Detailed information for compound 566691

Basic information

Technical information
  • TDR Targets ID: 566691
  • Name: Budesonide
  • MW: 430.534 | Formula: C25H34O6
  • H donors: 2 H acceptors: 4 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@@H]1O[C@H]2[C@](O1)(C(=O)CO)[C@@]1([C@@H](C2)[C@@H]2CCC3=CC(=O)C=C[C@@]3([C@H]2[C@H](C1)O)C)C
  • InChi: 1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21+,22+,23-,24-,25+/m0/s1
  • InChiKey: VOVIALXJUBGFJZ-VXKMTNQYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chlorophenyl-N-methylhydrazonopropanedinitrile
  • 51333-22-3
  • 51372-29-3
  • BUDESONIDE (11beta,16alpha(R))
  • EINECS 257-161-7
  • (4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
  • 16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi prolyl oligopeptidase family protein 0.0357 0.3434 0.3433
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0535 0.0533
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0186 0.1704 0.1702
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0191 0.019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.016 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0017
Brugia malayi cathepsin L-like precursor 0.0675 0.6637 0.6636
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0057 0.0402 0.0376
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1311 0.2799
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0535 0.0533
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1008 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2708 0.2707
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1311 1
Loa Loa (eye worm) fibroinase 0.1008 1 1
Brugia malayi nuclear receptor NHR-88 0.0033 0.016 0.0159
Entamoeba histolytica hypothetical protein, conserved 0.0057 0.0402 0.0376
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0402 0.04
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.1704 0.1702
Trypanosoma cruzi cysteine protease, putative 0.0519 0.5067 0.5054
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.016 0.0159
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0057 0.0402 0.0376
Onchocerca volvulus 0.0043 0.0265 0.0264
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Schistosoma mansoni hypothetical protein 0.0036 0.0191 0.019
Toxoplasma gondii hypothetical protein 0.0057 0.0402 0.0402
Brugia malayi Matrixin family protein 0.0051 0.034 0.0339
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0155 0.0153
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.1704 0.1681
Schistosoma mansoni ap endonuclease 0.0023 0.0055 0.0054
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.016 0.0159
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0068
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.016 0.0159
Echinococcus granulosus cathepsin l cysteine peptidase 0.1008 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0787 0.0786
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0402 0.04
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0186 0.1704 0.1702
Echinococcus multilocularis cathepsin b 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2708 0.2707
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0184 0.0342
Loa Loa (eye worm) prolyl oligopeptidase 0.0481 0.4677 0.4677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1008 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.043 0.0429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0453 0.0452
Brugia malayi hypothetical protein 0.0037 0.02 0.0199
Brugia malayi Death domain containing protein 0.0017 0.0001 0.000000036438
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Echinococcus multilocularis cysteine protease 0.1008 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.1704 0.5906
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0095 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.016 0.0159
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0186 0.1704 0.1681
Schistosoma mansoni hypothetical protein 0.0041 0.0242 0.024
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0576 0.055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0787 0.0786
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0535 0.0533
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Plasmodium vivax unspecified product 0.0519 0.5067 0.5066
Schistosoma mansoni hypothetical protein 0.0035 0.0184 0.0182
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0675 0.6637 0.6636
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.016 0.0159
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0095 0.0095
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.1704 0.1702
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0186 0.1704 0.1702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0576 0.0574
Entamoeba histolytica cysteine proteinase 2 0.0519 0.5067 0.5054
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.1704 0.1702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Brugia malayi hypothetical protein 0.0036 0.0191 0.019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Echinococcus granulosus dna polymerase kappa 0.002 0.0027 0.0025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0027 0.0025
Plasmodium vivax vivapain-3 0.0519 0.5067 0.5066
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.02 0.0199
Loa Loa (eye worm) hypothetical protein 0.0041 0.0242 0.024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0055 0.0054
