Detailed information for compound 565382

Basic information

Technical information
  • TDR Targets ID: 565382
  • Name: 2,5-dihydroxybenzoate
  • MW: 153.112 | Formula: C7H5O4-
  • H donors: 2 H acceptors: 4 LogP: 1.94 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)C(=O)[O-])O
  • InChi: 1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1
  • InChiKey: WXTMDXOMEHJXQO-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 2,5-dihydroxybenzoic acid
  • thiamine thiazolone
  • 490-80-2
  • Hydroquinonecarboxylate
  • Benzoic acid, 2,5-dihydroxy-, ion(1-)
  • ZINC00001507
  • c0325

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0031 0.0488 0.0413
Echinococcus multilocularis carbonic anhydrase 0.0134 0.375 0.3792
Schistosoma mansoni hypothetical protein 0.0134 0.375 0.3792
Loa Loa (eye worm) hypothetical protein 0.0068 0.1648 0.1615
Brugia malayi CHE-14 protein 0.0042 0.0816 0.1109
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.2581 0.2582
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0281 0.0193
Trichomonas vaginalis STE family protein kinase 0.0074 0.1835 1
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1104 0.5811
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.3908 0.3957
Schistosoma mansoni hypothetical protein 0.004 0.0768 0.0703
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1104 0.1396
Schistosoma mansoni hypothetical protein 0.0171 0.4902 0.4986
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0266 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1104 0.5811
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.2581 0.3509
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1104 0.5811
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0266 0.0361
Brugia malayi MH2 domain containing protein 0.0118 0.3239 0.4403
Loa Loa (eye worm) hypothetical protein 0.003 0.0449 0.0373
Echinococcus granulosus carbonic anhydrase 0.0134 0.375 0.3792
Entamoeba histolytica fatty acid elongase, putative 0.0043 0.0854 0.3068
Trichomonas vaginalis ran, putative 0.0022 0.0196 0.0607
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0488 0.0413
Echinococcus granulosus carbonic anhydrase II 0.0248 0.7357 0.753
Leishmania major hypothetical protein, conserved 0.0025 0.0281 0.0263
Echinococcus multilocularis dual specificity mitogen activated protein 0.0074 0.1835 0.1809
Schistosoma mansoni protein kinase 0.0074 0.1835 0.1809
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0331 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0196 0.0146
Leishmania major importin beta-1 subunit, putative 0.0025 0.0268 0.0245
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0268 0.0245
Schistosoma mansoni hypothetical protein 0.0323 0.9741 1
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0266 0.0183
Schistosoma mansoni ran 0.0022 0.0196 0.011
Echinococcus granulosus slit 2 protein 0.0024 0.0266 0.0183
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0074 0.1835 0.2402
Echinococcus multilocularis carbonic anhydrase 0.0134 0.375 0.3792
Schistosoma mansoni hypothetical protein 0.004 0.0768 0.0703
Leishmania major carbonic anhydrase-like protein 0.0248 0.7357 1
Echinococcus granulosus pikachurin 0.0024 0.0266 0.0183
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.375 0.5097
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0074 0.1835 0.2402
Echinococcus multilocularis importin subunit beta 1 0.003 0.0449 0.0373
Leishmania major GTP-binding protein, putative 0.0022 0.0196 0.0146
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.9741 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.375 0.3792
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0268 0.1019
Schistosoma mansoni hypothetical protein 0.0031 0.0488 0.0413
Brugia malayi MAP kinase sur-1 0.0051 0.1104 0.15
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2647 0.265
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.2581 0.2582
Schistosoma mansoni importin beta-1 0.003 0.0449 0.0373
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.375 0.5097
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.375 0.3792
Echinococcus granulosus expressed conserved protein 0.0092 0.2394 0.2387
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0281 0.0193
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0196 0.011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1104 0.1396
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.7357 0.753
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0074 0.1835 0.2495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0266 0.0183
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3239 0.3263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0488 0.0413
Schistosoma mansoni slit 0.0024 0.0266 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1648 0.224
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0196 0.011
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0449 0.0982
Echinococcus granulosus carbonic anhydrase 0.0134 0.375 0.3792
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0281 0.0193
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0816 0.0753
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.7357 1
Echinococcus multilocularis geminin 0.0171 0.4902 0.4986
Loa Loa (eye worm) hypothetical protein 0.0042 0.0816 0.0753
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0098 0.0011
Giardia lamblia Kinase, STE STE20 0.0074 0.1835 1
Brugia malayi EGF-like domain containing protein 0.0024 0.0266 0.0361
Loa Loa (eye worm) hypothetical protein 0.0134 0.375 0.3792
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0488 0.0413
Toxoplasma gondii hypothetical protein 0.0134 0.375 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1104 0.1051
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0331 1 1
Schistosoma mansoni carbonic anhydrase 0.0134 0.375 0.3792
Schistosoma mansoni hypothetical protein 0.0171 0.4902 0.4986
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1104 0.1396
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.2581 1
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0331 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0098 0.0011
Schistosoma mansoni hypothetical protein 0.0031 0.0488 0.0413
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1104 0.1051
Brugia malayi hypothetical protein 0.0025 0.0281 0.0381
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.375 0.3792
Entamoeba histolytica fatty acid elongase, putative 0.0043 0.0854 0.3068
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0488 0.0664
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1104 0.1051
Entamoeba histolytica fatty acid elongase, putative 0.0043 0.0854 0.3068
Loa Loa (eye worm) hypothetical protein 0.0031 0.0488 0.0413
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.375 0.3792
Plasmodium falciparum carbonic anhydrase 0.0134 0.375 0.3693
Echinococcus multilocularis protein patched 0.0042 0.0816 0.0753
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0281 0.0522
Echinococcus multilocularis slit 2 protein 0.0024 0.0266 0.0183
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.009 0.0122
