Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Nitric oxide synthase, inducible | 0.141 | 0.8717 | 1 |
Leishmania major | p450 reductase, putative | 0.1591 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1591 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0982 | 0.5684 | 0.5684 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1591 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0982 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0181 | 0 | 0.5 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0609 | 0.3033 | 0.3033 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1591 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0609 | 0.3033 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0609 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1591 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0982 | 0.5684 | 0.5684 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1591 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0609 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0789 | 0.4316 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1591 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0609 | 0.3033 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1591 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0609 | 0.3033 | 0.3033 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0181 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0609 | 0.3033 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1591 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1591 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0181 | 0 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0609 | 0.3033 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1591 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1591 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1591 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1591 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.141 | 0.8717 | 0.8717 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0801 | 0.4402 | 0.4402 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1591 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0982 | 0.5684 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0982 | 0.5684 | 0.5684 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0609 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0609 | 0.3033 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.141 | 0.8717 | 0.8717 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0609 | 0.3033 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.141 | 0.8717 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1591 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0609 | 0.3033 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0609 | 0.3033 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1591 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0181 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1591 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1591 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0789 | 0.4316 | 0.4316 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0982 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0181 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0789 | 0.4316 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0609 | 0.3033 | 0.3033 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.141 | 0.8717 | 0.8159 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Loa Loa (eye worm) | flavodoxin family protein | 0.0609 | 0.3033 | 0.3033 |
Brugia malayi | flavodoxin family protein | 0.0609 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.1591 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1591 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1591 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 410 nM | Inhibition of thrombin | ChEMBL. | No reference |
Ki (binding) | = 410 nM | Inhibition of thrombin | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.