TDR Targets

Basic information

Technical information

TDR Targets ID: 565139
Name: (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperi dine-3,4,5-triol hydrochloride
MW: 255.739 | Formula: C10H22ClNO4
H donors: 4 H acceptors: 4 LogP: 0.17 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN1C[C@H](O)[C@H]([C@@H]([C@H]1CO)O)O.Cl
InChi: 1S/C10H21NO4.ClH/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12;/h7-10,12-15H,2-6H2,1H3;1H/t7-,8+,9-,10-;/m1./s1
InChiKey: QPAFAUYWVZMWPR-ZSOUGHPYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3R,4R,5S)-1-butyl-2-methylol-piperidine-3,4,5-triol hydrochloride
miglustat
(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; hydron; chloride
(2R,3R,4R,5S)-1-butyl-2-methylol-piperidine-3,4,5-triol; hydron; chloride
MLS000069516
N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE
N-Butyldeoxynojirimycin
N-Butyl-DNJ, HCl
N-Butyldeoxynojirimycin, Hydrochloride
NB-DNJ
SMR000058560
NB-DNJ, HCl
B8299_SIGMA

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0023	0.024	0.0268
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.1085	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0329	0.0348
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0956	0.1421
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.1825	0.2384
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.1825	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0956	0.0149
Echinococcus granulosus	zinc finger protein	0.0022	0.019	0.016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.141	0.2151
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Brugia malayi	intermediate filament protein	0.0033	0.0626	0.0843
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.1085	0.1485
Loa Loa (eye worm)	transcription factor SMAD2	0.0134	0.4843	0.6524
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0999	0.0499
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.141	0.1819
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0073	0.0098
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0626	0.0843
Trypanosoma brucei	protein kinase, putative	0.0062	0.1825	1
Brugia malayi	Bromodomain containing protein	0.0043	0.1063	0.1432
Echinococcus granulosus	lamin	0.0033	0.0626	0.0753
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.141	0.1819
Echinococcus granulosus	lamin dm0	0.0033	0.0626	0.0753
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0956	0.1288
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.1825	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.1085	0.1485
Schistosoma mansoni	lamin	0.0033	0.0626	0.089
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0953	0.1197
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.1085	0.1462
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0999	0.0499
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0956	0.0149
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0999	0.0499
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0999	0.1491
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1066	0.1437
Schistosoma mansoni	bromodomain containing protein	0.0071	0.2227	0.3467
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0999	0.0499
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0956	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.1085	0.1485
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0956	0.1202
Echinococcus multilocularis	musashi	0.0033	0.0626	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1177	0.1585
Brugia malayi	beta-lactamase family protein	0.0041	0.0956	0.1288
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0956	0.0149
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0999	0.0499
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.1825	1
Brugia malayi	Bromodomain containing protein	0.0084	0.2774	0.3737
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.7423	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.141	0.1819
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0999	0.1491
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0956	0.1288
Brugia malayi	beta-lactamase family protein	0.0041	0.0956	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0956	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0601	0.081
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.1825	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0999	0.0499
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.1825	1
Schistosoma mansoni	alpha-glucosidase	0.0169	0.6288	1
Onchocerca volvulus		0.0041	0.0956	0.0982
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.0999	0.0499
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0329	0.0412
Loa Loa (eye worm)	inositol-1	0.0042	0.0999	0.1347
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.1825	0.2819
Echinococcus multilocularis	zinc finger protein	0.0022	0.019	0.016
Echinococcus multilocularis	lamin dm0	0.0033	0.0626	0.0753
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.1825	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0329	0.0348
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0956	0.0149
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0626	0.089
Brugia malayi	Inositol-1	0.0042	0.0999	0.1347
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.1825	0.2384
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0956	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0999	0.0499
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0999	0.1261
Brugia malayi	MH2 domain containing protein	0.0134	0.4843	0.6524
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.0999	0.5
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.1085	0.1462
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.2061	0.2705
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.1825	0.2384
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.7423	1
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.1825	1
Onchocerca volvulus		0.0114	0.3989	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.1825	0.2384
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0953	0.1197
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.1085	1
Echinococcus granulosus	intermediate filament protein	0.0033	0.0626	0.0753
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.1085	0.1485
Echinococcus multilocularis	lamin	0.0033	0.0626	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1266	0.1705
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.2061	0.2705
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.1085	0.1485
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.141	0.19
Onchocerca volvulus		0.0041	0.0956	0.0982
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0956	0.0149
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0956	0.0149
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0956	0.0149
Loa Loa (eye worm)	hypothetical protein	0.008	0.2574	0.3468
Brugia malayi	beta-lactamase	0.0041	0.0956	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0626	0.0843
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.1085	0.1377
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0956	0.1202
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1085	0.1485
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.1825	1
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0956	0.0149
Schistosoma mansoni	zinc finger protein	0.0022	0.019	0.0189
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.7423	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0956	0.0149
Schistosoma mansoni	alpha-glucosidase	0.0169	0.6288	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.1085	0.1485
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.141	0.19
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.024	0.0323
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.1825	1
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0626	0.0843
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1085	0.1485
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0101	0.0136
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.1085	0.1485
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0999	1
Brugia malayi	MAP kinase sur-1	0.0062	0.1825	0.2459
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.141	0.1819
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.1085	0.1377
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Trypanosoma brucei	glucosidase, putative	0.0044	0.1085	0.1485
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.1825	0.5
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.7423	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.1825	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.7423	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1085	0.1485
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.1825	1
Onchocerca volvulus		0.0041	0.0956	0.0982
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0956	0.0149
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.141	0.2151
Schistosoma mansoni	lamin	0.0033	0.0626	0.089
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.141	0.2151
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1085	0.1485
Brugia malayi	PHD-finger family protein	0.0028	0.0439	0.0591
Schistosoma mansoni	alpha glucosidase	0.0044	0.1085	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0956	0.1288
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.1085	0.1485
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0999	0.1261
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0956	0.1421
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.1825	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0626	0.0843
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.1825	0.2459
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0956	0.1288
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.1085	0.1485
Loa Loa (eye worm)	MH2 domain-containing protein	0.0134	0.4843	0.6524

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Substrate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Substrate. (Class of assay: confirmatory) [Related pubchem assays: 1466, 1473 ]	ChEMBL.	No reference
Potency (functional)	1.2589 uM	PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1466, AID1473, AID2293]	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
ChEMBL: CHEMBL1329690
PubChem: 6603107

Bibliographic References

No literature references available for this target.

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Detailed information for compound 565139