Detailed information for compound 564124

Basic information

Technical information
  • TDR Targets ID: 564124
  • Name: 5-chloro-2-hydroxy-3-[N'-(2-hydroxy-4-oxo-cyc lohexa-2,5-dien-1-ylidene)hydrazino]benzenesu lfonic acid
  • MW: 344.728 | Formula: C12H9ClN2O6S
  • H donors: 4 H acceptors: 6 LogP: 1.61 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C/C(=N/Nc2cc(Cl)cc(c2O)S(=O)(=O)O)/C(=C1)O
  • InChi: 1S/C12H9ClN2O6S/c13-6-3-9(12(18)11(4-6)22(19,20)21)15-14-8-2-1-7(16)5-10(8)17/h1-5,15,17-18H,(H,19,20,21)
  • InChiKey: RQIJHLQABPWAQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-2-hydroxy-3-[N'-(2-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)hydrazino]benzenesulfonic acid
  • 5-chloro-2-hydroxy-3-[2-(2-hydroxy-4-oxo-cyclohexa-2,5-dien-1-ylidene)hydrazinyl]benzenesulfonic acid
  • 5-chloro-2-hydroxy-3-[N'-(2-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)hydrazino]besylic acid
  • 5-chloro-2-hydroxy-3-[2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]benzenesulfonic acid
  • 4-chloro-3-(2,4-dihydroxyphenylazo)-2-hydroxybenzene-1-sulfonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.2835 0.8837
Entamoeba histolytica hypothetical protein 0.0037 0.0751 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0129 0.0129
Loa Loa (eye worm) carboxylesterase 0.0132 0.3635 0.3625
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0431 0.0417
Brugia malayi Carboxylesterase family protein 0.0132 0.3635 0.3635
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0431 0.0825
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0182 0.0587
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0431 0.1005
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0022 0.0318 0.0303
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0168 0.1815
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0215 0.3978
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0431 0.0431
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0215 0.0281
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0045
Schistosoma mansoni acetylcholinesterase 0.0022 0.0318 0.0732
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0015 0.0015
Onchocerca volvulus 0.0022 0.0318 0.0601
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.3368 0.3358
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0153
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Echinococcus granulosus carboxylesterase 5A 0.0132 0.3635 0.3625
Loa Loa (eye worm) glutathione reductase 0.0046 0.1043 0.1029
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0968 0.0968
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0345 0.0707
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0431 0.0825
Brugia malayi Carboxylesterase family protein 0.0022 0.0318 0.0318
Brugia malayi hypothetical protein 0.0022 0.0318 0.0318
Entamoeba histolytica acetyltransferase, GNAT family 0.0032 0.0625 0.7663
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1043 0.1029
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0022 0.0318 0.0385
Echinococcus granulosus survival motor neuron protein 1 0.0342 1 1
Brugia malayi glutathione reductase 0.0046 0.1043 0.1043
Leishmania major trypanothione reductase 0.0046 0.1043 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0345 0.2435
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0431 0.0431
Brugia malayi hypothetical protein 0.0037 0.0751 0.0751
Echinococcus granulosus dna polymerase kappa 0.0019 0.0215 0.02
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0709 0.0694
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0431 0.1005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0021 0.0289 0.0662
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0431 0.0417
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0129 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0431 0.0417
Mycobacterium ulcerans carboxylesterase, LipT 0.0022 0.0318 0.8752
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0431 0.0431
Brugia malayi Carboxylesterase family protein 0.0022 0.0318 0.0318
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0431 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0431 0.0417
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0215 0.0482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0345 0.0707
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0168 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0345 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0182 0.0587
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0129 0.0906
Leishmania major DNA polymerase eta, putative 0.0031 0.0575 0.488
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0149 0.4155 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0431 0.0417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Brugia malayi hypothetical protein 0.0014 0.006 0.006
Schistosoma mansoni thyroid hormone receptor 0.0149 0.4155 1
Schistosoma mansoni hypothetical protein 0.007 0.1756 0.4205
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Leishmania major DNA polymerase kappa, putative 0.0019 0.0215 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0021 0.0289 0.0662
Echinococcus granulosus BC026374 protein S09 family 0.0022 0.0318 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0751 0.0736
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.007 0.1756 0.1756
Leishmania major DNA polymerase eta, putative 0.0044 0.0968 0.9187
Echinococcus granulosus para nitrobenzyl esterase 0.0022 0.0318 0.0303
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0431 0.0825
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0021 0.0289 0.0274
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0182 0.0587
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0968 0.9187
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0431 0.1005
Trypanosoma brucei trypanothione reductase 0.0046 0.1043 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0215 0.0175
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.3635 0.3625
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0215 0.0175
Onchocerca volvulus 0.0023 0.0345 0.0655
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.2835 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0431 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0431 0.0431
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1043 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0153
Brugia malayi nuclear receptor RXR 0.0012 0.0015 0.0015
Brugia malayi Carboxylesterase family protein 0.0022 0.0318 0.0318
Brugia malayi Carboxylesterase family protein 0.0132 0.3635 0.3635
Onchocerca volvulus 0.0179 0.5056 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.2835 0.8837
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0132 0.3635 0.3625
Loa Loa (eye worm) carboxylesterase 0.0022 0.0318 0.0303
Echinococcus granulosus histone acetyltransferase KAT2B 0.0117 0.3183 0.3172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.0326 0.075
Onchocerca volvulus 0.0023 0.0326 0.0616
