Detailed information for compound 56594

Basic information

Technical information
  • TDR Targets ID: 56594
  • Name: 7-methyl-4H-indeno[1,2-d][1,3]thiazol-2-amine hydroiodide
  • MW: 330.188 | Formula: C11H11IN2S
  • H donors: 1 H acceptors: 1 LogP: 3.53 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c1nc(sc1C2)N.I
  • InChi: 1S/C11H10N2S.HI/c1-6-2-3-7-5-9-10(8(7)4-6)13-11(12)14-9;/h2-4H,5H2,1H3,(H2,12,13);1H
  • InChiKey: PREKDQDLYJZGCR-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 7-methyl-4H-indeno[1,2-d]thiazol-2-amine hydroiodide
  • (7-methyl-4H-indeno[1,2-d]thiazol-2-yl)amine hydroiodide
  • 7-methyl-4H-indeno[3,2-d][1,3]thiazol-2-amine hydroiodide
  • 7-methyl-4H-indeno[3,2-d]thiazol-2-amine hydroiodide
  • (7-methyl-4H-indeno[3,2-d]thiazol-2-yl)amine hydroiodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.045 0.2005
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.001 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0262 0.1313
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0294
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2435
Onchocerca volvulus 0.001 0.001 0.0197
Echinococcus granulosus dna polymerase eta 0.0114 0.052 0.2058
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Entamoeba histolytica hypothetical protein 0.001 0.001 0.0066
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0112 0.408
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0065 0.1851
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0015 0.006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0039 0.0595
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0117 0.0565
Echinococcus multilocularis replication factor c subunit 1 0.001 0.001 0.0041
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0039 0.0154
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0008 0.0033
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0237 0.094
Leishmania major hypothetical protein, conserved 0.0025 0.0084 0.1473
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.1203 0.1668
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0056 0.0932
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0125
Leishmania major DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0065 0.2238
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0039 0.0138
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2435
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0039 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.1079 0.1495
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0133 0.0447
Trypanosoma brucei unspecified product 0.0042 0.0169 0.3146
Trypanosoma brucei DNA polymerase eta, putative 0.0114 0.052 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0031
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0008 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Toxoplasma gondii thioredoxin reductase 0.01 0.0452 0.1595
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Chlamydia trachomatis DNA ligase 0.001 0.001 0.0002
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.001 0.0039
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0262 0.0254
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0237 0.5154
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0056 0.0932
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0133 0.491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0111 0.4052
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Echinococcus granulosus GPCR family 2 0.0031 0.0117 0.0465
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0578 0.2793 0.2787
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Giardia lamblia DNA damage repair protein 0.0019 0.0056 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Brugia malayi MH1 domain containing protein 0.0025 0.0086 0.0404
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.006
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0088 0.0412
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0015 0.0036
Echinococcus multilocularis cpg binding protein 0.0032 0.0119 0.0472
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0008 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0452 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.2062 0.817
Schistosoma mansoni DNA ligase IV 0.001 0.001 0.0041
Loa Loa (eye worm) RNA binding protein 0.0065 0.028 0.1231
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.046 0.2213 0.8766
Brugia malayi MH1 domain containing protein 0.0014 0.0031 0.0119
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0133 0.2803
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0015 0.006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0015 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Echinococcus granulosus dnaJ subfamily B 0.0429 0.2062 0.817
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0404 0.1939 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0065 0.0258
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis C-MYB, putative 0.003 0.0111 0.4052
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0039 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0237 0.5154
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0237 0.1185
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Schistosoma mansoni DNA helicase recq1 0.0021 0.0065 0.0258
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0243 0.0841
Echinococcus multilocularis smad 0.0025 0.0086 0.0342
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.006
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0039 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0039 0.0109
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0237 0.5154
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Schistosoma mansoni Smad4 0.0011 0.0018 0.0073
Plasmodium vivax glutathione reductase, putative 0.01 0.0452 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0008 0.0033
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0015 0.0155
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0069
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0039 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0133 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Leishmania major DNA polymerase eta, putative 0.0114 0.052 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0015 0.006
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0015 0.006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0084 0.1473
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0056 0.0932
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0086 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Trichomonas vaginalis MYB72, putative 0.003 0.0111 0.4052
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0015 0.006
Leishmania major hypothetical protein, conserved 0.0056 0.0237 0.4476
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.1203 0.1668
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0008 0.0033
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.0465
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0065 0.0258
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0015 0.006
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0237 0.094
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0056 0.0932
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0039 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0086 0.0354
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0008 0.0033
Schistosoma mansoni coup transcription factor 0.0011 0.0015 0.006
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis dna polymerase eta 0.0114 0.052 0.2058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0133 0.2435
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0065 0.2238
