TDR Targets

Basic information

Technical information

TDR Targets ID: 569107
Name: (E)-2-cyano-3-(3-hydroxyphenyl)prop-2-enoate
MW: 188.16 | Formula: C10H6NO3-
H donors: 1 H acceptors: 4 LogP: 2.1 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N#CC(=Cc1cccc(c1)O)C(=O)[O-]
InChi: 1S/C10H7NO3/c11-6-8(10(13)14)4-7-2-1-3-9(12)5-7/h1-5,12H,(H,13,14)/p-1/b8-4+
InChiKey: HPLNTJVXWMJLNJ-XBXARRHUSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-2-cyano-3-(3-hydroxyphenyl)-2-propenoate
(E)-2-cyano-3-(3-hydroxyphenyl)acrylate
alpha-cyano-3-hydroxycinnamate
54673-07-3
ZINC00155097

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.002	0.0527	0.1133
Trypanosoma brucei	unspecified product	0.002	0.0527	0.3512
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0319	0.1931
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0045	0.138	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0527	0.1048
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0208	0.0416
Schistosoma mansoni	tyrosine kinase	0.006	0.1888	0.4221
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0042	0.0045
Echinococcus granulosus	dna polymerase kappa	0.002	0.0527	0.1133
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0527	0.0973
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0045	0.138	0.2984
Brugia malayi	hypothetical protein	0.0005	0.0042	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0319	0.1931
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0023	0.005
Onchocerca volvulus		0.001	0.0208	0.2229
Brugia malayi	polk-prov protein	0.0006	0.0065	0.0095
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0165	0.0321
Brugia malayi	Protein kinase domain containing protein	0.0074	0.2371	0.5278
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0208	0.0465
Schistosoma mansoni	tyrosine kinase	0.0134	0.4402	0.9842
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0147	0.4812	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0527	0.3512
Brugia malayi	Furin-like cysteine rich region family protein	0.0061	0.1924	0.4274
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0208	0.2229
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0208	0.0416
Giardia lamblia	Cathepsin B precursor	0.0045	0.138	0.1324
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0208	0.0416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0208	0.0416
Schistosoma mansoni	tyrosine kinase	0.0061	0.1924	0.4303
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0208	0.0416
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0208	0.0416
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0208	0.0416
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0527	0.1048
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0023	0.005
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0105	0.0185
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0208	0.0416
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1444	0.323
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0527	0.0973
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0208	0.0416
Schistosoma mansoni	tyrosine kinase	0.006	0.1888	0.4221
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0134	0.4402	0.9841
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0527	0.3512
Schistosoma mansoni	zinc finger protein	0.0005	0.0023	0.005
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0105	0.0234
Trypanosoma brucei	unspecified product	0.0014	0.0319	0.1931
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0208	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0073	0.2334	0.5195
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0208	0.0416
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0165	0.0321
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0045	0.138	0.3086
Brugia malayi	steroid hormone receptor	0.001	0.0208	0.0416
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0527	0.1133
Trypanosoma brucei	unspecified product	0.0014	0.0319	0.1931
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0208	0.0465
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0527	0.1133
Leishmania major	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0208	0.0416
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0527	0.3512
Echinococcus granulosus	epidermal growth factor receptor	0.0061	0.1924	0.4274
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0045	0.138	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0061	0.1924	0.4274
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1444	0.3195
Brugia malayi	hypothetical protein	0.0005	0.0042	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1745	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0042	0.0045
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0208	0.0416
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Schistosoma mansoni	DNA polymerase IV / kappa	0.0006	0.0065	0.0145
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0854	0.1868
Schistosoma mansoni	tyrosine kinase	0.0134	0.4402	0.9842
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0042	0.0095
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0527	0.1048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0208	0.0416
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0208	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0137	0.4473	1
Brugia malayi	Protein kinase domain containing protein	0.0134	0.4402	0.9841
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.4473	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0042	0.0045
Loa Loa (eye worm)	TK/INSR protein kinase	0.0134	0.4402	0.9841
Treponema pallidum	fructose-bisphosphate aldolase	0.03	1	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0208	0.0416
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0208	0.0416
Brugia malayi	nuclear hormone receptor	0.001	0.0208	0.0416
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Echinococcus multilocularis	cathepsin b	0.0137	0.4473	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0854	0.1868
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0147	0.4812	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0911	0.2036
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0527	0.1178
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0134	0.4402	0.9841
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0042	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0045	0.138	0.1308
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0105	0.0185
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.4473	1
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0208	0.2229
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0042	0.0045
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1444	0.323
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0208	0.0416
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0023	0.005
Onchocerca volvulus		0.0029	0.0854	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0061	0.1924	0.4274
