Detailed information for compound 567506

Basic information

Technical information
  • TDR Targets ID: 567506
  • Name: 2-[2-(2-aminophenyl)sulfanylethylsulfanyl]ani line
  • MW: 276.42 | Formula: C14H16N2S2
  • H donors: 2 H acceptors: 0 LogP: 3.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccccc1SCCSc1ccccc1N
  • InChi: 1S/C14H16N2S2/c15-11-5-1-3-7-13(11)17-9-10-18-14-8-4-2-6-12(14)16/h1-8H,9-10,15-16H2
  • InChiKey: BSYVFGQQLJNJJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-[(2-aminophenyl)thio]ethylthio]aniline
  • [2-[2-[(2-aminophenyl)thio]ethylthio]phenyl]amine
  • Cyanacure
  • 5,8-dideazaisopteroyl triglutamate
  • 52411-33-3
  • 85340-40-5
  • Bis(o-aminophenylthio)ethane
  • CCRIS 3551
  • CCRIS 7519
  • Cynacure
  • EINECS 257-901-9
  • ZINC02577673
  • 2,2'-(1,2-Ethanediylbis(thio))bisbenzenamine
  • 2,2'-(Ethylenedithio)dianiline
  • 4-13-00-00916 (Beilstein Handbook Reference)
  • BRN 2739761
  • Benzenamine, 2,2'-(1,2-ethanediylbis(thio))bis-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Schistosoma mansoni glutamate synthase 0.001 0.0026 0.0042
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0156 0.0313
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0061 0.0124
Onchocerca volvulus 0.0029 0.0255 0.0809
Echinococcus multilocularis geminin 0.0503 0.6173 0.6173
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0077 0.0177
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.0061 0.0124
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0156 0.0382
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0382 0.2803
Schistosoma mansoni endoplasmin 0.0091 0.103 0.1669
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0061 0.0275
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0382 0.0855
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1222 0.9416
Echinococcus multilocularis thioredoxin glutathione reductase 0.0114 0.1315 0.1315
Mycobacterium ulcerans esterase/lipase LipP 0.0106 0.1222 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1172 0.1899
Loa Loa (eye worm) hypothetical protein 0.0068 0.0748 0.1916
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0134 0.0134
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0061 0.0084
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0134 0.0129
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0026 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1222 0.198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0085 0.0961 0.7356
Plasmodium vivax heat shock protein, putative 0.0344 0.419 1
Brugia malayi Pre-SET motif family protein 0.0208 0.2496 0.6451
Plasmodium vivax glutathione reductase, putative 0.0112 0.1296 0.3051
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.5837 0.5837
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0085 0.0961 0.2733
Schistosoma mansoni smad1 5 8 and 0.0016 0.0099 0.0161
Echinococcus multilocularis tar DNA binding protein 0.0318 0.3864 0.3864
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0061 0.0275
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0134 0.1074
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4989 0.8082
Trypanosoma cruzi heat shock protein 85, putative 0.0091 0.103 0.7904
Brugia malayi Thioredoxin reductase 0.0112 0.1296 0.334
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0156 0.0313
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0061 0.0102
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.0638
Plasmodium falciparum heat shock protein 90, putative 0.0053 0.0556 0.1272
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0679 0.8361 1
Mycobacterium tuberculosis Probable hydrolase 0.0106 0.1222 0.1435
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0935 0.1514
Onchocerca volvulus 0.0049 0.0513 0.1722
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0277 0.0449
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0061 0.0292
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0382 0.2803
Echinococcus multilocularis cpg binding protein 0.003 0.0275 0.0275
Brugia malayi Endoplasmin precursor 0.0091 0.103 0.2649
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0382 0.0855
Echinococcus multilocularis expressed protein 0.0048 0.0492 0.0492
Loa Loa (eye worm) endoplasmin 0.0091 0.103 0.2649
Toxoplasma gondii heat shock protein 75, putative 0.006 0.065 0.1498
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0026 0.0042
Echinococcus granulosus importin subunit beta 1 0.0028 0.0249 0.0404
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3652 0.9452
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0099 0.0161
Onchocerca volvulus 0.0106 0.1222 0.423
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1222 0.423
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0026 0.0045
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0382 0.3811
Entamoeba histolytica heat shock protein 90, putative 0.0091 0.103 1
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0186 0.0564
Trypanosoma brucei trypanothione reductase 0.0112 0.1296 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0183 0.0554
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.0061 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1222 0.9416
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0134 0.0849
Echinococcus granulosus beta LACTamase domain containing family member 0.0106 0.1222 0.198
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0061 0.0084