Brugia malayi cathepsin L precursor 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0095 0.0093
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0481 0.4677 0.4677
Entamoeba histolytica hypothetical protein 0.0036 0.0191 0.0165
Giardia lamblia Encystation-specific protease 0.0186 0.1704 0.5906
Onchocerca volvulus Prolyl endopeptidase homolog 0.0057 0.0402 0.04
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0576 0.1196
Trypanosoma cruzi cysteine peptidase, putative 0.0519 0.5067 0.5054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0535 0.0533
Schistosoma mansoni hypothetical protein 0.0205 0.1891 0.189
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.2866 1
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0402 0.04
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Brugia malayi cathepsin Z-like cysteine proteinase 0.0186 0.1704 0.1702
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.1704 0.1681
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0021 0.0039 0.0037
Onchocerca volvulus 0.0021 0.0039 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0535 0.0533
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0077 0.0599 0.0597
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0265 0.1854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Echinococcus multilocularis cathepsin L 0.0186 0.1704 0.1702
Brugia malayi steroid hormone receptor 0.007 0.0535 0.0533
Entamoeba histolytica cysteine proteinase 1, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) cysteine protease 0.1008 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.016 0.0159
Entamoeba histolytica hypothetical protein 0.0036 0.0191 0.0165
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0057 0.0402 0.04
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0535 0.0533
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0535 0.0533
Brugia malayi Cathepsin L-like precursor 0.0675 0.6637 0.6636
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0186 0.1704 0.1658
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.02 0.0199
Loa Loa (eye worm) matrix metalloproteinase 0.0021 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Brugia malayi Nuclear hormone receptor E75 0.0033 0.016 0.0159
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1704 0.1702
Schistosoma mansoni nuclear receptor 0.0033 0.016 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Onchocerca volvulus 0.0062 0.0453 0.0452
Loa Loa (eye worm) hypothetical protein 0.1008 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0576 0.055
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0186 0.1704 0.1702
Echinococcus multilocularis Ankyrin 0.0018 0.0003 0.0001
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0186 0.1704 0.1702
Trichomonas vaginalis set domain proteins, putative 0.0493 0.4804 0.4789
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Giardia lamblia Cysteine protease 0.0186 0.1704 0.5906
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0419 0.0418
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0535 0.0533
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1704 0.1702
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1704 0.1702
Trypanosoma cruzi cysteine peptidase, putative 0.1008 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0402 0.0376
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0837 0.8273 0.8273
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.016 0.0159
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0519 0.5067 0.5054
Onchocerca volvulus 0.0493 0.4805 0.4804
Echinococcus granulosus Ankyrin 0.0018 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.5067 0.5054
Brugia malayi Nuclear hormone receptor-like 1 0.007 0.0535 0.0533
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.1704 0.1702
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0333 0.319 0.3189
Brugia malayi Matrixin family protein 0.0021 0.0039 0.0037
Giardia lamblia Cysteine protease 0.0186 0.1704 0.5906
Onchocerca volvulus Cathepsin L homolog 0.0186 0.1704 0.1702
Onchocerca volvulus Cathepsin F homolog 0.1008 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0675 0.6637 0.6636
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0787 0.0786
Schistosoma mansoni cathepsin S (C01 family) 0.0186 0.1704 0.1702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.016 0.0159
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.1704 0.1681
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0535 0.0533
Schistosoma mansoni coup transcription factor 0.007 0.0535 0.0533
Onchocerca volvulus Cathepsin L homolog 0.1008 1 1
Plasmodium falciparum peptidase, putative 0.0057 0.0402 0.0349
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0535 0.0533
Schistosoma mansoni hypothetical protein 0.0058 0.0414 0.0413
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.016 0.0159
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0675 0.6637 0.6636
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0186 0.1704 0.1702
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0018 0.0017
Brugia malayi beta-lactamase 0.0074 0.0576 0.0574
Toxoplasma gondii prolyl endopeptidase 0.0057 0.0402 0.0402
Brugia malayi nuclear receptor RXR 0.0037 0.02 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0787 0.0786
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Giardia lamblia Cysteine protease 0.0186 0.1704 0.5906
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0184 0.0806
