Detailed information for compound 565415

Basic information

Technical information
  • TDR Targets ID: 565415
  • Name: [[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo- pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-o xido-phosphoryl] phosphate
  • MW: 399.165 | Formula: C10H13N2O11P2---
  • H donors: 2 H acceptors: 8 LogP: -3.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)([O-])[O-])[O-])n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1
  • InChiKey: UJLXYODCHAELLY-XLPZGREQSA-K  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2-tetrahydrofuranyl]methoxy-oxidophosphoryl] phosphate
  • [[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] phosphate
  • [[(2R,3S,5R)-5-(2,4-diketo-5-methyl-pyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl] phosphate
  • [[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-oxidophosphoryl] phosphate
  • thymidine 5'-diphosphate
  • [[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy-oxido-phosphoryl] phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0178 0.1449 0.2934
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0466 0.0455
Trypanosoma cruzi hexose transporter, putative 0.0178 0.1449 0.3771
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0466 0.0455
Brugia malayi Protein kinase domain containing protein 0.0093 0.0699 0.0667
Echinococcus multilocularis dual specificity 0.0093 0.0699 0.0689
Loa Loa (eye worm) hypothetical protein 0.0092 0.0692 0.066
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0299 0.0287
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0036 0.0001
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0081 0.0592 0.0581
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0094 0.0708 0.0697
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0699 0.174
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0439 0.375 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0439 0.375 0.75
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0466 0.0455
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0205 0.017
Trypanosoma cruzi hexose transporter 0.0178 0.1449 0.3771
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0735 0.1837
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0044 0.0009
Loa Loa (eye worm) hypothetical protein 0.0086 0.0636 0.0603
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1148 1 1
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0205 0.04
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0057 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0592 0.1198
Trichomonas vaginalis glucose transporter, putative 0.0178 0.1449 0.2934
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0057 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0373 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0205 0.0149
Onchocerca volvulus 0.0081 0.0592 0.7297
Schistosoma mansoni hypothetical protein 0.0574 0.494 0.4934
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0205 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.2152 0.2124
Onchocerca volvulus 0.0081 0.0592 0.7297
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1148 1 1
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Brugia malayi hypothetical protein 0.0081 0.0592 0.0559
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0057 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0035 0.0024
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0574 0.494 0.4934
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus multilocularis synaptic vesicle 2 protein 0.0081 0.0592 0.0581
Echinococcus granulosus microtubule associated protein 2 0.0716 0.6191 0.6187
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Trichomonas vaginalis glucose transporter, putative 0.0081 0.0592 0.1198
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0081 0.0592 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Giardia lamblia Hexose transporter 0.0081 0.0592 0.1781
Mycobacterium ulcerans hypothetical protein 0.0037 0.0205 0.0149
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0735 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0094 0.0708 0.1111
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0735 0.1837
Onchocerca volvulus 0.006 0.0409 0.3847
Onchocerca volvulus 0.0081 0.0592 0.7297
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0205 0.0414
Echinococcus multilocularis cpg binding protein 0.0063 0.0439 0.0428
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0636 0.1928
Echinococcus multilocularis General substrate transporter 0.0493 0.4228 0.4222
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0094 0.0708 0.0697
Entamoeba histolytica protein kinase, putative 0.0093 0.0699 0.214
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni glucose transport protein 0.0574 0.494 0.4934
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0299 0.0264
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0024
Echinococcus granulosus dna polymerase eta 0.002 0.0057 0.0045
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0057 0.0115
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0024
Echinococcus multilocularis dihydrofolate reductase 0.1148 1 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0093 0.0699 0.1861
Echinococcus granulosus synaptic vesicle 2 protein 0.0081 0.0592 0.0581
Trypanosoma cruzi hexose transporter, putative 0.0081 0.0592 0.1449
Onchocerca volvulus Putative transporter 0.0081 0.0592 0.7297
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0205 0.04
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0205 0.0193
Toxoplasma gondii facilitative glucose transporter GT1 0.0574 0.494 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0373 0.0339
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0636 0.1928
Trichomonas vaginalis myo-inositol transporter, putative 0.0081 0.0592 0.1198
Mycobacterium ulcerans lipase LipD 0.0037 0.0205 0.0149
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0094 0.0708 0.0697