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Brugia malayi nuclear receptor NHR-67 0.0012 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0215 0.1763
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0035 0.0715 0.641
Brugia malayi ecdysone receptor 0.0012 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0021 0.0289 0.0662
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1043 0.1029
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0431 0.0431
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0168 0.043
Schistosoma mansoni gliotactin 0.0022 0.0318 0.0732
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0431 0.1005
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.006 0.006
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0015 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.3368 0.3358
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0345 0.237
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0318 0.0732
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.2835 0.8837
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0431 0.0431
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0168 0.043
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.006 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0431 0.1005
Plasmodium falciparum glutathione reductase 0.0046 0.1043 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0318 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0431 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0139 0.0035
Schistosoma mansoni BC026374 protein (S09 family) 0.0022 0.0318 0.0732
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0139 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.2835 0.8837
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0345 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0022 0.0318 0.0385
Plasmodium vivax glutathione reductase, putative 0.0046 0.1043 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0431 0.0417
Mycobacterium tuberculosis Carboxylesterase LipT 0.0022 0.0318 0.0619
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0431 0.0417
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0023 0.0326 0.2159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0431 0.1005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0139 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.0301 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0182 0.0587
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0045
Brugia malayi nuclear hormone receptor 0.0012 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0431 0.0417
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0022 0.0318 0.0303
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0182 0.0587
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.006 0.0045
Schistosoma mansoni hypothetical protein 0.0037 0.0751 0.1776
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0129 0.0906
Echinococcus granulosus histone acetyltransferase KAT2B 0.0035 0.0715 0.07
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0345 1
Entamoeba histolytica hypothetical protein 0.0037 0.0751 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.4155 0.4146
Brugia malayi Thioredoxin reductase 0.0046 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0431 0.0431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0709 0.0694
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0021 0.0289 0.0274
Brugia malayi nuclear receptor NHR-88 0.0012 0.0015 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0215 0.0943
Onchocerca volvulus 0.007 0.1756 0.3454
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0431 0.1005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Echinococcus multilocularis BC026374 protein (S09 family) 0.0022 0.0318 0.0303
Plasmodium falciparum thioredoxin reductase 0.0046 0.1043 1
Schistosoma mansoni hypothetical protein 0.0123 0.3368 0.8098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Brugia malayi conserved hypotetical protein 0.0012 0.0015 0.0015
Brugia malayi tailless protein 0.0012 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0024 0.0372 0.0861
Plasmodium falciparum histone acetyltransferase GCN5 0.0032 0.0625 0.5435
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0215 0.0281
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0023 0.0326 0.0311
Mycobacterium ulcerans hypothetical protein 0.0023 0.0345 1
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3635 0.3625
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0431 0.0417
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0431 0.0417
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0431 0.0417
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0318 0.0619
Toxoplasma gondii thioredoxin reductase 0.0046 0.1043 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0431 0.0431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0431 0.0417
Trypanosoma brucei unspecified product 0.0019 0.0215 0.1763
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.006 0.006
Loa Loa (eye worm) carboxylesterase 0.0022 0.0318 0.0303
Loa Loa (eye worm) hypothetical protein 0.0132 0.3635 0.3625
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0157 0.4399 0.439
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0215 0.0943
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1043 1
Plasmodium vivax SET domain protein, putative 0.0023 0.0326 0.2159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0431 0.0431
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.006 0.0108
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0431 0.1005
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0035 0.0715 0.641
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0431 0.0417
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0182 0.0587
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3191 1
Onchocerca volvulus 0.0022 0.0318 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0431 0.0417
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.2835 0.8749
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0021 0.0289 0.0274
Treponema pallidum NADH oxidase 0.0016 0.0129 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0968 0.9261
Loa Loa (eye worm) hypothetical protein 0.0023 0.0345 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0372 0.0357
Giardia lamblia DINP protein human, muc B family 0.0019 0.0215 0.1735
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Brugia malayi steroid hormone receptor 0.0026 0.0431 0.0431
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0751 0.1776
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0345 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0215 0.0943
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0215 0.02
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1043 0.1029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0129 0.0114
Brugia malayi hypothetical protein 0.0014 0.006 0.006
Brugia malayi nuclear hormone receptor 0.0026 0.0431 0.0431
Loa Loa (eye worm) acetyltransferase 0.012 0.3285 0.3274
