Detailed information for compound 566897

Basic information

Technical information
  • TDR Targets ID: 566897
  • Name: 4-nitrobenzo[c]isochromen-6-one
  • MW: 241.199 | Formula: C13H7NO4
  • H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc2c1oc(=O)c1c2cccc1
  • InChi: 1S/C13H7NO4/c15-13-10-5-2-1-4-8(10)9-6-3-7-11(14(16)17)12(9)18-13/h1-7H
  • InChiKey: UGPKHPNHRLQNBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-nitro-6-benzo[c][2]benzopyranone
  • 4-nitro-6H-dibenzo(b,d)pyran-6-one
  • 4-nitro-6-benzo[c]isochromenone
  • 51640-90-5
  • 6H-Dibenzo(b,d)pyran-6-one, 4-nitro-
  • CCRIS 7715
  • 4-Nitro-6H-dibenzo[b,d]pyran-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0181 0.5431 0.5
Echinococcus granulosus tar DNA binding protein 0.0063 0.1333 0.1163
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0203 0.0011
Brugia malayi PHD-finger family protein 0.003 0.0203 0.0269
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1333 0.13
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0181 0.5431 1
Echinococcus multilocularis GPCR, family 2 0.0064 0.1398 0.123
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0181 0.5431 0.5
Schistosoma mansoni hypothetical protein 0.0076 0.1792 0.1632
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.2535 0.2389
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1792 0.1632
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1792 0.1632
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0192 1
Brugia malayi RNA, U transporter 1 0.0084 0.2061 0.3286
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 1 1
Brugia malayi TAR-binding protein 0.0063 0.1333 0.2104
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0419 0.0231
Schistosoma mansoni hypothetical protein 0.003 0.0203 0.0011
Schistosoma mansoni hypothetical protein 0.0064 0.1398 0.123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.6195 0.6181
Schistosoma mansoni hypothetical protein 0.0064 0.1398 0.123
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.3975 0.6394
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0203 0.0307
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.2535 0.2389
Schistosoma mansoni hypothetical protein 0.0139 0.3975 0.3857
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0037 1
Brugia malayi RNA binding protein 0.0063 0.1333 0.2104
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.6195 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0155
Echinococcus multilocularis snurportin 1 0.0314 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0192 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.1333 0.13
Schistosoma mansoni hypothetical protein 0.0314 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0203 0.0307
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0192 0.0286
Echinococcus granulosus geminin 0.0184 0.5533 0.5445
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0181 0.5431 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1398 0.123
Echinococcus multilocularis peregrin 0.003 0.0203 0.0011
Schistosoma mansoni hypothetical protein 0.0064 0.1398 0.123
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1333 0.1163
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1333 0.1163
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1398 0.123
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1398 0.221
Brugia malayi Importin beta-1 subunit 0.0029 0.0192 0.0251
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0181 0.5431 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1398 0.123
Plasmodium vivax hypothetical protein, conserved 0.003 0.0203 0.0307
Loa Loa (eye worm) hypothetical protein 0.0064 0.1398 0.1366
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.6195 1
Giardia lamblia PHD finger protein 15 0.003 0.0203 0.5
Loa Loa (eye worm) hypothetical protein 0.0051 0.0935 0.0901
Echinococcus granulosus peregrin 0.003 0.0203 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1845 0.1686
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1333 0.13
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0203 0.0166
Trichomonas vaginalis hypothetical protein 0.0181 0.5431 1
Brugia malayi jmjC domain containing protein 0.0097 0.2535 0.4056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0037 1
Echinococcus granulosus GPCR family 2 0.0064 0.1398 0.123
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1333 0.1163
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1333 0.1163
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1398 0.1366
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1333 0.1163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1792 0.1632
Onchocerca volvulus Alhambra homolog 0.003 0.0203 0.5
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0181 0.5431 1
Entamoeba histolytica hypothetical protein 0.0076 0.1792 1
Plasmodium falciparum importin beta, putative 0.0029 0.0192 0.0286
Loa Loa (eye worm) hypothetical protein 0.0204 0.6195 0.6181
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0181 0.5431 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1333 0.2104
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0203 0.0011
Brugia malayi jmjC domain containing protein 0.0036 0.0419 0.0619
Brugia malayi Bromodomain containing protein 0.003 0.0203 0.0269
Schistosoma mansoni hypothetical protein 0.0184 0.5533 0.5445
Brugia malayi hypothetical protein 0.0076 0.1792 0.2849
Plasmodium falciparum phd finger protein, putative 0.003 0.0203 0.0307
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0419 0.0231
Entamoeba histolytica hypothetical protein 0.0076 0.1792 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0419 0.0383
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0203 0.0011
Loa Loa (eye worm) hypothetical protein 0.0139 0.3975 0.3952
Entamoeba histolytica hypothetical protein 0.0076 0.1792 1
Leishmania major hypothetical protein, conserved 0.0025 0.0037 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0419 0.0231
Schistosoma mansoni hypothetical protein 0.0184 0.5533 0.5445
Plasmodium vivax importin-beta 2, putative 0.0029 0.0192 0.0286
Entamoeba histolytica hypothetical protein 0.0076 0.1792 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1398 0.221
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0604 0.0421
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1294 0.1262
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1333 0.1163
Echinococcus multilocularis geminin 0.0184 0.5533 0.5445
Schistosoma mansoni hypothetical protein 0.0064 0.1398 0.123
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0604 0.0421
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0419 0.0231
Plasmodium falciparum enoyl-acyl carrier reductase 0.0181 0.5431 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1398 0.123

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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