Detailed information for compound 565158

Basic information

Technical information
  • TDR Targets ID: 565158
  • Name: 1-(2,2-dimethyltetrahydropyran-4-yl)-4-(p-tol yl)-4,8-dihydro-2H-pyrazolo[3,4-e][1,4]thiaze pine-3,7-dione
  • MW: 387.496 | Formula: C20H25N3O3S
  • H donors: 2 H acceptors: 3 LogP: 2.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(c2c(N1)n(nc2O)C1CCOC(C1)(C)C)c1ccc(cc1)C
  • InChi: 1S/C20H25N3O3S/c1-12-4-6-13(7-5-12)17-16-18(21-15(24)11-27-17)23(22-19(16)25)14-8-9-26-20(2,3)10-14/h4-7,14,17H,8-11H2,1-3H3,(H,21,24)(H,22,25)
  • InChiKey: IXSTZASRIKIXAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,2-dimethyl-4-tetrahydropyranyl)-4-(p-tolyl)-4,8-dihydro-2H-pyrazolo[3,4-e][1,4]thiazepine-3,7-dione
  • 1-(2,2-dimethyloxan-4-yl)-4-(4-methylphenyl)-4,8-dihydro-2H-pyrazolo[3,4-e][1,4]thiazepine-3,7-dione
  • 1-(2,2-dimethyltetrahydropyran-4-yl)-4-(p-tolyl)-4,8-dihydro-2H-pyrazolo[3,4-e][1,4]thiazepine-3,7-quinone
  • 1-(2,2-dimethyloxan-4-yl)-4-(4-methylphenyl)-4,8-dihydro-2H-pyrazolo[5,4-e][1,4]thiazepine-3,7-dione
  • 1-(2,2-dimethyltetrahydropyran-4-yl)-4-(4-methylphenyl)-4,8-dihydro-2H-pyrazolo[5,4-e][1,4]thiazepine-3,7-dione
  • 1-(2,2-dimethyl-4-tetrahydropyranyl)-4-(4-methylphenyl)-4,8-dihydro-2H-pyrazolo[5,4-e][1,4]thiazepine-3,7-dione
  • 1-(2,2-dimethyltetrahydropyran-4-yl)-4-(4-methylphenyl)-4,8-dihydro-2H-pyrazolo[5,4-e][1,4]thiazepine-3,7-quinone
  • A3758/0159335
  • 1-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-hydroxy-4-(4-methylphenyl)-4,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7(6H)-one
  • MLS000051440
  • SMR000079765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus orexin receptor type 2 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.3985 0.3985
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi ORL1-like opioid receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni adenoreceptor 0.008 0.3985 0.3985
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.3985 0.3985
Schistosoma mansoni amine GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.3985 0.3985
Echinococcus granulosus G protein coupled receptor 139 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine receptor 0.008 0.3985 0.3985
Brugia malayi GnHR receptor homolog 0.008 0.3985 0.3985
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0131 1 0.5
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0131 1 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.3985 0.3985
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0131 1 0.5
Schistosoma mansoni opsin-like receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.3985 0.3985
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0131 1 0.5
Schistosoma mansoni opsin-like receptor 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.214 0.214
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni tar DNA-binding protein 0.0065 0.214 0.214
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Brugia malayi Dopamine receptor protein 2 0.008 0.3985 0.3985
Echinococcus multilocularis g protein coupled receptor 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptide receptor 0.008 0.3985 0.3985
Echinococcus granulosus somatostatin receptor 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.3985 0.3985
Brugia malayi G-protein coupled receptor 0.008 0.3985 0.3985
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.3985 0.3985
Schistosoma mansoni hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptide s receptor 0.008 0.3985 0.3985
Echinococcus multilocularis fmrfamide receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.3985 0.3985
Brugia malayi Dopamine receptor 0.008 0.3985 0.3985
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.3985 0.3985
Echinococcus granulosus serotonin receptor 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Toxoplasma gondii adenosylhomocysteinase, putative 0.0131 1 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0131 1 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Brugia malayi Dopamine receptor protein 1 0.008 0.3985 0.3985
Echinococcus multilocularis G protein coupled receptor 139 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptides capa receptor 0.008 0.3985 0.3985
Schistosoma mansoni opsin-like receptor 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus g protein coupled receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.3985 0.3985
Loa Loa (eye worm) adenosylhomocysteinase 0.0131 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.3985 0.5
Onchocerca volvulus 0.008 0.3985 0.5
Schistosoma mansoni adenosylhomocysteinase 0.0081 0.4069 0.4069
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.3985 0.3985
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0131 1 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.3985 0.3985
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptide receptor 0.008 0.3985 0.3985
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) TYRA-2 protein 0.008 0.3985 0.3985
Echinococcus granulosus g protein coupled receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) RNA binding protein 0.0065 0.214 0.214
Brugia malayi neuropeptide F receptor 0.008 0.3985 0.3985
Echinococcus multilocularis tar DNA binding protein 0.0065 0.214 0.214
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Brugia malayi G protein-coupled receptor 0.008 0.3985 0.3985
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide receptor 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis adenosylhomocysteinase 0.0131 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni tar DNA-binding protein 0.0065 0.214 0.214
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.3985 0.3985
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) TAR-binding protein 0.0065 0.214 0.214
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.3985 0.3985
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0131 1 0.5
Echinococcus granulosus fmrfamide receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptide s receptor 0.008 0.3985 0.3985
Brugia malayi putative neuropeptide receptor 0.008 0.3985 0.3985
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0131 1 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni adenosylhomocysteinase 0.0131 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni amine GPCR 0.008 0.3985 0.3985
