Detailed information for compound 56914

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 519.571 | Formula: C21H17N3O7S3
  • H donors: 2 H acceptors: 7 LogP: 2.06 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)/C=C/[S+](c1ccc(cc1)[N+](=O)[O-])[O-])Cc1cccs1
  • InChi: 1S/C21H17N3O7S3/c25-16(10-14-2-1-8-32-14)22-17-19(26)23-18(21(27)28)12(11-33-20(17)23)7-9-34(31)15-5-3-13(4-6-15)24(29)30/h1-9,17,20H,10-11H2,(H,22,25)(H,27,28)/b9-7+/t17-,20-,34?/m1/s1
  • InChiKey: JHKRJCXODDQCSE-GZIDQUEZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi beta-lactamase 0.0038 0.0254 0.0239
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0053
Echinococcus multilocularis 0.0039 0.0265 0.0302
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0056 0.0165
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Mycobacterium ulcerans hypothetical protein 0.0038 0.0254 0.3534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Schistosoma mansoni gliotactin 0.0046 0.0341 0.0733
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Carboxylesterase family protein 0.0272 0.2716 0.2705
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0782 0.0891
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Brugia malayi photoreceptor-specific nuclear receptor 0.0161 0.1554 0.1541
Mycobacterium tuberculosis Conserved protein 0.0038 0.0254 0.0903
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0341 0.1081
Brugia malayi beta-lactamase family protein 0.0038 0.0254 0.0239
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0056 1
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0132 0.015
Schistosoma mansoni cytochrome P450 0.0039 0.0265 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0254 0.0903
Onchocerca volvulus 0.0038 0.0254 0.1337
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0849 0.8772 1
Onchocerca volvulus 0.0076 0.0658 0.3723
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0161 0.1554 0.3567
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0161 0.1554 0.1541
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0265 0.0948
Plasmodium vivax vivapain-2 0.0019 0.0056 0.0123
Loa Loa (eye worm) carboxylesterase 0.0272 0.2716 0.2716
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0265 0.0948
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0265 0.372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0161 0.1554 0.1554
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0622 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0161 0.1554 0.1772
Echinococcus granulosus jun protein 0.0088 0.0782 0.2103
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0032 0.0016
Leishmania major cathepsin L-like protease 0.0072 0.061 0.9784
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0057 0.0029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0161 0.1554 0.1772
Echinococcus granulosus ecdysone induced protein 78C 0.0161 0.1554 0.4181
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0254 0.0254
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0361 0.0361
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0341 0.1274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0161 0.1554 0.1554
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0056 0.015
Schistosoma mansoni lamin 0.0028 0.0152 0.0289
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0057 0.0028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0085 0.0754 0.0754
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0076 0.0658 0.075
Schistosoma mansoni nuclear hormone receptor 0.0161 0.1554 0.3567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0161 0.1554 0.1541
Schistosoma mansoni hypothetical protein 0.0039 0.0265 0.0554
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Mycobacterium leprae putative cytochrome p450 0.0039 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Echinococcus granulosus geminin 0.0367 0.3717 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0152 0.0152
Echinococcus granulosus thyroid hormone receptor alpha 0.0076 0.0658 0.1771
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0341 0.1081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0361 0.0361
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0658 0.0644
Loa Loa (eye worm) acetylcholinesterase 1 0.0272 0.2716 0.2716
Onchocerca volvulus 0.0019 0.0056 0.0165
Schistosoma mansoni hypothetical protein 0.0303 0.3046 0.7054
Mycobacterium tuberculosis Conserved protein 0.0038 0.0254 0.0903
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0265 0.372
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0678 0.1519
Schistosoma mansoni intermediate filament proteins 0.0028 0.0152 0.0289
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1925 0.5178
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0254 0.3534
Echinococcus granulosus acetylcholinesterase 0.0272 0.2716 0.7308
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0658 0.075
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0161 0.1554 0.9013
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0254 0.0752
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0161 0.1554 0.1541
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0574 0.1276
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0028
Brugia malayi hypothetical protein 0.0069 0.0583 0.0569
Brugia malayi Carboxylesterase family protein 0.0046 0.0341 0.0326
Onchocerca volvulus 0.0046 0.0341 0.1852
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0265 0.0948
Mycobacterium ulcerans beta-lactamase 0.0038 0.0254 0.3534
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0455 0.0519
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0455 0.0441
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0406 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) cysteine protease 0.0019 0.0056 0.0056
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0265 0.372
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.2387 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0658 0.3723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0057 0.0029
Loa Loa (eye worm) carboxylesterase 0.0046 0.0341 0.0341
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0057 0.0057
Onchocerca volvulus Bile acid receptor homolog 0.0161 0.1554 0.9013
Echinococcus multilocularis cysteine protease 0.0019 0.0056 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0265 0.0948
Loa Loa (eye worm) cytochrome P450 0.0039 0.0265 0.0265
Onchocerca volvulus 0.0046 0.0341 0.1852
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0262 0.2611 0.7025
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0265 0.0948
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0265 0.372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.0161 0.1554 0.1541
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0057 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0161 0.1554 0.4181
