Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0051 | 0.139 |
Echinococcus granulosus | tar DNA binding protein | 0.0258 | 0.3104 | 0.3538 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0418 | 0.031 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0218 | 0.0059 |
Loa Loa (eye worm) | TAR-binding protein | 0.0258 | 0.3104 | 0.7701 |
Loa Loa (eye worm) | RNA binding protein | 0.0258 | 0.3104 | 0.7701 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0218 | 0.0069 |
Trypanosoma brucei | glucosidase, putative | 0.0073 | 0.0751 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0258 | 0.3104 | 0.2992 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0073 | 0.0751 | 0.071 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0073 | 0.0751 | 0.1862 |
Schistosoma mansoni | microtubule-associated protein tau | 0.068 | 0.8482 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0218 | 0.0069 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.016 | 0.0397 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.2772 | 0.3139 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1324 | 0.3285 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0218 | 0.054 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0131 | 1 |
Leishmania major | glycosyl hydrolase-like protein | 0.0027 | 0.0164 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0051 | 0.0127 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0131 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0131 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0051 | 0.0127 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0131 | 1 |
Onchocerca volvulus | 0.0027 | 0.016 | 0.0138 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0131 | 0.0325 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0131 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0051 | 0.5 |
Brugia malayi | RNA binding protein | 0.0258 | 0.3104 | 0.7701 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0751 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0218 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0051 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0131 | 0.0325 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0751 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0285 | 0.3444 | 0.3946 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0331 | 0.4031 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0331 | 0.4031 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0331 | 0.4031 | 0.3934 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0051 | 0.0127 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0331 | 0.4031 | 0.4651 |
Onchocerca volvulus | 0.0027 | 0.016 | 0.0138 | |
Brugia malayi | intermediate filament protein | 0.0027 | 0.016 | 0.0397 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0051 | 0.0127 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0131 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.1088 | 0.2698 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0131 | 1 |
Onchocerca volvulus | 0.0047 | 0.0418 | 0.1354 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0073 | 0.0751 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0073 | 0.0751 | 1 |
Brugia malayi | TAR-binding protein | 0.0258 | 0.3104 | 0.7701 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0218 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0218 | 0.0069 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0131 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.016 | 0.0397 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0131 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0218 | 0.0069 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0131 | 0.0325 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.2772 | 0.2655 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0027 | 0.0164 | 0.0528 |
Schistosoma mansoni | alpha glucosidase | 0.0073 | 0.0751 | 0.071 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0218 | 0.054 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0258 | 0.3104 | 0.7701 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.016 | 0.0397 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.1088 | 0.2698 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0051 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0073 | 0.0751 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0685 | 0.17 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0685 | 0.17 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1324 | 0.3285 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0685 | 0.0631 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0751 | 1 |
Brugia malayi | hypothetical protein | 0.0232 | 0.2772 | 0.6877 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0027 | 0.0164 | 0.0406 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.3104 | 0.3538 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0218 | 0.0059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.3104 | 0.3538 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.1088 | 0.2698 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1324 | 0.3285 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0073 | 0.0751 | 0.1862 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.0131 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0073 | 0.0751 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0218 | 0.0069 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0751 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0258 | 0.3104 | 0.7701 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0131 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0751 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0073 | 0.0751 | 1 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0027 | 0.0164 | 0.0154 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0331 | 0.4031 | 0.3934 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0218 | 0.054 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0131 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0073 | 0.0751 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0418 | 0.031 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0751 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.068 | 0.8482 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0131 | 0.0325 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0073 | 0.0751 | 0.06 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0073 | 0.0751 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0218 | 0.0069 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0051 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.3104 | 0.3538 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2772 | 0.6877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.3104 | 0.3538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0258 | 0.3104 | 0.3538 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0218 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0164 | 0.0406 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0751 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0418 | 0.1038 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0131 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.1088 | 0.2698 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.016 | 0.0397 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0073 | 0.0751 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0154 | 0.0382 |
Onchocerca volvulus | 0.0191 | 0.2253 | 1 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.068 | 0.8482 | 0.8458 |
Schistosoma mansoni | alpha-glucosidase | 0.0285 | 0.3444 | 0.3946 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0131 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.