Detailed information for compound 568767

Basic information

Technical information
  • TDR Targets ID: 568767
  • Name: 4-dichloroarsanylaniline hydrochloride
  • MW: 274.407 | Formula: C6H7AsCl3N
  • H donors: 1 H acceptors: 0 LogP: 3.5 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cl[As](c1ccc(cc1)N)Cl.Cl
  • InChi: 1S/C6H6AsCl2N.ClH/c8-7(9)5-1-3-6(10)4-2-5;/h1-4H,10H2;1H
  • InChiKey: WXNHRNHYHZWRNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-dichloroarsinoaniline hydrochloride
  • (4-dichloroarsinophenyl)amine hydrochloride
  • (4-dichloroarsanylphenyl)azanium chloride
  • (4-dichloroarsanylphenyl)ammonium chloride
  • (4-dichloroarsinophenyl)ammonium chloride
  • 4-aminophenyldichloroarsine
  • 5410-78-6
  • 4-Anilinodichloroarsine, hydrochloride
  • ANILINE, p-DICHLOROARSINO-, HYDROCHLORIDE
  • Aniline, p-(dichloroarsino)-, hydrochloride
  • Arsine, (p-aminophenyl)dichloro-, hydrochloride
  • Arsonous dichloride, (4-aminophenyl)-, monohydrochloride (9CI)
  • NSC 12683
  • p-Dichloroarsinoaniline hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0309 0.0617
Echinococcus granulosus Ankyrin 0.0031 0.0177 0.0005
Schistosoma mansoni hypothetical protein 0.004 0.029 0.0239
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0353
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0518 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3119 0.6088
Trypanosoma brucei GMP reductase 0.0409 0.5012 1
Toxoplasma gondii IMP dehydrogenas 0.0409 0.5012 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0309 0.0137
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0175 0.0283
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0404 0.4953 1
Brugia malayi TAR-binding protein 0.0261 0.3119 0.6166
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0076 0.0151
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0175 0.0202
Loa Loa (eye worm) hypothetical protein 0.0299 0.3603 0.7189
Loa Loa (eye worm) hypothetical protein 0.0051 0.0429 0.0856
Schistosoma mansoni hypothetical protein 0.004 0.029 0.0239
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0076 0.0151
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0309 0.0279
Echinococcus multilocularis protein patched 0.0042 0.0309 0.0137
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0179 0.2063 0.4027
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2028 0.6311
Schistosoma mansoni hypothetical protein 0.0031 0.0175 0.0002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0175 0.035
Schistosoma mansoni netrin receptor unc5 0.0031 0.0175 0.0002
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0304 0.3676 0.3564
Entamoeba histolytica hypothetical protein 0.0076 0.0749 0.715
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1018 0.1909
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Loa Loa (eye worm) TAR-binding protein 0.0261 0.3119 0.6224
Schistosoma mansoni patched 1 0.0042 0.0309 0.0279
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0409 0.5012 1
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3119 0.6088
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0409 0.5012 0.4923
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0175 0.0002
Echinococcus multilocularis geminin 0.0167 0.1913 0.1769
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0151
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0183 0.2123 0.4147
Loa Loa (eye worm) hypothetical protein 0.0067 0.0636 0.1269
Echinococcus multilocularis expressed conserved protein 0.0091 0.0943 0.0782
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.1823 0.3109
Echinococcus multilocularis protein dispatched 1 0.0047 0.0385 0.0214
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0409 0.5012 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0175 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0261 0.3119 0.2997
Echinococcus granulosus tar DNA binding protein 0.0261 0.3119 0.6088
Leishmania major inosine-5-monophosphate dehydrogenase 0.0409 0.5012 1
Trypanosoma cruzi GMP reductase 0.0409 0.5012 1
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3119 0.6088
Brugia malayi Uncoordinated protein 44 0.0031 0.0175 0.0202
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0151
Schistosoma mansoni hypothetical protein 0.004 0.029 0.0239
Brugia malayi Death domain containing protein 0.0031 0.0175 0.0202
Onchocerca volvulus 0.0299 0.3603 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1551 0.1401
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.2055 0.4099
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1551 0.2845
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0174 0.02
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0179 0.2063 0.4027
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0617
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0749 0.1188
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0261 0.3119 0.6224
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0151
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0409 0.5012 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0304 0.3676 0.7238
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0636 0.1135
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.4101 0.8032