Schistosoma mansoni tar DNA-binding protein 0.0065 0.214 0.214
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.3985 0.3985
Echinococcus multilocularis sex peptide receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus g-protein coupled receptor 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptide Y receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.3985 0.3985
Echinococcus multilocularis allatostatin A receptor 0.008 0.3985 0.3985
Schistosoma mansoni amine GPCR 0.008 0.3985 0.3985
Schistosoma mansoni histamine h1 receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.3985 0.3985
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.3985 0.5
Echinococcus granulosus g protein coupled receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) follicle stimulating hormone receptor 0.008 0.3985 0.3985
Echinococcus multilocularis serotonin receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine receptor 0.008 0.3985 0.3985
Echinococcus granulosus adenosylhomocysteinase 0.0131 1 1
Echinococcus multilocularis fmrfamide receptor 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Schistosoma mansoni myosin xvIII 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.3985 0.3985
Brugia malayi Serotonin receptor 0.008 0.3985 0.3985
Brugia malayi TAR-binding protein 0.0065 0.214 0.214
Brugia malayi RE15519p 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Schistosoma mansoni neuropeptide receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Brugia malayi AKH receptor 0.008 0.3985 0.3985
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.3985 0.3985
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.3985 0.3985
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.3985 0.3985
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus tar DNA binding protein 0.0065 0.214 0.214
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.3985 0.3985
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni adenosylhomocysteinase 0.0081 0.4069 0.4069
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.3985 0.3985
Echinococcus multilocularis somatostatin receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus allatostatin A receptor 0.008 0.3985 0.3985
Schistosoma mansoni adenosylhomocysteinase 0.0081 0.4069 0.4069
Echinococcus granulosus neuropeptide receptor 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus sex peptide receptor 0.008 0.3985 0.3985
Plasmodium falciparum adenosylhomocysteinase 0.0131 1 0.5
Echinococcus multilocularis serotonin receptor 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptide Y receptor 0.008 0.3985 0.3985
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.3985 0.3985
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.3985 0.3985
Schistosoma mansoni tar DNA-binding protein 0.0065 0.214 0.214
Onchocerca volvulus 0.008 0.3985 0.5
Brugia malayi follicle stimulating hormone receptor 0.008 0.3985 0.3985
Schistosoma mansoni amine GPCR 0.008 0.3985 0.3985
Brugia malayi RNA binding protein 0.0065 0.214 0.214
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.3985 0.3985
Echinococcus multilocularis g protein coupled receptor 0.008 0.3985 0.3985
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.3985 0.3985
Schistosoma mansoni adenosylhomocysteinase 0.0081 0.4069 0.4069
Entamoeba histolytica adenosylhomocysteinase, putative 0.0131 1 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.3985 0.3985
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.3985 0.3985
Schistosoma mansoni hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.3985 0.3985
Brugia malayi neuropeptide F receptor 0.008 0.3985 0.3985
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Schistosoma mansoni amine GPCR 0.008 0.3985 0.3985
Leishmania major S-adenosylhomocysteine hydrolase 0.0131 1 0.5
Echinococcus granulosus neuropeptides capa receptor 0.008 0.3985 0.3985
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.3985 0.3985
Brugia malayi hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.3985 0.3985
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0131 1 0.5
Brugia malayi Melatonin receptor type 1A 0.008 0.3985 0.3985
Brugia malayi larval opioid receptor 0.008 0.3985 0.3985
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.3985 0.3985
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.3985 0.3985
Echinococcus multilocularis orexin receptor type 2 0.008 0.3985 0.3985
Brugia malayi sulfakinin receptor protein 0.008 0.3985 0.3985
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0131 1 0.5
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.3985 0.3985
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.3985 0.3985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.3985 0.3985
Echinococcus multilocularis neuropeptide receptor 0.008 0.3985 0.3985
Schistosoma mansoni hypothetical protein 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Schistosoma mansoni tar DNA-binding protein 0.0065 0.214 0.214
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.3985 0.3985
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.3985 0.3985
Schistosoma mansoni hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus neuropeptide receptor A26 0.008 0.3985 0.3985
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.3985 0.3985
Brugia malayi Serotonin receptor 0.008 0.3985 0.3985
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.214 0.214
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus multilocularis g protein coupled receptor 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine receptor 0.008 0.3985 0.3985
Brugia malayi G-protein coupled receptor 0.008 0.3985 0.3985
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.3985 0.3985
Onchocerca volvulus 0.008 0.3985 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.3985 0.3985
Schistosoma mansoni neuropeptide receptor 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.3985 0.3985
Echinococcus multilocularis g-protein coupled receptor 0.008 0.3985 0.3985
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.008 0.3985 0.3985
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.3985 0.3985

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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