Detailed information for compound 569116

Basic information

Technical information
  • TDR Targets ID: 569116
  • Name: 4-hydroxytetrahydrofuran-2-one
  • MW: 102.089 | Formula: C4H6O3
  • H donors: 1 H acceptors: 2 LogP: -0.79 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CC(=O)OC1
  • InChi: 1S/C4H6O3/c5-3-1-4(6)7-2-3/h3,5H,1-2H2
  • InChiKey: FUDDLSHBRSNCBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-hydroxy-2-tetrahydrofuranone
  • 4-hydroxyoxolan-2-one
  • 3,4-dihydroxybutanoic acid gamma-lactone
  • 5469-16-9
  • NSC26907
  • 2(3H)-Furanone, dihydro-4-hydroxy-
  • 3,4-Dihydroxybutyric acid gamma-lactone
  • AI3-05623
  • NSC 26907
  • 4-Hydroxydihydro-2(3H)-furanone
  • ST5410648

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0117 0.1139 0.1139
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.0819 0.1109
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0215 0.2009
Leishmania major GTP-binding protein, putative 0.0022 0.0001 0.0002
Echinococcus multilocularis cpg binding protein 0.0034 0.015 0.015
Mycobacterium ulcerans beta-lactamase 0.0111 0.1071 0.2842
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0756 0.0756
Schistosoma mansoni hypothetical protein 0.0117 0.1139 0.136
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1071 0.1071
Brugia malayi MH2 domain containing protein 0.0758 0.8793 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0222 0.0222
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0361 0.0431
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.064 0.7384 1
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.7945 0.9486
Brugia malayi isocitrate dehydrogenase 0.0033 0.0134 0.0152
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor 0.013 0.1296 0.1474
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0222 0.0252
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.2173 0.2173
Mycobacterium tuberculosis Conserved protein 0.0111 0.1071 0.1303
Schistosoma mansoni ran 0.0022 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0253 0.2757 0.3136
Loa Loa (eye worm) hypothetical protein 0.0045 0.0279 0.0317
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0094 0.0127
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0222 0.0222
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1071 0.5
Schistosoma mansoni nuclear hormone receptor 0.004 0.0222 0.0265
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1071 0.1303
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.0756 0.0756
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.0756 0.0756
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.0756 0.0903
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Leishmania major mitochondrial DNA polymerase beta 0.064 0.7384 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.0756 0.0756
Echinococcus granulosus importin subunit beta 1 0.0029 0.0094 0.0112
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0456 0.5185 0.5897
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.002 0.0023
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0222 0.0265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1071 0.1279
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.1139 0.1295
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0001 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0758 0.8793 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.0756 0.0903
Schistosoma mansoni tar DNA-binding protein 0.0456 0.5185 0.6191
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0361 0.0361
Brugia malayi nuclear hormone receptor 0.0085 0.0756 0.086
Mycobacterium tuberculosis Conserved protein 0.0111 0.1071 0.1303
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0756 0.086
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1071 0.1303
Brugia malayi Latrophilin receptor protein 2 0.0117 0.1139 0.1295
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1049 0.1252
Schistosoma mansoni hypothetical protein 0.0253 0.2757 0.3292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.1054 0.1427
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0348 0.1755
Brugia malayi hypothetical protein 0.0045 0.0279 0.0317
Echinococcus granulosus cpg binding protein 0.0034 0.015 0.0179
Onchocerca volvulus 0.004 0.0222 0.108
Schistosoma mansoni cpg binding protein 0.0034 0.015 0.0179
Schistosoma mansoni coup transcription factor 0.0085 0.0756 0.0903
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0134 0.0181
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.0263
Mycobacterium leprae Probable lipase LipE 0.0111 0.1071 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0134 0.0152
Schistosoma mansoni zinc finger protein 0.004 0.0222 0.0265
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1071 0.1279
Trichomonas vaginalis esterase, putative 0.0111 0.1071 0.3557
Brugia malayi hypothetical protein 0.0109 0.1049 0.1193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.0756 0.086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1071 0.2842
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Schistosoma mansoni hypothetical protein 0.0043 0.0261 0.0311
Echinococcus granulosus microtubule associated protein 2 0.0687 0.7945 0.9486
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0094 0.0094
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0094 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0756 0.086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0756 0.0903
