Detailed information for compound 567662

Basic information

Technical information
  • TDR Targets ID: 567662
  • Name: N,N-dimethyl-1-phenothiazin-10-yl-propan-2-am ine; hydron; tetraiodomercury(2-)
  • MW: 994.643 | Formula: C17H20HgI4N2S
  • H donors: 0 H acceptors: 0 LogP: 7.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: I[Hg-2](I)(I)I.CN(C(CN1c2ccccc2Sc2c1cccc2)C)C.[H+].[H+]
  • InChi: 1S/C17H20N2S.Hg.4HI/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;;;;;/h4-11,13H,12H2,1-3H3;;4*1H/q;+2;;;;/p-2
  • InChiKey: VIJNXISIZZXEGJ-UHFFFAOYSA-L  

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-dimethyl-1-(10-phenothiazinyl)-2-propanamine; hydron; tetraiodomercury(2-)
  • dimethyl-(1-methyl-2-phenothiazin-10-yl-ethyl)amine; hydron; tetraiodomercury(2-)
  • N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine; hydron; tetraiodomercury(2-)
  • promethazine tetraiodomercurate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi trypanothione reductase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Curated by TDR Targets No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania infantum dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania infantum acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania major acetoin dehydrogenase e3 component-like protein Get druggable targets OG5_138783 All targets in OG5_138783
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania donovani 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei dihydrolipoamide dehydrogenase Get druggable targets OG5_143064 All targets in OG5_143064
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Get druggable targets OG5_138783 All targets in OG5_138783
Leishmania braziliensis dihydrolipoamide dehydrogenase Get druggable targets OG5_149690 All targets in OG5_149690
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_138783 All targets in OG5_138783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_138783 All targets in OG5_138783
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Get druggable targets OG5_143064 All targets in OG5_143064
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_143064 All targets in OG5_143064
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Leishmania mexicana dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major dihydrolipoamide dehydrogenase, putative Get druggable targets OG5_149690 All targets in OG5_149690
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Get druggable targets OG5_138783 All targets in OG5_138783
Trypanosoma brucei dihydrolipoamide dehydrogenase Get druggable targets OG5_149690 All targets in OG5_149690
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Get druggable targets OG5_138783 All targets in OG5_138783

