Detailed information for compound 568685

Basic information

Technical information
  • TDR Targets ID: 568685
  • Name: sodium (2-carboxylatophenoxy)sulfanyl-ethyl-m ercury
  • MW: 421.819 | Formula: C9H10HgNaO3S
  • H donors: 0 H acceptors: 2 LogP: 3.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[Hg]SOc1ccccc1C(=O)[O-].[NaH+]
  • InChi: 1S/C7H6O3S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10-11;1-2;;/h1-4,11H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2
  • InChiKey: JYICQOIIFGXCFI-UHFFFAOYSA-L  

Network

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Synonyms

  • sodium [(2-carboxylatophenoxy)thio]-ethylmercury
  • sodium [(2-carboxylatophenoxy)thio]-ethyl-mercury
  • sodium (2-carboxylatophenoxy)sulfanyl-ethylmercury
  • Thimerosal

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References
Plasmodium falciparum esterase, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium vivax unspecified product Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Neospora caninum hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Toxoplasma gondii hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 371 aa 380 aa 41.0 %
Plasmodium falciparum lysophospholipase, putative esterase, putative 373 aa 405 aa 51.6 %
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 353 aa 379 aa 44.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0139 0.015
Brugia malayi Cell death protein 3 precursor 0.0166 0.2909 0.8179
Echinococcus granulosus caspase 0.0227 0.4108 0.4108
Trypanosoma brucei metacaspase MCA3 0.0086 0.1342 0.4213
Brugia malayi beta-lactamase family protein 0.0038 0.0398 0.112
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0139 0.0146
Loa Loa (eye worm) hypothetical protein 0.008 0.1227 0.2053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Plasmodium vivax lysophospholipase, putative 0.0178 0.3139 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0736 0.1231
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0818 0.0818
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0398 0.0398
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.0996
Plasmodium falciparum lysophospholipase, putative 0.0173 0.3055 0.9726
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0227 0.4108 0.4108
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0178 0.3139 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0095 0.0095
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.1342 0.4097
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.0996
Trypanosoma brucei metacaspase 0.0086 0.1342 0.4213
Echinococcus granulosus caspase 2 0.0166 0.2909 0.2909
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0141 0.0157
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Schistosoma mansoni hypothetical protein 0.0528 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.2634 0.8414
Echinococcus multilocularis caspase 3 0.0141 0.2426 0.2426
Trypanosoma cruzi monoglyceride lipase, putative 0.0173 0.3055 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.2634 0.2634
Loa Loa (eye worm) hypothetical protein 0.003 0.0251 0.042
Leishmania major monoglyceride lipase, putative 0.0173 0.3055 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0398 0.0996
Schistosoma mansoni ran 0.0022 0.0095 0.0095
Mycobacterium ulcerans lysophospholipase 0.0173 0.3055 1
Echinococcus granulosus snurportin 1 0.0323 0.5976 0.5976
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0095 0.0095
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0086 0.1342 0.3773
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0398 0.0666
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0684 0.1936
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0141 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.3055 0.9726
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0173 0.3055 1
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0139 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.3055 0.9726
Trypanosoma brucei metacaspase MCA2 0.0086 0.1342 0.4213
Echinococcus multilocularis geminin 0.0528 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.8342
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.1609 0.3042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0736 0.2068
Plasmodium falciparum importin beta, putative 0.003 0.0251 0.0513
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.1609 0.1609
Plasmodium falciparum lysophospholipase, putative 0.0173 0.3055 0.9726
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.3055 0.9726
Brugia malayi beta-lactamase family protein 0.0038 0.0398 0.112
Schistosoma mansoni hypothetical protein 0.0038 0.0395 0.0395
Brugia malayi hypothetical protein 0.0025 0.0141 0.0398
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0251 0.0513
Trypanosoma brucei Metacaspase-4 0.0086 0.1342 0.4213
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0398 0.1025
Plasmodium vivax metacaspase 1, putative 0.0086 0.1342 0.4097
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0086 0.1342 0.1342
Schistosoma mansoni caspase-7 (C14 family) 0.0227 0.4108 0.4108
Leishmania major hypothetical protein, conserved 0.0025 0.0141 0.0157
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0818 0.2301
Plasmodium falciparum metacaspase 1 0.0086 0.1342 0.4097
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0398 0.1025
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.4379 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.2634 0.8342
Echinococcus multilocularis snurportin 1 0.0323 0.5976 0.5976
Schistosoma mansoni hypothetical protein 0.0528 1 1
Brugia malayi beta-lactamase 0.0038 0.0398 0.112
Onchocerca volvulus Cell death protein 3 homolog 0.0166 0.2909 0.795
Trichomonas vaginalis esterase, putative 0.0038 0.0398 0.0996
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.1342 0.4097
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0398 0.0996
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.3055 0.9726
Plasmodium vivax hypothetical protein, conserved 0.0086 0.1342 0.4097
Mycobacterium tuberculosis Possible lysophospholipase 0.0173 0.3055 0.6675
Plasmodium falciparum esterase, putative 0.0173 0.3055 0.9726
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0398 0.0398
Schistosoma mansoni hypothetical protein 0.0323 0.5976 0.5976
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0395 0.1111
Plasmodium vivax PST-A protein 0.0173 0.3055 0.9726
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0398 0.0996
Plasmodium vivax importin-beta 2, putative 0.003 0.0251 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Echinococcus granulosus caspase 8 0.0086 0.1342 0.1342