Loa Loa (eye worm) hypothetical protein 0.0055 0.0401 0.0456
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.0756 0.0756
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.5203 0.5203
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0222 0.0222
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.0756 0.3942
Schistosoma mansoni hypothetical protein 0.0723 0.8375 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.0819 0.1109
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1071 0.1279
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0222 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0756 0.086
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1379 0.1568
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0756 0.086
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.028 0.093
Brugia malayi Zinc finger, C2H2 type family protein 0.031 0.3443 0.3915
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.002 0.002
Echinococcus granulosus Smad4 0.0052 0.0361 0.0431
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0279 0.0317
Entamoeba histolytica hypothetical protein 0.0109 0.1049 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0756 0.0903
Schistosoma mansoni cpg binding protein 0.0032 0.0128 0.0153
Schistosoma mansoni Smad4 0.0052 0.0361 0.0431
Schistosoma mansoni cpg binding protein 0.0034 0.015 0.0179
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0222 0.0252
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.0756 0.0903
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.1139 0.1139
Brugia malayi RNA binding protein 0.0456 0.5185 0.5897
Entamoeba histolytica hypothetical protein 0.0109 0.1049 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0134 0.0134
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0348 0.0415
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0215 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0756 0.0903
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0431 0.0431
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0094 0.0127
Schistosoma mansoni thyroid hormone receptor 0.0085 0.0756 0.0903
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0134 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.0756 0.086
Loa Loa (eye worm) hypothetical protein 0.0135 0.1354 0.1539
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1071 0.3557
Brugia malayi beta-lactamase 0.0111 0.1071 0.1218
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0215 0.2009
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1071 0.3557
Brugia malayi Nuclear hormone receptor E75 0.004 0.0222 0.0252
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.0756 0.3942
Brugia malayi MH1 domain containing protein 0.0029 0.0085 0.0097
Loa Loa (eye worm) zinc finger protein 0.031 0.3443 0.3915
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0557 0.0666
Loa Loa (eye worm) hypothetical protein 0.0105 0.0993 0.1129
Echinococcus granulosus GPCR family 2 0.0117 0.1139 0.136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0756 0.086
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.0756 0.086
Schistosoma mansoni hypothetical protein 0.0117 0.1139 0.136
Schistosoma mansoni tar DNA-binding protein 0.0456 0.5185 0.6191
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1379 0.1646
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0134 0.016
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Onchocerca volvulus 0.0111 0.1071 0.5628
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Schistosoma mansoni smad1 5 8 and 0.0052 0.0361 0.0431
Onchocerca volvulus 0.0111 0.1071 0.5628
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0993 0.1185
Echinococcus granulosus tar DNA binding protein 0.0456 0.5185 0.6191
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1071 0.1218
Echinococcus multilocularis expressed conserved protein 0.0098 0.0917 0.0917
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1071 0.1303
Schistosoma mansoni hypothetical protein 0.0312 0.3472 0.4145
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Loa Loa (eye worm) TAR-binding protein 0.0456 0.5185 0.5897
Loa Loa (eye worm) MBCTL1 0.0058 0.0431 0.049
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0431 0.0515
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0215 0.0245
Schistosoma mansoni hypothetical protein 0.0723 0.8375 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1049 0.1049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0175 0.1831 0.2186
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.0756 0.0903
Entamoeba histolytica hypothetical protein 0.0109 0.1049 1
Brugia malayi steroid hormone receptor 0.0085 0.0756 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.0756 0.086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0001 0.0013
Mycobacterium ulcerans hypothetical protein 0.0337 0.3768 1
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0279 0.0317
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0134 0.0181
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.002 0.0024
Schistosoma mansoni importin beta-1 0.0029 0.0094 0.0112
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1071 0.145
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.028 0.0334
Brugia malayi beta-lactamase family protein 0.0111 0.1071 0.1218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.0756 0.086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1071 0.1303