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum thioredoxin reductase dihydrolipoamide dehydrogenase, putative 550 aa 523 aa 19.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 551 aa 549 aa 22.9 %
Brugia malayi Thioredoxin reductase dihydrolipoamide dehydrogenase, putative 551 aa 497 aa 20.3 %
Plasmodium falciparum thioredoxin reductase dihydrolipoamide dehydrogenase, putative 550 aa 523 aa 19.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 510 aa 550 aa 25.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 189 aa 197 aa 20.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast dihydrolipoamide dehydrogenase, putative 510 aa 550 aa 26.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0224 0.2564 0.7992
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.006 0.0436 0.1246
Plasmodium falciparum glutathione reductase 0.0274 0.3206 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0496 0.1531
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0496 0.0062
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.2564 0.768
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0673 0.8364 0.8289
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0165 0.1795 0.559
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0496 0.1547
Plasmodium vivax ferrodoxin reductase, putative 0.006 0.0436 0.1246
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.006 0.0436 0.1345
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.08 1 1
Schistosoma mansoni glutamate synthase 0.006 0.0436 0.1345
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0224 0.2564 0.768
Toxoplasma gondii thioredoxin reductase 0.0274 0.3206 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0224 0.2564 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0224 0.2564 0.7969
Plasmodium vivax glutathione reductase, putative 0.0274 0.3206 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.006 0.0436 0.1246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0019
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.2564 0.768
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.006 0.0436 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.08 1 1
Brugia malayi glutamate synthase 0.006 0.0436 0.1345
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.006 0.0436 0.1345
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0042 0.0113
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0673 0.8364 0.8289
Brugia malayi Thioredoxin reductase 0.0274 0.3206 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0496 0.1531
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0589 0.7269 0.7145
Schistosoma mansoni glutamate synthase 0.006 0.0436 0.1345
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.006 0.0436 0.1345
Schistosoma mansoni sulfide quinone reductase 0.006 0.0436 0.1345
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0224 0.2564 0.7969
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0006 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0113
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0496 0.1531
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0224 0.2564 0.7992
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0224 0.2564 0.768
Plasmodium falciparum thioredoxin reductase 0.0274 0.3206 1
Loa Loa (eye worm) programmed cell death 8 0.006 0.0436 0.1361
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.2564 0.2224
Trichomonas vaginalis mercuric reductase, putative 0.0224 0.2564 0.9654
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.006 0.0436 0.1345
Treponema pallidum NADH oxidase 0.0224 0.2564 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0496 0.0062
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0496 0.1531
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0496 0.0062
Toxoplasma gondii selenide, water dikinase 0.006 0.0436 0.1246
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0147 0.0441
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0673 0.8364 0.8289
Schistosoma mansoni hypothetical protein 0.006 0.0436 0.1345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.08 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0224 0.2564 0.2224
Echinococcus granulosus thioredoxin glutathione reductase 0.0274 0.3206 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.006 0.0436 0.1246
Brugia malayi glutathione reductase 0.0274 0.3206 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.2564 1
Plasmodium falciparum glutathione reductase 0.0224 0.2564 0.768
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0113
Echinococcus multilocularis glutamate synthase 0.006 0.0436 0.1345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0042 0.0113
Trypanosoma brucei trypanothione reductase 0.0274 0.3206 0.2896
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0224 0.2564 0.7969
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0274 0.3206 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0436 0.1361
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0042 0.0113
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0496 0.0062
Schistosoma mansoni sulfide quinone reductase 0.006 0.0436 0.1345
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0224 0.2564 0.2224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0042 0.0113
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0224 0.2564 0.7992
Plasmodium falciparum thioredoxin reductase 0.0224 0.2564 0.768
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.006 0.0436 0.1246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0589 0.7269 0.7145
Brugia malayi Pre-SET motif family protein 0.0029 0.0042 0.0113
Brugia malayi Pre-SET motif family protein 0.0202 0.2279 0.7103
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0224 0.2564 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0589 0.7269 0.7145
Plasmodium vivax thioredoxin reductase, putative 0.0274 0.3206 1
Leishmania major trypanothione reductase 0.0274 0.3206 0.2896
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0147 0.0441
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.006 0.0436 0.1345
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0224 0.2564 0.768
Onchocerca volvulus 0.023 0.264 1
Loa Loa (eye worm) thioredoxin reductase 0.0274 0.3206 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0224 0.2564 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2279 0.7109
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0224 0.2564 1
Schistosoma mansoni glutamate synthase 0.006 0.0436 0.1345
Trypanosoma cruzi trypanothione reductase, putative 0.0224 0.2564 0.2224
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0165 0.1795 0.559
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0224 0.2564 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.2564 0.768
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.2564 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.006 0.0436 0.1345
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0042 0.0113
Toxoplasma gondii NADPH-glutathione reductase 0.0224 0.2564 0.7969
Trypanosoma cruzi trypanothione reductase, putative 0.0274 0.3206 0.2896
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.006 0.0436 0.1246
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.006 0.0436 0.1361
Trichomonas vaginalis glutathione reductase, putative 0.0224 0.2564 0.9654
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0029 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0006 0.0019
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.006 0.0436 0.1345
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.006 0.0436 0.1345
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.006 0.0436 0.1345
Echinococcus granulosus glutamate synthase 0.006 0.0436 0.1345
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0673 0.8364 0.8289
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0224 0.2564 0.2224
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.006 0.0436 0.1345
Schistosoma mansoni disulfide oxidoreductase 0.006 0.0436 0.1345
Onchocerca volvulus 0.006 0.0436 0.1634
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.006 0.0436 0.1345
Echinococcus multilocularis thioredoxin glutathione reductase 0.0274 0.3206 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.264 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0224 0.2564 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.006 0.0436 0.1246
Onchocerca volvulus 0.0029 0.0042 0.0137
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0589 0.7269 0.7145
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0224 0.2564 0.7992
Loa Loa (eye worm) glutathione reductase 0.0274 0.3206 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.006 0.0436 0.1345
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.006 0.0436 0.1345
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.006 0.0436 0.1345
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0496 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.006 0.0436 0.1345

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54712  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 38071  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 30042  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 48719  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54571  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from specific protein inhibition (ECO:0000020) Trypanosoma cruzi 54642  
Annotator: millerja@u.washington.edu Comment: Effect depends on catalytic action of different peroxidase systems, specifically MPO, Mb, and HRP, on PTZ yielding PTZ+- cation radicals which result in LADH inactivation. References: 17017892
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro assay (ECO:0000181) Trypanosoma cruzi 35349  
Annotator: millerja@u.washington.edu Comment: Inhibition of epimastigotes; Paglini-Oliva & Rivarola 2003. Central nervous system agents used as Trypanosoma cruzi infection chemotherapy: phenothiazines and related compounds. Current Medicinal Chemistry - Anti-Infective Agents 2(4): 323-333. References:
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro assay (ECO:0000181) Trypanosoma cruzi 50541  
Annotator: millerja@u.washington.edu Comment: Inhibition of epimastigotes; Paglini-Oliva & Rivarola 2003. Central nervous system agents used as Trypanosoma cruzi infection chemotherapy: phenothiazines and related compounds. Current Medicinal Chemistry - Anti-Infective Agents 2(4): 323-333. References:
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 54712  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 38071  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 30042  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 48719  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 54571  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 54642  
Annotator: millerja@u.washington.edu Comment: Abstract only; other compounds may be listed in manuscript. References: 12688423

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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