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0527	0.1048
Plasmodium falciparum	DNA repair protein REV1, putative	0.0006	0.0065	0.5
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0137	0.4473	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0105	0.0185
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0208	0.0416
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0147	0.4812	0.5
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0208	0.0465
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0208	0.0465
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0208	0.0416
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1971	0.4407
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0208	0.0465
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0208	0.0416
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1444	0.3195
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0208	0.0416
Schistosoma mansoni	cpg binding protein	0.0029	0.0854	0.1909
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1444	0.323
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0042	0.0045
Leishmania major	DNA polymerase eta, putative	0.002	0.0527	0.3512
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0105	0.0185
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0208	0.0416
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0208	0.0416
Schistosoma mansoni	tyrosine kinase	0.0061	0.1924	0.4303
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0165	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0208	0.0416
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0023	0.005
Echinococcus granulosus	dna polymerase eta	0.002	0.0527	0.1133
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0527	0.0448
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0208	0.0416
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0161	0.0312
Plasmodium vivax	DNA repair protein REV1, putative	0.0006	0.0065	0.5
Echinococcus granulosus	cathepsin b	0.0137	0.4473	1
Echinococcus multilocularis	cpg binding protein	0.0031	0.0911	0.1996
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0208	0.0416
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0208	0.0416
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0208	0.0465
Giardia lamblia	Cathepsin B precursor	0.0045	0.138	0.1324
Schistosoma mansoni	tyrosine kinase	0.0061	0.1924	0.4303
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0042	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0208	0.0416
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0208	0.0465
Brugia malayi	cathepsin B-like cysteine proteinase	0.0137	0.4473	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0527	0.1178
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0208	0.0416
Echinococcus granulosus	insulin receptor	0.0134	0.4402	0.9841
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0527	0.1133
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0208	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0065	0.0095
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0042	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0208	0.0416
Echinococcus granulosus	epidermal growth factor receptor	0.0061	0.1924	0.4274
Schistosoma mansoni	tyrosine kinase	0.006	0.1888	0.4221
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.4473	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0042	0.0095
Schistosoma mansoni	nuclear receptor	0.0005	0.0023	0.005
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0208	0.0465
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1444	0.3195
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0527	0.1133
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.03	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0208	0.0416
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.03	1	1
Echinococcus multilocularis		0.0018	0.0451	0.0962
Brugia malayi	nuclear receptor NHR-88	0.001	0.0208	0.0416
Echinococcus multilocularis	insulin receptor	0.0134	0.4402	0.9841
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0208	0.0465
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0208	0.0416
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0208	0.0416
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0208	0.0416
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0208	0.0465
Brugia malayi	nuclear receptor RXR	0.0005	0.0042	0.0045
Giardia lamblia	Cathepsin B precursor	0.0045	0.138	0.1324
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0527	0.3512
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0208	0.2229
Schistosoma mansoni	nuclear receptor	0.0005	0.0023	0.005
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0208	0.0416
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Toxoplasma gondii	cathepsin B	0.0045	0.138	0.7827
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Echinococcus granulosus	cathepsin b	0.0137	0.4473	1
Brugia malayi	ecdysteroid receptor	0.001	0.0208	0.0416
Schistosoma mansoni	cpg binding protein	0.0031	0.0911	0.2036
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0208	0.0416
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0527	0.1048
Echinococcus multilocularis	cathepsin b	0.0137	0.4473	1
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0527	0.3512
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0137	0.4473	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0061	0.1924	0.4274
Echinococcus multilocularis	dna polymerase eta	0.002	0.0527	0.1133
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0061	0.1924	0.4274
Echinococcus granulosus	cpg binding protein	0.0031	0.0911	0.1996
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0319	0.1931
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0023	0.005
Schistosoma mansoni	coup transcription factor	0.001	0.0208	0.0465
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0208	0.0416
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0208	0.0416
Loa Loa (eye worm)	cathepsin B	0.0045	0.138	0.3051
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0208	0.0465
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0208	0.0416
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0527	0.3512
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0208	0.0416
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0527	0.1133
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0527	0.1133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1444	0.3195
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0527	0.0448
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1444	0.3195
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0208	0.0416
Schistosoma mansoni	DNA polymerase eta	0.002	0.0527	0.1178
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0208	0.0416
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1444	0.3195
Giardia lamblia	DINP protein human, muc B family	0.002	0.0527	0.0465

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 6931226

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 569107