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0265 0.372
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0058 0.0035
Entamoeba histolytica hypothetical protein 0.0026 0.0132 0.1219
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0265 0.0948
Brugia malayi hypothetical protein 0.0046 0.0341 0.0326
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0057 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0161 0.1554 0.1541
Schistosoma mansoni hypothetical protein 0.0078 0.0678 0.1519
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0658 0.075
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0132 0.1465
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0265 0.0948
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.9148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi nuclear receptor NHR-88 0.0161 0.1554 0.1541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0053
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0073 0.0622 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0265 0.0948
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0057 0.0069
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0622 0.1674
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0132 0.0242
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0406 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Echinococcus multilocularis FTZ F1 alpha 0.0161 0.1554 0.1772
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0265 0.372
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0028 0.0075
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0073 0.0622 0.0709
Echinococcus multilocularis cysteine protease 0.0019 0.0056 0.0064
Mycobacterium ulcerans lipase LipD 0.0038 0.0254 0.3534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0161 0.1554 0.4181
Onchocerca volvulus 0.0019 0.0056 0.0165
Echinococcus multilocularis nuclear receptor nhr 48 0.0076 0.0658 0.075
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0028 0.000000022945
Echinococcus granulosus death domain containing protein 0.0016 0.0028 0.0075
Onchocerca volvulus 0.005 0.0383 0.2097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0254 0.029
Schistosoma mansoni thyroid hormone receptor 0.0423 0.4306 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0073 0.0622 0.1389
Onchocerca volvulus 0.0076 0.0658 0.3723
Brugia malayi Cytochrome P450 family protein 0.0048 0.0361 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Brugia malayi hypothetical protein 0.0078 0.0678 0.0663
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.1158
Brugia malayi Cytochrome P450 family protein 0.0039 0.0265 0.025
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0029 0.0003
Brugia malayi hypothetical protein 0.0085 0.0754 0.074
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0132 0.0354
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0161 0.1554 0.4181
Loa Loa (eye worm) hypothetical protein 0.0272 0.2716 0.2716
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0073 0.0622 0.2472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0161 0.1554 0.1554
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0254 0.3583
Loa Loa (eye worm) hypothetical protein 0.005 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.1554 0.4181
Onchocerca volvulus 0.0019 0.0056 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0265 0.0948
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0361 0.5512
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0161 0.1554 0.1541
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0028 0.0032
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0057 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0254 0.0752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Echinococcus multilocularis neuroligin 0.0046 0.0341 0.0389
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0161 0.1554 0.3567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0161 0.1554 0.1554
Schistosoma mansoni nuclear receptor nhr-48 0.0076 0.0658 0.1474
Brugia malayi hypothetical protein 0.0076 0.0658 0.0644
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0265 0.3774
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1821 0.6684
Brugia malayi nuclear hormone receptor 0.0161 0.1554 0.1541
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0161 0.1554 0.3567
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0383 0.083
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0254 0.0903
Loa Loa (eye worm) beta-lactamase 0.0038 0.0254 0.0254
Onchocerca volvulus 0.0069 0.0583 0.3281
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0028 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0161 0.1554 0.3567
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Leishmania major cathepsin L-like protease 0.0072 0.061 0.9784
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0341 0.0733
Leishmania major cytochrome p450-like protein 0.0039 0.0265 0.3692
Brugia malayi Carboxylesterase family protein 0.0046 0.0341 0.0326
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0254 0.9276
Schistosoma mansoni hypothetical protein 0.0036 0.0233 0.048
Schistosoma mansoni hypothetical protein 0.0054 0.0421 0.0918
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0057 0.0042
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0057 0.0028
Leishmania major cathepsin L-like protease 0.0072 0.061 0.9784
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0254 0.0903
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0053 0.5
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0032 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0161 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Brugia malayi mbt repeat family protein 0.005 0.0383 0.0368
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0085 0.0756 0.0756
Brugia malayi beta-lactamase family protein 0.0038 0.0254 0.0239
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Onchocerca volvulus 0.0019 0.0056 0.0165
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0254 0.0239
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0265 0.372
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0093 0.0679
Brugia malayi nuclear receptor NHR-88 0.0076 0.0658 0.0644
Brugia malayi small heat shock protein 0.0648 0.6661 0.6656
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0119 0.1019
Loa Loa (eye worm) DR-78 0.0076 0.0658 0.0658
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.1019
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.1158
Echinococcus multilocularis carboxylesterase 5A 0.0272 0.2716 0.3096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0076 0.0658 0.1474
Echinococcus multilocularis lamin dm0 0.0028 0.0152 0.0173
Echinococcus multilocularis geminin 0.0367 0.3717 0.4237
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0658 0.1474
