Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0099 | 0.123 | 0.123 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0078 | 0.0925 | 0.0925 |
Brugia malayi | Animal haem peroxidase family protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Onchocerca volvulus | 0.07 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.07 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0098 | 0.1209 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.07 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0078 | 0.0925 | 0.0925 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.07 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0098 | 0.1209 | 0.5 |
Echinococcus multilocularis | fibropellin Ia | 0.0078 | 0.0925 | 0.0925 |
Trichomonas vaginalis | immunophilin, putative | 0.0098 | 0.1209 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.07 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0086 | 0.1034 | 0.012 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0098 | 0.1209 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0098 | 0.1209 | 0.0314 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.07 | 1 | 1 |
Onchocerca volvulus | 0.07 | 1 | 1 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0099 | 0.123 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0098 | 0.1209 | 0.0314 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0078 | 0.0925 | 0.0925 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0078 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0078 | 0.0925 | 0.0925 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.07 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.07 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.07 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0098 | 0.1209 | 0.0314 |
Schistosoma mansoni | immunophilin | 0.0099 | 0.123 | 0.0336 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0099 | 0.123 | 0.5 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0078 | 0.0925 | 0.0925 |
Echinococcus multilocularis | neural cadherin | 0.0078 | 0.0925 | 0.0925 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0098 | 0.1209 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.07 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0099 | 0.123 | 0.0336 |
Leishmania major | fk506-binding protein 1-like protein | 0.0098 | 0.1209 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.07 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0099 | 0.123 | 0.0336 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0098 | 0.1209 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0098 | 0.1209 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.07 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.07 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0078 | 0.0925 | 0.0925 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0078 | 0.0925 | 0.0925 |
Schistosoma mansoni | peroxidasin | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0098 | 0.1209 | 0.0314 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0098 | 0.1209 | 0.0314 |
Loa Loa (eye worm) | animal heme peroxidase | 0.07 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0098 | 0.1209 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0078 | 0.0925 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1013 | 0.0097 |
Onchocerca volvulus | Peroxidasin homolog | 0.07 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0098 | 0.1209 | 0.0314 |
Brugia malayi | Animal haem peroxidase family protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Onchocerca volvulus | 0.07 | 1 | 1 | |
Toxoplasma gondii | EGF family domain-containing protein | 0.0078 | 0.0925 | 0.5 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0078 | 0.0925 | 0.0925 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0086 | 0.1034 | 0.012 |
Echinococcus multilocularis | slit 2 protein | 0.0078 | 0.0925 | 0.0925 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.07 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0098 | 0.1209 | 0.1209 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0086 | 0.1034 | 0.1034 |
Brugia malayi | Peroxidasin | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.07 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.07 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0098 | 0.1209 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 7.08 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
Log 1/C (binding) | = 7.08 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
pKD (binding) | = 7.23 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 7.8 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 7.23 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 7.8 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.