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0237 0.4476
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0262 0.1037
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0015 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0315 0.1247
Schistosoma mansoni cpg binding protein 0.0032 0.0119 0.0472
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Echinococcus multilocularis GPCR, family 2 0.0031 0.0117 0.0465
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0008 0.0033
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0237 0.4476
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0465
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0182 0.0786
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0018 0.0073
Loa Loa (eye worm) TAR-binding protein 0.0065 0.028 0.1231
Giardia lamblia Myb 1-like protein 0.003 0.0112 0.0469
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0133 0.0565
Schistosoma mansoni DNA helicase recq5 0.0021 0.0065 0.0258
Brugia malayi isocitrate dehydrogenase 0.0015 0.0039 0.0158
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0237 0.094
Brugia malayi MH2 domain containing protein 0.0025 0.0086 0.0404
Brugia malayi Smad1 0.0025 0.0086 0.0404
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0262 0.0254
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0133 0.491
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0237 0.5154
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Leishmania major DNA polymerase eta, putative 0.0072 0.0314 0.5974
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0262 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0133 0.2803
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0031
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0133 0.2435
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.1203 0.1668
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0015 0.0031
Giardia lamblia DINP protein human, muc B family 0.0061 0.0262 0.115
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0018 0.0073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.006
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0237 0.5154
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0133 0.0447
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0086 0.0342
Brugia malayi CXXC zinc finger family protein 0.003 0.0111 0.053
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0262 0.8272
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0578 0.2793 0.3888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0031
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0053
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.4476
Toxoplasma gondii ATPase, AAA family protein 0.001 0.001 0.0007
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0018 0.0073
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0015 0.006
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0039 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0036
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0015 0.006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0237 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0315 0.1247
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0125
Giardia lamblia hypothetical protein 0.0056 0.0237 0.1038
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0018 0.0045
Plasmodium falciparum thioredoxin reductase 0.0035 0.0133 0.2803
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0262 0.1037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0117 0.0495
Loa Loa (eye worm) PDE1B protein 0.0056 0.0237 0.1038
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1473 0.7171 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0015 0.006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0262 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0065 0.0258
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0452 0.1792
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0117 0.0565
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0056 0.0932
Loa Loa (eye worm) MH2 domain-containing protein 0.0369 0.1768 0.798
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.045 0.2289
Onchocerca volvulus 0.003 0.0111 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0015 0.006
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Echinococcus multilocularis Smad4 0.0025 0.0086 0.0342
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0452 0.1792
Schistosoma mansoni hypothetical protein 0.0523 0.2524 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.0932
Leishmania major DNA damage repair protein, putative 0.0019 0.0056 0.0932
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0439
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0294
Loa Loa (eye worm) hypothetical protein 0.0114 0.052 0.2319
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0056 0.0932
Brugia malayi hypothetical protein 0.0016 0.0041 0.0169
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0086 0.0342
Leishmania major DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.1203 0.1668
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0039 0.0685
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.001 0.0079
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0182 0.072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Loa Loa (eye worm) hypothetical protein 0.01 0.045 0.2005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.1079 0.1495
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0314 0.5974
Treponema pallidum ATP-dependent DNA helicase 0.0011 0.0015 0.0007
Schistosoma mansoni cpg binding protein 0.0032 0.0119 0.0472
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0262 0.4958
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0065 0.0258
Echinococcus granulosus Smad4 0.0025 0.0086 0.0342
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0008 0.0033
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0134
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0523 0.2524 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus dna polymerase kappa 0.0061 0.0262 0.1037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0262 0.0354
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0018 0.0045
Schistosoma mansoni DNA polymerase eta 0.0114 0.052 0.2058
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0018 0.0052
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0111 0.3352
Schistosoma mansoni Smad4 0.0025 0.0086 0.0342
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.001 0.0066
Schistosoma mansoni hypothetical protein 0.0429 0.2062 0.817
Schistosoma mansoni topbp1 0.001 0.001 0.0041
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni Smad4 0.0011 0.0018 0.0073
Loa Loa (eye worm) nuclear factor I 0.0014 0.0031 0.0104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.046 0.2213 0.7918
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0452 0.8684
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Loa Loa (eye worm) RecQ helicase 0.0021 0.0065 0.0257
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Brugia malayi steroid hormone receptor 0.0011 0.0015 0.0036
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0262 0.1037
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Plasmodium falciparum glutathione reductase 0.01 0.0452 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0065 0.0257
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0015 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0015 0.0134
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.4476
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.001 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0296 0.1491
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0133 0.2435