Onchocerca volvulus 0.0081 0.0592 0.7297
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0306 0.0619
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0094 0.0708 0.0697
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0439 0.375 0.75
Loa Loa (eye worm) sugar transporter 0.0081 0.0592 0.0559
Brugia malayi major facilitator superfamily protein 0.0081 0.0592 0.0559
Mycobacterium ulcerans beta-lactamase 0.0037 0.0205 0.0149
Loa Loa (eye worm) major facilitator superfamily transporter 0.0081 0.0592 0.0559
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0057 0.0045
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0082 0.0607 0.0596
Trypanosoma brucei glucose transporter 1E 0.0178 0.1449 0.3862
Echinococcus granulosus dna polymerase kappa 0.002 0.0057 0.0045
Leishmania major glucose transporter, lmgt3 0.0178 0.1449 0.3771
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0146
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0306 0.0619
Onchocerca volvulus 0.0081 0.0592 0.7297
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0094 0.0708 0.0697
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0299 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0179 0.0167
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.2152 0.2124
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Echinococcus multilocularis solute carrier family 22 0.0081 0.0592 0.0581
Loa Loa (eye worm) glutaminase 0.0279 0.2342 0.2315
Entamoeba histolytica hypothetical protein 0.0093 0.0699 0.214
Loa Loa (eye worm) beta-lactamase 0.0037 0.0205 0.017
Echinococcus granulosus solute carrier family 22 0.0081 0.0592 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0205 0.0414
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0179 0.0167
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0466 0.0433
Plasmodium falciparum hexose transporter 0.0574 0.494 1
Echinococcus multilocularis Smad4 0.0018 0.0035 0.0024
Schistosoma mansoni sugar transporter 0.0081 0.0592 0.0581
Leishmania major glucose transporter/membrane transporter D2, putative 0.0178 0.1449 0.3771
Echinococcus multilocularis dna polymerase kappa 0.002 0.0057 0.0045
Echinococcus granulosus dihydrofolate reductase 0.1148 1 1
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Onchocerca volvulus 0.0081 0.0592 0.7297
Onchocerca volvulus 0.0081 0.0592 0.7297
Brugia malayi beta-lactamase family protein 0.0037 0.0205 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1001 0.0991
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0044 0.0032
Toxoplasma gondii sugar transporter ST1 0.0081 0.0592 0.0868
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Brugia malayi CXXC zinc finger family protein 0.006 0.0409 0.0375
Onchocerca volvulus 0.0081 0.0592 0.7297
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0081 0.0592 0.0538
Trichomonas vaginalis glutaminase, putative 0.0279 0.2342 0.4741
Trichomonas vaginalis glucose transporter, putative 0.0178 0.1449 0.2934
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0466 0.0433
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0057 0.0022
Chlamydia trachomatis dihydrofolate reductase 0.1148 1 0.5
Plasmodium vivax hexose transporter 0.0574 0.494 1
Plasmodium vivax sugar transporter, putative 0.0081 0.0592 0.0868
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0081 0.0592 0.0868
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0057 0.0022
Echinococcus granulosus tar DNA binding protein 0.0066 0.0466 0.0455
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0057 0.0115
Echinococcus multilocularis dna polymerase eta 0.002 0.0057 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0735 0.2259
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Echinococcus granulosus Sugar transporter ERD6 protein 0.0081 0.0592 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Schistosoma mansoni cpg binding protein 0.0063 0.0439 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Leishmania major glucose transporter, lmgt1 0.0178 0.1449 0.3771
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0205 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0592 0.1198
Trypanosoma brucei THT1 - hexose transporter, putative 0.0178 0.1449 0.3862
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0735 0.1837
Entamoeba histolytica hypothetical protein 0.0103 0.0785 0.2425
Brugia malayi beta-lactamase 0.0037 0.0205 0.017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0036 0.0025
Onchocerca volvulus 0.0081 0.0592 0.7297
Echinococcus granulosus solute carrier family 22 0.0081 0.0592 0.0581
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Echinococcus granulosus solute carrier family 22 0.0081 0.0592 0.0581
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0361 0.306 1
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0025
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0081 0.0592 0.5
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0439 0.375 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0299 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0735 0.0724
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0036 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0036 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0205 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0146
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0735 0.0702
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0592 0.0559
Loa Loa (eye worm) dihydrofolate reductase 0.1148 1 1
Onchocerca volvulus 0.0081 0.0592 0.7297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0881 0.1476
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Echinococcus granulosus geminin 0.0357 0.3024 0.3016
Onchocerca volvulus 0.0081 0.0592 0.7297
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0735 0.0724
Onchocerca volvulus 0.0081 0.0592 0.7297
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Entamoeba histolytica protein kinase, putative 0.0093 0.0699 0.214
