Detailed information for compound 566450

Basic information

Technical information
  • TDR Targets ID: 566450
  • Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydrox y-8-methoxy-4-oxo-2-phenyl-chromen-7-yl)oxy-t etrahydropyran-2-carboxylic acid
  • MW: 460.388 | Formula: C22H20O11
  • H donors: 5 H acceptors: 7 LogP: 1.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(O[C@@H]2O[C@H](C(=O)O)[C@H]([C@@H]([C@H]2O)O)O)cc(c2c1oc(cc2=O)c1ccccc1)O
  • InChi: 1S/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1
  • InChiKey: LNOHXHDWGCMVCO-NTKSAMNMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(5-hydroxy-8-methoxy-4-oxo-2-phenyl-1-benzopyran-7-yl)oxy]-2-tetrahydropyrancarboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenyl-chromen-7-yl)oxy-oxane-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-4-keto-8-methoxy-2-phenyl-chromen-7-yl)oxy-tetrahydropyran-2-carboxylic acid
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid
  • oroxindin
  • wogonoside
  • (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(5-hydroxy-8-methoxy-4-oxo-2-phenyl-7-chromenyl)oxy]-2-tetrahydropyrancarboxylic acid
  • 51059-44-0
  • ACon1_000851
  • MEGxp0_000537