Echinococcus granulosus snurportin 1 0.0301 0.3652 0.5917
Brugia malayi MH2 domain containing protein 0.0016 0.0099 0.0234
Trypanosoma cruzi heat shock protein 85, putative 0.0091 0.103 0.7904
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0748 0.1211
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0382 0.2803
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0099 0.0234
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0078 0.0124
Loa Loa (eye worm) TAR-binding protein 0.0318 0.3864 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0402 0.0402
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0186 0.0564
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Brugia malayi RNA, U transporter 1 0.008 0.0898 0.2306
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0186 0.0301
Entamoeba histolytica malic enzyme, putative 0.0012 0.0045 0.019
Loa Loa (eye worm) glutathione reductase 0.0112 0.1296 0.334
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0061 0.0099
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0061 0.0084
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Plasmodium vivax importin-beta 2, putative 0.0028 0.0249 0.0536
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Schistosoma mansoni glutamate synthase 0.001 0.0026 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0271
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Trypanosoma cruzi heat shock protein 90, putative 0.0078 0.0866 0.6616
Mycobacterium ulcerans putative regultory protein 0.0013 0.0061 0.0292
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0935 0.1514
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0651
Brugia malayi MH2 domain containing protein 0.0237 0.2856 0.7385
Onchocerca volvulus 0.0106 0.1222 0.423
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.1756
Schistosoma mansoni tar DNA-binding protein 0.0318 0.3864 0.6259
Schistosoma mansoni hypothetical protein 0.0083 0.0935 0.1514
Entamoeba histolytica Ran family GTPase 0.0021 0.0156 0.1297
Mycobacterium ulcerans hypothetical protein 0.0106 0.1222 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0134 0.0324
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0382 0.2803
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0077 0.0177
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0183 0.0554
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0026 0.0042
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0026 0.0042
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Plasmodium falciparum heat shock protein 90, putative 0.0344 0.419 1
Echinococcus granulosus smad 0.0016 0.0099 0.0161
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Schistosoma mansoni hypothetical protein 0.0083 0.0935 0.1514
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0382 0.1259
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2854 1
Plasmodium vivax endoplasmin, putative 0.0091 0.103 0.2411
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0026 0.0042
Echinococcus granulosus glutamate synthase 0.001 0.0026 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Echinococcus granulosus neuropeptide s receptor 0.0476 0.5837 0.9457
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0849
Toxoplasma gondii ABC1 family protein 0.0106 0.1222 0.2872
Echinococcus granulosus heat shock protein 0.0091 0.103 0.1669
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0935 0.2401
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0061 0.0275
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0134 0.0902
Brugia malayi Melibiase family protein 0.0068 0.0748 0.1916
Brugia malayi beta-lactamase family protein 0.0106 0.1222 0.3147
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0382 0.2977
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0061 0.0374
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0382 0.0855
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0061 0.0275
Echinococcus granulosus cpg binding protein 0.003 0.0275 0.0446
Echinococcus granulosus thioredoxin glutathione reductase 0.0114 0.1315 0.213
Mycobacterium ulcerans lipase LipD 0.0106 0.1222 1
Trypanosoma brucei malic enzyme 0.0023 0.0186 0.1255
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0061 0.0084
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0849
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0402 0.0903
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0061 0.0292
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0061 0.0042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0035
Brugia malayi glutamate synthase 0.001 0.0026 0.0045
Onchocerca volvulus 0.0106 0.1222 0.423
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0186 0.0458
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0255 0.0414
Brugia malayi Pre-SET motif family protein 0.003 0.0277 0.0695
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0156 0.0313
Leishmania major DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0134 0.0324
Loa Loa (eye worm) programmed cell death 8 0.001 0.0026 0.0045
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.006 0.065 0.065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0277 0.0449
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0866 0.6616
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0402 0.102
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Leishmania major importin beta-1 subunit, putative 0.0023 0.0183 0.1232
