Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.7434 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2525 | 0.3396 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0458 | 0.0458 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0458 | 0.0616 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.6352 | 0.8543 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7434 | 0.7434 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.289 | 0.2252 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.6747 | 0.6747 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.6352 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.7434 | 0.7204 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.6352 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.7434 | 0.7204 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.6352 | 0.8543 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2901 | 0.2783 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.6194 | 0.8332 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.6194 | 0.8332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7434 | 0.7434 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.7434 | 0.7392 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7434 | 0.7434 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7434 | 0.7434 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.8556 | 0.8426 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0458 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.7896 | 0.7861 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0163 | 0.0163 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2525 | 0.3396 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.6352 |
Schistosoma mansoni | eyes absent homolog | 0.0085 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.7434 | 0.7434 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3267 | 0.3155 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.7434 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.7434 | 0.7392 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3562 | 0.3455 |
Brugia malayi | RNA binding protein | 0.0069 | 0.7434 | 0.7204 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.6352 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.7434 | 0.7392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 21.6899 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.