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus multilocularis acetylcholinesterase 0.0272 0.2716 0.3096
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Echinococcus multilocularis thyroid hormone receptor alpha 0.0423 0.4306 0.4909
Schistosoma mansoni steroid hormone receptor ad4bp 0.0161 0.1554 0.3567
Echinococcus granulosus nuclear receptor nhr 48 0.0076 0.0658 0.1771
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0161 0.1554 0.3567
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0658 0.1474
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0152 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0254 0.0903
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0119 0.0326
Echinococcus multilocularis jun protein 0.0088 0.0782 0.0891
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.1554 0.1772
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0341 0.0733
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.9148
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0265 0.0948
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0341 0.0733
Onchocerca volvulus 0.0046 0.0341 0.1852
Brugia malayi nuclear receptor NHR-67 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0574 0.1276
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0085 0.0754 0.1698
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0574 0.1543
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0265 0.372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0658 0.1771
Brugia malayi ecdysteroid receptor 0.0161 0.1554 0.1541
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0966 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.9148
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0341 0.0918
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0057 0.0069
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.061 1
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0383 0.0383
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0119 0.1158
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0119 0.1158
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0449 0.7098
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0265 0.0948
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.2697 0.2697
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0076 0.0658 0.3723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0161 0.1554 0.1772
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0119 0.1158
Schistosoma mansoni retinoic acid receptor RXR 0.0265 0.2638 0.61
Brugia malayi nuclear hormone receptor 0.0076 0.0658 0.0644
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0057 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.1554 0.1772
Onchocerca volvulus 0.0028 0.0152 0.0731
Brugia malayi nuclear receptor RXR 0.0085 0.0754 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0254 0.3583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0161 0.1554 0.1541
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0265 0.0713
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0265 0.372
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0265 0.0948
Brugia malayi Carboxylesterase family protein 0.0272 0.2716 0.2705
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Schistosoma mansoni nuclear receptor 0.0076 0.0658 0.1474
Loa Loa (eye worm) MBCTL1 0.0057 0.0455 0.0455
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0383 0.103
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0265 0.372
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0073 0.0622 0.0607
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0161 0.1554 0.1772
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0119 0.0104
Brugia malayi intermediate filament protein 0.0028 0.0152 0.0136
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0056 0.0064
Schistosoma mansoni acetylcholinesterase 0.0046 0.0341 0.0733
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0009
Echinococcus multilocularis acetylcholinesterase 0.0272 0.2716 0.3096
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0254 0.0752
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0085 0.0754 0.086
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0341 0.0733
Schistosoma mansoni hypothetical protein 0.0262 0.2611 0.6037
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0132 0.1344
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0057 0.0065
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0341 0.0389
Brugia malayi Cytochrome P450 family protein 0.0039 0.0265 0.025
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0161 0.1554 0.1541
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0076 0.0658 0.0644
Entamoeba histolytica hypothetical protein 0.0078 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0076 0.0658 0.0644
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0254 0.0684
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0574 0.0654
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0341 0.0389
Brugia malayi Cathepsin L-like precursor 0.0019 0.0056 0.004
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0265 0.0948
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0341 0.5065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.1554 0.4181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0754 0.1698
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0455 0.0999
Mycobacterium tuberculosis Conserved protein 0.0038 0.0254 0.0903
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0265 0.0948
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0057 0.0154
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0254 0.0903
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0056 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0119 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0161 0.1554 0.1541
Trichomonas vaginalis esterase, putative 0.0038 0.0254 0.0752
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0179 0.1742 0.1986
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0265 1
Schistosoma mansoni coup transcription factor 0.0161 0.1554 0.3567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0161 0.1554 0.1554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0574 0.2265
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0383 0.0436
Brugia malayi mbt repeat family protein 0.005 0.0383 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0265 0.372
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0161 0.1554 0.3567
Schistosoma mansoni hypothetical protein 0.0367 0.3717 0.8622
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0056 0.0165
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0265 0.372
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0341 0.1274