Brugia malayi Carboxylesterase family protein 0.0022 0.0318 0.0318
Trichomonas vaginalis set domain proteins, putative 0.0179 0.5056 1
Onchocerca volvulus 0.0022 0.0318 0.0601
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0153
Giardia lamblia Histone acetyltransferase GCN5 0.0032 0.0625 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0431 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763
Schistosoma mansoni survival motor neuron protein 0.007 0.1756 0.4205
Echinococcus granulosus dna polymerase eta 0.0044 0.0968 0.0954
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0215 0.0943
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0035 0.0715 0.1189
Echinococcus multilocularis dna polymerase eta 0.0044 0.0968 0.0954
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0345 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0345 0.2435
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.006 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0342 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0326 0.0311
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0575 0.488
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0372 0.0372
Brugia malayi hypothetical protein 0.0018 0.0182 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0345 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0345 0.2435
Brugia malayi Pre-SET motif family protein 0.0023 0.0326 0.0326
Brugia malayi hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.012 0.3285 0.7897
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0431 0.0431
Brugia malayi ecdysteroid receptor 0.0026 0.0431 0.0431
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0215 0.02
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0044 0.0968 0.0954
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0215 0.1763
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0035 0.0715 0.641
Brugia malayi nuclear receptor RXR 0.0014 0.006 0.006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0035 0.0715 0.1189
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0215 0.02
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable reductase 0.0105 0.2835 0.8837
Brugia malayi nuclear receptor NHR-88 0.0026 0.0431 0.0431
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3191 1
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0431 0.0417
Loa Loa (eye worm) hypothetical protein 0.0022 0.0318 0.0303
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0022 0.0318 0.0619
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0431 0.0431
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0215 0.02
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0215 0.0482
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0431 0.0431
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0575 0.488
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0431 0.0417
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0129 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0751 0.0736
Onchocerca volvulus 0.0022 0.0318 0.0601
Brugia malayi Pre-SET motif family protein 0.0157 0.4399 0.4399
Onchocerca volvulus 0.0026 0.0431 0.0825
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0345 0.0345
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1043 0.2985
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0345 0.237
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0129 0.0906
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.3635 0.3625
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0345 0.237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0139 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0431 0.0431
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0345 0.0345
Entamoeba histolytica hypothetical protein 0.0037 0.0751 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.012 0.3285 0.3274
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3635 0.3625
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0431 0.0431
Onchocerca volvulus 0.0022 0.0318 0.0601
Echinococcus granulosus acetylcholinesterase 0.0132 0.3635 0.3625
Echinococcus granulosus acetylcholinesterase 0.0132 0.3635 0.3625
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0129 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0021 0.0289 0.0274
Schistosoma mansoni neuroligin 3 (S09 family) 0.0022 0.0318 0.0732
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0021 0.0289 0.0289
Echinococcus multilocularis neuroligin 0.0022 0.0318 0.0303
Echinococcus multilocularis survival motor neuron protein 1 0.0342 1 1
Schistosoma mansoni coup transcription factor 0.0026 0.0431 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0431 0.0431
Brugia malayi Cytochrome P450 family protein 0.0018 0.0188 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0021 0.0289 0.0274
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0129 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0431 0.1005
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.0326 0.0311
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0188 0.0173
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0431 0.0417
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0215 0.1763
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.006 0.0045
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0022 0.0318 0.0732
Echinococcus multilocularis para nitrobenzyl esterase 0.0022 0.0318 0.0303
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0182 0.144
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0326 0.075
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.3635 0.8742
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0431 0.0417
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0431 0.1005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0431 0.0417
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3191 1
Leishmania major hypothetical protein, conserved 0.0018 0.0182 0.0587
Schistosoma mansoni DNA polymerase eta 0.0044 0.0968 0.2302
Entamoeba histolytica hypothetical protein 0.0037 0.0751 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0431 0.0417
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.0326 0.0311
Loa Loa (eye worm) hypothetical protein 0.0017 0.0168 0.0153
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0431 0.0417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0215 0.0943
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3191 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0345 0.033
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0431 0.0417
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0345 1
Brugia malayi acetyltransferase, GNAT family protein 0.012 0.3285 0.3285
Loa Loa (eye worm) hypothetical protein 0.0023 0.0345 0.033
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0215 0.3978
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0129 0.0906
Echinococcus granulosus neuroligin 0.0022 0.0318 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0215 0.1763

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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