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Schistosoma mansoni thyroid hormone receptor 0.007 0.0535 0.0533
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Leishmania major cathepsin L-like protease 0.1008 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0561 0.5485 0.5485
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0017
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Trypanosoma cruzi cysteine proteinase, putative 0.0519 0.5067 0.5054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0055 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.02 0.0199
Mycobacterium tuberculosis Hypothetical protein 0.0035 0.0184 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0027 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.1704 0.1681
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0085 0.0127
Mycobacterium leprae Probable lipase LipE 0.0074 0.0576 0.4002
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0519 0.5067 0.5066
Schistosoma mansoni cathepsin B (C01 family) 0.0186 0.1704 0.1702
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0242 0.2267 0.2267
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.02 0.0199
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.1704 0.1681
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0357 0.3434 0.3416
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0333 0.319 0.3189
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0077 0.0599 0.0597
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0086 0.006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1008 1 1
Plasmodium vivax unspecified product 0.0333 0.319 0.3188
Echinococcus granulosus cathepsin L 0.0519 0.5067 0.5066
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0535 0.0533
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0186 0.1704 0.1702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Plasmodium falciparum serine repeat antigen 3 0.0186 0.1704 0.1658
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0186 0.1704 0.1681
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1008 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Echinococcus multilocularis cathepsin b 0.0186 0.1704 0.1702
Echinococcus granulosus neuropeptide s receptor 0.0561 0.5485 0.5485
Brugia malayi Matrixin family protein 0.0021 0.0039 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Plasmodium falciparum serine repeat antigen 9 0.0186 0.1704 0.1658
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.1704 0.1702
Onchocerca volvulus Matrilysin homolog 0.0047 0.0298 0.0296
Schistosoma mansoni lamin 0.0033 0.0155 0.0153
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.5067 0.5054
Echinococcus granulosus cathepsin L cysteine protease 0.0519 0.5067 0.5066
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0186 0.1704 0.1681
Echinococcus granulosus GPCR family 2 0.0019 0.0018 0.0017
Brugia malayi nuclear receptor NHR-88 0.007 0.0535 0.0533
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0186 0.1704 0.1702
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0057 0.0402 0.0376
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0357 0.3434 0.3433
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0055 0.0001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.1704 0.5906
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0535 0.0533
Onchocerca volvulus 0.1008 1 1
Giardia lamblia Cathepsin L-like protease 0.0186 0.1704 0.5906
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.016 0.0159
Brugia malayi Matrixin family protein 0.0021 0.0039 0.0037
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0057 0.0402 0.0376
Loa Loa (eye worm) DR-78 0.0033 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.006 0.0434 0.0432
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0535 0.0533
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Plasmodium vivax SET domain protein, putative 0.0062 0.0453 0.0451
Trypanosoma cruzi major cysteine proteinase, putative 0.0186 0.1704 0.1681
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0535 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.6637 0.6628
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Leishmania major cathepsin L-like protease 0.1008 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Mycobacterium ulcerans hypothetical protein 0.0035 0.0184 0.1222
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0027 0.0025
Giardia lamblia Alanyl dipeptidyl peptidase 0.0057 0.0402 0.132
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0576 0.0574
Brugia malayi hypothetical protein 0.0037 0.02 0.0199
Brugia malayi beta-lactamase family protein 0.0074 0.0576 0.0574
Onchocerca volvulus 0.0074 0.0576 0.0574
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0535 0.0533
Leishmania major cathepsin L-like protease 0.1008 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Echinococcus granulosus Transglutaminase 0.0035 0.0184 0.0182
Schistosoma mansoni lamin 0.0033 0.0155 0.0153
Loa Loa (eye worm) hypothetical protein 0.0032 0.0149 0.0147
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0453 0.0452
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0057 0.0402 0.0376
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0055 0.01
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.5067 0.5054
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0057 0.0402 0.0376
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0017
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.1704 0.1681