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0256 0.3088 0.3674
Toxoplasma gondii thioredoxin reductase 0.0112 0.1296 0.3051
Plasmodium vivax hypothetical protein, conserved 0.0106 0.1222 0.2872
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0402 0.0903
Mycobacterium tuberculosis Conserved protein 0.0106 0.1222 0.1435
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0324
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0061 0.0275
Plasmodium falciparum glutathione reductase 0.0112 0.1296 0.3051
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0513 0.1308
Mycobacterium tuberculosis Probable dehydrogenase 0.0256 0.3088 0.3674
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0061 0.0982
Leishmania major GTP-binding protein, putative 0.0021 0.0156 0.1025
Echinococcus granulosus tumor protein p63 0.0337 0.4103 0.6647
Trypanosoma cruzi heat shock protein 90, putative 0.0091 0.103 0.7904
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0134 0.0849
Loa Loa (eye worm) hypothetical protein 0.0083 0.0935 0.2401
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0061 0.0124
Echinococcus granulosus tar DNA binding protein 0.0318 0.3864 0.6259
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4989 0.4989
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0134 0.0129
Echinococcus multilocularis lamin dm0 0.0027 0.0233 0.0233
Leishmania major DNA topoisomerase ii 0.0013 0.0061 0.0275
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0061 0.0982
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0233 0.0582
Echinococcus granulosus expressed protein 0.0048 0.0492 0.0797
Loa Loa (eye worm) hypothetical protein 0.004 0.0402 0.102
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0061 0.0084
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0372 0.272
Onchocerca volvulus 0.0027 0.0233 0.0732
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0106 0.1222 0.3147
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0156 0.0253
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0048 0.0492 0.1252
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0026 0.0026
Trypanosoma cruzi heat shock protein, putative 0.006 0.065 0.4911
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0254 0.0635
Brugia malayi hypothetical protein 0.0037 0.0353 0.0893
Mycobacterium tuberculosis Probable oxidoreductase 0.0284 0.3445 0.4101
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0061 0.0061
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Echinococcus granulosus lamin dm0 0.0027 0.0233 0.0378
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1222 0.423
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0135
Mycobacterium tuberculosis Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarbo 0.0023 0.0186 0.0191
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0249 0.1756
Loa Loa (eye worm) hypothetical protein 0.003 0.0277 0.0695
Schistosoma mansoni sulfide quinone reductase 0.001 0.0026 0.0042
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0061 0.0374
Brugia malayi MH1 domain containing protein 0.0016 0.0099 0.0234
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0256 0.3088 0.3674
Loa Loa (eye worm) heat shock protein 90 0.0091 0.103 0.2649
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0669 0.1084
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0061 0.0292
Schistosoma mansoni smad1 5 8 and 0.0016 0.0099 0.0161
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0556 0.1873
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0061 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1645 0.1645
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0935 0.1514
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0061 0.0099
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0061 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1222 0.423
Trypanosoma brucei heat shock protein 90, putative 0.0091 0.103 0.7904
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0085 0.0961 1
Brugia malayi MH2 domain containing protein 0.0016 0.0099 0.0234
Echinococcus multilocularis musashi 0.0027 0.0233 0.0233
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0382 0.2977
Brugia malayi glutathione reductase 0.0112 0.1296 0.334
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0061 0.0124
Mycobacterium leprae Probable lipase LipE 0.0106 0.1222 0.3499
Plasmodium falciparum importin beta, putative 0.0028 0.0249 0.0536
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0061 0.0042
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0112 0.1296 0.1524
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0382 0.3811
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0134 0.0902
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.0061 0.0348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0318 0.3864 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0106 0.1222 0.1435
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0935 0.2401
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.006 0.006
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0156 0.0382
Schistosoma mansoni ran 0.0021 0.0156 0.0253
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.006 0.065 0.1053
Brugia malayi hypothetical protein 0.0037 0.0353 0.0893
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0061 0.0102
