Detailed information for compound 56902

Basic information

Technical information
  • TDR Targets ID: 56902
  • Name: 2-(3-chlorophenyl)indene-1,3-dione
  • MW: 256.684 | Formula: C15H9ClO2
  • H donors: 0 H acceptors: 2 LogP: 3.7 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C15H9ClO2/c16-10-5-3-4-9(8-10)13-14(17)11-6-1-2-7-12(11)15(13)18/h1-8,13H
  • InChiKey: CXVIGZJKUNHFRZ-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(3-chlorophenyl)indane-1,3-dione
  • 2-(3-chlorophenyl)indane-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0123 0.0123
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0859 0.0859
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0013 0.0013
Brugia malayi steroid hormone receptor 0.0083 0.0493 0.1324
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.031 0.031
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0123 0.0306
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0042 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0493 0.0493
Brugia malayi nuclear receptor NHR-88 0.0027 0.0123 0.0306
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0493 0.1322
Brugia malayi nuclear hormone receptor 0.0027 0.0123 0.0306
Schistosoma mansoni zinc finger protein 0.0027 0.0123 0.0123
Brugia malayi nuclear receptor RXR 0.0055 0.031 0.0819
Echinococcus multilocularis thyroid hormone receptor alpha 0.0221 0.1412 0.1412
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0039 0.0075
Schistosoma mansoni microtubule-associated protein tau 0.1508 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0493 0.1324
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0123 0.0123
Brugia malayi nuclear receptor NHR-67 0.0027 0.0123 0.0306
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Loa Loa (eye worm) hypothetical protein 0.0055 0.031 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0493 0.1324
Schistosoma mansoni hypothetical protein 0.0447 0.2925 0.2925
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0493 0.1324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0493 0.1324
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0493 0.1324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0493 0.0493
Onchocerca volvulus 0.026 0.1673 0.453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0493 0.1324
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0123 0.0123
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.0245 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0162 0.6391
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0493 0.1324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0493 0.1322
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1412 0.1412
Brugia malayi nuclear hormone receptor 0.0083 0.0493 0.1324
Brugia malayi nuclear receptor RXR 0.0027 0.0123 0.0306
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0042 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0161 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0493 0.0493
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0123 0.0123
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0493 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0493 0.1322
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0123 0.0306
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0097 0.0353
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0123 0.0232
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0493 0.0493
Brugia malayi conserved hypotetical protein 0.0027 0.0123 0.0306
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0123 0.0123
Echinococcus granulosus cpg binding protein 0.0033 0.0161 0.0161
Echinococcus granulosus dnaJ subfamily B 0.0447 0.2925 0.2925
Loa Loa (eye worm) hypothetical protein 0.0055 0.031 0.0817
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0493 0.0493
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.031 0.0817
Brugia malayi ecdysteroid receptor 0.0556 0.3646 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0493 0.0493
Trichomonas vaginalis set domain proteins, putative 0.026 0.1673 1
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0493 0.0493
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0493 0.0493
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0074 0.0435 0.1096
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Brugia malayi hypothetical protein 0.0055 0.031 0.0819
Onchocerca volvulus 0.0083 0.0493 0.1258
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0493 0.0493
Brugia malayi hypothetical protein 0.0055 0.031 0.0819
Loa Loa (eye worm) hypothetical protein 0.0074 0.0435 0.1161
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.031 0.0819
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0123 0.0123
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0123 0.0304
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0493 0.0493
Brugia malayi nuclear receptor NHR-88 0.0083 0.0493 0.1324
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0039 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0493 0.0493
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.015 0.0376
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0493 0.0493
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0123 0.0306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0493 0.0493
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.031 0.031
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0123 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0162 0.0162
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0123 0.0123
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0345 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0493 0.1258
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0054 0.03 0.03
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0123 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0162 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.031 0.031
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0493 0.1322
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0123 0.0304
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0123 0.0123
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0097 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0097 0.0353
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0123 0.0123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Loa Loa (eye worm) hypothetical protein 0.0055 0.031 0.0817