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0055 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1704 0.1681
Brugia malayi cathepsin F-like cysteine proteinase 0.0333 0.319 0.3189
Brugia malayi Matrixin family protein 0.0021 0.0039 0.0037
Entamoeba histolytica hypothetical protein 0.0036 0.0191 0.0165
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0184 0.0342
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.016 0.0159
Brugia malayi nuclear receptor RXR 0.0033 0.016 0.0159
Brugia malayi Uncoordinated protein 44 0.0017 0.0001 0.000000036438
Echinococcus multilocularis cathepsin L 0.0519 0.5067 0.5066
Toxoplasma gondii preprocathepsin c precursor, putative 0.0186 0.1704 0.1704
Mycobacterium ulcerans lipase LipD 0.0074 0.0576 0.4273
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0414 0.0413
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0402 0.04
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0331 0.0329
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0357 0.3434 0.3416
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0535 0.0533
Leishmania major cathepsin L-like protease 0.1008 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0576 0.0574
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0057 0.0402 0.2918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0535 0.0533
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0434 0.0432
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0057 0.0402 0.0376
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0535 0.0533
Echinococcus granulosus cathepsin l1 0.1008 1 1
Plasmodium falciparum serine repeat antigen 4 0.0186 0.1704 0.1658
Onchocerca volvulus 0.0074 0.0576 0.0574
Schistosoma mansoni hypothetical protein 0.0062 0.0457 0.0455
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Giardia lamblia Hypothetical protein 0.0186 0.1704 0.5906
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0055 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Trypanosoma cruzi cysteine peptidase, putative 0.1008 1 1
Onchocerca volvulus 0.1008 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0576 0.0574
Loa Loa (eye worm) hypothetical protein 0.0173 0.1568 0.1567
Plasmodium falciparum serine repeat antigen 8 0.0186 0.1704 0.1658
Brugia malayi conserved hypotetical protein 0.0033 0.016 0.0159
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0357 0.3434 0.3416
Trypanosoma brucei prolyl endopeptidase 0.0057 0.0402 0.0376
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0057 0.0402 0.0376
Echinococcus granulosus single minded 2 0.0043 0.0265 0.0264
Plasmodium falciparum serine repeat antigen 2 0.0186 0.1704 0.1658
Brugia malayi tailless protein 0.0033 0.016 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0055 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.02 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0787 0.0786
Brugia malayi hypothetical protein 0.0027 0.0095 0.0093
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0186 0.1704 0.1658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0535 0.0533
Brugia malayi hypothetical protein 0.0033 0.016 0.0159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0055 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0576 0.055
Trypanosoma brucei prolyl oligopeptidase, putative 0.0057 0.0402 0.0376
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.016 0.0159
Trichomonas vaginalis peptide N-glycanase, putative 0.0035 0.0184 0.0157
Brugia malayi PAS domain containing protein 0.0059 0.0419 0.0418
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.02 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.1008 1 1
Trichomonas vaginalis esterase, putative 0.0074 0.0576 0.055
Trypanosoma cruzi oligopeptidase b 0.0057 0.0402 0.0376
Brugia malayi Hemopexin family protein 0.003 0.0128 0.0126
Echinococcus multilocularis Transglutaminase 0.0035 0.0184 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0519 0.5067 0.504
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0576 0.4273
Giardia lamblia Hypothetical protein 0.0186 0.1704 0.5906
Loa Loa (eye worm) hypothetical protein 0.0021 0.0034 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0535 0.0533
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0535 0.0533
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0576 0.1196
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0675 0.6637 0.6628
Brugia malayi Pre-SET motif family protein 0.0062 0.0453 0.0452
Onchocerca volvulus 0.0033 0.0155 0.0153
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0186 0.1704 0.1658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0086 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0453 0.0452
Schistosoma mansoni cathepsin s 0.0333 0.319 0.3189
Echinococcus granulosus Dipeptidyl peptidase 9 0.0357 0.3434 0.3433
Echinococcus granulosus FTZ F1 alpha 0.007 0.0535 0.0533
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0535 0.0533
Brugia malayi nuclear hormone receptor 0.0033 0.016 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0535 0.0533
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.4199 0.4199
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Entamoeba histolytica prolyl oligopeptidase family protein 0.0057 0.0402 0.0376
Giardia lamblia Cysteine protease 0.0186 0.1704 0.5906
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Onchocerca volvulus 0.0033 0.016 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0787 0.0786