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Brugia malayi glutathione reductase 0.01 0.0452 0.2299
Echinococcus granulosus cpg binding protein 0.0032 0.0119 0.0472
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0065 0.0257
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.1079 0.1495
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0056 0.0171
Mycobacterium ulcerans hypothetical protein 0.0019 0.0056 0.0048
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.001 0.0007
Brugia malayi nuclear receptor NHR-88 0.0011 0.0015 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0262 0.115
Trypanosoma brucei unspecified product 0.0061 0.0262 0.4958
Schistosoma mansoni smad 0.0025 0.0086 0.0342
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis glutamate synthase 0.0009 0.0008 0.0033
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.4476
Brugia malayi MH1 domain containing protein 0.0025 0.0086 0.0404
Brugia malayi Thioredoxin reductase 0.01 0.0452 0.2299
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0008 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0015 0.006
Brugia malayi hypothetical protein 0.001 0.001 0.001
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0056 0.0932
Loa Loa (eye worm) hypothetical protein 0.0068 0.0296 0.1306
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0111 0.0464
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.046 0.2213 0.8766
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0065 0.0257
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi ecdysteroid receptor 0.0011 0.0015 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0056 0.0932
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0216
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0065 0.0294
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0065 0.1278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi hypothetical protein 0.001 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0182 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0056 0.1073
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.1038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0036
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0008 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.045 0.2289
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Trypanosoma brucei unspecified product 0.0042 0.0169 0.3146
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0013 0.011
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0086 0.0342
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0237 0.1185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0276 0.1093
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2435
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0404 0.1939 0.7682
Leishmania major trypanothione reductase 0.01 0.0452 0.8684
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0017 0.0069
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0015 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0182 0.0898
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0086 0.0342
Brugia malayi MH2 domain containing protein 0.0011 0.0018 0.0052
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1473 0.7171 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0262 0.1037
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.0314 0.1097
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0065 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0036
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.001 0.0041
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0133 0.2435
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.006
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.5154
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0133 0.0174
Loa Loa (eye worm) hypothetical protein 0.046 0.2213 1
Echinococcus granulosus replication factor c subunit 1 0.001 0.001 0.0041
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0262 0.1037
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Echinococcus multilocularis geminin 0.0523 0.2524 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0237 0.1185
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0237 0.094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0133 0.0645
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0182 0.072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.1079 0.1495
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0065 0.1278
Trichomonas vaginalis MYB3r3, putative 0.003 0.0111 0.4052
Plasmodium falciparum glutathione reductase 0.0035 0.0133 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0133 0.0125
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0033
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0008 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0015 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.006
Trypanosoma brucei trypanothione reductase 0.01 0.0452 0.8684
Trichomonas vaginalis MYB, putative 0.003 0.0112 0.408
Echinococcus multilocularis tar DNA binding protein 0.0065 0.028 0.1108
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.046 0.2213 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0452 0.062
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Echinococcus granulosus tar DNA binding protein 0.0065 0.028 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0112 0.408
Brugia malayi hypothetical protein 0.0072 0.0315 0.1587
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0133 0.0125
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.001 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0015 0.0673
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0065 0.0204
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0039 0.0158
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0008 0.0033
Schistosoma mansoni topbp1 0.001 0.001 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0031
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Echinococcus granulosus smad 0.0025 0.0086 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0169 0.3146
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0237 0.094
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0237 0.4476
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0465
Echinococcus granulosus glutamate synthase 0.0009 0.0008 0.0033
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trichomonas vaginalis C-MYB, putative 0.003 0.0111 0.4052
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0009
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0036
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0036
Mycobacterium tuberculosis Probable reductase 0.0228 0.1079 0.1495
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Giardia lamblia Hypothetical protein 0.0056 0.0237 0.1038
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0237 0.094
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.1079 0.1495
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0088 0.0412
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0008 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0015 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0036
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0015 0.006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0015 0.0036
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.016
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0039 0.0154
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0056 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0036
Onchocerca volvulus 0.0011 0.0015 0.0673
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.001 0.0045
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni smad 0.0011 0.0018 0.0073