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.7945 0.7945
Mycobacterium tuberculosis Conserved hypothetical protein 0.0337 0.3768 0.4584
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0134 0.1248
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Brugia malayi hypothetical protein 0.004 0.0222 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0279 0.0333
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0303 0.336 0.455
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0215 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0993 0.0993
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0361 0.0431
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1071 0.1303
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1379 0.1568
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.336 0.455
Schistosoma mansoni hypothetical protein 0.0312 0.3463 0.4135
Brugia malayi conserved hypotetical protein 0.004 0.0222 0.0252
Brugia malayi MH1 domain containing protein 0.0029 0.0085 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1071 0.3557
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1071 0.2842
Schistosoma mansoni tar DNA-binding protein 0.0456 0.5185 0.6191
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0222 0.0252
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0215 0.0245
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0279 0.0317
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0348 0.0415
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.0756 0.086
Loa Loa (eye worm) beta-lactamase 0.0111 0.1071 0.1218
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0134 0.0134
Schistosoma mansoni nuclear receptor 0.004 0.0222 0.0265
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0134 0.0152
Brugia malayi MH2 domain containing protein 0.0052 0.0361 0.041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0134 0.0134
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0215 0.0245
Loa Loa (eye worm) DR-78 0.004 0.0222 0.0252
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0431 0.0431
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0361 0.041
Brugia malayi nuclear receptor NHR-88 0.0085 0.0756 0.086
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1071 1
Echinococcus multilocularis Smad4 0.0052 0.0361 0.0361
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.002 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0279 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0758 0.8793 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0045 0.0279 0.0317
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0222 0.108
Schistosoma mansoni smad 0.0023 0.002 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.0756 0.086
Schistosoma mansoni patched 1 0.0045 0.028 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0037
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0348 0.0415
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0348 0.0415
Echinococcus multilocularis snurportin 1 0.0312 0.3472 0.3472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1379 0.1646
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.1012 0.1208
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.0756 0.086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.0756 0.086
Brugia malayi Nuclear hormone receptor E75 0.004 0.0222 0.0252
Brugia malayi RNA, U transporter 1 0.0083 0.0737 0.0839
Loa Loa (eye worm) hypothetical protein 0.0045 0.0279 0.0317
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1071 0.1303
Brugia malayi MH2 domain containing protein 0.0023 0.002 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0085 0.0756 0.0756
Loa Loa (eye worm) hypothetical protein 0.0045 0.028 0.0319
Mycobacterium ulcerans hypothetical protein 0.0111 0.1071 0.2842
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0085 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0222 0.0265
Echinococcus multilocularis tar DNA binding protein 0.0456 0.5185 0.5185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0106
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0222 0.0222
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.0756 0.0903
Echinococcus granulosus expressed conserved protein 0.0098 0.0917 0.1095
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Brugia malayi tailless protein 0.004 0.0222 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.0756 0.086
Schistosoma mansoni hypothetical protein 0.0043 0.0261 0.0311
Plasmodium falciparum importin beta, putative 0.0029 0.0094 0.4349
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.028 0.0319
Brugia malayi beta-lactamase family protein 0.0111 0.1071 0.1218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.0756 0.086
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Echinococcus granulosus snurportin 1 0.0312 0.3472 0.4145
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1071 0.1303
Brugia malayi mbt repeat family protein 0.0051 0.0348 0.0395
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0134 0.016
Loa Loa (eye worm) RNA binding protein 0.0456 0.5185 0.5897
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0222 0.108
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0431 0.0515
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.0756 0.086
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.2173 0.2595