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.0061 0.0124
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0156 0.1297
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0061 0.0084
Schistosoma mansoni intermediate filament proteins 0.0027 0.0233 0.0378
Giardia lamblia Malic enzyme 0.0023 0.0186 0.1588
Echinococcus multilocularis tumor protein p63 0.0337 0.4103 0.4103
Brugia malayi intermediate filament protein 0.0027 0.0233 0.0582
Mycobacterium ulcerans beta-lactamase 0.0106 0.1222 1
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2856 0.7385
Plasmodium falciparum thioredoxin reductase 0.0112 0.1296 0.3051
Trypanosoma brucei NADP-dependent malic enzyme, cytosolic 0.0023 0.0186 0.1255
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0061 0.0135
Echinococcus granulosus geminin 0.0503 0.6173 1
Schistosoma mansoni hypothetical protein 0.0083 0.0935 0.1514
Loa Loa (eye worm) hypothetical protein 0.0106 0.1222 0.3147
Schistosoma mansoni smad1 5 8 and 0.0016 0.0099 0.0161
Entamoeba histolytica malic enzyme, putative 0.0012 0.0045 0.019
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0061 0.0374
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0156 0.0156
Entamoeba histolytica hypothetical protein 0.0023 0.0183 0.1559
Echinococcus multilocularis Smad4 0.0016 0.0099 0.0099
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0061 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0134 0.0324
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Trypanosoma cruzi heat shock protein 85, putative 0.0091 0.103 0.7904
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1645 0.4245
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0382 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0106 0.1222 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0061 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.1172 0.1899
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0061 0.0042
Echinococcus multilocularis beta LACTamase domain containing family member 0.0106 0.1222 0.1222
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0106 0.1222 0.3147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Trichomonas vaginalis heat shock protein, putative 0.0078 0.0866 0.2972
Leishmania major hypothetical protein, conserved 0.0106 0.1222 0.9416
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.0061 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0106 0.1222 0.423
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0026 0.0026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0748 0.1211
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0061 0.0135
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0382 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0961 0.3304
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0935 0.1514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0156 0.1025
Schistosoma mansoni hypothetical protein 0.0408 0.4989 0.8082
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0061 0.0084
Loa Loa (eye worm) thioredoxin reductase 0.0112 0.1296 0.334
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0023 0.0186 0.0458
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0061 0.0982
Mycobacterium ulcerans malate dehydrogenase 0.0023 0.0186 0.1333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Trichomonas vaginalis malic enzyme, putative 0.0017 0.0111 0.03
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.1172 0.1172
Trypanosoma cruzi trypanothione reductase, putative 0.0112 0.1296 1
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Trypanosoma cruzi malic enzyme 0.0023 0.0186 0.1255
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0961 0.3304
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Treponema pallidum NADH oxidase 0.0039 0.0382 0.3811
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1172 0.1899
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0106 0.1222 0.1435
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0061 0.0292
Echinococcus granulosus lamin 0.0027 0.0233 0.0378
Loa Loa (eye worm) RNA binding protein 0.0318 0.3864 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Mycobacterium tuberculosis Probable esterase LipL 0.0106 0.1222 0.1435
Trypanosoma brucei heat shock protein 84, putative 0.006 0.065 0.4911
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0284 0.3445 0.4101
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.1172 0.1172
Schistosoma mansoni hypothetical protein 0.0301 0.3652 0.5917
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0382 0.2803
Echinococcus granulosus intermediate filament protein 0.0027 0.0233 0.0378
Trichomonas vaginalis esterase, putative 0.0106 0.1222 0.423
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0249 0.0536
Plasmodium vivax heat shock protein 86, putative 0.0091 0.103 0.2411
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0402 0.102
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0446
Mycobacterium tuberculosis Conserved protein 0.0106 0.1222 0.1435
Brugia malayi beta-lactamase 0.0106 0.1222 0.3147
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0382 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0134 0.0381
Schistosoma mansoni glutamate synthase 0.001 0.0026 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0277 0.0449
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0186 0.1255
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0277 0.0449
