Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0235 | 0.1022 | 0.1022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0046 | 0.0011 |
Echinococcus granulosus | dihydrofolate reductase | 0.0235 | 0.1022 | 0.1022 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0813 | 0.3721 | 0.3721 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0813 | 0.3721 | 0.3721 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.0518 | 0.0518 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0577 | 0.262 | 0.262 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.015 | 0.015 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.2156 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.015 | 0.015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0047 | 0.0012 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0045 | 0.0132 | 0.0132 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1334 | 0.6158 | 0.6158 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.2156 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.2156 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.0518 | 0.0518 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0235 | 0.1022 | 0.1022 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0045 | 0.0132 | 0.0132 |
Echinococcus multilocularis | geminin | 0.0181 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.2156 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1334 | 0.6158 | 0.6158 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.2156 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0045 | 0.0132 | 0.0132 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0132 | 0.0132 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.015 | 0.015 |
Schistosoma mansoni | dihydrofolate reductase | 0.0235 | 0.1022 | 0.1022 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0089 | 0.0054 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.2156 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Schistosoma mansoni | histone J3 methyltransferase | 0.0067 | 0.0236 | 0.0236 |
Giardia lamblia | GTOR | 0.0045 | 0.0132 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0047 | 0.0047 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0089 | 0.0054 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0036 | 0.0089 | 0.0089 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0132 | 0.0098 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0089 | 0.0054 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0132 | 0.0098 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0235 | 0.1022 | 0.1022 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.0769 | 0.0769 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0577 | 0.262 | 0.262 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0047 | 0.0047 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0045 | 0.0132 | 0.0132 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0101 | 0.0101 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0577 | 0.262 | 0.178 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.2156 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0275 | 0.1205 | 0.1205 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.2156 | 1 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0045 | 0.0132 | 0.0132 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0045 | 0.0132 | 0.0132 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0045 | 0.0132 | 0.0032 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0036 | 0.0089 | 0.0089 |
Brugia malayi | hypothetical protein | 0.0275 | 0.1205 | 0.1205 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.015 | 0.015 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0101 | 0.0101 |
Echinococcus multilocularis | histone h3 methyltransferase | 0.0067 | 0.0236 | 0.0236 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0275 | 0.1205 | 0.1174 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.2156 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0101 | 0.0101 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0694 | 0.3168 | 0.3168 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0047 | 0.0047 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0235 | 0.1022 | 0.1022 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.0518 | 0.0518 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0046 | 0.0011 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0045 | 0.0132 | 0.0132 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0045 | 0.0132 | 0.0098 |
Brugia malayi | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 0.0067 | 0.0236 | 0.0236 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0694 | 0.3168 | 0.3168 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0047 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0047 | 0.0047 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0047 | 0.0047 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0047 | 0.0047 |
Onchocerca volvulus | 0.0577 | 0.262 | 0.5 | |
Schistosoma mansoni | adenosylhomocysteinase | 0.2156 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0275 | 0.1205 | 0.1205 |
Loa Loa (eye worm) | thymidylate synthase | 0.0577 | 0.262 | 0.262 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.2156 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.2156 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0045 | 0.0132 | 0.0132 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.0769 | 0.0769 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0101 | 0.0101 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0089 | 0.0054 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.015 | 0.015 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.2156 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0047 | 0.0047 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.015 | 0.015 |
Echinococcus multilocularis | thymidylate synthase | 0.0577 | 0.262 | 0.262 |
Plasmodium falciparum | adenosylhomocysteinase | 0.2156 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.2156 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.2156 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.015 | 0.015 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0045 | 0.0132 | 0.0032 |
Echinococcus granulosus | geminin | 0.0181 | 0.0769 | 0.0769 |
Brugia malayi | dihydrofolate reductase family protein | 0.0235 | 0.1022 | 0.1022 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0813 | 0.3721 | 0.3721 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0813 | 0.3721 | 0.3721 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0045 | 0.0132 | 0.0132 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0089 | 0.0054 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.2156 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0813 | 0.3721 | 0.3721 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0677 | 0.3085 | 0.3061 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0101 | 0.0067 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0101 | 0.0101 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0047 | 0.0047 |
Mycobacterium ulcerans | thymidylate synthase | 0.0577 | 0.262 | 0.178 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0021 | 0.0021 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0694 | 0.3168 | 0.3168 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1334 | 0.6158 | 0.6158 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.2156 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0047 | 0.0047 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0047 | 0.0047 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1334 | 0.6158 | 0.6158 |
Brugia malayi | thymidylate synthase | 0.0577 | 0.262 | 0.262 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0235 | 0.1022 | 0.5 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0019 | 0.0009 | 0.0009 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0047 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0078 | 0.0043 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0063 | 0.0028 |
Echinococcus granulosus | thymidylate synthase | 0.0577 | 0.262 | 0.262 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0045 | 0.0132 | 0.0132 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.015 | 0.015 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0036 | 0.0089 | 0.0089 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0813 | 0.3721 | 0.3721 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0236 | 0.0236 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.015 | 0.015 |
Echinococcus granulosus | histone h3 methyltransferase | 0.0067 | 0.0236 | 0.0236 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0034 | 0.0078 | 0.0078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0058 | 0.0023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.