Mycobacterium ulcerans hypothetical protein 0.0025 0.0119 0.1158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Loa Loa (eye worm) carboxylesterase 0.0046 0.0341 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0254 0.0752
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0678 0.0773
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0056 0.015
Schistosoma mansoni thyroid hormone receptor 0.0423 0.4306 1
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0028 0.0075
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1821 0.6684
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0076 0.0658 0.1771
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0265 0.4038
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.061 1
Onchocerca volvulus 0.0046 0.0341 0.1852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0161 0.1554 0.1541
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0383 0.083
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0093
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0056 0.0065
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0056 1
Onchocerca volvulus 0.0019 0.0056 0.0165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0032 0.0032
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0361 0.5413
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0057 0.0031
Brugia malayi Cytochrome P450 family protein 0.0048 0.0361 0.0346
Onchocerca volvulus 0.0019 0.0056 0.0165
Brugia malayi cytochrome P450 0.0039 0.0265 0.025
Echinococcus granulosus FTZ F1 alpha 0.0161 0.1554 0.4181
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0341 0.0733
Loa Loa (eye worm) hypothetical protein 0.0272 0.2716 0.2716
Loa Loa (eye worm) nuclear hormone receptor 0.0076 0.0658 0.0658
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0254 0.0752
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0265 0.372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Onchocerca volvulus 0.0161 0.1554 0.9013
Entamoeba histolytica hypothetical protein 0.0078 0.0678 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) ctsf protein 0.0019 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0161 0.1554 0.1554
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0265 0.372
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0265 0.372
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0383 0.2097
Schistosoma mansoni zinc finger protein 0.0076 0.0658 0.1474
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0132 0.0116
Brugia malayi hypothetical protein 0.0076 0.0658 0.0644
Echinococcus granulosus Nuclear hormone receptor HR96 0.0076 0.0658 0.1771
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0076 0.0658 0.075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0086
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0056 0.0064
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0057 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0383 0.0436
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0161 0.1554 0.9013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Brugia malayi bZIP transcription factor family protein 0.0088 0.0782 0.0767
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.061 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0341 0.0389
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0341 0.1274
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0161 0.1554 0.4181
Schistosoma mansoni hypothetical protein 0.0071 0.0609 0.1358
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0265 0.0265
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0265 0.3692
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0265 0.0948
Schistosoma mansoni jun-related protein 0.0071 0.0609 0.1358
Echinococcus granulosus neuroligin 0.0046 0.0341 0.0918
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0056 0.0065
Echinococcus granulosus Ankyrin 0.0016 0.0029 0.0079
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0754 0.074
Brugia malayi hypothetical protein 0.0085 0.0754 0.074
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0233 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0076 0.0658 0.1474
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0383 0.083
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0265 0.372
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0057 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0265 0.0948
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.1721 1
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0056 0.004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0265 0.0948
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0545 0.8824
Onchocerca volvulus 0.002 0.0068 0.024
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0254 1
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0254 0.0903
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0161 0.1554 0.1541
Schistosoma mansoni hypothetical protein 0.0367 0.3717 0.8622
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0057 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0161 0.1554 0.1541
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0053 0.0053
Onchocerca volvulus 0.0025 0.0119 0.0539
Leishmania major hypothetical protein, conserved 0.0038 0.0254 0.3506
Onchocerca volvulus 0.0019 0.0056 0.0165
Echinococcus granulosus acetylcholinesterase 0.0272 0.2716 0.7308
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0119 0.1158
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0265 0.372
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0574 1
Leishmania major cytochrome p450-like protein 0.0039 0.0265 0.3692
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0678 0.1823
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Brugia malayi conserved hypotetical protein 0.0076 0.0658 0.0644
Echinococcus granulosus GPCR family 2 0.0017 0.0032 0.0086
Toxoplasma gondii ABC1 family protein 0.0038 0.0254 0.3834
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Loa Loa (eye worm) fibroinase 0.0019 0.0056 0.0056
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0056 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0057 0.0028
Brugia malayi nuclear hormone receptor family member nhr-6 0.0076 0.0658 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Entamoeba histolytica hypothetical protein 0.0078 0.0678 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0455 0.0519
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0265 0.0948
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0119 0.0326
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus multilocularis musashi 0.0028 0.0152 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.112
Schistosoma mansoni nuclear receptor 0.0076 0.0658 0.1474
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0265 0.3756
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0489 0.0489
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0726 0.1953
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1925 0.2194