Mycobacterium ulcerans [NAD] dependent malate oxidoreductase Mez 0.0012 0.0045 0.0159
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0935 0.0935
Trichomonas vaginalis heat shock protein, putative 0.0066 0.072 0.2452
Toxoplasma gondii heat shock protein 90, putative 0.0091 0.103 0.2411
Trichomonas vaginalis ran, putative 0.0021 0.0156 0.046
Trichomonas vaginalis endoplasmin, putative 0.0066 0.072 0.2452
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0134 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0318 0.3864 0.6259
Wolbachia endosymbiont of Brugia malayi malic enzyme 0.0012 0.0045 0.0204
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0026 0.0026
Mycobacterium ulcerans heat shock protein 90 0.0085 0.0961 0.7812
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0186 0.0564
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0271
Toxoplasma gondii TIM10 family protein, putative 0.0048 0.0492 0.1118
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0026 0.0042
Brugia malayi RNA recognition motif domain containing protein 0.0318 0.3864 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1172 0.1899
Loa Loa (eye worm) NADP-malic enzyme 0.0017 0.0111 0.0265
Trichomonas vaginalis D-aminoacylase, putative 0.0106 0.1222 0.423
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0134 0.0381
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0061 0.0275
Echinococcus granulosus heat shock protein 90 0.0078 0.0866 0.1404
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0382 0.0619
Toxoplasma gondii melibiase subfamily protein 0.0102 0.1172 0.2753
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0271
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0061 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0045
Giardia lamblia Grp94/Hsp90 0.0085 0.0961 0.9307
Schistosoma mansoni tar DNA-binding protein 0.0318 0.3864 0.6259
Echinococcus multilocularis smad 0.0016 0.0099 0.0099
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Trypanosoma cruzi malic enzyme 0.0023 0.0186 0.1255
Giardia lamblia DINP protein human, muc B family 0.0019 0.0134 0.1074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0156 0.1025
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0061 0.0275
Mycobacterium tuberculosis Conserved protein 0.0013 0.0061 0.0042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0382 0.0382
Leishmania major trypanothione reductase 0.0112 0.1296 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0134 0.0849
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0492 0.1118
Giardia lamblia Pms1-like protein 0.0013 0.0061 0.0348
Trypanosoma cruzi Heat shock protein 83, putative 0.0091 0.103 0.7904
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0382 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0061 0.0292
Plasmodium vivax SET domain protein, putative 0.003 0.0277 0.0602
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0134 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1645 0.2665
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.5837 0.9457
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0492 0.1118
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0061 0.0275
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0156 0.1025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0227 0.0566
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0115
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2496 0.6451
Onchocerca volvulus 0.0027 0.0233 0.0732
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0061 0.0292
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0061 0.0275
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0061 0.0084
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.0382 0.3547
Echinococcus multilocularis lamin 0.0027 0.0233 0.0233
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0186 0.0186
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0061 0.0135
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0061 0.0042
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0061 0.0042
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0186 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0588 0.135
Echinococcus granulosus heat shock protein 90 0.0091 0.103 0.1669
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0026 0.0026
Schistosoma mansoni heat shock protein 0.0091 0.103 0.1669
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0026 0.0026
Schistosoma mansoni importin beta-1 0.0028 0.0249 0.0404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1645 0.1645
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0061 0.0124
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0061 0.0099
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0061 0.0042
Schistosoma mansoni smad 0.0016 0.0099 0.0161
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0061 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0183 0.0554
Schistosoma mansoni tar DNA-binding protein 0.0318 0.3864 0.6259
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0078 0.0126
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1222 0.9416
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0061 0.0061
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0134 0.0217
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0061 0.0084
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0134 0.0849
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0048 0.0492 0.1252