Giardia lamblia Alanyl dipeptidyl peptidase 0.0057 0.0402 0.132
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0057 0.0402 0.0817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.1704 0.1681
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.016 0.0159
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.016 0.0159
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0576 0.0574
Echinococcus multilocularis musashi 0.0033 0.0155 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Schistosoma mansoni ap endonuclease 0.0023 0.0055 0.0054
Brugia malayi hypothetical protein 0.0185 0.1692 0.1691
Schistosoma mansoni nuclear receptor 0.0033 0.016 0.0159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0055 0.0029
Schistosoma mansoni cathepsin C 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Echinococcus granulosus bloom syndrome protein 0.0026 0.0086 0.0085
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0357 0.3434 0.3416
Leishmania major cathepsin L-like protease 0.1008 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0576 0.055
Loa Loa (eye worm) matrixin family protein 0.0051 0.034 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.0184 0.1222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0481 0.4677 0.4677
Onchocerca volvulus 0.1008 1 1
Brugia malayi ecdysone receptor 0.0033 0.016 0.0159
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0453 0.0453
Onchocerca volvulus 0.007 0.0535 0.0533
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0191 0.019
Onchocerca volvulus 0.0675 0.6637 0.6636
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0186 0.1704 0.1702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0535 0.0533
Brugia malayi Cathepsin L-like precursor 0.1008 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1008 1 1
Trypanosoma cruzi oligopeptidase b 0.0057 0.0402 0.0376
Echinococcus granulosus geminin 0.0205 0.1891 0.189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0535 0.0533
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0519 0.5067 0.5054
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.016 0.0159
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0086 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Toxoplasma gondii exonuclease III APE 0.0023 0.0055 0.0055
Trypanosoma cruzi cysteine proteinase, putative 0.0519 0.5067 0.5054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0519 0.5067 0.5066
Onchocerca volvulus 0.0058 0.0414 0.0413
Brugia malayi nuclear receptor NHR-67 0.0033 0.016 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0298 0.0296
Echinococcus multilocularis prolyl endopeptidase 0.0057 0.0402 0.04
Onchocerca volvulus Cathepsin L homolog 0.1008 1 1
Plasmodium vivax unspecified product 0.0186 0.1704 0.1702
Mycobacterium ulcerans beta-lactamase 0.0074 0.0576 0.4273
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0535 0.0533
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0434 0.0432
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.1704 0.1681
Onchocerca volvulus 0.1008 1 1
Leishmania major oligopeptidase b 0.0057 0.0402 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0186 0.1704 0.1702
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.003 0.0128 0.0126
Echinococcus granulosus acylamino acid releasing enzyme 0.0057 0.0402 0.04
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0185 0.1692 0.1691
Loa Loa (eye worm) hypothetical protein 0.0062 0.0453 0.0452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0787 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0037 0.02 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.1704 0.1681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Brugia malayi Cathepsin L-like precursor 0.0333 0.319 0.3189
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0018 0.0017
Schistosoma mansoni nuclear hormone receptor 0.007 0.0535 0.0533
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0453 0.0452
Giardia lamblia Transglutaminase/protease, putative 0.0035 0.0184 0.0553
Echinococcus multilocularis GPCR, family 2 0.0019 0.0018 0.0017
Toxoplasma gondii cathepsin CPC1 0.0186 0.1704 0.1704
Echinococcus granulosus lamin dm0 0.0033 0.0155 0.0153
Loa Loa (eye worm) matrixin family protein 0.0047 0.0298 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0576 0.4273
Brugia malayi Cathepsin L-like precursor 0.1008 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1008 1 1
Brugia malayi hypoxia-induced factor 1 0.0182 0.1661 0.166
Echinococcus granulosus intermediate filament protein 0.0033 0.0155 0.0153
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0724 0.0722
Leishmania major cathepsin L-like protease 0.1008 1 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0085 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0535 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0535 0.0533
Trypanosoma cruzi prolyl endopeptidase 0.0057 0.0402 0.0376
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0535 0.0533
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0724 0.0722
Entamoeba histolytica hypothetical protein 0.0036 0.0191 0.0165
Loa Loa (eye worm) beta-lactamase 0.0074 0.0576 0.0574
Mycobacterium tuberculosis Probable peptidase 0.0057 0.0402 0.0817
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0535 0.0533
Loa Loa (eye worm) hypothetical protein 0.0197 0.1815 0.1814
Leishmania major cathepsin L-like protease 0.1008 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1008 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0001
