Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.0644 | 0.8083 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.1324 | 0.1214 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0076 | 0.2936 | 0.2848 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.5419 | 0.5361 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0076 | 0.2936 | 0.2848 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.002 | 0.0644 | 0.7217 |
Schistosoma mansoni | SET domain protein | 0.0009 | 0.0161 | 0.0037 |
Echinococcus multilocularis | snurportin 1 | 0.0248 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.5419 | 0.5361 |
Leishmania major | GTP-binding protein, putative | 0.0017 | 0.0512 | 0.1378 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0332 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.381 | 0.3732 |
Schistosoma mansoni | SET domain protein | 0.0026 | 0.0894 | 0.078 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0013 | 0.0332 | 0.0211 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0076 | 0.2936 | 0.2902 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0009 | 0.0184 | 0.006 |
Brugia malayi | Ets-domain containing protein | 0.0008 | 0.0157 | 0.0034 |
Loa Loa (eye worm) | RNA binding protein | 0.0051 | 0.1906 | 0.1805 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0058 | 0.2207 | 0.2109 |
Schistosoma mansoni | kinase | 0.0039 | 0.1399 | 0.129 |
Loa Loa (eye worm) | TAR-binding protein | 0.0051 | 0.1906 | 0.1805 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0015 | 0.0437 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.1906 | 0.1805 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.9814 | 0.9812 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0008 | 0.0137 | 0.0013 |
Echinococcus granulosus | ewsr:fli fusion protein type | 0.0008 | 0.0157 | 0.0033 |
Brugia malayi | RNA binding protein | 0.0051 | 0.1906 | 0.1839 |
Echinococcus granulosus | ETS transcription factor Elf 5 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | geminin | 0.0137 | 0.5419 | 0.5361 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0332 | 0.074 |
Plasmodium vivax | importin-beta 2, putative | 0.0023 | 0.0764 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.0604 | 0.0486 |
Echinococcus multilocularis | ETS transcription factor Elf 5 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0184 | 0.006 |
Echinococcus granulosus | tar DNA binding protein | 0.0051 | 0.1906 | 0.1805 |
Echinococcus multilocularis | protein C ets 2 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0076 | 0.2936 | 0.2848 |
Schistosoma mansoni | gabp alpha | 0.0058 | 0.2207 | 0.2109 |
Brugia malayi | DNA-binding protein D-ETS-3 | 0.0008 | 0.0157 | 0.0034 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.1324 | 0.1214 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0008 | 0.0137 | 0.0013 |
Brugia malayi | TAR-binding protein | 0.0051 | 0.1906 | 0.1839 |
Schistosoma mansoni | importin beta-1 | 0.0023 | 0.0764 | 0.0648 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0023 | 0.0764 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0137 | 0.0013 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.0644 | 0.1847 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0076 | 0.2936 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0008 | 0.0137 | 0.0204 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0017 | 0.0507 | 0.5908 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0038 | 0.1357 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0764 | 0.0648 |
Echinococcus granulosus | geminin | 0.0137 | 0.5419 | 0.5361 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0009 | 0.0184 | 0.006 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0037 | 0.1324 | 0.1214 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0019 | 0.0583 | 0.1293 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0023 | 0.0764 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0023 | 0.0764 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0008 | 0.0137 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0644 | 0.0526 |
Echinococcus multilocularis | ets variant gene 4 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.0604 | 0.0486 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0008 | 0.0137 | 0.0013 |
Brugia malayi | hypothetical protein | 0.0243 | 0.9814 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0177 | 0.7088 | 0.7051 |
Onchocerca volvulus | 0.0243 | 0.9814 | 1 | |
Brugia malayi | Fli-1 protein | 0.0177 | 0.7088 | 0.7186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0512 | 0.1743 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0013 | 0.0332 | 0.074 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0157 | 0.0033 |
Leishmania major | importin beta-1 subunit, putative | 0.0019 | 0.0583 | 0.1632 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0764 | 0.2601 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0512 | 0.5977 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0512 | 0.1378 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0157 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0157 | 0.0033 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.002 | 0.0644 | 0.1847 |
Trypanosoma brucei | polo-like protein kinase | 0.0076 | 0.2936 | 1 |
Echinococcus multilocularis | ETS transcription factor Elf 1 | 0.0008 | 0.0157 | 0.0033 |
Brugia malayi | Isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0215 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Schistosoma mansoni | ets-related | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | histone lysine N methyltransferase NSD3 | 0.0026 | 0.0894 | 0.078 |
Brugia malayi | isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0215 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0058 | 0.2207 | 0.2109 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Echinococcus granulosus | histone lysine N methyltransferase H3 lysine 36 | 0.0009 | 0.0161 | 0.0037 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0013 | 0.0347 | 0.0332 |
Schistosoma mansoni | ran | 0.0017 | 0.0512 | 0.0392 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0037 | 0.1324 | 0.1238 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0076 | 0.2936 | 0.2902 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.1906 | 0.1805 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.1906 | 0.1805 |
Entamoeba histolytica | Ran family GTPase | 0.0017 | 0.0512 | 0.1378 |
Entamoeba histolytica | hypothetical protein | 0.0019 | 0.0583 | 0.1632 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0013 | 0.0332 | 0.3112 |