Leishmania major mitochondrial DNA polymerase beta 0.0338 0.4101 0.8155
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0 0.5
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0226 0.2666 0.5247
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Echinococcus granulosus death domain containing protein 0.0031 0.0175 0.0002
Loa Loa (eye worm) IMP dehydrogenase 1 0.0409 0.5012 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1037 0.1783
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0409 0.5012 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0076 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3119 0.6088
Brugia malayi hypothetical protein 0.0076 0.0749 0.1365
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1823 0.3109
Echinococcus multilocularis Ankyrin 0.0031 0.0177 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0174 0.0348
Loa Loa (eye worm) RNA binding protein 0.0261 0.3119 0.6224
Onchocerca volvulus Putative GMP reductase 0.0179 0.2063 0.5635
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0226 0.2666 0.5319
Entamoeba histolytica hypothetical protein 0.0076 0.0749 0.715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1034 0.1941
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0151
Entamoeba histolytica hypothetical protein 0.0076 0.0749 0.715
Schistosoma mansoni hypothetical protein 0.0167 0.1913 0.3594
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0175 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0174 0.0348
Entamoeba histolytica hypothetical protein 0.0076 0.0749 0.715
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0175 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1034 0.1941
Mycobacterium ulcerans hypothetical protein 0.0178 0.2055 0.4099
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0309 0.0279
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.3033 0.6051
Brugia malayi hypothetical protein 0.0299 0.3603 0.7146
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0076 0.0151
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0174 0.02
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0076 0.0151
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0409 0.5012 1
Echinococcus granulosus expressed conserved protein 0.0091 0.0943 0.1588
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.035
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2028 0.6311
Brugia malayi RNA recognition motif domain containing protein 0.0261 0.3119 0.6166
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0749 0.0585
Echinococcus granulosus geminin 0.0167 0.1913 0.3594
Brugia malayi RNA binding protein 0.0261 0.3119 0.6166
Loa Loa (eye worm) hypothetical protein 0.0098 0.1034 0.2062
Schistosoma mansoni hypothetical protein 0.0167 0.1913 0.3594
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0749 0.1188
Loa Loa (eye worm) hypothetical protein 0.0097 0.1018 0.2031
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0409 0.5012 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0409 0.5012 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0151
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0177 0.0005
Leishmania major guanosine monophosphate reductase 0.0409 0.5012 1
Schistosoma mansoni hypothetical protein 0.0067 0.0636 0.0954
Schistosoma mansoni hypothetical protein 0.004 0.029 0.0239
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1034 0.2062
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0404 0.4953 0.9882
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0409 0.5012 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.1913 0.5209
Loa Loa (eye worm) GMP reductase 0.0179 0.2063 0.4117
Schistosoma mansoni tar DNA-binding protein 0.0261 0.3119 0.6088
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.4101 0.8032
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0338 0.4101 0.8032
Brugia malayi CHE-14 protein 0.0042 0.0309 0.0474
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0076 0.0151
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0175 0.0002
Schistosoma mansoni hypothetical protein 0.0076 0.0749 0.1188
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0409 0.5012 1
Brugia malayi Protein kinase domain containing protein 0.0031 0.0175 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1913 0.5889
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0076 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3033 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1823 0.3541
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1018 0.1744
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0409 0.5012 1
Trypanosoma cruzi GMP reductase 0.0409 0.5012 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0404 0.4953 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0183 0.2123 0.4235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0076 0.0151
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1018 0.0858
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.3033 0.599
Brugia malayi GMP reductase 0.0179 0.2063 0.4027
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0409 0.5012 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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