TDR Targets

Basic information

Technical information

TDR Targets ID: 563207
Name: 4-isopropyl-2-(4-nitrophenyl)morpholine
MW: 250.294 | Formula: C13H18N2O3
H donors: 0 H acceptors: 2 LogP: 2.05 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(N1CCOC(C1)c1ccc(cc1)[N+](=O)[O-])C
InChi: 1S/C13H18N2O3/c1-10(2)14-7-8-18-13(9-14)11-3-5-12(6-4-11)15(16)17/h3-6,10,13H,7-9H2,1-2H3
InChiKey: IKRIJCFBDQXYMM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-nitrophenyl)-4-propan-2-yl-morpholine
2-(4-nitrophenyl)-4-propan-2-ylmorpholine
2-(4-nitrophenyl)-4-isopropylmorpholine
41191-16-6
2-(p-Nitrophenyl)-4-isopropylmorpholine
Morpholine, 4-(1-methylethyl)-2-(4-nitrophenyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2282	0.5844
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.3905	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.2055	0.4405
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0733	0.1572
Schistosoma mansoni	lamin	0.0029	0.4665	0.7378
Schistosoma mansoni	hypothetical protein	0.0017	0.2055	0.325
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1296	0.1296
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0672	0.1442
Onchocerca volvulus		0.0029	0.4665	1
Onchocerca volvulus		0.0011	0.0672	0.1442
Plasmodium vivax	replication factor C subunit 1, putative	0.0011	0.0672	0.2682
Schistosoma mansoni	intermediate filament proteins	0.0029	0.4665	0.7378
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0733	0.1572
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2507	0.2507
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.3905	1
Giardia lamblia	Replication factor C, subunit 1	0.0011	0.0672	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3905	0.3905
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.3905	1
Echinococcus granulosus	lamin dm0	0.0029	0.4665	1
Entamoeba histolytica	hypothetical protein	0.0011	0.0672	0.1722
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0733	0.0733
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.1411	0.3026
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.2055	0.4405
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0011	0.0672	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3905	0.3905
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0733	0.0733
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0733	0.116
Loa Loa (eye worm)	hypothetical protein	0.0029	0.455	0.455
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0733	0.1572
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0672	1
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0672	1
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.2507	1
Loa Loa (eye worm)	hypothetical protein	0.0054	1	1
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0672	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2507	0.2507
Onchocerca volvulus		0.0011	0.0733	0.1572
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0733	0.116
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.2507	1
Echinococcus multilocularis	lamin dm0	0.0029	0.4665	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.4665	0.4665
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0733	0.0733
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0733	0.1572
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0733	0.0733
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.2507	0.6421
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0733	0.1572
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0672	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2507	0.2507
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3905	0.3905
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0733	0.0733
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.1745	0.1745
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3905	0.3905
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0733	0.116
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.2055	0.2055
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0733	0.1572
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0733	0.0733
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0672	1
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0672	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0733	0.1572
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0.0672	0.1722
Brugia malayi	hypothetical protein	0.0011	0.0672	0.0672
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0733	0.1572
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.1745	0.1745
Echinococcus granulosus	nibrin	0.0011	0.0672	0.1442
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0733	0.116
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0733	0.0733
Echinococcus multilocularis	musashi	0.0029	0.4665	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3905	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0733	0.0733
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0733	0.0733
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0733	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.2507	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.6322	0.6322
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.3905	1
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.4665	0.4665
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Onchocerca volvulus		0.0012	0.09	0.193
Echinococcus multilocularis	GPCR, family 2	0.0017	0.2055	0.4405
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.2055	0.2055
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3905	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Schistosoma mansoni	hypothetical protein	0.0017	0.2055	0.325
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.3905	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.2507	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0733	0.1572
Treponema pallidum	DNA ligase (lig)	0.0011	0.0672	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0672	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.2055	0.2055
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0733	0.0733
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0672	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0733	0.0733
Schistosoma mansoni	hypothetical protein	0.0017	0.2055	0.325
Schistosoma mansoni	DNA ligase IV	0.0011	0.0672	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0026	0.3905	0.3905
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0672	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0672	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0733	0.116
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0672	1
Schistosoma mansoni	lamin	0.0029	0.4665	0.7378
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0672	0.0672
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2282	0.5844
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1296	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1411	0.1411
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2282	0.5844
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.3905	1
Brugia malayi	ecdysteroid receptor	0.0011	0.0733	0.0733
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0733	0.1572
Brugia malayi	steroid hormone receptor	0.0011	0.0733	0.0733
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0672	0.0672
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0733	0.1572
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.3905	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0733	0.0733
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0733	0.0733
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.3905	1
Echinococcus multilocularis	lamin	0.0029	0.4665	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.4665	0.4665
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.6322	0.6322
Onchocerca volvulus		0.0026	0.3905	0.8371
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0733	0.1572
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.1411	0.3026
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0733	0.116
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0733	0.116
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0672	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0733	0.116
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3905	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0733	0.0733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0733	0.0733
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0672	0.1722
Trypanosoma cruzi	FHA domain containing protein, putative	0.0011	0.0672	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.4665	0.4665
Schistosoma mansoni	topbp1	0.0011	0.0672	0.1064
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0733	0.0733
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0733	0.116
Echinococcus granulosus	GPCR family 2	0.0017	0.2055	0.4405
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0733	0.0733
Schistosoma mansoni	hypothetical protein	0.0037	0.6322	1
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0672	0.1442
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2507	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0019	0.2507	0.2507
Onchocerca volvulus		0.0029	0.4665	1
Brugia malayi	topoisomerase	0.0011	0.0672	0.0672
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0733	0.1572
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.3905	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0733	0.1572
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.2055	0.4405
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0733	0.0733
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0733	0.1572
Brugia malayi	intermediate filament protein	0.0029	0.4665	0.4665
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.3905	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0733	0.0733
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0672	0.1064
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0733	0.0733
Echinococcus granulosus	lamin	0.0029	0.4665	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.3905	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0733	0.116
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0733	0.1572
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3905	1
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0.0672	0.1722
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0672	0.0672
Plasmodium falciparum	replication factor C subunit 1, putative	0.0011	0.0672	0.2682
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0733	0.1572
Echinococcus multilocularis	nibrin	0.0011	0.0672	0.1442
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.3905	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0672	1
Brugia malayi	hypothetical protein	0.0011	0.0672	0.0672
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.3905	1
Brugia malayi	nuclear hormone receptor	0.0011	0.0733	0.0733
Schistosoma mansoni	coup transcription factor	0.0011	0.0733	0.116
Echinococcus granulosus	intermediate filament protein	0.0029	0.4665	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0733	0.116
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0672	1
Schistosoma mansoni	topbp1	0.0011	0.0672	0.1064
Loa Loa (eye worm)	hypothetical protein	0.0017	0.2055	0.2055
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.2055	0.4405
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.2282	0.5844
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0733	0.1572
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0733	0.1572
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0672	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0733	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0672	0.0672
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0733	0.0733
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.3905	0.3905
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0733	0.0733
Schistosoma mansoni	hypothetical protein	0.0017	0.2055	0.325
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0672	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0733	0.1572
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0733	0.116
Mycobacterium ulcerans	hypothetical protein	0.0026	0.3905	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 3016255

Bibliographic References

No literature references available for this target.

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Detailed information for compound 563207