Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | glutathione reductase | 0.0049 | 0.1558 | 0.287 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.2384 | 0.3159 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.2846 | 0.3781 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0522 | 0.0655 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.004 | 0.1131 | 0.1474 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0914 | 0.0882 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2846 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0424 | 0.2552 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1558 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0914 | 0.5773 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0914 | 0.1684 |
Schistosoma mansoni | lamin | 0.0056 | 0.1909 | 0.2521 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2846 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0914 | 0.1182 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1131 | 0.7199 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0914 | 0.0882 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.004 | 0.1131 | 0.1414 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.004 | 0.1131 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0124 | 0.5135 | 0.5118 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1558 | 0.287 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0035 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0914 | 0.3742 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.004 | 0.1131 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0664 | 0.048 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0914 | 0.8019 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0914 | 0.0882 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.2846 | 0.3781 |
Echinococcus granulosus | geminin | 0.0172 | 0.7469 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.5428 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.5428 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0124 | 0.5135 | 0.5118 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.004 | 0.1131 | 0.7199 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.1909 | 0.3517 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0424 | 0.2552 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0914 | 0.3742 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.4542 | 0.4523 |
Onchocerca volvulus | 0.0056 | 0.1909 | 1 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.2384 | 0.3159 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.2846 | 0.3781 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1558 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1131 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0914 | 0.8019 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.004 | 0.1131 | 0.4666 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.1909 | 0.2968 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1131 | 0.1474 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.004 | 0.1131 | 0.4666 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.1558 | 1 |
Schistosoma mansoni | lamin | 0.0056 | 0.1909 | 0.2521 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2846 | 1 |
Leishmania major | trypanothione reductase | 0.0049 | 0.1558 | 0.6482 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0914 | 0.3742 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0424 | 0.0781 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.4542 | 0.4523 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0111 | 0.4542 | 0.8595 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.4542 | 0.4523 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0914 | 0.1684 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0914 | 0.1182 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0124 | 0.5135 | 0.5118 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7469 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0035 | 0.0065 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.2384 | 1 |
Schistosoma mansoni | ap endonuclease | 0.004 | 0.1131 | 0.1474 |
Toxoplasma gondii | exonuclease III APE | 0.004 | 0.1131 | 0.4666 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.2384 | 0.3159 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.1558 | 1 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.5428 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0914 | 0.1182 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.1909 | 0.2521 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.1909 | 0.3517 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.1909 | 0.2521 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1558 | 0.2266 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.1909 | 0.2521 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0914 | 0.0882 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0424 | 0.1654 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0914 | 0.0882 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0914 | 0.0882 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0914 | 0.8019 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0914 | 0.3742 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0914 | 0.3742 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1131 | 0.7199 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0914 | 0.5773 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1558 | 0.6482 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.4542 | 0.4523 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1558 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.4542 | 0.4523 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.004 | 0.1131 | 0.11 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.004 | 0.1131 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.1909 | 0.2521 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.2384 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0424 | 0.2552 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0473 | 0.0098 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0914 | 0.5773 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.2384 | 0.3159 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0473 | 0.0098 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0914 | 0.0882 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0914 | 0.8019 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0914 | 0.0882 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.004 | 0.1131 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1909 | 0.2968 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.186 | 0.287 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0424 | 0.2552 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.2384 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0914 | 0.098 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0914 | 0.5773 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0124 | 0.5135 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.1558 | 0.2048 |
Echinococcus multilocularis | musashi | 0.0056 | 0.1909 | 0.2521 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.2384 | 0.2357 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0424 | 0.2552 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.2384 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0424 | 0.1654 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0914 | 0.8019 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0424 | 0.2552 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.2846 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1558 | 0.2266 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.2384 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.1909 | 0.2968 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0914 | 0.1684 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0914 | 0.098 |
Brugia malayi | hypothetical protein | 0.0076 | 0.2846 | 0.5243 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.4542 | 0.4523 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0914 | 0.1684 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0522 | 0.0655 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.004 | 0.1131 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0914 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0522 | 0.0196 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.1558 | 0.2048 |
Trichomonas vaginalis | ap endonuclease, putative | 0.004 | 0.1131 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.2846 | 0.3781 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0664 | 0.1224 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.004 | 0.1131 | 0.7199 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0914 | 0.0882 |
Echinococcus granulosus | lamin | 0.0056 | 0.1909 | 0.2521 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0914 | 0.0882 |
Echinococcus multilocularis | lamin | 0.0056 | 0.1909 | 0.2521 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.004 | 0.1131 | 0.7199 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1558 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0914 | 0.3742 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0914 | 0.3742 |
Echinococcus multilocularis | geminin | 0.0172 | 0.7469 | 1 |
Onchocerca volvulus | 0.0056 | 0.1909 | 1 | |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.1558 | 0.1528 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0914 | 0.1182 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0914 | 0.8019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.