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0265 0.2638 0.7097
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0265 0.372
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0053 0.0045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0161 0.1554 0.1554
Onchocerca volvulus 0.0038 0.0254 0.1337
Loa Loa (eye worm) hypothetical protein 0.0025 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0038 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0057 0.0455 0.0455
Echinococcus granulosus cathepsin l1 0.0019 0.0056 0.015
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0056 0.0064
Echinococcus multilocularis Ankyrin 0.0016 0.0029 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0265 0.0948
Loa Loa (eye worm) hypothetical protein 0.0648 0.6661 0.6661
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0254 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0132 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1721 0.6305
Leishmania major cytochrome p450-like protein 0.0048 0.0361 0.5393
Brugia malayi Protein kinase domain containing protein 0.0016 0.0028 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0161 0.1554 0.1541
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0574 0.9145
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0262 0.2611 0.2976
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.2697 0.2686
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0383 0.103
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0265 0.372
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0265 0.372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0161 0.1554 0.1554
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0361 0.5499
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0782 0.2103
Plasmodium vivax vivapain-2 0.0019 0.0056 0.0123
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0265 0.0948
Onchocerca volvulus 0.0046 0.0341 0.1852
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0076 0.0658 0.0658
Brugia malayi nuclear receptor RXR 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Onchocerca volvulus 0.0028 0.0152 0.0731
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.0146
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0085 0.0754 0.2029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0161 0.1554 0.1541
Brugia malayi nuclear hormone receptor family member odr-7 0.0076 0.0658 0.0644
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0265 0.3774
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0254 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.061 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0254 0.0903
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.2697 1
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0028 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0056 0.0056
Brugia malayi tailless protein 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Mycobacterium leprae Probable lipase LipE 0.0038 0.0254 0.9276
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0341 0.0918
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0058 0.0036
Brugia malayi orphan nuclear receptor NR2E1 0.0076 0.0658 0.0644
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.061 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0726 0.0827
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0341 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0161 0.1554 0.1541
Schistosoma mansoni RAR-like nuclear receptor 0.0161 0.1554 0.3567
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0361 0.5512
Onchocerca volvulus 0.0038 0.0254 0.1337
Echinococcus multilocularis GPCR, family 2 0.0017 0.0032 0.0036
Echinococcus multilocularis lamin 0.0028 0.0152 0.0173
Entamoeba histolytica hypothetical protein 0.0078 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0754 0.074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi Uncoordinated protein 44 0.0016 0.0028 0.0012
Echinococcus granulosus carboxylesterase 5A 0.0272 0.2716 0.7308
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0658 0.1771
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0119 0.112
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0254 0.3565
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0254 0.3534
Echinococcus granulosus lamin 0.0028 0.0152 0.0408
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0057 0.0065
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0073 0.0622 1
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0132 0.1369
Echinococcus multilocularis ecdysone induced protein 78C 0.0161 0.1554 0.1772
Echinococcus granulosus lamin dm0 0.0028 0.0152 0.0408
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0119 0.1019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0265 0.3774
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0057 0.0154
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0455 0.1225
Brugia malayi Death domain containing protein 0.0016 0.0028 0.0012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0272 0.2716 0.6283
Brugia malayi Carboxylesterase family protein 0.0046 0.0341 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0057 0.0006
Brugia malayi ecdysone receptor 0.0076 0.0658 0.0644
Echinococcus granulosus intermediate filament protein 0.0028 0.0152 0.0408
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0455 0.1225
Schistosoma mansoni lamin 0.0028 0.0152 0.0289
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0057 0.0028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Brugia malayi Carboxylesterase family protein 0.0046 0.0341 0.0326
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0152 0.0152
Giardia lamblia GTOR 0.0019 0.0057 0.5
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0056 0.0165
Loa Loa (eye worm) hypothetical protein 0.0046 0.0341 0.0341
Brugia malayi steroid hormone receptor 0.0161 0.1554 0.1541

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) 0 ug ml-1 Antibacterial activity of compound was measured against S. aureus (MR) CEF1198 organism; Not determined ChEMBL. No reference
MIC (functional) = 0.5 ug ml-1 Antibacterial activity of compound was measured against S. aureus A9537 organism ChEMBL. No reference
MIC (functional) = 64 ug ml-1 Antibacterial activity of compound was measured against S. aureus (MR) A20699 organism ChEMBL. No reference
MIC (functional) = 64 ug ml-1 Antibacterial activity of compound was measured against E. coli A15119 organism ChEMBL. No reference
MIC (functional) = 64 ug ml-1 Antibacterial activity of compound was measured against K. pneumoniae A9432 organism ChEMBL. No reference
MIC (functional) = 64 ug ml-1 Antibacterial activity of compound was measured against E. coli A15119 organism ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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