Brugia malayi hypothetical protein 0.0286 0.2708 0.2707
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0003 0.0001
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.016 0.0159
Plasmodium vivax vivapain-2 0.1008 1 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0057 0.0402 0.0376
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0186 0.1704 0.1702
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0576 0.1196
Echinococcus multilocularis cysteine protease 0.1008 1 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.1661 0.166
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0086 0.0085
Trypanosoma brucei oligopeptidase b 0.0057 0.0402 0.0376
Leishmania major hypothetical protein, conserved 0.0074 0.0576 0.055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0057 0.0402 0.04
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0055 0.0029
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0057 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.02 0.0199
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.1704 0.1702
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Brugia malayi Protein kinase domain containing protein 0.0017 0.0001 0.000000036438
Mycobacterium tuberculosis Conserved protein 0.0074 0.0576 0.1196
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0576 0.1196
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.04
Onchocerca volvulus 0.003 0.0128 0.0126
Echinococcus multilocularis geminin 0.0205 0.1891 0.189
Brugia malayi ecdysteroid receptor 0.007 0.0535 0.0533
Brugia malayi Nuclear hormone receptor E75 0.0033 0.016 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1704 0.1681
Loa Loa (eye worm) RecQ helicase 0.0026 0.0086 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0535 0.0533
Schistosoma mansoni nuclear hormone receptor 0.0033 0.016 0.0159
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0068
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0576 0.4002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0017
Echinococcus multilocularis dna polymerase kappa 0.002 0.0027 0.0025
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0057 0.0402 0.2583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0787 0.0786
Echinococcus multilocularis cathepsin L cysteine protease 0.1008 1 1
Brugia malayi Cathepsin L-like precursor 0.1008 1 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0057 0.0402 0.04
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0576 0.0574
Echinococcus multilocularis dna polymerase eta 0.002 0.0027 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0018 0.0017
Echinococcus multilocularis acylamino acid releasing enzyme 0.0057 0.0402 0.04
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0535 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Giardia lamblia Cathepsin L-like protease 0.0186 0.1704 0.5906
Schistosoma mansoni single-minded 0.0059 0.0419 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1008 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.0333 0.319 0.3189
Loa Loa (eye worm) hypothetical protein 0.0037 0.02 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0184 0.0806
Plasmodium vivax vivapain-1 0.0519 0.5067 0.5066
Entamoeba histolytica cysteine proteinase, putative 0.0675 0.6637 0.6628
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0402 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.1704 0.1681
Entamoeba histolytica hypothetical protein 0.0186 0.1704 0.1681
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0535 0.0533
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.016 0.0159
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0055 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0519 0.5067 0.5066
Brugia malayi hypothetical protein 0.0033 0.016 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0535 0.0533
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0093
Loa Loa (eye worm) hypothetical protein 0.0675 0.6637 0.6636
Schistosoma mansoni DNA polymerase eta 0.002 0.0027 0.0025
Echinococcus granulosus dna polymerase eta 0.002 0.0027 0.0025
Echinococcus multilocularis lamin 0.0033 0.0155 0.0153
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0055 0.0054
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.4615 1
Brugia malayi nuclear hormone receptor 0.007 0.0535 0.0533
Schistosoma mansoni nuclear hormone receptor 0.0033 0.016 0.0159
Echinococcus granulosus cathepsin L cysteine proteinase 0.1008 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0084
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0481 0.4677 0.4677
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0535 0.0533
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0001 0.000000036438
Brugia malayi Papain family cysteine protease containing protein 0.1008 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.016 0.0159
Brugia malayi prolyl oligopeptidase family protein 0.0481 0.4677 0.4677
Entamoeba histolytica cysteine protease, putative 0.1008 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0453 0.0452
Echinococcus multilocularis thyroid hormone receptor alpha 0.007 0.0535 0.0533
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0018 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1008 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1008 1 1
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Mycobacterium ulcerans hydrolase 0.0026 0.0085 0.0452