Trypanosoma cruzi malic enzyme, putative 0.0023 0.0186 0.1255
Trypanosoma brucei Heat shock protein 83, putative 0.0091 0.103 0.7904
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0048 0.0492 0.0797
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0256 0.3088 0.8958
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0284 0.3445 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0402 0.102
Brugia malayi Smad1 0.0016 0.0099 0.0234
Echinococcus multilocularis heat shock protein 0.0091 0.103 0.103
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Echinococcus granulosus dna polymerase kappa 0.0019 0.0134 0.0217
Loa Loa (eye worm) Smad1 0.0016 0.0099 0.0234
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0061 0.0374
Trichomonas vaginalis heat shock protein, putative 0.0091 0.103 0.355
Schistosoma mansoni sulfide quinone reductase 0.001 0.0026 0.0042
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0061 0.0042
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0186 0.0186
Brugia malayi TAR-binding protein 0.0318 0.3864 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0099 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2856 0.7385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0026 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.006 0.0096
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Schistosoma mansoni hypothetical protein 0.0503 0.6173 1
Brugia malayi NAD-dependent malic enzyme, mitochondrial precursor, putative 0.0012 0.0045 0.0094
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0061 0.0042
Onchocerca volvulus Malic enzyme homolog 0.0023 0.0186 0.0564
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1645 0.4245
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0382 0.0855
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.0131
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0061 0.0135
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0382 0.2803
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0026 0.0045
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0061 0.0135
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0061 0.0275
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0382 0.1259
Plasmodium falciparum thioredoxin reductase 0.0039 0.0382 0.0855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1645 0.2665
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.1172 0.1899
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0061 0.0061
Schistosoma mansoni malic enzyme 0.0012 0.0045 0.0073
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0061 0.0275
Schistosoma mansoni hypothetical protein 0.0503 0.6173 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.002 0.003
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0256 0.3088 0.3674
Echinococcus granulosus endoplasmin 0.0085 0.0961 0.1556
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Echinococcus granulosus NADP dependent malic enzyme 0.0023 0.0186 0.0301
Giardia lamblia Heat shock protein HSP 90-alpha 0.0078 0.0866 0.837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0135
Treponema pallidum heat shock protein 90 0.0085 0.0961 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0085 0.0961 0.1121
Schistosoma mansoni hypothetical protein 0.001 0.0026 0.0042
Echinococcus multilocularis snurportin 1 0.0301 0.3652 0.3652
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Schistosoma mansoni lamin 0.0027 0.0233 0.0378
Plasmodium falciparum glutathione reductase 0.0039 0.0382 0.0855
Trypanosoma brucei heat shock protein 90, putative 0.0091 0.103 0.7904
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0099 0.0161
Giardia lamblia Heat shock protein HSP 90-alpha 0.0091 0.103 1
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0061 0.0275
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0135
Echinococcus multilocularis heat shock protein 90 0.0078 0.0866 0.0866
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1645 0.2665
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0233 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0318 0.3864 0.6259
Echinococcus multilocularis endoplasmin 0.0085 0.0961 0.0961
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Schistosoma mansoni lamin 0.0027 0.0233 0.0378
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0061 0.0102
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0106 0.1222 0.1435
Mycobacterium tuberculosis Probable lipase LipE 0.0106 0.1222 0.1435
Brugia malayi Hsp90 protein 0.006 0.065 0.1663
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Onchocerca volvulus 0.0237 0.2854 1
Leishmania major heat shock protein, putative 0.006 0.065 0.4911
Mycobacterium tuberculosis Probable lipase LipD 0.0106 0.1222 0.1435
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0134 0.0134
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0061 0.0042
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0382 0.0427
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Schistosoma mansoni malic enzyme 0.0012 0.0045 0.0073
Schistosoma mansoni cpg binding protein 0.003 0.0275 0.0446
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0061 0.0124
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0061 0.0292
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0026 0.0045
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Toxoplasma gondii heat shock protein HSP90 0.0091 0.103 0.2411