Brugia malayi ImpB/MucB/SamB family protein 0.0114 0.052 0.2648
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0015 0.0224
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.1038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0056 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0237 0.094
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.003 0.0112 0.0371
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0404 0.1939 0.8758
Echinococcus granulosus geminin 0.0523 0.2524 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.1473
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.001 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.001 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0015 0.0673
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0056 0.0171
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0237 0.1185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0036
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.028 0.1108
Schistosoma mansoni glutamate synthase 0.0009 0.0008 0.0033
Brugia malayi topoisomerase 0.001 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0369 0.1768 0.9112
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0452 0.2014
Brugia malayi nuclear hormone receptor 0.0011 0.0015 0.0036
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.4476
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0018 0.0974
Loa Loa (eye worm) Smad1 0.0025 0.0086 0.0354
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0084 0.0271
Echinococcus multilocularis nibrin 0.001 0.001 0.0041
Loa Loa (eye worm) transcription factor SMAD2 0.0369 0.1768 0.798
Brugia malayi MH2 domain containing protein 0.0025 0.0086 0.0404
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.0342
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0237 0.4476
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi hypothetical protein 0.0025 0.0084 0.039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0465
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.1079 0.1495
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.001 0.0003
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0578 0.2793 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Brugia malayi polk-prov protein 0.0019 0.0056 0.0247
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.028 0.1231
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0182 0.072
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0015 0.006
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.001 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0036
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0015 0.006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2435
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Brugia malayi DKFZp564C0469 protein 0.001 0.001 0.001
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.001 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.006
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.001 0.0039
Brugia malayi RNA binding protein 0.0065 0.028 0.1406
Schistosoma mansoni hypothetical protein 0.0072 0.0315 0.1247
Trichomonas vaginalis conserved hypothetical protein 0.001 0.001 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0084 0.1697
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0018 0.0073
Schistosoma mansoni hypothetical protein 0.0068 0.0296 0.1174
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0039 0.0595
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.001 0.0039
Giardia lamblia Replication factor C, subunit 1 0.001 0.001 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.006
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.052 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0015 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0237 0.4476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Echinococcus granulosus bloom syndrome protein 0.0021 0.0065 0.0258
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0182 0.072
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2051 1 1
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0111 0.4052
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0086 0.0354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0262 0.0354
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0045
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0237 0.094
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0056 0.0222
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0578 0.2793 0.2787
Treponema pallidum DNA ligase (lig) 0.001 0.001 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0084 0.1473
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0237 0.094
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0237 0.094
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0495
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0031
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0262 0.4958
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0017 0.0069
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0237 0.094
Schistosoma mansoni smad1 5 8 and 0.0025 0.0086 0.0342
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0015 0.0673
Entamoeba histolytica hypothetical protein 0.0072 0.0315 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0465
Treponema pallidum NADH oxidase 0.0035 0.0133 0.0125
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0315 0.1247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0015 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0065 0.2238
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0008 0.0033
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0133 0.2435
Brugia malayi TAR-binding protein 0.0065 0.028 0.1406
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0237 0.9028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0133 0.2803
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0065 0.111
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0262 0.4958
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0237 0.094
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.006
Loa Loa (eye worm) glutathione reductase 0.01 0.0452 0.2014
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.001 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0237 0.4476
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0404 0.1939 0.7682
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0237 0.0822
Brugia malayi MH1 domain containing protein 0.0014 0.0031 0.0119
Leishmania major hypothetical protein, conserved 0.0056 0.0237 0.4476
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0237 0.9028
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0237 0.9028
Plasmodium falciparum thioredoxin reductase 0.01 0.0452 1
Echinococcus granulosus nibrin 0.001 0.001 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.028 0.1406
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0111 0.4052

Activities

Activity type Activity value Assay description Source Reference
AE activity (binding) = 72 % AE activity is the ratio of specific binding at the end of dissociation to specific binding at the end of 120 min of equilibration at 50 uM concentration to Adenosine A1 receptor ChEMBL. 12039562
AE activity (binding) = 72 % AE activity is the ratio of specific binding at the end of dissociation to specific binding at the end of 120 min of equilibration at 50 uM concentration to Adenosine A1 receptor ChEMBL. 12039562
EC50 (binding) = 4.2 uM Effective concentration against Adenosine A1 receptor ChEMBL. 12039562
EC50 (binding) = 4.2 uM Effective concentration against Adenosine A1 receptor ChEMBL. 12039562

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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