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0276 0.0272
Echinococcus multilocularis snurportin 1 0.0306 1 1
Onchocerca volvulus 0.0017 0.0273 0.1176
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1823 0.1823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.324 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0529 0.1632
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0273 0.0273
Trichomonas vaginalis ran, putative 0.0021 0.042 0.1295
Brugia malayi jmjC domain containing protein 0.0017 0.0276 0.0297
Echinococcus granulosus tar DNA binding protein 0.0129 0.4047 0.4047
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.1832 0.1832
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0273 0.3554
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.4047 0.4348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0474 0.1462
Onchocerca volvulus 0.0017 0.0273 0.1176
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0087 0.0268
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0674 0.259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.4047 0.4045
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0767 0.2368
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0664 0.8652
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0276 0.0276
Echinococcus multilocularis muscleblind protein 0.018 0.5774 0.5774
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.324 0.3237
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0083
Brugia malayi Cathepsin L-like precursor 0.0011 0.0087 0.0093
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.1832 0.1832
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.1395 0.4304
Brugia malayi 6-phosphofructokinase 0.0105 0.324 0.3481
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1853 0.572
Echinococcus multilocularis cysteine protease 0.0017 0.0273 0.0273
Leishmania major hypothetical protein, conserved 0.0017 0.0276 0.0011
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0276 0.0276
Entamoeba histolytica cysteine protease, putative 0.0017 0.0273 0.0842
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0273 0.0842
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.018 0.5774 0.5772
Brugia malayi Muscleblind-like protein 0.018 0.5774 0.6202
Schistosoma mansoni survival motor neuron protein 0.0058 0.1668 0.1668
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0474 0.1553
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0474 0.047
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0276 0.0276
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0004
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.042 0.5469
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0083
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0273 0.0273
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.042 0.042
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0273 0.0273
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0529 0.1632
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0664 0.2523
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0767 0.3191
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0273 0.1176
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0664 0.8652
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0273 0.0269
Plasmodium falciparum flap endonuclease 1 0.0031 0.0767 1
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0004
Brugia malayi Importin beta-1 subunit 0.0029 0.0674 0.0724
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1823 0.4877
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0664 0.8652
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.1832 0.1832
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0273 0.0842
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.324 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0474 0.1462
Leishmania major cathepsin L-like protease 0.0064 0.1853 0.5327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0129 0.4047 0.4047
Brugia malayi Smad1 0.0009 0.0004 0.0004
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0276 0.0276
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0767 0.2368
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0529 0.1632
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0087 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1823 0.4877
Brugia malayi jmjC domain containing protein 0.0017 0.0276 0.0297
Brugia malayi RNA, U transporter 1 0.0082 0.2451 0.2633
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0273 0.0273
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0276 0.0852
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0474 0.1462
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0276 0.0022
Brugia malayi jmjC domain containing protein 0.0017 0.0276 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.042 0.042
Brugia malayi phosphofructokinase 0.0105 0.324 0.3481
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0474 0.0474
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.324 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0273 0.0269
Loa Loa (eye worm) hypothetical protein 0.018 0.5774 0.5772
Loa Loa (eye worm) RNA binding protein 0.0129 0.4047 0.4045
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.9309 0.9309
Onchocerca volvulus 0.0017 0.0273 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0087 0.0268
Loa Loa (eye worm) hypothetical protein 0.0017 0.0276 0.0272
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0273 0.3554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Leishmania major hypothetical protein, conserved 0.0024 0.0529 0.0863
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0664 0.0688
Loa Loa (eye worm) phosphofructokinase 0.0105 0.324 0.3237
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0474 0.6173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Brugia malayi RNA binding protein 0.0129 0.4047 0.4348
Leishmania major cathepsin L-like protease 0.0064 0.1853 0.5327
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0767 0.0767
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0087 0.0093
Plasmodium vivax JmjC domain containing protein 0.0017 0.0276 0.3599
Entamoeba histolytica hypothetical protein 0.0023 0.0492 0.1518
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1853 0.572
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1823 0.4877
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Plasmodium vivax vivapain-2 0.0017 0.0273 0.3554
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0767 0.1667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Brugia malayi Cathepsin L-like precursor 0.0011 0.0087 0.0093
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0004
Plasmodium vivax vivapain-2 0.0017 0.0273 0.3554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0529 0.6891
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0674 0.2081
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0276 0.0276
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0664 0.5
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0664 0.2523
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0273 0.1176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Echinococcus granulosus Smad4 0.0009 0.0004 0.0004
Loa Loa (eye worm) ctsf protein 0.0017 0.0273 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.324 1
Leishmania major GTP-binding protein, putative 0.0021 0.042 0.0495
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0492 0.1518
Echinococcus granulosus smad 0.0009 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0273 0.0273
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.324 1
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0674 0.0674
Schistosoma mansoni importin beta-1 0.0029 0.0674 0.0674
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0664 0.5
Schistosoma mansoni hypothetical protein 0.0011 0.0077 0.0077
Onchocerca volvulus 0.0017 0.0273 0.1176
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.324 0.324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Brugia malayi hypothetical protein 0.0286 0.9309 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.4047 0.4047
Onchocerca volvulus 0.0017 0.0273 0.1176
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0529 0.1652
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.324 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0276 0.0276
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0492 0.1518
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0529 0.6891
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0276 0.0276
Brugia malayi TAR-binding protein 0.0129 0.4047 0.4348
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.042 0.0416
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0767 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0664 0.7024
