Detailed information for compound 567211

Basic information

Technical information
  • TDR Targets ID: 567211
  • Name: galline
  • MW: 135.824 | Formula: C5H6Ga
  • H donors: 0 H acceptors: 0 LogP: 0.75 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1=CC=C[GaH]=C1
  • InChi: 1S/C5H5.Ga/c1-3-5-4-2;/h1-5H;/b3-1?,5-4-;
  • InChiKey: JVFMQNJSQVWUKH-FNHJEZBOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-gallacyclohexa-1,3,5-triene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0684 0.1776
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0291 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0291 0.0756
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0691 0.0688
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0291 0.027
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.296 0.2958
Schistosoma mansoni thyroid hormone receptor 0.0143 0.347 0.3456
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0684 0.0681
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Onchocerca volvulus 0.0035 0.0691 0.3165
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.005 0.0048
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0291 0.1276
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0291 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0291 0.0756
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0291 0.0756
Brugia malayi hypothetical protein 0.0009 0.0022 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0291 0.0288
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0291 0.027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5593 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0691 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0291 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0291 0.0749
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Schistosoma mansoni hypothetical protein 0.0396 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0291 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0291 0.0756
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0022 0.0056
Brugia malayi nuclear receptor NHR-88 0.002 0.0291 0.0756
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0022 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0684 0.9888
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0124
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0291 0.0288
Brugia malayi nuclear receptor RXR 0.0009 0.0022 0.0056
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0691 0.0688
Echinococcus multilocularis dnaJ subfamily B 0.0396 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0291 0.0749
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0022 0.0019
Schistosoma mansoni alpha glucosidase 0.0035 0.0684 0.0664
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0022 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0291 0.0288
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0478
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Schistosoma mansoni alpha-glucosidase 0.0136 0.3285 0.327
Loa Loa (eye worm) beta-lactamase 0.0035 0.0691 0.1787
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0291 0.0288
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0022 0.0019
Toxoplasma gondii ABC1 family protein 0.0035 0.0691 0.0141
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0684 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0684 0.0681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.005 0.0048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0291 0.0288
Brugia malayi conserved hypotetical protein 0.0009 0.0022 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0143 0.347 0.3456
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0022 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0691 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0022 0.0019
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0022 0.0049
Onchocerca volvulus 0.0091 0.2135 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0684 0.9888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0291 0.0749
Trypanosoma brucei glucosidase, putative 0.0035 0.0684 0.9888
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0291 0.0288
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0684 0.9888
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0691 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0291 0.027
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0022 0.0056
Brugia malayi hypothetical protein 0.001 0.005 0.0131
Leishmania major hypothetical protein, conserved 0.0035 0.0691 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0291 0.0288
Echinococcus granulosus cpg binding protein 0.0029 0.0539 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0291 0.0756
Mycobacterium ulcerans beta-lactamase 0.0035 0.0691 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0691 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1303 0.1284
Brugia malayi ecdysone receptor 0.0009 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0124
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0291 0.0756
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0291 0.0756
Loa Loa (eye worm) DR-78 0.0009 0.0022 0.0049
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0117 0.0304
Mycobacterium leprae Probable lipase LipE 0.0035 0.0691 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0291 0.0288
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Brugia malayi tailless protein 0.0009 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.0013 0.0117 0.0297
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Onchocerca volvulus 0.0035 0.0691 0.3165
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0291 0.027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.005 0.0029
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0519
Schistosoma mansoni alpha-glucosidase 0.0136 0.3285 0.327
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0691 1
Onchocerca volvulus 0.0028 0.0498 0.2256
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0291 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0691 0.067
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0291 0.027
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0291 0.0749
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0022 0.0019
Trichomonas vaginalis esterase, putative 0.0035 0.0691 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0291 0.0756
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.005 0.0029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0684 0.9888
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Onchocerca volvulus 0.002 0.0291 0.1276
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0291 0.0288
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0291 0.0288
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0684 0.9888
Brugia malayi steroid hormone receptor 0.002 0.0291 0.0756
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0291 0.0749
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.005 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.3851 0.385
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0291 0.0288
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0022 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0684 0.9888
Brugia malayi beta-lactamase 0.0035 0.0691 0.1793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0291 0.0749
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0691 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0691 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.005 0.0124
Brugia malayi nuclear hormone receptor 0.0009 0.0022 0.0056
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0291 0.027
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0684 0.9888
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0291 0.1276
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0684 0.9888
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.3851 0.385
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0291 0.0756
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0022 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0291 0.0756
Schistosoma mansoni hypothetical protein 0.0123 0.296 0.2945
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0124
Brugia malayi beta-lactamase family protein 0.0035 0.0691 0.1793
Brugia malayi ecdysteroid receptor 0.002 0.0291 0.0756
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.114 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0291 0.0756
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.005 0.0131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.1288
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0022 0.0019
Schistosoma mansoni cpg binding protein 0.0029 0.0539 0.0519
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0691 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Brugia malayi nuclear receptor RXR 0.001 0.005 0.0131
Mycobacterium ulcerans hypothetical protein 0.0035 0.0691 0.5
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0684 0.9888
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0291 0.0756
Loa Loa (eye worm) hypothetical protein 0.001 0.005 0.0124
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0691 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0291 0.0288
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.347 0.3468
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0022 0.0019
Brugia malayi nuclear hormone receptor 0.002 0.0291 0.0756
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0684 0.9888
Brugia malayi beta-lactamase family protein 0.0035 0.0691 0.1793
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0691 0.067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0691 0.1787
Brugia malayi nuclear receptor NHR-88 0.0009 0.0022 0.0056
Onchocerca volvulus 0.0035 0.0691 0.3165
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0691 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0022 0.0056
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0684 0.177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0291 0.0756
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.3851 0.385
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0691 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Brugia malayi hypothetical protein 0.001 0.005 0.0131
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0022 0.0019
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0022 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.3851 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0291 0.0288
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0049
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0117 0.0453
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.296 0.2958
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0291 0.0288
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0691 0.5
Schistosoma mansoni coup transcription factor 0.002 0.0291 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0291 0.0756
Brugia malayi hypothetical protein 0.0009 0.0022 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0291 0.0749
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0684 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0022 0.0019
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0691 0.1793
Brugia malayi nuclear receptor NHR-67 0.0009 0.0022 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0291 0.0749
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0684 0.9888
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0291 0.0756
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.1294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0691 0.1787
Schistosoma mansoni nuclear hormone receptor 0.002 0.0291 0.027
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0291 0.1276
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0291 0.027
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0691 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0291 0.0288
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0684 0.9888
Echinococcus granulosus FTZ F1 alpha 0.002 0.0291 0.0288
Echinococcus multilocularis cpg binding protein 0.0029 0.0539 0.0537

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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