Trypanosoma brucei unspecified product 0.002 0.0057 0.0146
Leishmania major hypothetical protein, conserved 0.0037 0.0205 0.04
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0179 0.0167
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0205 0.0149
Loa Loa (eye worm) glutaminase 2 0.0279 0.2342 0.2315
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0001
Schistosoma mansoni cpg binding protein 0.006 0.0409 0.0398
Trichomonas vaginalis sugar transporter, putative 0.0178 0.1449 0.2934
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0081 0.0592 0.1574
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Loa Loa (eye worm) hypothetical protein 0.0092 0.0692 0.066
Toxoplasma gondii transporter, major facilitator family protein 0.0081 0.0592 0.0868
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.6191 0.6187
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni hypothetical protein 0.0357 0.3024 0.3016
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1148 1 1
Schistosoma mansoni glucose transport protein 0.0574 0.494 0.4934
Mycobacterium ulcerans integral membrane transport protein 0.0081 0.0592 0.0538
Schistosoma mansoni DNA polymerase eta 0.002 0.0057 0.0045
Trichomonas vaginalis esterase, putative 0.0037 0.0205 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0299 0.0287
Brugia malayi isocitrate dehydrogenase 0.0034 0.0179 0.0144
Trypanosoma brucei glucose transporter 2A 0.0178 0.1449 0.3862
Echinococcus granulosus smad 0.0018 0.0035 0.0024
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0735 0.0724
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.1449 0.2934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0299 0.0287
Schistosoma mansoni sugar transporter 0.0081 0.0592 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni hypothetical protein 0.0357 0.3024 0.3016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0036 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0466 0.0455
Schistosoma mansoni glucose transport protein 0.0574 0.494 0.4934
Schistosoma mansoni cpg binding protein 0.0063 0.0439 0.0428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0183
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0205 0.0193
Giardia lamblia Sugar-proton symporter 0.0081 0.0592 0.1781
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.1952 0.1906
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0081 0.0592 0.0538
Onchocerca volvulus 0.0081 0.0592 0.7297
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.0785 0.2425
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0179 0.0167
Schistosoma mansoni Smad4 0.0018 0.0035 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Loa Loa (eye worm) sugar transporter 0.0574 0.494 0.4922
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0179 0.0122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0205 0.0193
Echinococcus multilocularis solute carrier family 22 0.0081 0.0592 0.0581
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0179 0.0471
Echinococcus granulosus General substrate transporter 0.0493 0.4228 0.4222
Onchocerca volvulus 0.0081 0.0592 0.7297
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0205 0.0414
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0466 0.0433
Schistosoma mansoni glucose transporter 0.0081 0.0592 0.0581
Loa Loa (eye worm) major facilitator superfamily transporter 0.0081 0.0592 0.0559
Loa Loa (eye worm) RNA binding protein 0.0066 0.0466 0.0433
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0205 0.0193
Giardia lamblia DNA repair protein RAD52 0.0361 0.306 1
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transport protein, putative 0.0081 0.0592 0.1198
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0205 0.0149
Brugia malayi Sugar transporter family protein 0.0081 0.0592 0.0559
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0205 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0699 0.0689
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0439 0.375 0.75
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0179 0.033
Brugia malayi Sugar transporter family protein 0.0081 0.0592 0.0559
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0093 0.0699 0.174
Leishmania major hypothetical protein, conserved 0.0081 0.0592 0.1449
Mycobacterium ulcerans glutaminase 0.0279 0.2342 0.2298
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0094 0.0708 0.0675
Schistosoma mansoni smad 0.0018 0.0035 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0205 0.054
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0179 0.0144
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0205 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0299 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Trypanosoma brucei THT1 - hexose transporter, putative 0.0178 0.1449 0.3862
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0205 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0373 0.0339
Brugia malayi hypothetical protein 0.0081 0.0592 0.0559
Trypanosoma brucei polo-like protein kinase 0.0097 0.0735 0.1956
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0082 0.0607 0.0574
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0082 0.0607 0.0596
Leishmania major glucose transporter, lmgt2 0.0178 0.1449 0.3771
Mycobacterium ulcerans sugar transporter 0.0081 0.0592 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Trypanosoma cruzi sugar transporter, putative 0.0081 0.0592 0.1449
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0179 0.0167
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0205 0.017
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Echinococcus granulosus dual specificity 0.0093 0.0699 0.0689
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Schistosoma mansoni smad1 5 8 and 0.0018 0.0035 0.0024
Brugia malayi beta-lactamase family protein 0.0037 0.0205 0.017
Brugia malayi hypothetical protein 0.0081 0.0592 0.0559
