Detailed information for compound 568611

Basic information

Technical information
  • TDR Targets ID: 568611
  • Name: 2-(2-methoxy-4-methylsulfanyl-phenyl)-1H-imid azo[4,5-b]pyridine
  • MW: 271.338 | Formula: C14H13N3OS
  • H donors: 1 H acceptors: 2 LogP: 2.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(SC)ccc1c1nc2c([nH]1)cccn2
  • InChi: 1S/C14H13N3OS/c1-18-12-8-9(19-2)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13/h3-8H,1-2H3,(H,15,16,17)
  • InChiKey: AYNBMCKKJDSJEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-methoxy-4-(methylthio)phenyl]-1H-imidazo[4,5-b]pyridine
  • 2-(2-methoxy-4-methylsulfanylphenyl)-1H-imidazo[4,5-b]pyridine
  • AR-L 113 BS
  • 1H-Imidazo(4,5-b)pyridine, 2-(2-methoxy-4-(methylthio)phenyl)-
  • Sulmazole sulfide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ISWI complex protein 0.0031 0.0197 0.1614
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0318 0.0396
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0023 0.0106 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.3742
Loa Loa (eye worm) hypothetical protein 0.005 0.0424 0.1313
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0238 0.0216
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0425 0.1465
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.067 0.1218
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0425 0.5651
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2623 1
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0253 0.0783
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.067 0.1713
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0164 0.0508
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0641 0.1985
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.1042 0.1021
Brugia malayi hypothetical protein 0.0109 0.1113 0.3388
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0019
Echinococcus multilocularis lamin 0.0028 0.0164 0.0141
Brugia malayi Melibiase family protein 0.0069 0.0641 0.195
Brugia malayi hypothetical protein 0.0244 0.27 0.8217
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.067 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0425 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.3742
Schistosoma mansoni lamin 0.0028 0.0164 0.0199
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0045 0.0368 0.0459
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0297 0.0351
Treponema pallidum alginate O-acetylation protein (algI) 0.0023 0.0106 0.2342
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0189 0.1746
Onchocerca volvulus 0.0028 0.0164 0.023
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0641 0.0809
Onchocerca volvulus 0.005 0.0421 0.1253
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0106 0.0125
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.067 0.0829
Echinococcus granulosus zinc finger protein 0.0039 0.0298 0.0352
Echinococcus granulosus lamin dm0 0.0028 0.0164 0.0181
Schistosoma mansoni P2X receptor subunit 0.0068 0.0636 0.0802
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0019
Brugia malayi Bromodomain containing protein 0.0035 0.0253 0.0769
Echinococcus granulosus geminin 0.0682 0.7832 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0389 0.0469
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0297 0.3385
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0023 0.0106 0.0125
Brugia malayi MBOAT family protein 0.0023 0.0106 0.0323
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0297 0.0686
Brugia malayi RNA recognition motif domain containing protein 0.0264 0.2936 0.8935
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0465 0.0443
Loa Loa (eye worm) RNA binding protein 0.0264 0.2936 0.9096
Schistosoma mansoni ap endonuclease 0.0039 0.0297 0.0369
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0294 0.3286 0.4178
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.3742
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0425 0.0515
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1015 0.127
Loa Loa (eye worm) hypothetical protein 0.0053 0.0454 0.1406
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0106 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0425 0.1465
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0023 0.0106 0.0125
Mycobacterium tuberculosis Probable oxidoreductase 0.027 0.3008 0.5792
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0389 0.0487
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0132 0.1389 0.1369
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0425 0.1465
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0636 0.0614
Mycobacterium ulcerans epoxide hydrolase EphA 0.0328 0.3681 1
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0318 0.0377
Brugia malayi jmjC domain containing protein 0.01 0.1015 0.3089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0329
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.067 0.1218
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.067 0.2418
Onchocerca volvulus 0.003 0.0189 0.0327
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0238 0.0725
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0589 0.0725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0443 0.0537
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0297 0.3385
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0318 0.0396
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.067 0.2077
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.067 0.1218
Onchocerca volvulus 0.0238 0.2623 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.2587 0.8016
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0106 0.0227
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0197 0.1828
Loa Loa (eye worm) hypothetical protein 0.0077 0.074 0.2291
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0106 0.0227
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0682 0.0661