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0162 0.0162
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.031 0.0819
Schistosoma mansoni nuclear receptor 0.0027 0.0123 0.0123
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0097 1
Brugia malayi ecdysone receptor 0.0027 0.0123 0.0306
Schistosoma mansoni thyroid hormone receptor 0.0221 0.1412 0.1412
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0493 0.1324
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0039 0.0073
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0493 0.1324
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0075 0.0075
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0123 0.0306
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.2925 0.2925
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0493 0.1324
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0393 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0493 0.1322
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0039 0.0039
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0123 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0493 0.1322
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1463 0.3993
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0493 0.0493
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0493 0.1324
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0054 0.03 0.03
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0493 0.1324
Loa Loa (eye worm) hypothetical protein 0.0055 0.031 0.0817
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0054 0.03 0.03
Onchocerca volvulus Bile acid receptor homolog 0.0556 0.3646 1
Schistosoma mansoni cpg binding protein 0.0031 0.015 0.015
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0123 0.0123
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0493 0.0493
Onchocerca volvulus 0.0027 0.0123 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0493 0.1324
Onchocerca volvulus 0.0027 0.0123 0.0232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0493 0.0493
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0097 1
Schistosoma mansoni nuclear receptor 0.0027 0.0123 0.0123
Brugia malayi tailless protein 0.0027 0.0123 0.0306
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0493 0.1258
Brugia malayi CXXC zinc finger family protein 0.0031 0.015 0.0379
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0493 0.0493
Onchocerca volvulus 0.0031 0.015 0.0305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0162 0.0162
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0123 0.0232
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0039 0.0075
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0232 0.0605
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0162 0.0162
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0039 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0493 0.0493
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0493 0.0493
Brugia malayi Pre-SET motif family protein 0.0228 0.1463 0.3994
Loa Loa (eye worm) hypothetical protein 0.0556 0.3646 1
Schistosoma mansoni hypothetical protein 0.0138 0.0859 0.0859
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0493 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0493 0.1322
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0123 0.0306
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0123 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0493 0.1324
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0493 0.1324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0493 0.1324
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0033 0.0161 0.0161
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0123 0.0123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0162 0.4024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0123 0.0123
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0162 0.0412
Brugia malayi hypothetical protein 0.0027 0.0123 0.0306
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0055 0.031 0.0817
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0493 0.0493
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Brugia malayi hypothetical protein 0.0027 0.0123 0.0306
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.031 0.031
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0039 0.0039
Schistosoma mansoni cpg binding protein 0.0033 0.0161 0.0161
Echinococcus multilocularis microtubule associated protein 2 0.1508 1 1
Brugia malayi Pre-SET motif family protein 0.0033 0.0162 0.0414
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0083 0.0493 0.1322
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0232 0.6296
Schistosoma mansoni coup transcription factor 0.0083 0.0493 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0162 0.0162
Loa Loa (eye worm) DR-78 0.0027 0.0123 0.0304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0493 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0493 0.1322
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0304
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0232 1
Onchocerca volvulus 0.0033 0.0162 0.0341
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0493 0.0493
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0039 0.0039

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 60 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum cholesterol measured on the 16th day ChEMBL. 4067989
Control (functional) = 60 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum cholesterol measured on the 16th day ChEMBL. 4067989
Control (functional) = 70 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum cholesterol measured on the 9th day ChEMBL. 4067989
Control (functional) = 70 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum triglyceride measured on the 16th day ChEMBL. 4067989
Control (functional) = 70 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum cholesterol measured on the 9th day ChEMBL. 4067989
Control (functional) = 70 % Hypolipidemic activity in CF1 male mice at a dose of 20 mg/kg per day, serum triglyceride measured on the 16th day ChEMBL. 4067989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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