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0025
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Brugia malayi TAR-binding protein 0.0066 0.0466 0.0433
Trypanosoma brucei sugar transporter, putative 0.0081 0.0592 0.1574
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0217 0.0183
Schistosoma mansoni sugar transporter 0.0081 0.0592 0.0581
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0057 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0205 0.0414
Brugia malayi Sugar transporter family protein 0.0574 0.494 0.4922
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0057 0.0045
Echinococcus multilocularis solute carrier family 22 0.0081 0.0592 0.0581
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0179 0.033
Mycobacterium tuberculosis Conserved protein 0.0037 0.0205 0.0149
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0439 0.375 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0299 0.0287
Schistosoma mansoni hypothetical protein 0.0018 0.0036 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0299 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Entamoeba histolytica protein kinase domain containing protein 0.0093 0.0699 0.214
Schistosoma mansoni kinase 0.005 0.0317 0.0306
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0082 0.0607 0.0574
Echinococcus multilocularis smad 0.0018 0.0035 0.0024
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0081 0.0592 0.0538
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0574 0.494 0.4934
Trypanosoma cruzi glucose transporter, putative 0.0081 0.0592 0.1449
Schistosoma mansoni dihydrofolate reductase 0.1148 1 1
Trichomonas vaginalis sugar transporter, putative 0.0178 0.1449 0.2934
Toxoplasma gondii sugar transporter ST2 0.0081 0.0592 0.0868
Giardia lamblia Kinase, PLK 0.0097 0.0735 0.2259
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0044 0.0032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0179 0.033
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0035 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0036 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0574 0.494 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0179 0.0167
Echinococcus multilocularis solute carrier family 22 0.0081 0.0592 0.0581
Trypanosoma cruzi hexose transporter, putative 0.0178 0.1449 0.3771
Loa Loa (eye worm) hypothetical protein 0.0037 0.0205 0.017
Schistosoma mansoni hypothetical protein 0.0038 0.0217 0.0206
Onchocerca volvulus 0.0081 0.0592 0.7297
Toxoplasma gondii sugar transporter ST3 0.0081 0.0592 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0592 0.1198
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0057 0.0146
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0035 0.0024
Schistosoma mansoni glutaminase 0.0279 0.2342 0.2333
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0036 0.0025
Echinococcus granulosus solute carrier family 22 0.0081 0.0592 0.0581
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0094 0.0708 0.2167
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0179 0.0144
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0735 0.0702
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0466 0.0455
Echinococcus granulosus Smad4 0.0018 0.0035 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0081 0.0592 0.0538
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0093 0.0699 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0592 0.0559
Toxoplasma gondii ABC1 family protein 0.0037 0.0205 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0592 0.1198
Loa Loa (eye worm) hypothetical protein 0.0081 0.0592 0.0559
Echinococcus granulosus GPCR family 2 0.0018 0.0036 0.0025
Trypanosoma brucei THT1 - hexose transporter, putative 0.0178 0.1449 0.3862
Brugia malayi MH2 domain containing protein 0.0258 0.2152 0.2124
Trypanosoma cruzi hexose transporter, putative 0.0178 0.1449 0.3771
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0409 0.0375
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0093 0.0699 0.174
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0035 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0466 0.0455
Brugia malayi RNA binding protein 0.0066 0.0466 0.0433
Echinococcus multilocularis GPCR, family 2 0.0018 0.0036 0.0025
Brugia malayi glutaminase DH11.1 0.0279 0.2342 0.2315
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.6191 0.6187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0179 0.0167
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0179 0.0471
Trypanosoma brucei glucose transporter, putative 0.0178 0.1449 0.3862
Brugia malayi major facilitator superfamily protein 0.0081 0.0592 0.0559
Echinococcus multilocularis geminin 0.0357 0.3024 0.3016
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.1449 0.2934
Trypanosoma cruzi hexose transporter, putative 0.0097 0.0738 0.1845
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0057 0.0146
Brugia malayi Major Facilitator Superfamily protein 0.0081 0.0592 0.0559
Schistosoma mansoni sugar transporter 0.0081 0.0592 0.0581
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0373 0.0339
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0042 0.0007
Mycobacterium tuberculosis Conserved protein 0.0037 0.0205 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0592 0.1198
Echinococcus granulosus cpg binding protein 0.0063 0.0439 0.0428
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Onchocerca volvulus 0.0081 0.0592 0.7297
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0205 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis sugar transporter, putative 0.0081 0.0592 0.1198
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0205 0.0414
Brugia malayi Dihydrofolate reductase 0.1148 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0735 0.1488
Mycobacterium tuberculosis Conserved protein 0.0037 0.0205 0.0149
Leishmania major myo-inositol/proton symporter (MIT) 0.0081 0.0592 0.1449

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.