Detailed information for compound 56392

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.427 | Formula: C21H25NO5
  • H donors: 1 H acceptors: 3 LogP: 2.85 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C[C@H]([C@@H](N(C(=O)OCc1ccccc1)C)Cc1ccccc1)O
  • InChi: 1S/C21H25NO5/c1-22(21(25)27-15-17-11-7-4-8-12-17)18(19(23)14-20(24)26-2)13-16-9-5-3-6-10-16/h3-12,18-19,23H,13-15H2,1-2H3/t18-,19+/m0/s1
  • InChiKey: NTFJSFAGMHDILF-RBUKOAKNSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi cytochrome P450 0.008 0.2582 0.2578
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0005 0.002
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.002
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0005 0.5
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0005 0.5
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.008 0.2582 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.008 0.2582 1
Echinococcus granulosus cytochrome P450 2K1 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.008 0.2582 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0005 0.0005
Mycobacterium leprae putative cytochrome p450 0.008 0.2582 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.008 0.2582 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Mycobacterium leprae Conserved hypothetical protein 0.008 0.2582 0.5
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.008 0.2582 1
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0005 0.5
Loa Loa (eye worm) cytochrome P450 0.008 0.2582 0.2582
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0005 0.5
Brugia malayi Cytochrome P450 family protein 0.008 0.2582 0.2578
Schistosoma mansoni hypothetical protein 0.008 0.2582 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0005 0.0005
Brugia malayi Cytochrome P450 family protein 0.011 0.3717 0.3714
Leishmania major cytochrome p450-like protein 0.011 0.3717 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.002
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0005 0.5
Toxoplasma gondii cytochrome p450 superfamily protein 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.008 0.2582 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) CYP4Cod1 0.011 0.3717 0.3717
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0005 0.5
Leishmania major cytochrome p450-like protein 0.008 0.2582 0.6941
Onchocerca volvulus 0.0013 0.0005 0.5
Trypanosoma cruzi cytochrome P450, putative 0.011 0.3717 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.008 0.2582 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0005 0.5
Trypanosoma cruzi cytochrome P450, putative 0.011 0.3717 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.008 0.2582 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.002
Trichomonas vaginalis abcb9, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0276 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0005 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.002
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0005 0.5
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0005 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.008 0.2582 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0005 0.5
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.008 0.2582 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.011 0.3717 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.002
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0005 0.5
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.002
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0005 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0005 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.008 0.2582 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0656 0.0656
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.002
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.002
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.008 0.2582 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.3717 0.3717
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.011 0.3717 0.3717
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.008 0.2582 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0005 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Trypanosoma brucei cytochrome P450, putative 0.011 0.3717 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Echinococcus multilocularis 0.008 0.2582 1
Schistosoma mansoni cytochrome P450 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.008 0.2582 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0005 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.002
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.008 0.2582 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Trichomonas vaginalis abcb9, putative 0.0013 0.0005 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Leishmania major cytochrome p450-like protein 0.008 0.2582 0.6941
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.008 0.2582 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.008 0.2582 0.6941
Trichomonas vaginalis abcb9, putative 0.0013 0.0005 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0005 0.5
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0005 0.002
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.008 0.2582 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.008 0.2582 1
Trichomonas vaginalis taga, putative 0.0013 0.0005 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0005 0.5
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0005 0.5
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0005 0.5
Brugia malayi Cytochrome P450 family protein 0.011 0.3717 0.3714

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 17.1 uM Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the presence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) = 17.1 uM Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the presence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) > 89 uM Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) > 89 uM Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine ChEMBL. 10386932
Ratio (functional) = 5.2 Ratio of IC50 of cytotoxicity to the IC50 of MDR- reversal for P388/VMDRC.04 cells ChEMBL. 10386932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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