Detailed information for compound 566907

Basic information

Technical information
  • TDR Targets ID: 566907
  • Name: 2,5-dibromo-3,6-bis(3,5-dibromo-2,4,6-trimeth yl-phenyl)benzene-1,4-diol
  • MW: 819.838 | Formula: C24H20Br6O2
  • H donors: 2 H acceptors: 2 LogP: 10.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1c(Br)c(c(c(c1c1c(C)c(Br)c(c(c1C)Br)C)Br)O)c1c(C)c(Br)c(c(c1C)Br)C
  • InChi: 1S/C24H20Br6O2/c1-7-13(8(2)18(26)11(5)17(7)25)15-21(29)24(32)16(22(30)23(15)31)14-9(3)19(27)12(6)20(28)10(14)4/h31-32H,1-6H3
  • InChiKey: XEILUMHFFZWBGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,5-dibromo-3,6-bis(3,5-dibromo-2,4,6-trimethylphenyl)benzene-1,4-diol
  • 2,5-dibromo-3,6-bis(3,5-dibromo-2,4,6-trimethyl-phenyl)hydroquinone
  • 6943-85-7
  • NSC51694
  • 2,5-Dibromo-3,6-bis-(3,5-dibromomesityl)-hydroquinone
  • AIDS-017794
  • AIDS017794

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0413 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.4863 0.4863
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.4863 0.4863
Schistosoma mansoni thyroid hormone receptor 0.0094 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.4247 0.4247
Echinococcus granulosus FTZ F1 alpha 0.0094 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.4863 0.4863
Loa Loa (eye worm) hypothetical protein 0.005 0.4863 0.4863
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0094 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0413 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0413 0.0413
Onchocerca volvulus Bile acid receptor homolog 0.0094 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.4247 0.4247
Schistosoma mansoni nuclear receptor 0.0044 0.4247 0.4247
Brugia malayi nuclear receptor NHR-88 0.0094 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0094 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.4863 0.4863
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0413 0.0413
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0094 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.4247 0.4247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0094 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Schistosoma mansoni nuclear receptor 0.0044 0.4247 0.4247
Echinococcus multilocularis FTZ F1 alpha 0.0094 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.4247 0.4247
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.4863 0.4863
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0094 1 1
Brugia malayi nuclear hormone receptor 0.0044 0.4247 0.4247
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0094 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0044 0.4247 0.4247
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.3606 0.3606
Loa Loa (eye worm) hypothetical protein 0.0034 0.3013 0.3013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.4247 0.4247
Schistosoma mansoni nuclear hormone receptor 0.0094 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.3606 0.3606
Schistosoma mansoni RAR-like nuclear receptor 0.0094 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.4247 0.4247
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.4247 0.4247
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.4247 0.4247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.4247 0.4247
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.4019 0.4019
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi Nuclear hormone receptor E75 0.0044 0.4247 0.4247
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 1 1
Brugia malayi nuclear receptor RXR 0.005 0.4863 0.4863
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.4863 0.4863
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.4019 0.4019
Brugia malayi nuclear receptor NHR-88 0.0044 0.4247 0.4247
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0094 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.3311 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0094 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.4247 0.4247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0094 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0094 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.4247 0.4247
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0094 1 1
Schistosoma mansoni coup transcription factor 0.0094 1 1
Schistosoma mansoni zinc finger protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.005 0.4863 0.4863
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 1 1
Brugia malayi ecdysone receptor 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0094 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.4247 0.4247
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.4863 0.4863
Brugia malayi Nuclear hormone receptor-like 1 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.4863 0.4863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.4247 0.4247
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.4863 0.4863
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.4247 0.4247
Brugia malayi photoreceptor-specific nuclear receptor 0.0094 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0094 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0094 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0094 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.4247 0.4247
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.4247 0.4247
Brugia malayi nuclear hormone receptor 0.0094 1 1
Onchocerca volvulus 0.0094 1 1
Brugia malayi hypothetical protein 0.005 0.4863 0.4863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0094 1 1
Brugia malayi hypothetical protein 0.005 0.4863 0.4863
Schistosoma mansoni nuclear hormone receptor 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0094 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0413 0.0413
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0094 1 1
Brugia malayi hypothetical protein 0.0044 0.4247 0.4247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0094 1 1
Brugia malayi tailless protein 0.0044 0.4247 0.4247
Schistosoma mansoni nuclear hormone receptor 0.0044 0.4247 0.4247
Onchocerca volvulus Protein ultraspiracle homolog 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.4247 0.4247
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.4247 0.4247
Brugia malayi hypothetical protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi Nuclear hormone receptor E75 0.0044 0.4247 0.4247
Brugia malayi steroid hormone receptor 0.0094 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi Steroid receptor seven-up type 2 0.0094 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0094 1 1
Brugia malayi nuclear receptor RXR 0.0044 0.4247 0.4247
Echinococcus granulosus ecdysone induced protein 78C 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.3606 0.3606
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 1 1
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0413 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0094 1 1
Schistosoma mansoni thyroid hormone receptor 0.0094 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0094 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0413 0.0413
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0094 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0094 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.4247 0.4247
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.3311 1
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.4863 0.4863
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0094 1 1
Brugia malayi conserved hypotetical protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 1 1
Loa Loa (eye worm) DR-78 0.0044 0.4247 0.4247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0094 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.4247 0.4247
Brugia malayi nuclear receptor NHR-67 0.0044 0.4247 0.4247
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.3606 0.3606

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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