Detailed information for compound 566063

Basic information

Technical information
  • TDR Targets ID: 566063
  • Name: 2-hydrazino-3-(4-hydroxyphenyl)propanoic acid
  • MW: 196.203 | Formula: C9H12N2O3
  • H donors: 4 H acceptors: 3 LogP: -2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(C(=O)O)Cc1ccc(cc1)O
  • InChi: 1S/C9H12N2O3/c10-11-8(9(13)14)5-6-1-3-7(12)4-2-6/h1-4,8,11-12H,5,10H2,(H,13,14)
  • InChiKey: XJPHGGXFBWOHFL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydrazinyl-3-(4-hydroxyphenyl)propanoic acid
  • 2-hydrazino-3-(4-hydroxyphenyl)propionic acid
  • alpha-hydrazinophloretic acid
  • 5060-36-6
  • Benzenepropanoic acid, alpha-hydrazino-4-hydroxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0099 0.1711 0.2837
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0606 0.1005
Plasmodium vivax glutathione reductase, putative 0.0037 0.0345 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.1711 0.3263
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0343 0.0301
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0754 0.133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0514 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0618 0.1025
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.4833 0.4811
Loa Loa (eye worm) hypothetical protein 0.0044 0.0493 0.0529
Echinococcus granulosus neuropeptide receptor 0.0164 0.3132 0.3102
Schistosoma mansoni hypothetical protein 0.0297 0.6032 1
Onchocerca volvulus 0.0049 0.0618 0.0014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0754 0.0809
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1378 0.8342
Plasmodium falciparum thioredoxin reductase 0.0037 0.0345 0.5
Brugia malayi mbt repeat family protein 0.0049 0.0606 0.1031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0654 0.1128
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0754 0.125
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0448 0.9325 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0099 0.1711 0.3263
Echinococcus multilocularis G protein coupled receptor 139 0.0164 0.3132 0.3102
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0606 0.065
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.5046 1
Echinococcus multilocularis neuropeptide receptor A26 0.0479 1 1
Plasmodium falciparum glutathione reductase 0.0037 0.0345 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0514 0.0851
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0345 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0356 0.0314
Echinococcus multilocularis FTZ F1 alpha 0.0099 0.1711 0.1675
Mycobacterium tuberculosis Probable reductase 0.0084 0.1378 0.8342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0514 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0514 0.0473
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0875 0.0836
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1378 0.8342
Brugia malayi glutathione reductase 0.0037 0.0345 0.0503
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1378 0.8342
Loa Loa (eye worm) hypothetical protein 0.0242 0.4833 0.5183
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0043 0.0071
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0343 0.0301
Onchocerca volvulus Phospholipase A2 homolog 0.0448 0.9325 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.1584 1
Echinococcus multilocularis neuropeptide receptor 0.0164 0.3132 0.3102
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0606 0.0566
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0606 0.1005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0514 0.0473
Onchocerca volvulus Phospholipase A2 homolog 0.0094 0.1598 0.1138
Trypanosoma brucei trypanothione reductase 0.0037 0.0345 0.5
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0754 0.0714
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3346 0.1027
Echinococcus multilocularis neuropeptide s receptor 0.0479 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0345 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0875 0.0836
Echinococcus granulosus FTZ F1 alpha 0.0395 0.8171 0.8163
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0754 0.0714
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0514 0.0551
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0654 0.1128
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0618 0.1055
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0754 0.0714
Brugia malayi Thioredoxin reductase 0.0037 0.0345 0.0503
Schistosoma mansoni hypothetical protein 0.0035 0.0301 0.0499
Loa Loa (eye worm) hypothetical protein 0.0072 0.1122 0.1203
Brugia malayi mbt repeat family protein 0.0049 0.0606 0.1031
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.5046 0.5411
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0606 0.0566
Schistosoma mansoni hypothetical protein 0.0049 0.0618 0.1025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.1584 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.1711 0.1835
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0301 0.0415
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0099 0.1711 0.1675
Loa Loa (eye worm) hypothetical protein 0.0094 0.1598 0.1714
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0323
Loa Loa (eye worm) hypothetical protein 0.0051 0.0654 0.0702
Leishmania major trypanothione reductase 0.0037 0.0345 0.5
Schistosoma mansoni bromodomain containing protein 0.0065 0.0955 0.1583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0654 0.0702
Schistosoma mansoni hypothetical protein 0.008 0.128 0.2122
Schistosoma mansoni neuropeptide receptor 0.0164 0.3132 0.5192
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3346 0.1027
Echinococcus granulosus neuropeptide receptor A26 0.0479 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.4833 0.4811
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0345 0.037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0606 0.065
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1378 0.8342
Brugia malayi hypothetical protein 0.0242 0.4833 0.9571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1378 0.8342
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0514 0.0844
Brugia malayi Phospholipase A2 family protein 0.0094 0.1598 0.3036
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Brugia malayi Bromodomain containing protein 0.0077 0.1217 0.2266
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.3747 0.372
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0606 0.0566
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0356 0.0314
Loa Loa (eye worm) glutathione reductase 0.0037 0.0345 0.037
Toxoplasma gondii thioredoxin reductase 0.0037 0.0345 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0099 0.1711 0.1675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0514 0.0851
Brugia malayi Bromodomain containing protein 0.0039 0.0396 0.0606
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0754 0.0714
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.3152 0.292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0514 0.0851
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.3747 0.372
Loa Loa (eye worm) hypothetical protein 0.0039 0.0397 0.0426
Loa Loa (eye worm) MBCTL1 0.0056 0.0754 0.0809
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0606 0.1005
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.1584 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.5046 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0606 0.0566
Loa Loa (eye worm) hypothetical protein 0.0042 0.045 0.0483

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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