Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0031 | 0.051 | 0.0659 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0785 | 0.1085 |
Onchocerca volvulus | 0.0031 | 0.051 | 0.0781 | |
Onchocerca volvulus | 0.0084 | 0.1918 | 0.2936 | |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0084 | 0.1918 | 0.5 |
Entamoeba histolytica | AMP deaminase, putative | 0.0084 | 0.1918 | 0.1972 |
Treponema pallidum | adenosine deaminase | 0.0258 | 0.6533 | 0.5 |
Loa Loa (eye worm) | AMP deaminase | 0.0084 | 0.1918 | 0.286 |
Leishmania major | adenine aminohydrolase | 0.0258 | 0.6533 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0258 | 0.6533 | 1 |
Echinococcus granulosus | geminin | 0.0195 | 0.4852 | 0.7393 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4303 | 0.655 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0785 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0495 | 0.0658 |
Echinococcus multilocularis | musashi | 0.0031 | 0.051 | 0.0659 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0258 | 0.6533 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0258 | 0.6533 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.051 | 0.0681 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.051 | 0.0659 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0084 | 0.1918 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.4852 | 0.4576 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0258 | 0.6533 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0258 | 0.6533 | 1 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0258 | 0.6533 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.051 | 0.0659 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0258 | 0.6533 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0785 | 0.1025 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.1264 | 0.0795 |
Trypanosoma brucei | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0258 | 0.6533 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0785 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4303 | 0.655 |
Echinococcus multilocularis | geminin | 0.0195 | 0.4852 | 0.7393 |
Schistosoma mansoni | adenosine deaminase | 0.0258 | 0.6533 | 0.6347 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4303 | 0.655 |
Plasmodium vivax | adenosine deaminase, putative | 0.0258 | 0.6533 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.4852 | 0.4576 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.6533 | 1 |
Entamoeba histolytica | AMP deaminase, putative | 0.0084 | 0.1918 | 0.1972 |
Onchocerca volvulus | 0.0031 | 0.051 | 0.0781 | |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0258 | 0.6533 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.051 | 0.0596 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0084 | 0.1918 | 0.2936 |
Echinococcus multilocularis | adenosine deaminase | 0.0258 | 0.6533 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0258 | 0.6533 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.051 | 0.0659 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0785 | 0.0289 |
Mycobacterium ulcerans | adenosine deaminase | 0.0258 | 0.6533 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1918 | 0.286 |
Echinococcus multilocularis | AMP deaminase 2 | 0.0084 | 0.1918 | 0.2843 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0258 | 0.6533 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0258 | 0.6533 | 1 |
Brugia malayi | adenosine monophosphate deaminase | 0.0084 | 0.1918 | 0.2794 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0128 | 0.0091 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.051 | 0.0681 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.051 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4303 | 0.655 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0084 | 0.1918 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0085 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.051 | 0.0681 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.051 | 0.0596 |
Echinococcus granulosus | AMP deaminase 2 | 0.0084 | 0.1918 | 0.2843 |
Schistosoma mansoni | adenosine deaminase-related | 0.0258 | 0.6533 | 0.6347 |
Schistosoma mansoni | AMP deaminase | 0.0084 | 0.1918 | 0.1484 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.03 uM | Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]-OXO-M (oxotremorine) as the radioligand. | ChEMBL. | 7739014 |
Max stimulation (functional) | = 8 % | Maximum stimulation of phosphatidyl inositol in rat hippocampal tissue, activity is expressed as percent of carbachol response | ChEMBL. | 7739014 |
Max stimulation (functional) | = 8 % | Maximum stimulation of phosphatidyl inositol in rat hippocampal tissue, activity is expressed as percent of carbachol response | ChEMBL. | 7739014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.