0.7429
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.019 0.0886
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0058 0.035 0.3133
Loa Loa (eye worm) hypothetical protein 0.0455 0.3547 1
Schistosoma mansoni nuclear hormone receptor 0.0019 0.004 0.004
Echinococcus multilocularis snurportin 1 0.0271 0.2066 0.2056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0216 0.4699
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Echinococcus multilocularis isocitrate dehydrogenase 0.0058 0.035 0.0338
Schistosoma mansoni smad 0.0023 0.0075 0.0075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0019 0.0038 0.0818
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0216 0.4699
Entamoeba histolytica hypothetical protein 0.0426 0.3315 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0023 0.007 0.007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0216 0.1023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0367 0.3242
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0216 0.4699
Schistosoma mansoni alpha glucosidase 0.0038 0.019 0.019
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Schistosoma mansoni hypothetical protein 0.0789 0.6239 0.6239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.007 0.0141
Brugia malayi CXXC zinc finger family protein 0.0088 0.0597 0.1636
Schistosoma mansoni hypothetical protein 0.0144 0.1045 0.1045
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0104 0.0721 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.004 0.004
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0079 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0019 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0107 0.0094
Brugia malayi RNA binding protein 0.0058 0.0354 0.0945
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0058 0.035 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.004 0.0065
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0354 0.0953
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1227 0.6321
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0367 0.3242
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.004 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0032 0.0148 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.004 0.0056
Plasmodium vivax flap endonuclease 1, putative 0.0024 0.0079 0.0987
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0021 0.0447
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0058 0.035 0.7632
Brugia malayi TAR-binding protein 0.0058 0.0354 0.0945
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.004 0.0056
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0021 0.0447
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1299 0.6699
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0032 0.0144 0.0131
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0367 0.0367
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Trypanosoma brucei glucosidase, putative 0.0038 0.019 0.4132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.1929 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0104 0.0721 1
Schistosoma mansoni smad1 5 8 and 0.0023 0.0075 0.0075
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0144 0.1045 0.1034
Loa Loa (eye worm) hypothetical protein 0.0098 0.0678 0.1873
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0064 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.004 0.004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0058 0.035 0.0338
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0021 0.0447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0032 0.0148 0.0148
Brugia malayi Inositol-1 0.0041 0.0216 0.0553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.004 0.004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0144 0.1045 0.2906
Brugia malayi PHD-finger family protein 0.0028 0.0111 0.0257
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.125 0.3491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.004 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0219 0.1652 0.1652
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0094 0.0081
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0104 0.0721 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.004 0.004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.004 0.0027
Echinococcus granulosus smad 0.0023 0.0075 0.0062
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.004 0.0056
Schistosoma mansoni hypothetical protein 0.0144 0.1045 0.1045
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.019 0.0886
Echinococcus multilocularis geminin 0.0789 0.6239 0.6234
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0198 0.0307
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0271 0.2066 0.5805
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0445 0.0432
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.004 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0023 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Schistosoma mansoni smad1 5 8 and 0.0023 0.0075 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0028 0.0028
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0079 0.0178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.004 0.0027
Echinococcus multilocularis jumonji domain containing protein 0.0029 0.0124 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0065
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0058 0.035 0.7632
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0021 0.0057 0.0057
Echinococcus multilocularis PHD finger protein rhinoceros 0.0021 0.0057 0.0045
Schistosoma mansoni importin beta-1 0.0025 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0311 0.2389 0.2389
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0048 0.0145
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0198 0.0511
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0212 0.1593 0.4773
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0028 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0198 0.3804
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0219 0.1652 0.1641
Toxoplasma gondii LsmAD domain-containing protein 0.0071 0.0459 0.3566
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0107 0.0254
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0021 0.0053 0.0169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0152 0.0139
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0113
Echinococcus granulosus GPCR family 2 0.0144 0.1045 0.1034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0058 0.035 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.004 0.0056
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0039
Toxoplasma gondii exonuclease III APE 0.0039 0.0198 0.1442
Leishmania major GTP-binding protein, putative 0.0019 0.0038 0.0818
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Brugia malayi Calcitonin receptor-like protein seb-1 0.0455 0.3547 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1227 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0242 0.0636
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0021 0.0008
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0021 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0212 0.1593 0.8241
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0091 0.1993
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.004 0.0027
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0021 0.0447
Echinococcus granulosus geminin 0.0789 0.6239 0.6234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.004 0.0065
Brugia malayi MH2 domain containing protein 0.0342 0.264 0.7426
Schistosoma mansoni ap endonuclease 0.0039 0.0198 0.0198
Brugia malayi PHD-finger family protein 0.0021 0.0057 0.0105
Echinococcus granulosus flap endonuclease 1 0.0024 0.0079 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0058 0.035 0.0338
Loa Loa (eye worm) isocitrate dehydrogenase 0.0058 0.035 0.0943
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0219 0.1652 0.1641
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0019 0.0038 0.0818
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.019 0.0886
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0048 0.0145
Schistosoma mansoni mucolipin 0.0059 0.036 0.036
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0021 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0368 0.0355
Brugia malayi hypothetical protein 0.0046 0.0256 0.0669
Echinococcus multilocularis transcription factor eb 0.0099 0.0682 0.067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0028 0.0028
Brugia malayi hypothetical protein 0.0426 0.3315 0.9341
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0354 0.0341
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0198 0.4311
Brugia malayi ecdysteroid receptor 0.0019 0.004 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0091 0.1993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.004 0.0065
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.004 0.0027
Schistosoma mansoni hypothetical protein 0.0144 0.1045 0.1045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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