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1104 0.1051
Schistosoma mansoni cell polarity protein 0.0024 0.0266 0.0183
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0331 1 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0098 0.0133
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0266 0.0183
Entamoeba histolytica fatty acid elongase, putative 0.0043 0.0854 0.3068
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3239 0.3263
Schistosoma mansoni hypothetical protein 0.0068 0.1648 0.1615
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.7357 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0816 0.0753
Loa Loa (eye worm) hypothetical protein 0.0134 0.375 0.3792
Schistosoma mansoni patched 1 0.0042 0.0816 0.0753
Loa Loa (eye worm) hypothetical protein 0.0024 0.0266 0.0183
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0281 0.0263
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0074 0.1835 0.1809
Entamoeba histolytica hypothetical protein 0.0025 0.0268 0.0714
Echinococcus multilocularis GPCR, family 2 0.0031 0.0488 0.0413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2647 0.3598
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.375 0.5097
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0266 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.1115 0.1062
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0281 0.0263
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.375 0.5097
Entamoeba histolytica Ran family GTPase 0.0022 0.0196 0.0426
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0488 0.0664
Plasmodium falciparum importin beta, putative 0.003 0.0449 0.0363
Brugia malayi laminin alpha chain 0.0024 0.0266 0.0361
Loa Loa (eye worm) hypothetical protein 0.0025 0.0281 0.0198
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.7357 0.753
Trichomonas vaginalis STE family protein kinase 0.0074 0.1835 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.2629 0.2631
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0196 0.0107
Brugia malayi Cytochrome P450 family protein 0.0048 0.1021 0.1388
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0074 0.1835 0.2402
Trichomonas vaginalis STE family protein kinase 0.0074 0.1835 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0816 0.0753
Entamoeba histolytica fatty acid elongase, putative 0.0043 0.0854 0.3068
Brugia malayi RNA, U transporter 1 0.0086 0.222 0.3017
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1104 0.1051
Echinococcus multilocularis carbonic anhydrase 0.0134 0.375 0.3792
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0281 0.0263
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0196 0.011
Schistosoma mansoni hypothetical protein 0.004 0.0768 0.0703
Echinococcus granulosus carbonic anhydrase 0.0134 0.375 0.3792
Echinococcus multilocularis expressed conserved protein 0.0092 0.2394 0.2387
Echinococcus multilocularis snurportin 1 0.0323 0.9741 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.7357 1
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0098 0.0008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0196 0.0107
Echinococcus granulosus dual specificity mitogen activated protein 0.0074 0.1835 0.1809
Echinococcus granulosus importin subunit beta 1 0.003 0.0449 0.0373
Loa Loa (eye worm) hypothetical protein 0.0024 0.0266 0.0183
Schistosoma mansoni hypothetical protein 0.01 0.2663 0.2667
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0098 0.0008
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0098 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0098 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0196 0.0146
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0449 0.0495
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.375 0.3792
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.1021 0.0965
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0196 0.0146
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.7357 0.753
Brugia malayi Cytochrome P450 family protein 0.0019 0.0098 0.0133
Echinococcus granulosus geminin 0.0171 0.4902 0.4986
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.3908 0.3957
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0196 0.0266
Trypanosoma brucei protein kinase, putative 0.0051 0.1104 0.1396
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1104 0.1051
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0331 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2647 0.3598
Plasmodium vivax importin-beta 2, putative 0.003 0.0449 0.0363
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1104 0.1396
Echinococcus multilocularis pikachurin 0.0024 0.0266 0.0183
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.7357 1
Leishmania major cytochrome p450-like protein 0.0019 0.0098 0.0011
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.7357 0.753
Echinococcus granulosus GPCR family 2 0.0031 0.0488 0.0413
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.009 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1104 0.5811
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0449 0.0495
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0266 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1104 0.5811
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0268 0.1019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1104 0.2771
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0816 0.0753
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0331 1 1
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0266 0.0183
Schistosoma mansoni hypothetical protein 0.004 0.0768 0.0703
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0488 0.0413
Trypanosoma brucei RNA helicase, putative 0.01 0.2663 0.3541
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0816 0.4161
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0331 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1104 0.1396
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0196 0.0607
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1104 0.1396
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.375 0.5097
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.7357 1
Echinococcus granulosus snurportin 1 0.0323 0.9741 1
Schistosoma mansoni hypothetical protein 0.0031 0.0488 0.0413
Schistosoma mansoni ran 0.0022 0.0196 0.011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1104 0.1396
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0268 0.1019
Loa Loa (eye worm) hypothetical protein 0.0097 0.2581 0.2582
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0098 0.0008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0196 0.029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0488 0.0413
Brugia malayi Importin beta-1 subunit 0.003 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0099 0.2647 0.265
Echinococcus multilocularis protein dispatched 1 0.0048 0.1003 0.0947
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.7357 0.753

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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