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1113 0.1093
Schistosoma mansoni zinc finger protein 0.0031 0.0197 0.0242
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0682 0.0844
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0197 0.1611
Brugia malayi beta-lactamase family protein 0.0071 0.067 0.204
Mycobacterium leprae Probable lipase LipE 0.0071 0.067 1
Brugia malayi beta-lactamase 0.0071 0.067 0.204
Loa Loa (eye worm) hypothetical protein 0.0028 0.0164 0.0508
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.27 0.3428
Brugia malayi MBOAT family protein 0.0023 0.0106 0.0323
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0424 0.129
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0425 0.5651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0443 0.0556
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0425 0.5651
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0176 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.067 0.0846
Echinococcus multilocularis geminin 0.0682 0.7832 0.7827
Onchocerca volvulus 0.0071 0.067 0.2242
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0425 0.5651
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0106 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0443 0.0537
Echinococcus granulosus ferritin 0.0018 0.0048 0.0032
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1042 0.1321
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0425 0.4033
Mycobacterium ulcerans beta-lactamase 0.0071 0.067 0.1713
Schistosoma mansoni hypothetical protein 0.0034 0.0238 0.0294
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1042 0.1321
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2285 0.7078
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0019
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0197 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.2418
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0023 0.0106 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0071
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.067 0.1218
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0297 0.0969
Schistosoma mansoni hypothetical protein 0.0682 0.7832 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0045 0.0368 0.0345
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.27 0.2683
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.067 0.1218
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0023 0.0106 0.0083
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0023 0.0106 0.0329
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0132 0.1389 0.4303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0189 0.0231
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0238 0.0276
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0425 0.5651
Loa Loa (eye worm) hypothetical protein 0.0082 0.0795 0.2464
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0636 0.0784
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0238 0.0294
Brugia malayi Pre-SET motif family protein 0.003 0.0189 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0443 0.1347
Schistosoma mansoni hypothetical protein 0.005 0.0421 0.0528
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1113 0.1413
Loa Loa (eye worm) hhat protein 0.0023 0.0106 0.0329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.2508 0.7769
Schistosoma mansoni P2X receptor subunit 0.0068 0.0636 0.0802
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0297 0.3385
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0318 0.0984
Schistosoma mansoni sterol O-acyltransferase 1 0.0235 0.2587 0.3296
Echinococcus granulosus lamin 0.0028 0.0164 0.0181
Mycobacterium ulcerans lipase LipD 0.0071 0.067 0.1713
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Onchocerca volvulus 0.0071 0.067 0.2242
Brugia malayi MBOAT family protein 0.0023 0.0106 0.0323
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.058 0.1796
Echinococcus granulosus peregrin 0.0035 0.0253 0.0294
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0425 0.5651
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.1241 0.1221
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0197 0.0611
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0328 0.3681 0.711
Echinococcus multilocularis tar DNA binding protein 0.0264 0.2936 0.292
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0389 0.0469
Trichomonas vaginalis porcupine, putative 0.0023 0.0106 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0189 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0443 0.1372
Loa Loa (eye worm) hypothetical protein 0.0064 0.0589 0.1826
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0132 0.1389 0.1749
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0297 0.0488
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0589 0.0743
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0636 0.0784
Mycobacterium ulcerans short chain dehydrogenase 0.027 0.3008 0.8146
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.2418
Brugia malayi PHD-finger family protein 0.005 0.0423 0.1288
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0389 0.1205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0443 0.0556
Leishmania major hypothetical protein, conserved 0.0031 0.0197 0.1614
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.067 0.1218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0443 0.0421
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0329
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0197 0.1828
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.3742
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0132 0.1389 0.4303
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0338 0.0316
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0389 0.1124
Brugia malayi beta-lactamase family protein 0.0071 0.067 0.204
Brugia malayi Bromodomain containing protein 0.015 0.1601 0.4871