Onchocerca volvulus 0.0032 0.0128 0.0577
Plasmodium vivax importin-beta 2, putative 0.0029 0.0094 0.0874
Echinococcus granulosus smad 0.0052 0.0361 0.0431
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1379 0.1379
Leishmania major hypothetical protein, conserved 0.0111 0.1071 0.145
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1071 0.3557
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.0092
Brugia malayi nuclear receptor RXR 0.004 0.0222 0.0252
Brugia malayi TAR-binding protein 0.0456 0.5185 0.5897
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.0993 0.9466
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.0756 0.0903
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.0756 0.0903
Echinococcus granulosus FTZ F1 alpha 0.0085 0.0756 0.0903
Echinococcus granulosus dnaJ subfamily B 0.0458 0.5203 0.6213
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.1528 0.1825
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1071 0.145
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 1
Brugia malayi ecdysone receptor 0.004 0.0222 0.0252
Loa Loa (eye worm) hypothetical protein 0.0039 0.0215 0.0245
Onchocerca volvulus 0.0051 0.0348 0.1755
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.1528 0.1528
Loa Loa (eye worm) Smad1 0.0052 0.0361 0.041
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0222 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0128 0.0145
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1379 0.1646
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0222 0.0265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0369 0.4152 0.4722
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0117 0.1139 0.136
Schistosoma mansoni nuclear receptor 0.004 0.0222 0.0265
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0023
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.336 0.455
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.1887 1
Echinococcus multilocularis smad 0.0052 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0058 0.0431 0.049
Brugia malayi nuclear hormone receptor 0.004 0.0222 0.0252
Brugia malayi nuclear receptor RXR 0.0045 0.0279 0.0317
Brugia malayi nuclear receptor NHR-67 0.004 0.0222 0.0252
Schistosoma mansoni retinoic acid receptor RXR 0.0085 0.0756 0.0903
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.002 0.0024
Echinococcus multilocularis protein patched 0.0045 0.028 0.028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.0756 0.086
Brugia malayi MH2 domain containing protein 0.0052 0.0361 0.041
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0222 0.0222
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.3011 0.3424
Trypanosoma brucei mitochondrial DNA polymerase beta 0.064 0.7384 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1071 0.3557
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0222 0.0252
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.0756 0.086
Mycobacterium ulcerans lipase LipD 0.0111 0.1071 0.2842
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0222 0.0265
Echinococcus granulosus Protein patched homolog 1 0.0045 0.028 0.0334
Brugia malayi latrophilin 2 splice variant baaae 0.0253 0.2757 0.3136
Brugia malayi CHE-14 protein 0.0045 0.028 0.0319
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0369 0.4152 0.4722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1379 0.1646
Toxoplasma gondii hypothetical protein 0.0103 0.0977 0.9118
Onchocerca volvulus 0.0111 0.1071 0.5628
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0222 0.0265
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0092
Brugia malayi hypothetical protein 0.0045 0.0279 0.0317
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0134 0.1248
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.0756 0.0903
Schistosoma mansoni hypothetical protein 0.0043 0.0261 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0756 0.086
Brugia malayi hypothetical protein 0.0036 0.017 0.0193
Echinococcus granulosus geminin 0.0723 0.8375 1
Schistosoma mansoni smad 0.0052 0.0361 0.0431
Schistosoma mansoni smad1 5 8 and 0.0052 0.0361 0.0431
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.086
Onchocerca volvulus 0.004 0.0222 0.108
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0348 0.0348
Brugia malayi MH1 domain containing protein 0.0052 0.0361 0.041
Brugia malayi Importin beta-1 subunit 0.0029 0.0094 0.0106
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0431 0.049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0471 0.4394
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Entamoeba histolytica hypothetical protein 0.0109 0.1049 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Echinococcus multilocularis GPCR, family 2 0.0117 0.1139 0.1139
Echinococcus granulosus zinc finger transcription factor gli2 0.031 0.3443 0.4111
Loa Loa (eye worm) hypothetical protein 0.0051 0.0348 0.0395
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0134 0.0181
Mycobacterium tuberculosis Conserved protein 0.0111 0.1071 0.1303
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.028 0.028
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.3472 0.3948
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.0756 0.0756
Brugia malayi ecdysteroid receptor 0.0085 0.0756 0.086
Brugia malayi nuclear receptor NHR-88 0.004 0.0222 0.0252
