Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0413 | 0.1293 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.2054 | 0.4832 |
Onchocerca volvulus | 0.0029 | 0.0413 | 0.0007 | |
Loa Loa (eye worm) | acetyltransferase | 0.0154 | 0.3173 | 0.7274 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.1199 | 0.1056 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.0528 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.041 | 0.0281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.2482 | 0.5525 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.041 | 0.1719 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0827 | 0.1337 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.041 | 0.0255 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.2705 | 0.609 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.2875 | 0.276 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.041 | 0.1284 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0413 | 0.174 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0081 | 0.1564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2054 | 0.4441 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0055 | 0.0981 | 0.0851 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.0081 | 0.1564 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.2705 | 0.2587 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.1199 | 0.126 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 0.1482 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.2875 | 0.6765 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0545 | 0.0622 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0055 | 0.0981 | 0.0851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2705 | 0.8525 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0154 | 0.3173 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0462 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.041 | 0.1284 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2705 | 0.8525 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0055 | 0.0981 | 0.4744 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0154 | 0.3173 | 0.7466 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0151 | 0.311 | 0.7318 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0528 | 0.0265 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0545 | 0.0391 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0528 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.1617 | 0.3337 |
Echinococcus granulosus | peregrin | 0.0033 | 0.0494 | 0.0339 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.311 | 0.7115 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.041 | 0.1719 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0095 | 0.1865 | 0.1733 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.2705 | 0.6365 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0545 | 0.1708 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0095 | 0.1865 | 0.1733 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.2482 | 0.5525 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0274 | 0.5847 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0771 | 0.056 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0413 | 0.0972 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 0.1199 | 0.126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2705 | 0.8525 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0413 | 0.1293 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.2875 | 0.652 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.0528 | 0.1243 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.041 | 0.0255 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0083 | 0.1617 | 0.5092 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0528 | 0.0375 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2705 | 0.8525 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.2875 | 0.276 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0528 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0528 | 0.058 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0413 | 0.174 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.1617 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0688 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2875 | 0.906 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0154 | 0.3173 | 0.3062 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 0.2048 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.041 | 0.0965 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0827 | 0.0679 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 0.1199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1564 | 0.32 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0407 | 0.1697 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.039 | 0.0234 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 0.1199 | 0.3771 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0827 | 0.0679 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0274 | 0.5847 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.4869 | 1 |
Onchocerca volvulus | 0.023 | 0.4869 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.425 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.0528 | 0.1003 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0528 | 0.1656 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.2875 | 0.276 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0771 | 0.0622 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0827 | 0.1947 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0688 | 0.3624 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.1435 | 0.4516 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.0494 | 0.0339 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.2875 | 0.276 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.041 | 0.1719 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0528 | 0.058 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.2705 | 0.609 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0528 | 0.058 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.2705 | 0.609 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0528 | 0.0375 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0413 | 0.1293 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.2054 | 0.6469 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0545 | 0.1708 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.0528 | 0.253 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.041 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0867 | 0.1438 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0528 | 0.1656 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.0528 | 0.1243 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 0.2048 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0151 | 0.311 | 0.7318 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0827 | 0.26 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2875 | 0.906 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0545 | 0.0391 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0083 | 0.1617 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.2705 | 0.6365 |
Brugia malayi | jmjC domain containing protein | 0.0095 | 0.1865 | 0.4389 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.2482 | 0.584 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0827 | 0.1337 |
Schistosoma mansoni | neuropeptide receptor | 0.0106 | 0.2118 | 0.6671 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0827 | 0.0679 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.2875 | 0.906 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.0528 | 0.253 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 0.1199 | 0.1056 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 0.1199 | 0.126 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0407 | 0.1697 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0827 | 0.0679 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0462 | 1 | 1 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0106 | 0.2118 | 0.199 |
Brugia malayi | Probable ClpP-like protease | 0.0083 | 0.1617 | 0.3806 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0528 | 0.0265 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0771 | 0.056 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0029 | 0.0407 | 0.1697 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0003 | 0.0008 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0771 | 0.4196 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.1025 | 0.1838 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0661 | 0.0509 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0827 | 0.26 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0688 | 0.3075 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0827 | 0.1947 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0055 | 0.0981 | 0.0835 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0369 | 0.0213 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0827 | 0.26 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0827 | 0.26 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0413 | 0.0289 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0771 | 0.4196 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0528 | 0.698 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0528 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0106 | 0.2118 | 0.199 |
Brugia malayi | RNA binding protein | 0.0133 | 0.2705 | 0.6365 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.0494 | 0.1161 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.1091 | 0.2005 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0064 | 0.1199 | 0.282 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.0528 | 0.253 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0462 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0413 | 0.0258 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0083 | 0.1617 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0018 | 0.016 | 0.0493 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0151 | 0.311 | 0.7115 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0083 | 0.1617 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0149 | 0.3078 | 0.2965 |
Echinococcus granulosus | neuropeptide receptor | 0.0106 | 0.2118 | 0.199 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 0.1482 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.0528 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0827 | 0.0679 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0055 | 0.0981 | 0.0835 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.0528 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0771 | 0.4196 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.041 | 0.4744 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2705 | 0.8525 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0661 | 0.0509 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0827 | 0.0679 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0528 | 0.0375 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0413 | 0.1293 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0083 | 0.1617 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0528 | 0.0265 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.425 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0545 | 0.1282 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0413 | 0.0258 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.2705 | 0.2587 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0413 | 0.0258 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.041 | 0.1719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
24 literature references were collected for this gene.