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0738
Brugia malayi Hhat protein 0.0023 0.0106 0.0323
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0297 0.4391
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0023 0.0106 0.0949
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.067 0.1713
Loa Loa (eye worm) hypothetical protein 0.0054 0.0465 0.1442
Brugia malayi mbt repeat family protein 0.0047 0.0389 0.1184
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1113 0.1396
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0294 0.3286 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1015 0.0994
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0424 0.129
Onchocerca volvulus 0.0071 0.067 0.2242
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.1042 0.1021
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0023 0.0106 0.0083
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0023 0.0106 0.0106
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0164 0.0499
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0297 0.3385
Trichomonas vaginalis esterase, putative 0.0071 0.067 0.2418
Toxoplasma gondii hypothetical protein 0.0023 0.0106 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0106 0.0227
Echinococcus multilocularis lamin dm0 0.0028 0.0164 0.0141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0297 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0038
Schistosoma mansoni apoferritin-2 0.0018 0.0048 0.0051
Loa Loa (eye worm) hhat protein 0.0023 0.0106 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0589 0.0743
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.067 0.204
Schistosoma mansoni survival motor neuron protein 0.005 0.0421 0.0528
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0297 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0039
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0641 0.0809
Echinococcus granulosus p2X purinoceptor 4 0.0068 0.0636 0.0784
Schistosoma mansoni hypothetical protein 0.0109 0.1113 0.1413
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0389 0.0487
Brugia malayi follicle stimulating hormone receptor 0.0228 0.2508 0.7631
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0424 0.1313
Loa Loa (eye worm) MBCTL1 0.0054 0.0465 0.1442
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0023 0.0106 0.0083
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0297 0.0921
Loa Loa (eye worm) hypothetical protein 0.0031 0.0197 0.0611
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0106 0.0106
Mycobacterium leprae conserved hypothetical protein 0.0071 0.067 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0297 0.3385
Loa Loa (eye worm) hypothetical protein 0.0132 0.1389 0.4303
Plasmodium vivax hypothetical protein, conserved 0.0071 0.067 1
Brugia malayi MBOAT family protein 0.0023 0.0106 0.0323
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0106 0.0125
Leishmania major hypothetical protein, conserved 0.0071 0.067 1
Echinococcus granulosus sterol O acyltransferase 1 0.0235 0.2587 0.3284
Echinococcus multilocularis ferritin 0.0018 0.0048 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0329
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0297 1
Trypanosoma brucei protein kinase, putative 0.005 0.0425 0.5651
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.3742
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0023 0.0106 0.0106
Brugia malayi diacylglycerol acyltransferase 0.0023 0.0106 0.0323
Echinococcus multilocularis zinc finger protein 0.0039 0.0298 0.0275
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0158 0.049
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0023 0.0106 0.0106
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0589 0.0568
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.1241 0.156
Echinococcus granulosus fetal alzheimer antigen falz 0.0045 0.0368 0.0441
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0106 0.0329
Mycobacterium ulcerans hypothetical protein 0.0071 0.067 0.1713
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0297 0.0904
Trichomonas vaginalis transmembrane protein nessy, putative 0.0023 0.0106 0.0227
Echinococcus multilocularis peregrin 0.0035 0.0253 0.023
Trypanosoma brucei ISWI complex protein 0.0031 0.0197 0.1614
Plasmodium falciparum phd finger protein, putative 0.0031 0.0197 0.476
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0443 0.0421
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0425 0.1465
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0425 0.0533
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0244 0.27 0.8365
Onchocerca volvulus 0.0047 0.0389 0.1124
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0465 0.0585
Brugia malayi Pre-SET motif family protein 0.0209 0.2285 0.6953
Schistosoma mansoni hypothetical protein 0.0294 0.3283 0.4185
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0425 0.0403
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.5158 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0264 0.2936 0.9096
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0338 0.0403
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0106 0.0329
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0164 0.0508
Entamoeba histolytica hypothetical protein 0.0109 0.1113 1
Onchocerca volvulus Alhambra homolog 0.0031 0.0197 0.0361
Schistosoma mansoni P2X receptor subunit 0.0068 0.0636 0.0802
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.067 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.2319 0.7184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0443 0.0556
Brugia malayi PHD-finger family protein 0.0031 0.0197 0.06
Brugia malayi TAR-binding protein 0.0264 0.2936 0.8935
Schistosoma mansoni hypothetical protein 0.0031 0.0197 0.0242
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Entamoeba histolytica hypothetical protein 0.0109 0.1113 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Toxoplasma gondii melibiase subfamily protein 0.0103 0.1042 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0297 0.1896
