Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0112 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0127 | 0.5303 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0042 | 0.1135 | 0.1839 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.2834 | 0.5244 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4758 | 0.7333 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.1245 | 0.2036 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0036 | 0.0873 | 0.1466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1495 | 0.2486 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1495 | 0.2169 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0808 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0808 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0808 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0808 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0808 | 0.1098 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0873 | 0.1368 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1495 | 0.2183 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0873 | 0.1368 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0493 | 0.548 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1495 | 0.2664 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3087 | 0.4696 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4758 | 0.6904 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0691 | 0.8321 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0493 | 0.0602 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0808 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0038 | 0.0937 | 0.1302 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0808 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0808 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4906 | 0.7567 |
Schistosoma mansoni | bromodomain containing protein | 0.0135 | 0.5675 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0808 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1495 | 0.2664 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1495 | 0.2486 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1495 | 0.2664 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4758 | 0.7333 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1495 | 0.2486 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0493 | 0.548 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.4906 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.3531 | 0.5397 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.6448 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0808 | 0.1172 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0808 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0808 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0808 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0808 | 1 |
Brugia malayi | hypothetical protein | 0.0119 | 0.4906 | 0.7119 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0808 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0808 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0873 | 0.1368 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0691 | 0.8321 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0808 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0808 | 0.0703 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0112 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0493 | 0.548 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3333 | 0.5084 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.308 | 0.4469 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0048 | 0.1443 | 0.2565 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0808 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0808 | 0.1098 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0048 | 0.1443 | 0.2393 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0493 | 0.0716 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0036 | 0.0873 | 0.1466 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0493 | 0.548 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0808 | 0.134 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0493 | 1 |
Brugia malayi | PHD-finger family protein | 0.0053 | 0.1689 | 0.2451 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0112 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0808 | 0.125 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0808 | 0.0703 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0808 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0493 | 0.548 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0873 | 0.1466 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0808 | 0.0703 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0112 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0042 | 0.1135 | 0.1971 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0691 | 0.104 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0493 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0808 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0159 | 0.6892 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0042 | 0.1135 | 0.1971 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0808 | 0.1098 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.2834 | 0.5244 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0808 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0808 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0873 | 0.1201 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0808 | 0.0703 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0808 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0033 | 0.0691 | 0.8321 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0808 | 0.1172 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0808 | 0.1172 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0873 | 0.1368 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1495 | 0.2664 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0808 | 0.0703 |
Schistosoma mansoni | zinc finger protein | 0.0033 | 0.0691 | 0.104 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0493 | 0.548 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0044 | 0.1245 | 0.1788 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0808 | 0.125 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4906 | 0.7567 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0873 | 0.1466 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0127 | 0.5303 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0048 | 0.1443 | 0.2565 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.0691 | 0.8321 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0112 | 0.0163 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.4906 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0808 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0808 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0808 | 0.0703 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0808 | 0.0703 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.