Detailed information for compound 569256

Basic information

Technical information
  • TDR Targets ID: 569256
  • Name: 5-tetradecoxyfuran-2-carboxylic acid
  • MW: 324.455 | Formula: C19H32O4
  • H donors: 1 H acceptors: 2 LogP: 7.82 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCOc1ccc(o1)C(=O)O
  • InChi: 1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
  • InChiKey: CZRCFAOMWRAFIC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5-tetradecoxy-2-furancarboxylic acid
  • 5-myristyloxy-2-furoic acid
  • 5-(tetradecyloxy)-2-furancarboxylic acid
  • 54857-86-2
  • NCGC00165908-01
  • 2-Furancarboxylic acid, 5-(tetradecyloxy)-
  • 5-Tetradecyloxy-2-furonic acid
  • BRN 0539681
  • MDL 14514
  • Rmi 14514
  • 5-(Tetradecyloxy)-2-furoic acid
  • TOFA
  • RMI-14514

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3269 0.731
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0093 0.0112
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0341 0.0433
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.3269 0.7231
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.2049 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0093 0.0118
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0177 0.7863 0.954
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.1852 0.3911
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0301 0.0365
Loa Loa (eye worm) hypothetical protein 0.0023 0.0607 0.0519
Schistosoma mansoni hypothetical protein 0.0017 0.0332 0.0422
Schistosoma mansoni troponin I 0.0117 0.5027 0.6393
Echinococcus granulosus zinc finger protein 0.0023 0.0619 0.0751
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Echinococcus granulosus oncosphere protein Tso22e 0.0145 0.6352 0.7706
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.046 0.0871
Echinococcus granulosus transcription factor Dp 1 0.0046 0.1689 0.205
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0093 0.0112
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.2049 0.4666
Schistosoma mansoni DNA polymerase eta 0.0017 0.0341 0.0433
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0332 0.5
Echinococcus granulosus troponin i 0.0117 0.5027 0.6099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0093 0.0112
Loa Loa (eye worm) hypothetical protein 0.0117 0.5027 0.498
Schistosoma mansoni hypothetical protein 0.002 0.0466 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0301 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.046 0.0871
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0607 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0301 0.0383
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0341 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.1852 0.4102
Loa Loa (eye worm) hypothetical protein 0.0038 0.1284 0.1203
Mycobacterium ulcerans hypothetical protein 0.0023 0.0607 0.3277
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0716 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0607 0.0926
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0607 0.3277
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.4391 0.4338
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.1852 0.3911
Brugia malayi Troponin T 0.0069 0.2786 0.2718
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Loa Loa (eye worm) troponin 0.0069 0.2786 0.2718
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0607 0.3277
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0093 0.0112
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.1852 0.4217
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0093 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.1477 0.3232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0093 0.0112
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0301 0.0383
Loa Loa (eye worm) acetyltransferase 0.0177 0.7863 0.7843
Loa Loa (eye worm) hypothetical protein 0.0117 0.5027 0.498
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.4391 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0607 0.3277
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.046 0.0871
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.4391 0.5584
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0145 0.6352 0.7706
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0332 0.0242
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.4391 0.5327
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.209 0.2016
Leishmania major DNA polymerase eta, putative 0.0017 0.0341 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0607 0.3277
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0185 0.8242 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0301 0.0365
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0553 0.0671
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.209 0.2016
Echinococcus multilocularis dna polymerase eta 0.0017 0.0341 0.0413
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0093 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.1689 0.205
Loa Loa (eye worm) hypothetical protein 0.0069 0.2786 0.2718
Schistosoma mansoni troponin I 0.0117 0.5027 0.6393
Echinococcus multilocularis GPCR, family 2 0.0017 0.0332 0.0403
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0332 0.0242
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0341 0.4761
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0301 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Echinococcus granulosus dna polymerase eta 0.0017 0.0341 0.0413
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.4391 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0332 0.4633
Loa Loa (eye worm) hypothetical protein 0.0037 0.1276 0.1195
Schistosoma mansoni hypothetical protein 0.0017 0.0332 0.0422
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.4391 0.4338
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1738 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0093 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0242
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.2049 0.2486
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0093 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Brugia malayi hypothetical protein 0.0069 0.2786 0.2718
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.2049 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0287 0.4013
Loa Loa (eye worm) troponin T 0.0069 0.2786 0.2718
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0607 1
Schistosoma mansoni zinc finger protein 0.0023 0.0619 0.0787
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0093 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0607 0.0519
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0332 0.0403
Loa Loa (eye worm) hypothetical protein 0.0037 0.128 0.1198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0607 0.0657
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0332 0.0403
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0093 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1284 0.2785
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0093 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0093 0.0112
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0341 0.0413
Onchocerca volvulus Troponin I homolog 0.0117 0.5027 0.7883
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0607 0.3277
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0466 0.0376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0241
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.4391 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0093 0.0118
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.1168 0.1417
Trypanosoma brucei unspecified product 0.0042 0.1477 0.3232
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.4391 0.6867
