TDR Targets

Basic information

Technical information

TDR Targets ID: 569291
Name: (2S)-2-amino-5-ureido-pentanoic acid; 2-hydro xybutanedioic acid
MW: 309.273 | Formula: C10H19N3O8
H donors: 7 H acceptors: 8 LogP: -5.24 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)CC(C(=O)O)O.NC(=O)NCCC[C@@H](C(=O)O)N
InChi: 1S/C6H13N3O3.C4H6O5/c7-4(5(10)11)2-1-3-9-6(8)12;5-2(4(8)9)1-3(6)7/h4H,1-3,7H2,(H,10,11)(H3,8,9,12);2,5H,1H2,(H,6,7)(H,8,9)/t4-;/m0./s1
InChiKey: DROVUXYZTXCEBX-WCCKRBBISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2S)-2-amino-5-ureidopentanoic acid; 2-hydroxybutanedioic acid
(2S)-5-(aminocarbonylamino)-2-azanyl-pentanoic acid; 2-hydroxybutanedioic acid
(2S)-2-amino-5-ureido-valeric acid; 2-hydroxysuccinic acid
(2S)-2-amino-5-(carbamoylamino)pentanoic acid; 2-hydroxybutanedioic acid
citrulline malate
(2S)-2-amino-5-(aminocarbonylamino)pentanoic acid; 2-hydroxybutanedioic acid
54940-97-5
Citrulline malate (salt)
L-Ornithine, N5-(aminocarbonyl)-, mono(+-)-hydroxybutanedioate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0685	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Echinococcus granulosus	GPCR family 2	0.0017	0.0395	0.0479
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0104	0.4428	0.4428
Echinococcus multilocularis	zinc finger protein	0.0019	0.0493	0.0598
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0685	0.5
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0407	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.2142	0.2142
Schistosoma mansoni	bromodomain containing protein	0.0063	0.2516	0.3947
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0407	0.5
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0376	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0685	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0407	0.0407
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0395	0.0479
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0685	0.0942
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.1333	0.1333
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0376	0.059
Giardia lamblia	Kinase, PLK	0.0104	0.4428	0.5
Schistosoma mansoni	hypothetical protein	0.002	0.0542	0.085
Brugia malayi	MH2 domain containing protein	0.013	0.5647	0.5647
Brugia malayi	hypothetical protein	0.0069	0.2833	0.2833
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.125	0.1515
Loa Loa (eye worm)	hypothetical protein	0.007	0.2861	0.2861
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0407	0.139
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0685	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0685	0.0685
Brugia malayi	Bromodomain containing protein	0.0074	0.3059	0.3059
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1333	0.1333
Echinococcus granulosus	zinc finger protein	0.0019	0.0493	0.0598
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0685	0.0685
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.5647	0.5647
Onchocerca volvulus	Troponin T, skeletal muscle homolog	0.0145	0.6376	1
Loa Loa (eye worm)	troponin	0.0069	0.2833	0.2833
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0407	0.0407
Schistosoma mansoni	troponin I	0.0117	0.5059	0.7936
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0685	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0395	0.0395
Onchocerca volvulus	Troponin I homolog	0.0117	0.5059	0.7687
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0685	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1473	0.1473
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0685	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.5647	0.5647
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0104	0.4428	0.6577
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.4428	1
Brugia malayi	Troponin T	0.0069	0.2833	0.2833
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2833	0.2833
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0395	0.0479
Loa Loa (eye worm)	troponin T	0.0069	0.2833	0.2833
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.125	0.1515
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0407	0.0407
Brugia malayi	Troponin I	0.0117	0.5059	0.5059
Echinococcus granulosus	troponin i	0.0117	0.5059	0.613
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0685	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0631	0.0764
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.2351	0.2848
Loa Loa (eye worm)	hypothetical protein	0.0117	0.5059	0.5059
Schistosoma mansoni	troponin t invertebrate	0.0145	0.6376	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0185	0.8254	1
Schistosoma mansoni	kinase	0.0053	0.2047	0.3211
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0631	0.0989
Brugia malayi	Troponin T	0.0069	0.2833	0.2833
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0405	0.0405
Brugia malayi	Troponin T	0.0069	0.2833	0.2833
Schistosoma mansoni	hypothetical protein	0.0017	0.0395	0.062
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0376	0.0456
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0376	0.0456
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0376	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0223	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.5059	0.5059
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0376	0.0376
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0376	0.059
Schistosoma mansoni	troponin I	0.0117	0.5059	0.7936
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0376	0.059
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0395	0.0395
Brugia malayi	Bromodomain containing protein	0.0038	0.136	0.136
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0685	0.0942
Schistosoma mansoni	hypothetical protein	0.0037	0.1333	0.2091
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0685	0.0685
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0685	0.0685
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0104	0.4428	0.5364
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0407	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0395	0.062
Brugia malayi	serine/threonine-protein kinase plk-2	0.0104	0.4428	0.4428
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Schistosoma mansoni	troponin I	0.0117	0.5059	0.7936
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0407	0.0407
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0542	0.0542
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.2142	0.2142
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0685	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0185	0.8254	1
Schistosoma mansoni	zinc finger protein	0.0015	0.0295	0.0463
Brugia malayi	PHD-finger family protein	0.0025	0.074	0.074
Schistosoma mansoni	hypothetical protein	0.0017	0.0395	0.062
Trypanosoma brucei	polo-like protein kinase	0.0104	0.4428	1
Echinococcus multilocularis	troponin i	0.0117	0.5059	0.613
Echinococcus granulosus	oncosphere protein Tso22e	0.0145	0.6376	0.7725
Schistosoma mansoni	hypothetical protein	0.0017	0.0395	0.062
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.4428	1
Brugia malayi	Troponin family protein	0.0117	0.5059	0.5059
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0104	0.4428	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0685	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1363	0.1363
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0685	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0685	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0376	0.059
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1561	0.1561
Schistosoma mansoni	hypothetical protein	0.0015	0.0295	0.0463
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0395	0.0395
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0395	0.0479
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0104	0.4428	1
Schistosoma mansoni	zinc finger protein	0.0019	0.0493	0.0774
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0631	0.0764
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0395	0.0395
Trypanosoma cruzi	polo-like protein kinase, putative	0.0104	0.4428	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0104	0.4428	0.5364
Schistosoma mansoni	troponin I	0.0117	0.5059	0.7936
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.4428	0.6945
Schistosoma mansoni	hypothetical protein	0.0117	0.5059	0.7936
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0407	0.0407
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0685	1
Loa Loa (eye worm)	troponin I	0.0117	0.5059	0.5059
Onchocerca volvulus	Troponin T, skeletal muscle homolog	0.0069	0.2833	0.3776
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.2351	0.2848
Echinococcus multilocularis	oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22	0.0145	0.6376	0.7725
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0685	0.0942
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0685	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 162762

Bibliographic References

No literature references available for this target.

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Detailed information for compound 569291