Brugia malayi | Importin beta-1 subunit | 0.0023 | 0.0764 | 0.066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Echinococcus multilocularis | ewsr:fli fusion protein type | 0.0008 | 0.0157 | 0.0033 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0023 | 0.0764 | 0.2601 |
Echinococcus granulosus | ETS domain containing protein Elk 1 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0248 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0019 | 0.0604 | 0.0495 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0013 | 0.0332 | 0.5 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0512 | 0.1338 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.1324 | 0.1214 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.1906 | 0.1805 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0008 | 0.0137 | 0.0204 |
Echinococcus granulosus | ETS transcription factor Elf 1 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | ets | 0.0008 | 0.0157 | 0.0033 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0512 | 0.04 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.1324 | 0.1214 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.002 | 0.0644 | 0.2192 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.001 | 0.0234 | 0.0796 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Schistosoma mansoni | DNA helicase recq5 | 0.0008 | 0.0137 | 0.0013 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.3252 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0076 | 0.2936 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.001 | 0.0234 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0157 | 0.0033 |
Brugia malayi | RNA, U transporter 1 | 0.0066 | 0.2524 | 0.2476 |
Brugia malayi | transcription factor E74 isoform | 0.0008 | 0.0157 | 0.0034 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0051 | 0.1906 | 0.1839 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.0008 | 0.0157 | 0.0033 |
Leishmania major | hypothetical protein, conserved | 0.002 | 0.0644 | 0.1847 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0017 | 0.0512 | 0.0392 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Echinococcus granulosus | protein C ets 2 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0037 | 0.1324 | 0.1214 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0076 | 0.2936 | 1 |
Loa Loa (eye worm) | DNA-binding protein D-ETS-3 | 0.0008 | 0.0157 | 0.0033 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0076 | 0.2936 | 1 |
Brugia malayi | hypothetical protein | 0.0013 | 0.0348 | 0.0231 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0019 | 0.0583 | 0.1632 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0037 | 0.1324 | 0.1214 |
Brugia malayi | Ets-domain containing protein | 0.0058 | 0.2207 | 0.2149 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0051 | 0.1906 | 0.1805 |
Schistosoma mansoni | tar DNA-binding protein | 0.0051 | 0.1906 | 0.1805 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.001 | 0.0234 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1859 | 0.1756 |
Brugia malayi | hypothetical protein | 0.002 | 0.0644 | 0.0536 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0019 | 0.0583 | 0.1293 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0008 | 0.0137 | 0.0013 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0017 | 0.0512 | 0.1378 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0013 | 0.034 | 0.3377 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.3252 |
Trichomonas vaginalis | ran, putative | 0.0017 | 0.0512 | 0.1029 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0019 | 0.0604 | 0.137 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0076 | 0.2936 | 1 |
Trypanosoma brucei | transcription elongation factor s-II, putative | 0.0008 | 0.0124 | 0.0423 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0038 | 0.1357 | 0.4157 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0017 | 0.0512 | 0.416 |
Schistosoma mansoni | elf1 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | ets-related | 0.0177 | 0.7088 | 0.7051 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0013 | 0.0332 | 0.1132 |
Brugia malayi | Ets-domain containing protein | 0.0058 | 0.2207 | 0.2149 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.0008 | 0.0157 | 0.0033 |
Schistosoma mansoni | DNA helicase recq1 | 0.0008 | 0.0137 | 0.0013 |
Loa Loa (eye worm) | D-ets-2 protein | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | ETS domain containing protein Elk 1 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0017 | 0.0512 | 0.0392 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.002 | 0.0644 | 0.8122 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.0604 | 0.137 |
Schistosoma mansoni | ran | 0.0017 | 0.0512 | 0.0392 |
Trichomonas vaginalis | importin beta-1, putative | 0.0019 | 0.0583 | 0.1293 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.0604 | 0.0486 |
Loa Loa (eye worm) | ets-domain-containing protein | 0.0008 | 0.0157 | 0.0033 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0017 | 0.0512 | 0.6059 |
Entamoeba histolytica | recQ family helicase, putative | 0.001 | 0.0234 | 0.0389 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0008 | 0.0137 | 0.0013 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0017 | 0.0512 | 0.0392 |
Echinococcus multilocularis | tar DNA binding protein | 0.0051 | 0.1906 | 0.1805 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0013 | 0.0332 | 0.0211 |
Echinococcus multilocularis | histone lysine N methyltransferase, H3 lysine 36 | 0.0009 | 0.0161 | 0.0037 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0058 | 0.2207 | 0.2109 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.0008 | 0.0157 | 0.0033 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0013 | 0.0332 | 0.1132 |
Echinococcus granulosus | importin subunit beta 1 | 0.0023 | 0.0764 | 0.0648 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.002 | 0.0644 | 0.8083 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0248 | 1 | 1 |
Schistosoma mansoni | polyomavirus enhancer activator 3 pea3 | 0.0008 | 0.0157 | 0.0033 |
Echinococcus granulosus | histone lysine N methyltransferase NSD3 | 0.0026 | 0.0894 | 0.078 |
Giardia lamblia | Kinase, PLK | 0.0076 | 0.2936 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0008 | 0.0137 | 0.0013 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0037 | 0.1324 | 0.1214 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0076 | 0.2936 | 0.2848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.