Echinococcus multilocularis caspase 0.0227 0.4108 0.4108
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.5
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.3055 0.9726
Loa Loa (eye worm) hypothetical protein 0.0152 0.2634 0.4408
Plasmodium falciparum esterase, putative 0.0178 0.3139 1
Schistosoma mansoni ran 0.0022 0.0095 0.0095
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.1342 0.4097
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0227 0.4108 0.4108
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0672 0.1124
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0141 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Leishmania major hypothetical protein, conserved 0.0038 0.0398 0.1025
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0398 0.0996
Leishmania major metacaspase, putative 0.0086 0.1342 0.4213
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Echinococcus multilocularis apoptotic protease activating factor 1 0.008 0.1227 0.1227
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0139 0.0146
Echinococcus multilocularis caspase 8 0.0086 0.1342 0.1342
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0141 0.0153
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0052 0.0684 0.1077
Schistosoma mansoni caspase-7 (C14 family) 0.0166 0.2909 0.2909
Echinococcus granulosus apoptotic protease activating factor 1 0.008 0.1227 0.1227
Loa Loa (eye worm) hypothetical protein 0.0086 0.1342 0.2246
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0173 0.3055 0.9726
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0398 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1342 0.4097
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.2634 0.2634
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0141 0.0153
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.1342 0.4213
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0818 0.1056
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0684 0.1936
Toxoplasma gondii hypothetical protein 0.0178 0.3139 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0736 0.1231
Loa Loa (eye worm) hypothetical protein 0.0166 0.2909 0.4869
Echinococcus multilocularis caspase 2 0.0166 0.2909 0.2909
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.3055 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.1609 0.3042
Brugia malayi N-terminal motif family protein 0.0199 0.3557 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.3055 0.9726
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.5
Trypanosoma brucei metacaspase 5, putative 0.0086 0.1342 0.4213
Trypanosoma cruzi metacaspase, putative 0.0086 0.1342 0.4213
Echinococcus multilocularis importin subunit beta 1 0.003 0.0251 0.0251
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.3557 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.0159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0398 0.0666
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.3055 0.9726
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.1342 0.4213
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0818 0.1582
Plasmodium falciparum lysophospholipase, putative 0.0178 0.3139 1
Trypanosoma cruzi metacaspase, putative 0.0086 0.1342 0.4213
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.1342 0.4097
Echinococcus granulosus caspase 3 0.0141 0.2426 0.2426
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.5
Brugia malayi RNA, U transporter 1 0.0086 0.1342 0.3773
Schistosoma mansoni importin beta-1 0.003 0.0251 0.0251
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.2634 0.8342
Loa Loa (eye worm) hypothetical protein 0.0038 0.0395 0.0661
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0398 0.0996
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.2634 0.2634
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0398 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.3055 0.9726
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.2634 0.8342
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0251 0.0528
Leishmania major importin beta-1 subunit, putative 0.0025 0.0139 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0141 0.0157
Plasmodium falciparum lysophospholipase, putative 0.0173 0.3055 0.9726
Schistosoma mansoni hypothetical protein 0.008 0.1227 0.1227
Plasmodium falciparum esterase, putative 0.0178 0.3139 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.8414
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0818 0.2444
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0818 0.1582
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.3055 0.9726
Loa Loa (eye worm) beta-lactamase 0.0038 0.0398 0.0666
Echinococcus granulosus importin subunit beta 1 0.003 0.0251 0.0251
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0818 0.0818
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0095 0.0267
Plasmodium vivax unspecified product 0.0178 0.3139 1
Trypanosoma cruzi metacaspase, putative 0.0086 0.1342 0.4213
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0251 0.0528
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0818 0.0818
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.3055 1
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.3139 1
Entamoeba histolytica hypothetical protein 0.0025 0.0139 0.0146
Brugia malayi Probable ClpP-like protease 0.0152 0.2634 0.7406
Mycobacterium ulcerans hypothetical protein 0.0173 0.3055 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.1609 0.4558
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0398 0.112
Brugia malayi hypothetical protein 0.008 0.1227 0.3448
Brugia malayi Importin beta-1 subunit 0.003 0.0251 0.0706
Onchocerca volvulus 0.008 0.1227 0.2623
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.5976 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0736 0.2068
Loa Loa (eye worm) hypothetical protein 0.0199 0.3557 0.5952
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.2634 0.8414
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0398 0.1025
Schistosoma mansoni caspase-3 (C14 family) 0.0227 0.4108 0.4108
Echinococcus granulosus peptidase Clp S14 family 0.01 0.1609 0.1609
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0141 0.0153
Toxoplasma gondii hypothetical protein 0.0052 0.0684 0.1936
Trypanosoma cruzi metacaspase, putative 0.0086 0.1342 0.4213
Plasmodium falciparum metacaspase-like protein 0.0086 0.1342 0.4097
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

8 literature references were collected for this gene.

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