Schistosoma mansoni lamin 0.0028 0.0164 0.0199
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0465 0.0443
Echinococcus multilocularis expressed protein 0.0018 0.0048 0.0025
Echinococcus granulosus expressed protein 0.0018 0.0048 0.0032
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.2104 0.2664
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0323 0.1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1042 0.1321
Loa Loa (eye worm) hypothetical protein 0.0086 0.084 0.2603
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.067 0.2418
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0297 0.0969
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0297 0.0275
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0197 0.0242
Trypanosoma cruzi ISWI complex protein 0.0031 0.0197 0.1614
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.2104 0.2085
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0294 0.3286 0.327
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0023 0.0106 0.0125
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0465 0.0566
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0465 0.0566
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0294 0.3286 0.4189
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0023 0.0106 0.0949
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.067 0.0649
Schistosoma mansoni hypothetical protein 0.0023 0.0106 0.0125
Loa Loa (eye worm) hypothetical protein 0.0047 0.0389 0.1205
Onchocerca volvulus 0.0028 0.0164 0.023
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0425 0.1317
Brugia malayi MBOAT family protein 0.0023 0.0106 0.0323
Plasmodium vivax SET domain protein, putative 0.003 0.0189 0.1461
Brugia malayi MAP kinase sur-1 0.005 0.0425 0.1293
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0636 0.0614
Loa Loa (eye worm) hypothetical protein 0.0071 0.067 0.2077
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0013 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0389 0.0487
Toxoplasma gondii ABC1 family protein 0.0071 0.067 0.6406
Schistosoma mansoni hypothetical protein 0.0041 0.0323 0.0402
Loa Loa (eye worm) beta-lactamase 0.0071 0.067 0.2077
Schistosoma mansoni zinc finger protein 0.0023 0.0106 0.0125
Schistosoma mansoni P2X receptor subunit 0.0068 0.0636 0.0802
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0273 0.025
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1218
Schistosoma mansoni ferritin light chain 0.0018 0.0048 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.067 0.0846
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0197 0.0223
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0189 0.0166
Schistosoma mansoni jumonji domain containing protein 0.008 0.0773 0.0978
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.067 0.1218
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0425 0.5651
Entamoeba histolytica hypothetical protein 0.0109 0.1113 1
Schistosoma mansoni bromodomain containing protein 0.0127 0.1325 0.1683
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Schistosoma mansoni apoferritin-2 0.0018 0.0048 0.0051
Brugia malayi jmjC domain containing protein 0.0041 0.0318 0.0967
Entamoeba histolytica hypothetical protein 0.0109 0.1113 1
Schistosoma mansoni hypothetical protein 0.0682 0.7832 1
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0389 0.0367
Mycobacterium tuberculosis Conserved protein 0.0071 0.067 0.1218
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0389 0.0367
Echinococcus multilocularis p2X purinoceptor 4 0.0068 0.0636 0.0614
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0421 0.1283
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.007
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.1042 0.1305
Loa Loa (eye worm) hypothetical protein 0.0142 0.15 0.4647
Schistosoma mansoni ferritin light chain 0.0018 0.0048 0.0051
Loa Loa (eye worm) TAR-binding protein 0.0264 0.2936 0.9096
Toxoplasma gondii exonuclease III APE 0.0039 0.0297 0.2796
Brugia malayi Bromodomain containing protein 0.0077 0.0738 0.2246
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0023 0.0106 0.0329
Brugia malayi intermediate filament protein 0.0028 0.0164 0.0499
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0106 0.0083
Echinococcus granulosus tar DNA binding protein 0.0264 0.2936 0.373
Schistosoma mansoni ap endonuclease 0.0039 0.0297 0.0369
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0023 0.0106 0.0106
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0023 0.0106 0.0106
Schistosoma mansoni zinc finger protein 0.0039 0.0298 0.037
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0238 0.0294
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0465 0.1416
Schistosoma mansoni hypothetical protein 0.0031 0.0197 0.0242
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0106 0.0125
Brugia malayi mbt repeat family protein 0.0047 0.0389 0.1184
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.067 0.2418
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.067 1
Echinococcus granulosus intermediate filament protein 0.0028 0.0164 0.0181
Brugia malayi RNA binding protein 0.0264 0.2936 0.8935
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0641 0.2303
Loa Loa (eye worm) voltage-gated potassium channel 0.0289 0.3228 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0425 0.0403
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0106 0.0329
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.1042 0.1321
Echinococcus multilocularis sterol O acyltransferase 1 0.0235 0.2587 0.257
Echinococcus multilocularis musashi 0.0028 0.0164 0.0141
Schistosoma mansoni intermediate filament proteins 0.0028 0.0164 0.0199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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