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0233 0.0582
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.006 0.065 0.2206
Schistosoma mansoni malic enzyme 0.0023 0.0186 0.0301
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0277 0.0602
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0061 0.0292
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0249 0.0249
Onchocerca volvulus 0.003 0.0277 0.0887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0106 0.1222 0.198
Plasmodium vivax heat shock protein 90, putative 0.006 0.065 0.1498
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.0638
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0284 0.3445 0.4101
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0099 0.0099
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0061 0.0292
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0382 0.0855
Mycobacterium tuberculosis Conserved protein 0.0106 0.1222 0.1435
Echinococcus granulosus Smad4 0.0016 0.0099 0.0161
Echinococcus granulosus dna polymerase eta 0.0019 0.0134 0.0217
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0382 0.2977
Echinococcus multilocularis glutamate synthase 0.001 0.0026 0.0026
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0061 0.0099
Toxoplasma gondii Hsp90 domain-containing protein 0.0344 0.419 1
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0134 0.0849
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0402 0.0903
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0382 0.2803
Trypanosoma brucei heat shock protein, putative 0.0091 0.103 0.7904
Brugia malayi Importin beta-1 subunit 0.0028 0.0249 0.0623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0078 0.0866 0.1404
Loa Loa (eye worm) hypothetical protein 0.0028 0.0249 0.0623
Leishmania major malic enzyme, putative 0.0023 0.0186 0.1255
Brugia malayi RNA binding protein 0.0318 0.3864 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0061 0.0275
Loa Loa (eye worm) heat shock protein 75 0.006 0.065 0.1663
Entamoeba histolytica 90 kDa heat shock protein, putative 0.006 0.065 0.6213
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0382 0.2803
Schistosoma mansoni heat shock protein 0.0091 0.103 0.1669
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0061 0.0102
Entamoeba histolytica heat shock protein 90, putative 0.0091 0.103 1
Leishmania major hypothetical protein, conserved 0.0013 0.0061 0.0275
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0935 0.0935
Schistosoma mansoni ran 0.0021 0.0156 0.0253
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0748 0.2552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1645 0.2665
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0061 0.0292
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0183 0.1232
Schistosoma mansoni Smad4 0.0016 0.0099 0.0161
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0061 0.0124
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0099 0.0161
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0061 0.0374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1645 0.2665
Echinococcus multilocularis dna polymerase eta 0.0019 0.0134 0.0134
Schistosoma mansoni DNA polymerase eta 0.0019 0.0134 0.0217
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0048 0.0492 0.1118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0134 0.0849
Trichomonas vaginalis malic enzyme, putative 0.0012 0.0045 0.0067
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.0061 0.0124
Trichomonas vaginalis malic enzyme, putative 0.0023 0.0186 0.0564
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0277 0.0277
Loa Loa (eye worm) beta-lactamase 0.0106 0.1222 0.3147
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0026 0.0045
Brugia malayi heat shock protein 90 0.0091 0.103 0.2649
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0277 0.0277
Echinococcus multilocularis heat shock protein 90 0.0091 0.103 0.103
Trypanosoma brucei unspecified product 0.0019 0.0134 0.0849
Plasmodium falciparum heat shock protein 90 0.0091 0.103 0.2411
Leishmania major heat shock protein 83-1 0.0091 0.103 0.7904
Schistosoma mansoni endoplasmin 0.0091 0.103 0.1669
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0254 0.0635
Brugia malayi beta-lactamase family protein 0.0106 0.1222 0.3147
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0271
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.5837 0.5837
Loa Loa (eye worm) hypothetical protein 0.0027 0.0233 0.0582
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0277 0.0449
Brugia malayi MH1 domain containing protein 0.0016 0.0099 0.0234
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0061 0.0042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0382 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0382 0.2803
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0256 0.3088 0.3674
Mycobacterium tuberculosis Probable reductase 0.0256 0.3088 0.3674
Plasmodium falciparum endoplasmin, putative 0.0066 0.072 0.1665
Echinococcus multilocularis NADP dependent malic enzyme 0.0023 0.0186 0.0186
Mycobacterium leprae conserved hypothetical protein 0.0106 0.1222 0.3499
Plasmodium vivax thioredoxin reductase, putative 0.0112 0.1296 0.3051
Schistosoma mansoni heat shock protein 0.006 0.065 0.1053
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0513 0.0831

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.