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0093 0.0118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0093 0.0118
Echinococcus multilocularis troponin i 0.0117 0.5027 0.6099
Schistosoma mansoni coup transcription factor 0.0012 0.0093 0.0118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0716 0.1187
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0341 0.025
Loa Loa (eye worm) hypothetical protein 0.0223 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.1276 0.1623
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.1284 0.2785
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0607 0.3277
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.1168 0.1417
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0607 0.3277
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.3269 0.3966
Brugia malayi Bromodomain containing protein 0.0042 0.1478 0.1399
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0301 0.0365
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0093 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0332 0.0242
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.3269 0.3206
Schistosoma mansoni hypothetical protein 0.0017 0.0332 0.0422
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.1852 0.3911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0607 0.8479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0287 0.4013
Loa Loa (eye worm) hypothetical protein 0.0069 0.2765 0.2697
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0093 0.0112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0185 0.8242 1
Schistosoma mansoni hypothetical protein 0.0117 0.5027 0.6393
Brugia malayi acetyltransferase, GNAT family protein 0.0177 0.7863 0.7843
Brugia malayi Bromodomain containing protein 0.0077 0.3163 0.3099
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.1852 0.3911
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0287 0.4013
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0341 0.025
Schistosoma mansoni troponin I 0.0117 0.5027 0.6393
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0093 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0607 0.0519
Mycobacterium ulcerans DNA polymerase IV 0.005 0.1852 1
Schistosoma mansoni troponin I 0.0117 0.5027 0.6393
Loa Loa (eye worm) hypothetical protein 0.0017 0.0341 0.025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0301 0.0383
Loa Loa (eye worm) hypothetical protein 0.0023 0.0607 0.0519
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0093 0.0112
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0241
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3269 0.731
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0607 0.0519
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.2461 0.2986
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0287 0.4013
Schistosoma mansoni zinc finger protein 0.0015 0.0221 0.0281
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.1276 0.1195
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.3269 0.3206
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0553 0.0704
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0093 0.0112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0093 0.0118
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.3269 0.731
Loa Loa (eye worm) troponin I 0.0117 0.5027 0.498
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0093 0.0118
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0341 0.025
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.2049 1
Schistosoma mansoni troponin t invertebrate 0.0145 0.6352 0.8078
Echinococcus granulosus GPCR family 2 0.0017 0.0332 0.0403
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.2049 0.4666
Schistosoma mansoni hypothetical protein 0.0015 0.0221 0.0281
Trypanosoma brucei polo-like protein kinase 0.0104 0.4391 1
Brugia malayi Troponin T 0.0069 0.2786 0.2718
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0531 0.0443
Brugia malayi Troponin I 0.0117 0.5027 0.498
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0241
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.159 0.1512
Brugia malayi Troponin family protein 0.0117 0.5027 0.498
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.1852 0.4217
Brugia malayi PHD-finger family protein 0.0029 0.0864 0.0778
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0093 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.1852 0.4102
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0093 0.0112
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0145 0.6352 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0177 0.7863 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.3269 0.3966
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0093 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.2625 0.3339
Echinococcus granulosus dna polymerase kappa 0.005 0.1852 0.2247
Treponema pallidum bacterioferrin (TpF1) 0.001 0 0.5
Giardia lamblia Kinase, PLK 0.0104 0.4391 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.2461 0.2986
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0093 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Echinococcus multilocularis dna polymerase kappa 0.005 0.1852 0.2247
Schistosoma mansoni kinase 0.0053 0.1995 0.2537
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0607 0.0657
Schistosoma mansoni hypothetical protein 0.0017 0.0332 0.0422
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0341 0.0433
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.3269 0.7395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0241
Onchocerca volvulus 0.0023 0.0607 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0716 0.1464
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0553 0.0671
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.4391 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.7523 0.9128
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0341 0.0413
Brugia malayi Troponin T 0.0069 0.2786 0.2718
Loa Loa (eye worm) hypothetical protein 0.0017 0.0301 0.0211
Brugia malayi polk-prov protein 0.0038 0.1284 0.1203
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.193 0.4396
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0093 0.0112
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1738 0.2783
Echinococcus multilocularis zinc finger protein 0.0023 0.0619 0.0751
Loa Loa (eye worm) hypothetical protein 0.0023 0.0607 0.0519
Trypanosoma brucei ISWI complex protein 0.0015 0.0221 0.0314
Loa Loa (eye worm) hypothetical protein 0.0046 0.1678 0.16
Leishmania major DNA polymerase kappa, putative 0.0025 0.0716 0.1187
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0332 0.1791
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0069 0.2786 0.4303
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0341 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0332 0.0241
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.3269 0.4158
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1738 0.3451
Mycobacterium ulcerans DNA polymerase IV 0.005 0.1852 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0607 0.8479
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.4391 0.5327
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0093 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.1852 0.4102
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.193 0.4396
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0607 0.0926
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.4391 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0607 0.0926

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 11.9173 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485290, AID485312, AID504464, AID504474] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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