Plasmodium vivax vivapain-2 0.1008 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.2866 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0057 0.0402 0.04
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Loa Loa (eye worm) hypothetical protein 0.0333 0.319 0.3189
Loa Loa (eye worm) hypothetical protein 0.0074 0.0576 0.0574
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0357 0.3434 0.3433
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0535 0.0533
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0032 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0535 0.0533
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0357 0.3434 0.3416
Toxoplasma gondii cathepsin CPL 0.1008 1 1
Plasmodium falciparum serine repeat antigen 7 0.0186 0.1704 0.1658
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0535 0.0533
Brugia malayi beta-lactamase family protein 0.0074 0.0576 0.0574
Onchocerca volvulus 0.0035 0.0184 0.0182
Brugia malayi Cathepsin L-like precursor 0.0675 0.6637 0.6636
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.02 0.0199
Entamoeba histolytica prolyl oligopeptidase family protein 0.0057 0.0402 0.0376
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0576 0.1196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1008 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1008 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0186 0.1704 0.1681
Schistosoma mansoni thyroid hormone receptor 0.007 0.0535 0.0533
Echinococcus multilocularis neuropeptide receptor A26 0.0561 0.5485 0.5485
Loa Loa (eye worm) hypothetical protein 0.0037 0.02 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0576 0.055
Onchocerca volvulus 0.1008 1 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0576 0.0576
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0033 0.016 0.0159
Trypanosoma cruzi cruzipain precursor, putative 0.0333 0.319 0.3171
Brugia malayi Cathepsin L-like precursor 0.1008 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0576 0.055
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0535 0.0533
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0535 0.0533
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0186 0.1704 0.5906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1704 0.1681
Loa Loa (eye worm) hypothetical protein 0.0333 0.319 0.3189
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Onchocerca volvulus 0.0033 0.0155 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0402 0.0376
Brugia malayi Papain family cysteine protease containing protein 0.0519 0.5067 0.5066
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0055 0.0029
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.004
Loa Loa (eye worm) cathepsin B 0.0186 0.1704 0.1702
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0055 0.0062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2866 0.2847
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Leishmania major hypothetical protein, conserved 0.0027 0.0095 0.0068
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0265 0.0264
Toxoplasma gondii cathepsin B 0.0186 0.1704 0.1704
Onchocerca volvulus Matrilysin homolog 0.0021 0.0039 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.1704 0.1702
Schistosoma mansoni hypothetical protein 0.0205 0.1891 0.189
Leishmania major cathepsin L-like protease 0.1008 1 1
Echinococcus granulosus cysteine protease 0.0519 0.5067 0.5066
Onchocerca volvulus 0.0186 0.1704 0.1702
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0057 0.0402 0.0376
Plasmodium falciparum serine repeat antigen 6 0.0186 0.1704 0.1658
Onchocerca volvulus 0.0074 0.0576 0.0574
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Brugia malayi intermediate filament protein 0.0033 0.0155 0.0153
Echinococcus multilocularis neuropeptide s receptor 0.0561 0.5485 0.5485
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.016 0.0159
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0027 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1008 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0186 0.1704 0.1702
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.016 0.0159
Echinococcus granulosus cathepsin b 0.0186 0.1704 0.1702
Brugia malayi Cathepsin L-like cysteine proteinase 0.0675 0.6637 0.6636
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0535 0.0533
Leishmania major cysteine peptidase A (CPA) 0.1008 1 1
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Brugia malayi Thioredoxin family protein 0.0035 0.0184 0.0182
Echinococcus granulosus lamin 0.0033 0.0155 0.0153
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0535 0.0533
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0576 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0186 0.1704 0.1681
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0535 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0576 0.1196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0186 0.1704 0.1681
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0535 0.0533
Trypanosoma cruzi cruzipain precursor, putative 0.1008 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0186 0.1704 0.1702
Giardia lamblia Hypothetical protein 0.0035 0.0184 0.0553
Mycobacterium tuberculosis Long conserved protein 0.0035 0.0184 0.0342
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.5067 0.5054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186 0.1704 0.1702
Brugia malayi Pre-SET motif family protein 0.0433 0.4199 0.4199
