TDR Targets

Basic information

Technical information

TDR Targets ID: 563256
Name: 3,4,6,11-tetrahydro-2H-pyrimido[2,1-b]quinazo line hydrobromide
MW: 268.153 | Formula: C11H14BrN3
H donors: 1 H acceptors: 0 LogP: 1.69 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: C1CN=C2N(C1)Cc1c(N2)cccc1.Br
InChi: 1S/C11H13N3.BrH/c1-2-5-10-9(4-1)8-14-7-3-6-12-11(14)13-10;/h1-2,4-5H,3,6-8H2,(H,12,13);1H
InChiKey: WWURVFKKKVNVHI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,2,3,4-tetrahydropyrimido(1,2-c)quinazoline
41363-26-2
2H-Pyrimido(2,1-b)quinazoline, 1,3,4,6-tetrahydro-, monohydrobromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0378	0.0018
Schistosoma mansoni	hypothetical protein	0.005	0.1408	0.3394
Entamoeba histolytica	hypothetical protein	0.0115	0.4147	1
Entamoeba histolytica	hypothetical protein	0.0115	0.4147	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0048	0.1323	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0048	0.1323	0.1406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0496	0.1267
Loa Loa (eye worm)	hypothetical protein	0.0239	0.9412	0.9412
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0048	0.1323	0.1406
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0048	0.1323	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0903	0.556
Loa Loa (eye worm)	transcription factor SMAD2	0.0252	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0115	0.4147	0.4406
Loa Loa (eye worm)	hypothetical protein	0.0159	0.6028	0.6028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0484	0.1138
Schistosoma mansoni	hypothetical protein	0.0109	0.389	0.9379
Schistosoma mansoni	transcription factor LCR-F1	0.0115	0.4147	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.005	0.1408	0.1496
Schistosoma mansoni	hypothetical protein	0.005	0.1408	0.3394
Echinococcus granulosus	GPCR family 2	0.005	0.1408	0.1496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1323	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.0797	0.5
Brugia malayi	hypothetical protein	0.0239	0.9412	0.9412
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0159	0.6028	0.6028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0496	0.1267
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0038	0.0904	0.6514
Schistosoma mansoni	survival motor neuron protein	0.0049	0.1338	0.3226
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.1023	0.6827
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Brugia malayi	hypothetical protein	0.0115	0.4147	0.4147
Entamoeba histolytica	hypothetical protein	0.0115	0.4147	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0109	0.389	0.389
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0048	0.1323	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.005	0.1408	0.1496
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.1323	0.1323
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0903	0.556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1323	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0023	0.024	0.0985
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0378	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0903	0.556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0378	0.0018
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.005	0.1408	0.1496
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.005	0.1408	0.1496
Schistosoma mansoni	hypothetical protein	0.0115	0.4147	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0048	0.1323	1
Brugia malayi	Latrophilin receptor protein 2	0.005	0.1408	0.1408
Entamoeba histolytica	hypothetical protein	0.0115	0.4147	1
Schistosoma mansoni	hypothetical protein	0.005	0.1408	0.3394
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.9412	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0602	0.2387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0903	0.556
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0048	0.1323	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0159	0.6028	0.6028
Loa Loa (eye worm)	hypothetical protein	0.005	0.1408	0.1408
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.9412	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1323	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0159	0.6028	0.6028
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.005	0.1408	0.1408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Echinococcus multilocularis	GPCR, family 2	0.005	0.1408	0.1496
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.1323	0.1323
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0484	0.1138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0647	0.2856
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0048	0.1323	0.319
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0115	0.4147	0.4406
Giardia lamblia	GTOR	0.0048	0.1323	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0903	0.556
Onchocerca volvulus		0.0049	0.1338	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0252	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.005	0.1408	0.1408
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.1338	0.1338
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0048	0.1323	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0378	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0797	0.444
Loa Loa (eye worm)	hypothetical protein	0.0109	0.389	0.389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0496	0.1267
Schistosoma mansoni	hypothetical protein	0.0049	0.1338	0.3226
Schistosoma mansoni	hypothetical protein	0.005	0.1408	0.3394

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 6451715

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 563256