Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | Curated by TDR Targets | References |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 159 aa | 140 aa | 37.9 % |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 165 aa | 143 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.2489 | 0.2489 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2771 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2771 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2726 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2726 | 0.0316 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0157 | 0.2726 | 0.2726 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2771 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.2489 | 0.2489 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2771 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0157 | 0.2726 | 0.0316 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.2771 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0157 | 0.2726 | 0.2726 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.2771 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0157 | 0.2726 | 0.0316 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0157 | 0.2726 | 0.2726 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0157 | 0.2726 | 0.2726 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0157 | 0.2726 | 0.2726 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0157 | 0.2726 | 0.2726 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.2489 | 0.2489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium avium | 256134 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-27 | References: | 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | in vitro (MI:0492) | inferred from specific protein inhibition (ECO:0000020) | Mycobacterium avium | 5868 | |
Annotator: | crowther@u.washington.edu | Comment: | 2007-12-27 | References: | 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874 |
13 literature references were collected for this gene.