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0819 0.1109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1379 0.1379
Schistosoma mansoni hypothetical protein 0.0039 0.0215 0.0257
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0348 0.0348
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0431 0.0515
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0279 0.0333
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Schistosoma mansoni smad1 5 8 and 0.0052 0.0361 0.0431
Onchocerca volvulus 0.0085 0.0756 0.3942
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.3011 0.3424
Schistosoma mansoni hypothetical protein 0.0458 0.5203 0.6213
Trichomonas vaginalis ran, putative 0.0022 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0369 0.4152 0.4722
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Brugia malayi RNA recognition motif domain containing protein 0.0456 0.5185 0.5897
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0134 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.0756 0.086
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.1139 0.136
Echinococcus multilocularis geminin 0.0723 0.8375 0.8375
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0092
Schistosoma mansoni thyroid hormone receptor 0.0085 0.0756 0.0903
Schistosoma mansoni ran 0.0022 0.0001 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1071 0.1218
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2003 0.6653
Schistosoma mansoni Smad4 0.0023 0.002 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0175 0.1831 0.1831
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0222 0.0252
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Mycobacterium tuberculosis Possible penicillin-binding protein 0.071 0.822 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.0756 0.086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1049 0.1252
Schistosoma mansoni hypothetical protein 0.0043 0.0261 0.0311
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0085 0.0756 0.0903
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Brugia malayi Calcitonin receptor-like protein seb-1 0.0369 0.4152 0.4722
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0819 0.1109
Brugia malayi Steroid receptor seven-up type 2 0.0175 0.1831 0.2082
Loa Loa (eye worm) nuclear factor I 0.0029 0.0085 0.0097
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0222 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0456 0.5185 0.6191
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0134 0.6212
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.0993 0.1129
Schistosoma mansoni hypothetical protein 0.0117 0.1139 0.136
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0348 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0756 0.086
Brugia malayi CXXC zinc finger family protein 0.0032 0.0128 0.0145
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0001 0.0002
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0222 0.0265
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0279 0.0317
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.0756 0.0903
Echinococcus multilocularis protein dispatched 1 0.0051 0.0356 0.0356
Echinococcus multilocularis zinc finger transcription factor gli2 0.031 0.3443 0.3443
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0134 0.0181
Brugia malayi hypothetical protein 0.004 0.0222 0.0252
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0756 0.0903
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0222 0.0265
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1071 0.145
Entamoeba histolytica Ran family GTPase 0.0022 0.0001 0.0013
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0348 0.0415
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.1139 0.1295
Schistosoma mansoni hypothetical protein 0.0109 0.1049 0.1252
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1379 0.1646
Brugia malayi Smad1 0.0052 0.0361 0.041
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1887 0.6269
Schistosoma mansoni tar DNA-binding protein 0.0456 0.5185 0.6191
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0134 0.1248
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0361 0.041
Loa Loa (eye worm) hypothetical protein 0.0117 0.1139 0.1295
Brugia malayi mbt repeat family protein 0.0051 0.0348 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.0085 0.0756 0.3942
Schistosoma mansoni hypothetical protein 0.0117 0.1139 0.136
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.0756 0.0903
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0134 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2003 0.6653
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.3011 1
Schistosoma mansoni Smad4 0.0023 0.002 0.0024
Brugia malayi hypothetical protein 0.0036 0.017 0.0193
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0361 0.0431
Toxoplasma gondii ABC1 family protein 0.0111 0.1071 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1071 0.1218
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0279 0.0279
Brugia malayi MH1 domain containing protein 0.0052 0.0361 0.041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.0756 0.0903
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.064 0.7384 1
Schistosoma mansoni nuclear hormone receptor 0.004 0.0222 0.0265
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.002 0.0023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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