Leishmania major importin beta-1 subunit, putative 0.0023 0.0492 0.0738
Onchocerca volvulus 0.0017 0.0273 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1823 0.5224
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0474 0.0677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Schistosoma mansoni tar DNA-binding protein 0.0129 0.4047 0.4047
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0276 0.0272
Brugia malayi 6-phosphofructokinase 0.0105 0.324 0.3481
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.324 1
Plasmodium falciparum importin beta, putative 0.0029 0.0674 0.8786
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0276 0.3599
Onchocerca volvulus 0.0017 0.0273 0.1176
Schistosoma mansoni jumonji domain containing protein 0.0063 0.1832 0.1832
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0276 0.0276
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0474 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0273 0.1176
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.042 0.1295
Echinococcus multilocularis muscleblind protein 1 0.018 0.5774 0.5774
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1823 0.1823
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1832 0.1829
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Onchocerca volvulus 0.0058 0.1668 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.324 0.324
Loa Loa (eye worm) hypothetical protein 0.0286 0.9309 0.9308
Echinococcus multilocularis cysteine protease 0.0017 0.0273 0.0273
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1823 0.1823
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0077 0.0077
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0276 0.0276
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.324 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Echinococcus granulosus phd:f box containing protein 0.0017 0.0276 0.0276
Schistosoma mansoni Smad4 0.0009 0.0004 0.0004
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.324 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0492 0.1518
Loa Loa (eye worm) hypothetical protein 0.0024 0.0529 0.0525
Brugia malayi jmjC domain containing protein 0.0063 0.1832 0.1968
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0273 0.0842
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0474 0.1462
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0273 0.0842
Leishmania major cathepsin L-like protease 0.0064 0.1853 0.5327
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0023 0.0474 0.0474
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0276 0.0022
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.324 0.5
Schistosoma mansoni flap endonuclease-1 0.0028 0.0666 0.0666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0087 0.0268
Schistosoma mansoni hypothetical protein 0.0058 0.1668 0.1668
Loa Loa (eye worm) hypothetical protein 0.0017 0.0273 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.324 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0529 0.6891
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0767 0.2368
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1823 0.4877
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0276 0.0852
Loa Loa (eye worm) hypothetical protein 0.0017 0.0276 0.0272
Schistosoma mansoni tar DNA-binding protein 0.0129 0.4047 0.4047
Loa Loa (eye worm) fibroinase 0.0017 0.0273 0.0269
Schistosoma mansoni ap endonuclease 0.0023 0.0474 0.0474
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1823 0.1823
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0474 0.5
Echinococcus granulosus muscleblind protein 0.018 0.5774 0.5774
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.4018 0.4016
Echinococcus multilocularis tar DNA binding protein 0.0129 0.4047 0.4047
Echinococcus multilocularis smad 0.0009 0.0004 0.0004
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0004
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.042 0.0948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0664 0.2523
Brugia malayi jmjC domain containing protein 0.0063 0.1832 0.1968
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0276 0.0272
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.9309 0.9309
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0273 0.0273
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.324 1
Brugia malayi Flap endonuclease-1 0.0031 0.0767 0.0824
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.1832 0.1832
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1668 0.1792
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0273 0.0842
Brugia malayi Cathepsin L-like precursor 0.0017 0.0273 0.0293
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0474 0.1462
Brugia malayi hypothetical protein 0.0024 0.0529 0.0568
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.324 0.3237
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.324 1
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0276 0.0276
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0273 0.0269
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0767 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1832 0.1832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0664 0.2049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.1832 0.1832
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1823 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Brugia malayi MH2 domain containing protein 0.0128 0.4018 0.4316
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0077 0.0077
Echinococcus granulosus importin subunit beta 1 0.0029 0.0674 0.0674
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0664 0.8652
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.042 0.0451
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.042 0.1295
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0492 0.1518
Schistosoma mansoni ran 0.0021 0.042 0.042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.1667 0.5146
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0474 0.1462
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1853 0.572
Entamoeba histolytica Ran family GTPase 0.0021 0.042 0.1295
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0474 0.6173
Schistosoma mansoni hypothetical protein 0.0306 1 1
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0273 0.0293
Loa Loa (eye worm) hypothetical protein 0.0017 0.0276 0.0272
Schistosoma mansoni ran 0.0021 0.042 0.042
Brugia malayi jmjC domain containing protein 0.0017 0.0276 0.0297
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.042 0.1295
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.4018 0.4016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0674 0.0671
Toxoplasma gondii exonuclease III APE 0.0023 0.0474 0.1296
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.324 0.324
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0767 0.0764
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0276 0.0852
Echinococcus granulosus cathepsin l1 0.0011 0.0087 0.0087
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0474 0.0509
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1853 0.572
Brugia malayi hypothetical protein 0.0016 0.0239 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1853 0.572
Echinococcus granulosus flap endonuclease 1 0.0031 0.0767 0.0767
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0674 0.2081
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.324 1
Brugia malayi cathepsin L-like precursor 0.0011 0.0087 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0129 0.4047 0.4047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0276 0.0276
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0273 0.0273
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0276 0.0276
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.042 0.5469
Schistosoma mansoni smad 0.0009 0.0004 0.0004
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0767 0.2368
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0664 0.2049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0273 0.0842
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0664 0.2049
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0273 0.0842
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0276 0.0276
Plasmodium vivax importin-beta 2, putative 0.0029 0.0674 0.8786
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0273 0.3554
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0273 0.0273
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0129 0.4047 0.4045
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Echinococcus granulosus cathepsin l1 0.0017 0.0273 0.0273

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 uM Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA ChEMBL. 9214730

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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