Schistosoma mansoni intermediate filament proteins 0.0033 0.0155 0.0153
Brugia malayi hypothetical protein 0.0197 0.1815 0.1814
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0481 0.4677 0.4677
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0057 0.0402 0.04
Schistosoma mansoni cathepsin F (C01 family) 0.1008 1 1
Echinococcus multilocularis lamin dm0 0.0033 0.0155 0.0153
Brugia malayi fibroinase precursor 0.0186 0.1704 0.1702
Entamoeba histolytica prolyl oligopeptidase family protein 0.0057 0.0402 0.0376
Trypanosoma cruzi cysteine peptidase, putative 0.0333 0.319 0.3171
Onchocerca volvulus 0.1008 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0402 0.04
Loa Loa (eye worm) hypothetical protein 0.0037 0.02 0.0199
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0576 0.0574
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Brugia malayi Cathepsin L-like precursor 0.1008 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0155 0.0153
Onchocerca volvulus 0.0033 0.016 0.0159
Plasmodium falciparum serine repeat antigen 1 0.0186 0.1704 0.1658
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0155 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0001
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0186 0.1704 0.5906
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0535 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0186 0.1704 0.1681
Entamoeba histolytica cysteine protease, putative 0.0186 0.1704 0.1681
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0265 0.0264
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0576 0.1196
Toxoplasma gondii cathepsin CPC2 0.0186 0.1704 0.1704
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0787 0.0786
Trypanosoma brucei cysteine peptidase C (CPC) 0.0186 0.1704 0.1681
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0342
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0191 0.019
Entamoeba histolytica cysteine protease, putative 0.0519 0.5067 0.5054
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0001 0.000000036438
Schistosoma mansoni survival motor neuron protein 0.0058 0.0414 0.0413
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0242 0.024
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0535 0.0533
Giardia lamblia Cathepsin L precursor 0.0186 0.1704 0.5906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0675 0.6637 0.6628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0001 0.000000036438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1008 1 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.0576 0.4273
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0055 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1008 1 1
Giardia lamblia Cathepsin B precursor 0.0186 0.1704 0.5906
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.016 0.0159
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0186 0.1704 0.1681
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0027 0.0025
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0186 0.1704 0.1702
Schistosoma mansoni cathepsin F (C01 family) 0.1008 1 1
Echinococcus granulosus cathepsin b 0.0186 0.1704 0.1702
Mycobacterium ulcerans hypothetical protein 0.0035 0.0184 0.1222
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0535 0.0533
Mycobacterium tuberculosis Conserved protein 0.0074 0.0576 0.1196
Echinococcus granulosus cathepsin l1 0.0675 0.6637 0.6636
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0453 0.0452
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702
Echinococcus granulosus cathepsin L 0.0186 0.1704 0.1702
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0055 0.0054
Mycobacterium tuberculosis Conserved protein 0.0074 0.0576 0.1196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0434 0.0432
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.0184 0.1222
Loa Loa (eye worm) hypothetical protein 0.0286 0.2708 0.2707
Brugia malayi Papain family cysteine protease containing protein 0.0519 0.5067 0.5066
Loa Loa (eye worm) ctsf protein 0.1008 1 1
Schistosoma mansoni zinc finger protein 0.0033 0.016 0.0159
Echinococcus granulosus prolyl endopeptidase 0.0057 0.0402 0.04
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0576 0.055
Onchocerca volvulus 0.1008 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1008 1 1
Plasmodium falciparum serine repeat antigen 5 0.0186 0.1704 0.1658
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0453 0.0452
Loa Loa (eye worm) hypothetical protein 0.0186 0.1704 0.1702

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0009 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0015 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0022 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.006 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0106 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1381 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9496 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.9175 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.5205 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.9729 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.8022 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9301 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.8938 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.669 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 43.6465 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 54.4827 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.