Detailed information for compound 566028

Basic information

Technical information
  • TDR Targets ID: 566028
  • Name: 2-piperidin-1-ium-1-ylethyl N-phenylcarbamate chloride
  • MW: 284.782 | Formula: C14H21ClN2O2
  • H donors: 2 H acceptors: 1 LogP: 3.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)OCC[NH+]1CCCCC1.[Cl-]
  • InChi: 1S/C14H20N2O2.ClH/c17-14(15-13-7-3-1-4-8-13)18-12-11-16-9-5-2-6-10-16;/h1,3-4,7-8H,2,5-6,9-12H2,(H,15,17);1H
  • InChiKey: LUZGNDRQUWIDJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-phenylcarbamic acid 2-(1-piperidin-1-iumyl)ethyl ester chloride
  • N-phenylcarbamic acid 2-piperidin-1-ium-1-ylethyl ester chloride
  • 2-piperidinoethyl phenylcarbamate
  • 50594-06-4
  • CARBANILIC ACID, 2-(PIPERIDINOETHYL) ESTER, MONOHYDROCHLORIDE
  • 2-Piperidinoethyl carbanilate hydrochloride
  • 2-piperidin-1-ylethyl N-phenylcarbamate hydrochloride
  • 2-(1-piperidyl)ethyl N-phenylcarbamate hydrochloride
  • N-phenylcarbamic acid 2-(1-piperidyl)ethyl ester hydrochloride
  • N-phenylcarbamic acid 2-piperidinoethyl ester hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0215 0.0773
Echinococcus granulosus jumonji domain containing protein 0.004 0.0294 0.0294
Loa Loa (eye worm) TAR-binding protein 0.0204 0.278 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0123 0.0123
Brugia malayi jmjC domain containing protein 0.0035 0.0215 0.0773
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0243 0.0114
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1248 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1115 0.1115
Echinococcus multilocularis tar DNA binding protein 0.0204 0.278 0.278
Trypanosoma brucei protein kinase, putative 0.0103 0.1248 1
Schistosoma mansoni tar DNA-binding protein 0.0204 0.278 0.278
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0426 0.0715
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0243 0.0234
Loa Loa (eye worm) hypothetical protein 0.0049 0.0426 0.1531
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0426 0.1813
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.1248 0.449
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0426 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0243 0.0234
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0483 0.1739
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0225 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0426 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0243 0.0234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1088 0.3915
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1088 0.1088
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Schistosoma mansoni hypothetical protein 0.0036 0.0232 0.0232
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0426 1
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0243 0.0234
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.1248 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0444
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0483 0.1739
Mycobacterium ulcerans hypothetical protein 0.0049 0.0426 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0243 0.0114
Onchocerca volvulus 0.0037 0.0243 0.1481
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.086
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0215 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0426 0.1531
Onchocerca volvulus 0.0037 0.0243 0.1481
Loa Loa (eye worm) hypothetical protein 0.0157 0.2072 0.7453
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0426 0.0715
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0426 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.1248 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0483 0.1739
Schistosoma mansoni hypothetical protein 0.0035 0.0225 0.0225
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0239 0.9636
Schistosoma mansoni tar DNA-binding protein 0.0204 0.278 0.278
Onchocerca volvulus 0.0037 0.0243 0.1481
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1088 0.1088
Echinococcus multilocularis microtubule associated protein 2 0.0679 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0426 1
Brugia malayi jmjC domain containing protein 0.0094 0.1115 0.4009
Brugia malayi hypothetical protein 0.0035 0.0225 0.081
Brugia malayi PHD-finger family protein 0.0029 0.0123 0.0444
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1088 0.1088
Echinococcus multilocularis muscleblind protein 0.0157 0.2072 0.2072
Brugia malayi RNA binding protein 0.0204 0.278 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.1248 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1088 0.1088
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0426 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0426 1
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.278 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2072 0.7453
Brugia malayi beta-lactamase 0.0037 0.0243 0.0876
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0426 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0243 0.0234
Echinococcus granulosus tar DNA binding protein 0.0204 0.278 0.278
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0239 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0123 0.0123
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0215 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1088 0.1088
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.1248 1
Brugia malayi beta-lactamase family protein 0.0037 0.0243 0.0876
Loa Loa (eye worm) hypothetical protein 0.0129 0.1643 0.591
Onchocerca volvulus Huntingtin homolog 0.0129 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0232 0.0833
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.086
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0232 0.0833
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0483 0.1739
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0049 0.0435 0.1563
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0243 0.0876
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0243 0.0243
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0215 0.0215
Toxoplasma gondii ABC1 family protein 0.0037 0.0243 0.1067
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0426 0.1531
Onchocerca volvulus 0.0049 0.0426 0.259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Onchocerca volvulus Huntingtin homolog 0.0129 0.1643 1
Schistosoma mansoni microtubule-associated protein tau 0.0679 1 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0243 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0243 0.0114
Echinococcus granulosus muscleblind protein 0.0157 0.2072 0.2072
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.1248 0.1248
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.1248 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0243 0.0114
Brugia malayi beta-lactamase family protein 0.0037 0.0243 0.0876
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.086
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0243 0.0114
Mycobacterium tuberculosis Conserved protein 0.0037 0.0243 0.0114
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0243 0.0114
Echinococcus granulosus peregrin 0.0029 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.1248 0.1248
Brugia malayi MAP kinase sur-1 0.0103 0.1248 0.449
Brugia malayi Muscleblind-like protein 0.0157 0.2072 0.7453
Schistosoma mansoni hypothetical protein 0.0029 0.0123 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0225 0.0225
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0426 0.1531
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0243 0.0876
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0215 0.0215
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.278 1
Brugia malayi TAR-binding protein 0.0204 0.278 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0426 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0426 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0239 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1115 0.1115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1088 0.1088
Brugia malayi hypothetical protein 0.0129 0.1643 0.591
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0129 0.1643 0.591
Mycobacterium tuberculosis Conserved protein 0.0037 0.0243 0.0114
Echinococcus multilocularis peregrin 0.0029 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0049 0.0426 0.1531
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.1248 0.1248
Schistosoma mansoni tar DNA-binding protein 0.0204 0.278 0.278
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0243 0.0114
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0294 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1088 0.1088
Onchocerca volvulus Alhambra homolog 0.0029 0.0123 0.0751
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0426 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0426 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.3238 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.1248 1
Brugia malayi Bromodomain containing protein 0.0029 0.0123 0.0444
Loa Loa (eye worm) RNA binding protein 0.0204 0.278 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1088 0.3915
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0587 0.2112
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0426 0.1813
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0426 0.1813
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.1248 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0243 0.0876
Loa Loa (eye worm) beta-lactamase 0.0037 0.0243 0.0876
Mycobacterium tuberculosis Conserved protein 0.0037 0.0243 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0225 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0204 0.278 0.278
Echinococcus multilocularis muscleblind protein 1 0.0157 0.2072 0.2072
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1248 1
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.1248 0.1248
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0243 0.0243
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.1248 0.1248
Schistosoma mansoni tar DNA-binding protein 0.0204 0.278 0.278
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0123 0.0444
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0243 0.0243
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0426 0.1531

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.