Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.4131 | 0.4098 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0016 | 0.0451 | 0.0634 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1731 | 0.3163 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.4131 | 0.4098 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.2489 | 0.4662 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0451 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0451 | 0.0287 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1731 | 0.3163 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.01 | 0.4131 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.01 | 0.4131 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.1088 | 0.1036 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.0451 | 0.0292 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0818 | 0.0997 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.1082 | 0.1882 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.0451 | 0.0292 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.01 | 0.4131 | 1 |
Echinococcus multilocularis | phd:f box containing protein | 0.0016 | 0.0451 | 0.0634 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0451 | 0.0287 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.013 | 0.025 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5191 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5191 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5191 | 1 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5191 | 0.5828 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0818 | 0.1575 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1088 | 0.2095 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0818 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1088 | 0.1031 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1082 | 0.2085 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5191 | 0.5826 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1731 | 0.3163 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.01 | 0.4131 | 0.7907 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.2307 | 0.4303 |
Giardia lamblia | Kinase, CMGC MAPK | 0.01 | 0.4131 | 1 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0016 | 0.0451 | 0.0634 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.1088 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.2445 | 0.4711 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.1088 | 0.1892 |
Onchocerca volvulus | 0.003 | 0.1088 | 0.0084 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.1088 | 0.1892 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1731 | 0.1787 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.01 | 0.4131 | 1 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0016 | 0.0451 | 0.0634 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1082 | 0.2085 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0024 | 0.0818 | 0.5761 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.4796 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5191 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.2378 | 0.4581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5191 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.006 | 0.2378 | 0.4442 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0016 | 0.0451 | 0.0868 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.5539 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.2489 | 0.4662 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.2307 | 0.4303 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.006 | 0.2378 | 0.4581 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0451 | 0.0287 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1731 | 0.3334 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5191 | 0.5826 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5191 | 0.5826 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0016 | 0.0451 | 0.0868 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0016 | 0.0451 | 0.0287 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5191 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5191 | 0.5828 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.1013 | 0.1746 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.01 | 0.4131 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.8762 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1012 | 0.1949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1731 | 0.3334 |
Trypanosoma brucei | protein kinase, putative | 0.01 | 0.4131 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1731 | 0.3334 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.4131 | 0.7959 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.1082 | 0.1882 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.4131 | 0.4098 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1088 | 0.2095 |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0016 | 0.0451 | 0.0634 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.1088 | 0.1892 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0205 | 0.0149 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.01 | 0.4131 | 0.7907 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0024 | 0.0818 | 0.1575 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0024 | 0.0818 | 0.0997 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0024 | 0.0818 | 0.1359 |
Schistosoma mansoni | jumonji domain containing protein | 0.0016 | 0.0451 | 0.0868 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.1012 | 0.0948 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0818 | 0.0997 |
Echinococcus granulosus | phd:f box containing protein | 0.0016 | 0.0451 | 0.0634 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0024 | 0.0818 | 0.1359 |
Echinococcus granulosus | mitogen activated protein kinase | 0.01 | 0.4131 | 0.7907 |
Schistosoma mansoni | phd/f-box containing protein | 0.0016 | 0.0451 | 0.0868 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5191 | 0.5828 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.0451 | 0.0292 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.2307 | 0.2461 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0017 | 0.0521 | 0.0773 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0016 | 0.0451 | 0.0634 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0024 | 0.0818 | 0.0716 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.01 | 0.4131 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.1012 | 0.0943 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.0818 | 0.0721 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.2489 | 0.5539 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.2307 | 0.4445 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.2307 | 0.4303 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.2378 | 0.2539 |
Brugia malayi | MAP kinase sur-1 | 0.01 | 0.4131 | 0.4591 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.01 | 0.4131 | 0.7907 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0024 | 0.0818 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0451 | 0.0287 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5191 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0205 | 0.0149 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0024 | 0.0818 | 1 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0016 | 0.0451 | 0.0634 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.2165 | 0.4658 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.2378 | 0.2543 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.01 | 0.4131 | 0.4588 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.01 | 0.4131 | 1 |
Schistosoma mansoni | protein phosphatase 2C | 0.0016 | 0.0451 | 0.0868 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 0.4131 | 0.4098 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.1088 | 0.2095 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1731 | 0.1783 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0017 | 0.0521 | 0.0773 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.8762 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0024 | 0.0818 | 0.0721 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0024 | 0.0818 | 0.0766 |
Brugia malayi | jmjC domain containing protein | 0.0016 | 0.0451 | 0.0292 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1731 | 0.3163 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.4796 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.1088 | 0.1731 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.1088 | 0.2095 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.01 | 0.4131 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0024 | 0.0818 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.2489 | 0.5 |
Trichomonas vaginalis | chaperonin, putative | 0.0024 | 0.0818 | 0.0766 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.992 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.894 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.798 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.796 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.755 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.714 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.701 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.694 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.509 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.467 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.